EKS-TAR-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	355.2	5.3E-106	40	311	272

Status

Unreviewed

Ensembl Protein

ENSTRUP00000043300

UniProt Accession

H2V268;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000016904	ENSTRUP00000043301	ENSTRUT00000043446
ENSTRUG00000016904	ENSTRUP00000043302	ENSTRUT00000043447
ENSTRUG00000016904	ENSTRUP00000043300	ENSTRUT00000043445
ENSTRUG00000016904	ENSTRUP00000043299	ENSTRUT00000043444

Organism

Takifugu rubripes

Functional Description

Protein Length

1300

Protein Sequence
(FASTA)

MSLFQSALDF LAGPGSSGAA SRDQNDFVGQ VVELGDMKLR IKRVIAEGGF AFVYEAQDTS 60

SGKDYALKRL LSHEEEKNKE IIQEVCFMKK LSGHPNTVQF CSAASISKEE SDTGQAEFLI 120

LTELCKGQLV DFIKRVEQKA SLSCDTVLKI FYQACRAVQH MHKQKPPIIH RDLKIENLLI 180

SNQGTIKLCD FGSSTTVSHY PDYSWSAQKR SMVEDEITRN TTPAYRTPEM IDLYSNFPIN 240

EKQDIWALGC ILYLLCFKQH PFEDGAKLQI VNGKYSIPQN DVKYVVYHDL IRSMLKVNPE 300

ERLSITELVN LLQEIAAARN VNPKSPITEL LEQNGGFGNS AAQPPMPTQN LHNSAGVYDP 360

DQPGSGFLDI LKGGTERFLT NIKDTSSKVI QSVASYAKGD LDISYITSRI AVMSYPAEGV 420

ESAIKNNIED VRLFLDSRHA GHYAVYNLSR RSYRPSRFHN RVSECNWQLR RAPNLRSLFS 480

VCKNMHLWLK QDQRNICIVH CLDGKAASAV AVCSFLCFCR LFTTAEAAVY MFSMKRCPPG 540

ISPSHKRYIE YMCDMMAEEP IVPHCKPIII RSIVMTPVPL FNKQRNGCRP FCEVYVGDER 600

VLTTSQEYDR MRDFRMEDGK AEIPLNVTVQ GDVLVVIYHA RSTLGGRLQA KMASMKMFQI 660

QFHTGFVPRN ATTVKFAKYD LDACDIQEKY PDLFQVNLNI DVDPRDHPRT KSPPWEGFPT 720

KGLNPKILFS SRDEQQEILS KFGKPELPRQ PGSSAFYDAD SPQPVQTPEG SSANEPESPG 780

STDDNANNFF QTLDWEDVRC SQEASDSQGR GSMNDQDDLS DQSEGESFSY SAPSGEPLSR 840

KIPPPAAQEA PVSDTADLLG LNTDTQTSST ASSSAAHQGV QGGMKAATSN SNLLNDLFAP 900

PAGEAAPVQE DLLFNEPTGE AAATSKCSLK CLCDCVAAVG DFFDPFGMGT SSGVGSSQSS 960

GPDLFVDLLG SESSNAGKFP PTHANPAPSN SSLFDLNKLV NDTPKMTSSA SQPDLLGGWD 1020

SWATGKTASV SATTNKSSYT NTASGAPSMS KAKSQTFDPF ADLGNLGSNL PGSVPVCTSS 1080

GTSFSSKVPS SKPQAQPWQS GRPTTAPNKP WMSGSGPGSA KPPTVPPPTS TQHPKPNYNL 1140

NFSSVIGGRE ERGIRGPGFG PKPKVKEDDF EELLSTQGFA SRPDKKGPRT IAEMRREEMT 1200

KEIDPLQLQI LDWIEGKERN IRALMSTMHT VLWDETRWKP VGMSELVTPD QVKKYYRKAV 1260

LVVHPDKAAG KPYEEYAKMI FMELNDAWSE FENQGSKALF 1300

Nucleotide Sequence
(FASTA)

ATGTCTCTGT TTCAGTCGGC GTTGGATTTC CTAGCCGGGC CCGGCTCGTC GGGAGCGGCC 60

AGTCGGGACC AGAATGATTT CGTAGGACAG GTGGTTGAAC TCGGTGACAT GAAACTGAGG 120

ATAAAGAGGG TTATTGCGGA AGGTGGGTTT GCTTTTGTGT ACGAGGCCCA GGACACGAGC 180

AGCGGTAAAG ATTACGCTCT CAAGAGGCTG CTGTCTCATG AGGAAGAGAA GAACAAGGAA 240

ATCATACAGG AAGTCTGCTT CATGAAAAAG CTGTCGGGTC ATCCCAACAC GGTCCAGTTC 300

TGCTCCGCTG CATCCATCAG TAAGGAGGAG TCGGACACAG GCCAGGCTGA GTTCCTGATC 360

CTCACAGAGC TGTGTAAAGG TCAGCTGGTG GATTTTATCA AGAGGGTAGA GCAGAAGGCC 420

TCCCTTTCGT GCGACACGGT GTTGAAAATC TTCTACCAGG CGTGCCGCGC CGTCCAGCAC 480

ATGCACAAGC AGAAGCCTCC GATCATCCAC AGAGACCTCA AGATCGAGAA CCTCTTGATT 540

AGTAACCAGG GCACCATCAA GCTGTGTGAC TTCGGCAGCT CCACCACAGT GTCACATTAC 600

CCAGACTACA GCTGGTCGGC ACAGAAGAGG TCCATGGTGG AGGATGAGAT CACAAGAAAC 660

ACCACTCCTG CGTATCGAAC CCCAGAGATG ATCGACCTCT ACTCCAACTT CCCCATCAAT 720

GAGAAACAGG ACATCTGGGC CCTCGGATGC ATCCTCTACC TCTTGTGTTT TAAGCAGCAC 780

CCTTTCGAGG ATGGAGCCAA ACTGCAGATT GTCAACGGGA AATATTCCAT TCCGCAGAAC 840

GACGTCAAAT ACGTCGTCTA CCACGACCTC ATACGTTCTA TGTTGAAGGT GAACCCAGAG 900

GAGCGTCTGT CCATTACAGA GTTGGTCAAC CTGCTCCAGG AGATCGCAGC AGCACGCAAC 960

GTCAACCCCA AGTCCCCCAT TACAGAGCTG CTGGAGCAGA ACGGGGGTTT CGGCAACAGC 1020

GCAGCCCAGC CGCCCATGCC GACCCAAAAC CTCCACAACA GTGCAGGGGT TTATGACCCC 1080

GACCAGCCAG GCAGCGGCTT CTTGGATATC TTAAAGGGAG GAACAGAGCG CTTCCTGACC 1140

AACATTAAGG ACACGTCCTC CAAGGTCATC CAGTCCGTAG CCAGCTATGC CAAAGGGGAT 1200

CTGGATATTT CCTACATCAC TTCCAGAATA GCGGTCATGT CCTACCCAGC AGAAGGGGTG 1260

GAATCGGCTA TAAAGAACAA CATAGAGGAC GTACGGCTGT TCCTGGATTC ACGCCACGCT 1320

GGCCACTATG CTGTCTACAA CCTCTCCAGA CGATCATACA GGCCTTCCCG ATTCCATAAC 1380

AGAGTGTCTG AATGTAACTG GCAGCTGCGA CGTGCCCCCA ACCTGCGCAG TCTCTTCAGT 1440

GTGTGTAAGA ACATGCATCT GTGGCTCAAA CAGGACCAAA GGAACATCTG TATAGTTCAC 1500

TGTCTGGACG GCAAAGCGGC GTCGGCTGTG GCGGTTTGCT CCTTCCTGTG TTTCTGTCGC 1560

CTCTTCACCA CGGCTGAGGC GGCCGTCTAC ATGTTCTCCA TGAAGCGCTG CCCACCTGGC 1620

ATATCGCCCT CGCACAAGAG GTACATCGAG TACATGTGTG ACATGATGGC AGAAGAGCCC 1680

ATCGTTCCCC ACTGCAAGCC CATAATAATT CGTTCCATCG TCATGACTCC CGTACCTCTG 1740

TTCAACAAGC AAAGAAACGG CTGCAGGCCG TTCTGTGAGG TTTATGTAGG AGACGAGAGA 1800

GTCCTCACCA CATCCCAGGA ATACGACCGA ATGAGGGATT TTAGAATGGA AGACGGGAAG 1860

GCAGAGATAC CCCTTAATGT AACGGTCCAA GGAGATGTAC TGGTGGTGAT ATATCATGCA 1920

AGATCCACGC TGGGAGGTCG TCTGCAAGCC AAGATGGCGT CCATGAAGAT GTTTCAGATC 1980

CAGTTCCACA CCGGTTTTGT CCCCAGAAAC GCGACCACCG TCAAGTTTGC AAAGTATGAT 2040

TTAGATGCCT GCGACATACA GGAGAAGTAC CCAGACCTGT TCCAGGTGAA TTTGAACATT 2100

GACGTAGATC CCAGGGACCA TCCCAGGACC AAGAGCCCTC CCTGGGAGGG CTTCCCAACC 2160

AAGGGCCTCA ACCCCAAAAT CCTCTTCTCC TCACGTGATG AACAACAGGA GATACTCAGC 2220

AAATTTGGGA AACCGGAGCT ACCTCGTCAG CCGGGATCAT CAGCGTTTTA TGATGCCGAC 2280

TCCCCGCAGC CAGTTCAGAC CCCAGAAGGT TCCAGTGCAA ATGAACCAGA GTCTCCTGGG 2340

AGCACAGATG ATAACGCCAA CAACTTTTTC CAGACACTAG ATTGGGAAGA TGTGCGTTGC 2400

TCTCAAGAGG CCTCAGACAG TCAAGGGAGG GGCTCCATGA ATGACCAAGA TGATCTGAGT 2460

GATCAGTCTG AAGGAGAATC CTTTTCTTAC TCGGCCCCCA GTGGAGAGCC GCTGTCACGT 2520

AAGATCCCCC CTCCTGCAGC CCAGGAAGCT CCCGTCAGCG ACACGGCTGA CCTCCTGGGT 2580

TTGAACACGG ACACTCAAAC ATCTTCCACG GCTTCATCCT CTGCTGCCCA TCAAGGCGTT 2640

CAGGGAGGAA TGAAAGCTGC AACGAGCAAC AGTAACCTCC TCAATGACCT GTTTGCGCCC 2700

CCTGCTGGCG AGGCAGCCCC AGTACAGGAA GACTTGCTCT TCAATGAGCC AACAGGCGAG 2760

GCTGCAGCCA CTTCAAAATG CAGTCTAAAG TGTCTTTGTG ACTGTGTTGC AGCTGTGGGT 2820

GACTTCTTTG ATCCCTTTGG TATGGGAACC AGCTCTGGTG TTGGTTCCAG CCAGTCCTCT 2880

GGACCTGACC TGTTTGTAGA CTTATTGGGT TCTGAGAGTT CAAATGCTGG CAAATTTCCT 2940

CCAACCCACG CTAACCCCGC CCCATCCAAC TCAAGCCTCT TTGACCTCAA TAAACTAGTG 3000

AACGATACTC CTAAGATGAC CTCATCAGCC AGCCAGCCGG ACCTACTTGG TGGCTGGGAC 3060

AGCTGGGCCA CTGGGAAAAC TGCAAGTGTG AGTGCTACCA CTAACAAATC CAGCTATACT 3120

AACACAGCTT CTGGTGCACC ATCTATGTCA AAGGCCAAGT CTCAGACCTT TGATCCTTTT 3180

GCTGACCTGG GAAACCTGGG TTCCAATTTA CCAGGTAGCG TCCCTGTCTG CACTTCTTCT 3240

GGGACCTCTT TTAGCTCAAA GGTTCCTTCT TCAAAGCCTC AAGCCCAGCC CTGGCAGTCT 3300

GGAAGACCCA CCACAGCCCC AAACAAACCT TGGATGTCTG GGTCAGGACC TGGTTCAGCC 3360

AAACCACCCA CCGTGCCTCC GCCCACAAGC ACACAGCACC CCAAACCCAA CTACAACCTG 3420

AACTTCTCTT CTGTCATTGG TGGCAGAGAG GAGAGAGGGA TTCGTGGGCC AGGTTTTGGC 3480

CCCAAACCAA AGGTGAAGGA GGACGACTTT GAGGAGTTGC TGTCAACTCA GGGTTTTGCT 3540

TCAAGACCCG ATAAGAAGGG ACCAAGGACC ATAGCAGAAA TGAGACGGGA GGAGATGACG 3600

AAGGAAATAG ACCCACTTCA ATTACAGATT TTGGACTGGA TCGAAGGGAA GGAGCGAAAC 3660

ATCCGAGCGC TGATGTCGAC TATGCACACG GTGCTGTGGG ACGAGACCCG CTGGAAGCCC 3720

GTGGGCATGT CTGAGCTGGT GACGCCTGAT CAGGTGAAGA AATACTACAG GAAAGCTGTG 3780

CTGGTGGTCC ATCCAGATAA GGCGGCAGGA AAGCCGTATG AAGAGTATGC CAAGATGATC 3840

TTCATGGAAT TAAATGATGC CTGGTCAGAG TTTGAGAACC AGGGCTCCAA AGCGCTCTTC 3900

TGA 3903

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         ri++v+aeGGfa+vy a+d+s+g+ yalKr+l++eee+++ei++E+++mkklsgh+n v+

Q: 40    RIKRVIAEGGFAFVYEAQDTSSGKDYALKRLLSHEEEKNKEIIQEVCFMKKLSGHPNTVQ  99

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+l+l+e+ck g+lvd++++ ++k +ls++++lki+++ +rav

Q: 100   FCsaASISKEESDTGQAEFLILTELCK-GQLVDFIKRVEQKASLSCDTVLKIFYQACRAV  158

         **7667789999999************.8************99*****************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlk+eN+l+s++g+++lcD+GS tt ++ ++   s+q++s++++ei+

Q: 159   QHMHKQKPPIIHRDLKIENLLISNQGTIKLCDFGSSTTVSHYPDyswSAQKRSMVEDEIT  218

         *******************************************99999************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt+ yr+PE+idlysn++i+ek+DiWaLGc+lY lcf ++Pfe+++kl i+ngkysiP

Q: 219   RNTTPAYRTPEMIDLYSNFPINEKQDIWALGCILYLLCFKQHPFEDGAKLQIVNGKYSIP  278

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlel  269

         +n+  +   ++li++ml+v+peeR++i+++++l

Q: 279   QNDVKYVVYHDLIRSMLKVNPEERLSITELVNL  311

         *****************************9987

Domain Sequence
(FASTA)

RIKRVIAEGG FAFVYEAQDT SSGKDYALKR LLSHEEEKNK EIIQEVCFMK KLSGHPNTVQ 60

FCSAASISKE ESDTGQAEFL ILTELCKGQL VDFIKRVEQK ASLSCDTVLK IFYQACRAVQ 120

HMHKQKPPII HRDLKIENLL ISNQGTIKLC DFGSSTTVSH YPDYSWSAQK RSMVEDEITR 180

NTTPAYRTPE MIDLYSNFPI NEKQDIWALG CILYLLCFKQ HPFEDGAKLQ IVNGKYSIPQ 240

NDVKYVVYHD LIRSMLKVNP EERLSITELV NL 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013