EKS-TAR-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	453.6	4.6E-136	1099	1358	260

Status

Unreviewed

Ensembl Protein

ENSTRUP00000043860

UniProt Accession

H2V3S7;

Protein Name

Protein Synonyms/Alias

Gene Name

PRGFR1

Gene Synonyms/Alias

PRGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017114	ENSTRUP00000043862	ENSTRUT00000044008
ENSTRUG00000017114	ENSTRUP00000043863	ENSTRUT00000044009
ENSTRUG00000017114	ENSTRUP00000043854	ENSTRUT00000044000
ENSTRUG00000017114	ENSTRUP00000043860	ENSTRUT00000044006
ENSTRUG00000017114	ENSTRUP00000043855	ENSTRUT00000044001
ENSTRUG00000017114	ENSTRUP00000043861	ENSTRUT00000044007
ENSTRUG00000017114	ENSTRUP00000043856	ENSTRUT00000044002
ENSTRUG00000017114	ENSTRUP00000043857	ENSTRUT00000044003
ENSTRUG00000017114	ENSTRUP00000043858	ENSTRUT00000044004
ENSTRUG00000017114	ENSTRUP00000043859	ENSTRUT00000044005

Organism

Takifugu rubripes

Functional Description

Protein Length

1401

Protein Sequence
(FASTA)

RMNLCSFPAA VLLLWALSAS AEGHCQKSPE PNKLNLSVSY ELPTFTAEFP IQNVVTLDGI 60

IYVGATNRIY ALAPSLTKLS EYRTGPLLAN QTCGQKVANA SSGGGRKDNL NVALVVENIY 120

DKGLFSCGSA DNGVCRRHVL EDDVSLDEEG RQKSVDELVY CFTDLKQDKG QPRDSDVVVS 180

PSGSQVLNVE SNMIMFFVGN SEIPGSGNVT GPTARPHTMS LRKMKTSQNG FTFFSNRSYM 240

DLIPPLRGSY YLRYVYSFHS GPFTYFLTVQ QVSKDSQTYH TRIVRMCSSD HDIRRYVEMP 300

LECISTDKRR RRSMEDVKVF NILQAATVTK VGSDVELQRQ LRLEEGDDVL FAAFARGKPN 360

STEATPNSAI CVMSLKLINS MFKMYMQKCN TVDLYHFTGS DKKSCYNVKL SRRENPAMFC 420

KGKEGKYRLQ VTQFVQRLEY WQKVLTNTLV TSITVVTVHG RAVGYLGTAD GRHIQVKVAF 480

SRFASPHVNI RLDSRPVSGS VVLPGQDPSE GALLLTTGNK ITKVPLIGPG CDHLTTCTSC 540

LVSSRVTECG WCEGRCTRAN QCPPSVWTQE YCTPVVTKVF PTSGPIRGST TVTMCGRNFG 600

FDKTESFKAS LVTVEVAGVP CKLSRQDYAS RWTEIQCSPM FSGNFMPSGH TVKVTSGHKI 660

ATIEGFTFVD PVVSEIFPTF GPKSGNTMLT IRGAFLDTGN KREVTVGKAA CKIQSLSATM 720

LTCKTPPHAV PSKQPVRLTV DSVARDAPVL YTYHQDPIIS SIQPSRSFVS GGCTVAAHGL 780

FLQSGLQPQM VLTTGQDAEV FHVSCVYGEN RTSIQCTTPS LAKLALQPPV VTKVAFVLDG 840

YMTEQWDLIY VEDPLFQDPK LTSKDNKSIV ELKGDRMDRE AMKCQVLTVS NHSCESLTLV 900

GNTLECTVPT ELQTTTSKEL QVEWRQADSI RHLGKVTLAQ EQDYTGLIVG CMCVSLLLLL 960

LGTLLLWKKN KHIDDLSEVW YDGRGHIQHL DRLANARSVS PTNEMVSHES VDYRTNLLED 1020

QGSDRPETCR AGPPIYGGNG ELLSPRLVAL GSGLGLGMEG ELVSPLLMAP VHIDPSCLHP 1080

DLLTEVQHVV IAREQLLLHL NQVIGRGHFG CVFHGTLLEP DGQKQHCAVK SLNRITDLEE 1140

VSQFLKEGII MKDFSHPNVL SLLGICLPPE GSPLMVLPYM KHGDLRNFIR DESHNPTVKD 1200

LMGFGLQVAR GMEYLASKKF VHRDLAARNC MLDESYTVKV ADFGLARDVY DKEYYSVHNK 1260

SGVKLPVKWM ALESLQTHKF TSKSDVWSFG VLLWELMTRG APPYSDVNSF DITVFLLQGR 1320

RLLQPEFCPD ALYTVMIECW HPNPERRPSF SELVEPISSI FSSFSGEHYI LLNTTYVNIE 1380

KLNPYPSLFA STHLTPSSSS L 1401

Nucleotide Sequence
(FASTA)

AGGATGAATC TCTGCTCCTT TCCTGCCGCC GTGCTGCTGC TGTGGGCCCT GAGTGCCAGC 60

GCCGAGGGCC ACTGCCAAAA ATCCCCTGAG CCCAACAAGC TGAACCTCTC CGTCAGCTAC 120

GAGCTGCCGA CCTTCACTGC AGAATTCCCC ATCCAGAACG TGGTGACCCT CGACGGCATC 180

ATCTACGTGG GGGCCACGAA CAGGATCTAC GCCTTGGCCC CGAGCCTCAC CAAGCTGTCG 240

GAGTACCGCA CGGGGCCACT TCTCGCCAAC CAGACTTGTG GTCAGAAAGT AGCCAACGCG 300

AGCTCTGGCG GCGGCAGAAA GGACAACCTC AACGTCGCTC TGGTGGTGGA AAACATTTAC 360

GACAAAGGGC TGTTCAGCTG CGGCTCGGCG GACAACGGCG TTTGCCGCCG CCACGTCCTG 420

GAAGACGACG TTAGCCTGGA CGAAGAGGGT AGACAGAAGA GCGTGGACGA ACTGGTCTAT 480

TGCTTCACTG ACCTTAAACA GGACAAGGGC CAACCCCGAG ACTCCGATGT GGTGGTCAGC 540

CCTTCGGGTT CTCAGGTGCT TAATGTGGAG AGCAACATGA TCATGTTTTT CGTTGGAAAC 600

TCGGAAATTC CTGGCTCCGG AAACGTAACG GGACCCACGG CGCGTCCCCA CACCATGTCC 660

CTGCGGAAAA TGAAGACCAG CCAGAACGGG TTCACCTTTT TCTCCAATCG GTCATACATG 720

GACCTGATCC CCCCCCTCCG CGGGAGCTAC TACCTGCGAT ACGTCTACTC CTTCCACAGC 780

GGGCCGTTCA CCTACTTCCT CACCGTGCAG CAGGTGAGCA AGGACTCCCA GACCTACCAC 840

ACGCGCATCG TGCGCATGTG CTCCTCCGAC CACGACATCC GCCGTTACGT GGAGATGCCG 900

CTGGAGTGCA TCAGCACAGA TAAACGGCGG CGGCGCTCCA TGGAAGACGT GAAGGTCTTC 960

AACATCCTTC AAGCGGCCAC CGTCACCAAG GTGGGCAGCG ACGTGGAGCT GCAGAGGCAG 1020

CTGAGGCTGG AGGAAGGCGA CGACGTGCTC TTCGCCGCCT TCGCCCGGGG AAAGCCCAAC 1080

TCCACGGAGG CGACGCCGAA CTCCGCCATC TGCGTCATGT CCCTGAAGCT CATCAACAGC 1140

ATGTTCAAGA TGTACATGCA GAAGTGCAAC ACGGTCGACC TGTATCACTT CACAGGATCG 1200

GACAAGAAGT CCTGCTACAA CGTGAAACTT TCACGAAGAG AAAACCCCGC CATGTTCTGT 1260

AAAGGGAAAG AGGGCAAGTA TCGCCTGCAG GTCACCCAGT TTGTCCAGAG GTTGGAGTAC 1320

TGGCAAAAGG TGCTGACGAA CACCTTGGTC ACCTCTATCA CCGTGGTTAC GGTCCACGGC 1380

CGCGCAGTAG GGTACCTCGG CACCGCAGAT GGACGACACA TCCAGGTAAA GGTGGCGTTT 1440

TCACGATTTG CCTCCCCCCA CGTGAACATC CGCTTGGACT CGAGACCCGT GTCGGGAAGT 1500

GTCGTGCTGC CGGGCCAGGA CCCCTCTGAA GGAGCTCTCC TTCTTACCAC AGGAAACAAG 1560

ATCACAAAGG TTCCTCTGAT TGGCCCTGGC TGCGATCACC TGACCACCTG CACCTCCTGC 1620

TTGGTGTCGT CGCGGGTGAC AGAATGTGGT TGGTGTGAGG GACGTTGCAC TCGAGCCAAC 1680

CAGTGTCCCC CCTCCGTCTG GACGCAGGAG TACTGCACAC CCGTCGTCAC AAAGGTCTTT 1740

CCAACATCTG GACCGATTCG TGGCTCCACA ACGGTGACTA TGTGCGGACG CAACTTTGGT 1800

TTCGACAAGA CGGAGAGCTT CAAGGCGTCC CTGGTGACGG TGGAGGTGGC GGGAGTTCCC 1860

TGCAAGCTTT CCAGACAAGA CTACGCCAGC AGGTGGACTG AGATCCAGTG TTCACCCATG 1920

TTTTCTGGGA ATTTTATGCC ATCGGGACAC ACGGTGAAAG TGACCAGTGG CCACAAAATA 1980

GCCACGATAG AGGGCTTCAC CTTTGTGGAC CCCGTCGTTT CTGAGATTTT TCCAACGTTC 2040

GGGCCAAAAT CTGGGAACAC CATGCTGACC ATCAGAGGAG CCTTCCTGGA CACTGGAAAC 2100

AAGCGAGAGG TGACAGTCGG GAAAGCAGCC TGTAAGATTC AGAGCTTGTC CGCGACCATG 2160

CTAACGTGTA AGACGCCTCC GCACGCCGTT CCCTCCAAGC AACCCGTGAG GCTGACGGTG 2220

GACTCGGTGG CGCGTGACGC CCCGGTGCTG TACACCTACC ACCAAGACCC CATCATCAGC 2280

AGCATCCAGC CCTCGCGCTC CTTCGTCAGT GGGGGCTGCA CAGTGGCGGC TCATGGCCTG 2340

TTCCTCCAGT CTGGCCTGCA GCCACAGATG GTCCTCACCA CCGGGCAGGA TGCTGAGGTG 2400

TTTCACGTGA GCTGCGTGTA CGGCGAGAAC CGGACGTCCA TCCAGTGCAC GACGCCCTCT 2460

CTGGCCAAAC TGGCTCTGCA GCCGCCGGTG GTCACCAAGG TGGCGTTTGT CCTGGATGGC 2520

TACATGACGG AGCAGTGGGA CCTGATCTAT GTGGAGGACC CACTTTTCCA GGACCCCAAG 2580

CTCACCTCAA AGGACAACAA GAGCATCGTA GAGCTCAAAG GCGACAGGAT GGACCGGGAG 2640

GCCATGAAAT GTCAGGTTTT GACCGTTTCT AACCACAGCT GCGAGAGCCT GACGCTGGTT 2700

GGAAACACGC TGGAGTGCAC CGTTCCCACC GAGCTGCAGA CCACCACCTC CAAGGAGCTG 2760

CAGGTGGAGT GGCGGCAGGC CGACTCCATC AGACATTTGG GCAAGGTGAC GTTGGCGCAG 2820

GAGCAGGACT ACACGGGCCT GATAGTGGGC TGCATGTGCG TCAGCCTGCT GCTGCTGCTG 2880

CTGGGAACGC TGCTGTTGTG GAAGAAGAAC AAGCACATCG ATGATCTGTC TGAGGTGTGG 2940

TATGATGGCC GGGGTCACAT CCAGCATCTG GACAGGCTGG CTAACGCGAG GAGCGTCAGT 3000

CCCACTAATG AAATGGTGTC CCACGAGTCA GTGGACTATA GAACAAACCT GCTGGAGGAT 3060

CAAGGTAGTG ACAGGCCCGA GACTTGCAGG GCGGGTCCTC CCATCTACGG TGGCAATGGG 3120

GAGCTCCTGT CACCCAGACT GGTGGCGCTG GGAAGCGGGT TGGGTCTGGG AATGGAGGGC 3180

GAGCTGGTGT CGCCATTACT GATGGCCCCC GTCCACATCG ACCCATCCTG CCTCCACCCA 3240

GACTTGCTAA CTGAGGTGCA GCATGTGGTG ATCGCCAGGG AGCAGCTGCT GCTCCACCTC 3300

AACCAGGTCA TCGGCAGAGG TCACTTTGGC TGCGTCTTCC ACGGGACTCT GCTTGAACCT 3360

GATGGACAGA AGCAGCACTG TGCTGTCAAG TCTCTGAACC GCATCACAGA TTTGGAGGAG 3420

GTGTCCCAGT TCCTAAAGGA GGGGATCATC ATGAAGGACT TCAGCCACCC AAATGTTCTC 3480

TCTCTGCTGG GAATCTGTCT ACCGCCAGAG GGATCTCCAC TCATGGTTCT GCCCTACATG 3540

AAGCACGGCG ACCTGCGCAA CTTCATCCGT GACGAGTCGC ATAACCCAAC GGTGAAGGAC 3600

TTGATGGGCT TCGGGCTGCA GGTAGCCAGA GGGATGGAAT ATCTGGCCAG CAAGAAGTTT 3660

GTCCATCGAG ACCTCGCTGC CAGGAACTGC ATGCTGGATG AGAGCTACAC TGTAAAGGTG 3720

GCGGACTTTG GTCTGGCCAG AGACGTTTAT GATAAAGAAT ATTACAGTGT CCACAACAAG 3780

AGCGGAGTCA AGCTCCCCGT CAAGTGGATG GCTCTGGAAA GCCTCCAGAC GCACAAGTTC 3840

ACCAGCAAGT CAGACGTGTG GTCGTTTGGC GTGCTGCTGT GGGAACTGAT GACGCGCGGA 3900

GCCCCGCCGT ACTCCGATGT GAACTCCTTC GACATCACCG TGTTCCTCCT GCAGGGGAGG 3960

AGGCTGCTGC AGCCCGAGTT CTGCCCCGAT GCTCTCTACA CGGTGATGAT CGAGTGCTGG 4020

CACCCCAATC CCGAGCGGCG GCCCTCTTTC TCCGAGCTGG TGGAGCCCAT CTCCTCCATA 4080

TTCTCCAGTT TTAGCGGCGA GCACTACATC CTGCTCAACA CCACCTACGT CAACATCGAA 4140

AAGCTGAACC CTTACCCCTC CCTGTTCGCC TCCACCCACC TCACTCCATC TTCTTCCTCC 4200

CTC 4203

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viG+GhfG+v++g+l++++++k+++avksl+ritd+e+v++fl+eg++mk+++hpn

Q: 1099  HLNQVIGRGHFGCVFHGTLLEPDGQKQHCAVKSLNRITDLEEVSQFLKEGIIMKDFSHPN  1158

         789*********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsllGi+l++eg+pl+vlpymk+Gdl++fir+e++n+tvkdl++f+lqva+gmeylask

Q: 1159  VLSLLGICLPPEGSPLMVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVARGMEYLASK  1218

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardv+dke+y+v+++ + +lpvkw+aleslqt+

Q: 1219  KFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKSGVKLPVKWMALESLQTH  1278

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k ft+ksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly vm+

Q: 1279  K-FTSKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYTVMI  1337

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsiis  262

         +cw+++p++rp+fs+lv  is

Q: 1338  ECWHPNPERRPSFSELVEPIS  1358

         *****************9886

Domain Sequence
(FASTA)

HLNQVIGRGH FGCVFHGTLL EPDGQKQHCA VKSLNRITDL EEVSQFLKEG IIMKDFSHPN 60

VLSLLGICLP PEGSPLMVLP YMKHGDLRNF IRDESHNPTV KDLMGFGLQV ARGMEYLASK 120

KFVHRDLAAR NCMLDESYTV KVADFGLARD VYDKEYYSVH NKSGVKLPVK WMALESLQTH 180

KFTSKSDVWS FGVLLWELMT RGAPPYSDVN SFDITVFLLQ GRRLLQPEFC PDALYTVMIE 240

CWHPNPERRP SFSELVEPIS 260

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013