EKS-TAR-00586

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00586

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.5	4.1E-102	20	318	299

Status

Unreviewed

Ensembl Protein

ENSTRUP00000043574

UniProt Accession

H2V2Z1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017013	ENSTRUP00000043572	ENSTRUT00000043717
ENSTRUG00000017013	ENSTRUP00000043573	ENSTRUT00000043718
ENSTRUG00000017013	ENSTRUP00000043574	ENSTRUT00000043719

Organism

Takifugu rubripes

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG NGLVFSAVDT DCDKRVAVKK IILTDPQSVK 60

HALREIKIIR RLDHDNIVKV FETLGPSGRR LTEDVVSLTE VNSVYIVQEY METDLCQLLE 120

RGLLSEGHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFV NTEDLVLKIG DFGLARIMDP 180

HYSHKIQGHL SEGLVTKWYR SPRLLLSPNN YTKAIDMWAA GCIFAEMLTG KTLFAGAHEL 240

EQMQLILESI PVLREEDRQE LHSVIPVFIR NDMSKPHTPL AKLLPDVSPQ ALDFLEKILT 300

FNPMDRLTAE EALAHPYMAD YSFPLDEPVS LHPFHIEDEV DDILLMDQSH SHTWDSCASR 360

CHESQLSEAD WHLHSIHDPD EVQVDPRGLS DVTDEEEVQV DPRKYADGDW EKFLDEPSFD 420

YSLHFLPDRS CHTCNYKAVS PSYLDNLIWR DSEVNHYYEP KLIIDLSNWK E 471

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTTTGAGTC CCTGATGAAC ATCCATGGTT TTGACCTGGG TTCCCGCTAC 60

ATGGACTTAA AGCCACTTGG TTATGGAGGG AATGGCCTGG TCTTCTCCGC CGTCGACACG 120

GATTGTGATA AGCGTGTGGC TGTGAAGAAA ATAATCTTGA CTGACCCGCA GAGTGTGAAG 180

CATGCCCTGC GGGAAATCAA GATCATCAGA CGCCTCGATC ATGATAACAT TGTCAAGGTT 240

TTTGAGACAT TGGGCCCTAG TGGTCGCAGG CTAACGGAGG ATGTGGTGTC CCTGACGGAG 300

GTTAACTCGG TGTACATTGT GCAAGAGTAC ATGGAGACAG ACCTTTGTCA ATTGTTGGAG 360

AGGGGCCTTC TTTCAGAGGG CCATGCCAGA CTCTTCATGT ACCAGCTCCT CAGGGGCCTT 420

AAGTATATCC ACTCTGCTAA CGTGCTGCAC CGAGACCTCA AGCCCGCTAA CTTGTTTGTC 480

AATACGGAAG ACCTGGTACT TAAGATTGGG GACTTTGGCC TGGCTCGCAT CATGGACCCC 540

CACTATTCTC ACAAGATACA GGGCCATCTT TCAGAGGGCC TAGTCACCAA GTGGTATAGA 600

TCGCCCCGTC TGCTGCTCTC TCCTAATAAC TACACCAAAG CCATCGACAT GTGGGCAGCT 660

GGCTGCATCT TTGCCGAGAT GCTCACAGGG AAAACCCTCT TTGCTGGTGC CCACGAGCTG 720

GAGCAGATGC AGCTGATCCT GGAGTCCATA CCTGTGCTGC GGGAAGAAGA CCGCCAAGAG 780

CTCCACAGCG TCATCCCGGT CTTCATTCGT AACGATATGT CCAAGCCTCA CACACCACTA 840

GCCAAGCTGC TGCCTGATGT CTCTCCCCAG GCCTTGGATT TCTTGGAGAA GATCTTGACG 900

TTTAACCCCA TGGACCGCCT GACTGCTGAA GAGGCCCTGG CCCACCCCTA TATGGCTGAC 960

TACTCCTTCC CTTTAGATGA GCCAGTCTCT CTGCACCCCT TCCACATAGA GGATGAAGTA 1020

GATGATATCC TGCTTATGGA CCAGAGCCAC AGCCACACCT GGGACAGTTG TGCTAGCAGA 1080

TGTCATGAAA GTCAGCTCTC TGAGGCTGAC TGGCACCTAC ACAGCATCCA CGACCCAGAT 1140

GAAGTTCAGG TTGACCCAAG AGGACTCTCT GATGTAACAG ATGAAGAGGA GGTTCAGGTG 1200

GATCCTCGCA AATATGCTGA TGGAGATTGG GAGAAGTTCC TGGATGAGCC ATCCTTTGAC 1260

TACTCCCTTC ATTTCCTTCC AGACAGATCC TGCCATACGT GTAACTACAA GGCCGTGTCA 1320

CCCTCATACC TAGACAACCT CATCTGGAGG GACAGTGAAG TCAACCACTA CTACGAACCC 1380

AAGCTCATTA TTGACCTCTC CAACTGGAAG GAA 1413

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk+   +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGNGLVFSAVDTDCDKRVAVKKII--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++ + p+         +l+e+++vY+v+e+metdL++++++  ls+ h++l++yq+l

Q: 78    VKVFETLGPSGrrltedvvSLTEVNSVYIVQEYMETDLCQLLERGLLSEGHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk....lteyvatr  167

         rglky+Hsanv+HrDlKP+Nl+vn++   lki dFGlar++d+++++k    l+e ++t+

Q: 138   RGLKYIHSANVLHRDLKPANLFVNTEDLvLKIGDFGLARIMDPHYSHKiqghLSEGLVTK  197

         ************************876449**************99999999********

S: 168   wYraPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseef  227

         wYr+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++  +ee+

Q: 198   WYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVLREED  257

         ************************************************************

S: 228   lkkieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehp  287

          ++++s  +  +i++ ++k+++++++l+p+ s++ald+lek+L+++p++R+++eeaL+hp

Q: 258   RQELHSV-IPVFIRNDMSKPHTPLAKLLPDVSPQALDFLEKILTFNPMDRLTAEEALAHP  316

         ******5.****************************************************

S: 288   Yl  289

Y+

Q: 317   YM  318

*7

Domain Sequence
(FASTA)

YMDLKPLGYG GNGLVFSAVD TDCDKRVAVK KIILTDPQSV KHALREIKII RRLDHDNIVK 60

VFETLGPSGR RLTEDVVSLT EVNSVYIVQE YMETDLCQLL ERGLLSEGHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF VNTEDLVLKI GDFGLARIMD PHYSHKIQGH LSEGLVTKWY 180

RSPRLLLSPN NYTKAIDMWA AGCIFAEMLT GKTLFAGAHE LEQMQLILES IPVLREEDRQ 240

ELHSVIPVFI RNDMSKPHTP LAKLLPDVSP QALDFLEKIL TFNPMDRLTA EEALAHPYM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013