EKS-TAR-00130

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00130

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	330.0	4.0E-98	3708	4052	345

Status

Unreviewed

Ensembl Protein

ENSTRUP00000044638

UniProt Accession

H2V604;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017418	ENSTRUP00000044638	ENSTRUT00000044789
ENSTRUG00000017418	ENSTRUP00000044639	ENSTRUT00000044790
ENSTRUG00000017418	ENSTRUP00000044640	ENSTRUT00000044791
ENSTRUG00000017418	ENSTRUP00000044641	ENSTRUT00000044792

Organism

Takifugu rubripes

Functional Description

Protein Length

4115

Protein Sequence
(FASTA)

LSGSLVVVWW FIMSSSGGIH AHLLKLHQSL SDEDPRAAAL KSHDIVGDLF QECLETTTEN 60

KLAFQTSLLF SKELGLLSFL RKSLGREELR ETRVEVLCFL EKFLDRVSPR VKGWDQTYAA 120

DITDTCTSLY SKEKGAKCRA AVLELLLKIL HKTKASSVAA DLRIGEMFNR YYGELCQGSK 180

LQDSVLGKVY ELLGVLAEVH PSDMVNHSDK LYRAYLGALK EQMTSATKEP KLLVVAGCLR 240

GLSALMVNFP KTKEEDPTSV KEIFHYALKT IRPQMEMNRY AVTFAGLQLL AKHASQFSSF 300

FMDHYRNMFE VMSKLCGHVN PEMRKTSSFA LEAFLKQIAL QVAADVEEHK SVLKFFMHTF 360

CGIIKTMDST YKELSIAIRG YGFFAAPCKK VCPQDVDLMY TELIQRCKIM YLTESDGDED 420

GYFQLPSFLD SIASILIHLD KVPEVYTPTL ERLLVVQVES FPQYSEKMQS ACCKSILKVL 480

VAMASKGPVM WGFISSVVYQ GLIRVCSKPI VLEVSWVTCV ATYSCKSSEV RIGKWKVPSS 540

HNYLPLYKTL LSCDRLKDSG FLDGSFESLN SGLFPLSRLV YDMFVKSVLQ IVSKLDLSVQ 600

KVSGEEHSCQ SPGDADHVLP SSDPTAHLLP NKTKDFTAFI NLVDFCSELL LKEQLEYFRS 660

WLYPLSHELV FYSIRSPLVS GFYKLLSAAM TIAKKIKYFQ GVDRKGVTSP QTDPVRDACL 720

ALFSKFGKEV CAKMKQYKDE LLASCLTFVL SLHHSIIAAD IKAYCPALEV ALKLGLSHVP 780

LADAALDALE SWSANIPPET MQPCFSSVLP LLDGYLKSHL NHNKDDGVWE VMSSVSSTSH 840

RGYNRVMTKL LKKSSQLVTE EAPFVMVRMR VVKLLGRLGG KINRNLVTGR ETQQEMMKKF 900

VAWDSERRLS FAVPFADMKP LIYLDPFLPR ICELALSTTD RQTKVVACEL LHSLVIYTVG 960

KNAQIVEGEN TLPPMYKLHK RLFPVLLRLA CDVDQVTRQL FEPLVMQLIH WFTNNKKFES 1020

QDTVAVLEAI MDGLVDPVDS TLRDFSGRCI EEFVKWSIKQ TTPKQQERSP TNMKSLFKRI 1080

YSLALHPNGF RRLGAALAFN SVYRLFREES SLVDQFVFEV LVIFVESLAL AHSDEQSLGT 1140

VQQCGGAIDH LQRIVQHKCA SLNQPSAQRR RPRSFPAEGA VCLSDVVLWL LEQCGRPQTE 1200

CRHKCMQLFY EFAPLLPGRK SLPQWFDGML KSRGGTFLTS GFEGGGLLSQ PTLRDRKGPF 1260

SVRATLQWMD LLLASLDCYT TFINLHILKP PHMISLGESS RFLKAVHFFL TELATRDLSA 1320

AERRFQLGKG TSHFSPREMD QYNFSKCTIT VRLLEFSTMV LTRSDQDLLK LLEKDVFIPA 1380

FFELVAAVVC EPSTVGFNMA DVVVMKNLPD VCVAALKALL TSPYHTLMES SIREKISQSS 1440

VEKLCAADLN GSDSAIQLDQ LEPVLSACRQ IHKAGYLSSI LNSQDASYAV SLGSGLLMMV 1500

FKGIAPGQDR EALPSLDSST KRLADGLLQL AFSLNQQGEQ LVDLLLNTMT VPGGQPLSHG 1560

EYFYSLFKST INTELLKNLE ITVPLIMKAS SGNSTMVSML LNGLLDYSFR ERSVRATREK 1620

KLVKEILGGW ECFRSWWDGP SATPETKTAT ILLLSKLLQI DSSACSNINH SAFRPVFSTF 1680

TGLLVDKSFQ LNLKSQALLV LPFFTMLPEE LLAELQSCLD TLVVSHFPIQ SDEFAKGSLH 1740

RNNYMDCIRK LLDALELSQS PLLLRLMAGV LCRDRRHIME EQFQNSFQKI AKRASADQQL 1800

RLLEAAYQVV QTGQVPLSSL LQAMERVVLP LAKHCSSTAI SLFFVSNICD ISAVLLGRFT 1860

KTNVAEFEVQ ILKKIGCYKL MELMYSRLPK EEVYSKESCI NRAYCRTDTA EGNELSKSLI 1920

KILFEAFTEN MSGETQLLEL RRLYHCAAYN CAVAAISCSF SEPRFFTGFL FSEKPEKNQL 1980

ILENLIDVKR TYNFPVEIEV PLERSKKYVA IRKAATDENE GISNKPDAPV YLSSQSFMSD 2040

SSLSEEMSQF DFSTGVQSFS FSSQKVDGQR RNVAKKEPGE ETIPSQDAVV DLEMDELNQH 2100

ECMATLTGLI GHMHRNNITP KTDQENAPAE LPPWMKYLHT KLSNPTTHLN IRLFIAKMII 2160

NTEEVFRPYA KYFLGPLIQL VVCGDNGGDG IHFMVVDIVV TVLSWTGVAK PKGNPRDEVL 2220

ANRLLEFLMK HSFHSNRAVF RHNLQIIRTL VECWKDCLHV PYRLIYERFC GTDGNKKDNS 2280

VGLQLLGIIL ANNLAAYDPS CGVAYTRYIQ ALTNNVTFVR YKDLYAAAAE IIGLMLKNLT 2340

HTPELHQELL SMAVNKIGNL KRMSMDDKFI ICLNKVSKHF PPFMDRFVNH LFFLLPKSHG 2400

FLKTSCLECV LGRAEVIPDV FLQLKTSGFI QTMGHREEMK QRVCLDIVHK IVALLTPEEL 2460

QEVLGPVTAF ISHPSPVCRE RMYDILMWIL DNYSDEESME DSTSVRILDV AKESLLQGLS 2520

EENQGLQLYV RNFWSQEKRL PAATLERMLA VLQSLYSSKT EKCFLSLATD LLLEMTSQSP 2580

DFQRHMFEYP LSECTFQDYR IDSNWRVRST VMTPMFVETL NSQAQESVAS QPGTMKGKLR 2640

ATQTSLEFSQ TQTGHRTTYN WLTGRSMGTL AEYSLGSESA SSSSLMVFDK DERRIKARKP 2700

VGEGFGTKLL SGSSEQGGGP TTANEQRSNI LALRRRFLKD RRNASLAYAQ KEIQQQRRKK 2760

EEAADKRLQK EVQVTLYRNY RVGDFPDIQI SYSSLITPLQ ALAQRDPVVA KQLFSSLFAG 2820

ILEEMEKQKP RKEVVKIKEE LQQNMCALLS RSTLCFPPFV ACVQDMCYHH KDLQQLNPAL 2880

VSSTSLLSLQ QPLGVLLLEE SLVHHGGLEE PPSKRSRGHK EIPPDTNKLW SRLYRSMEDY 2940

DVVRGIFGGK VGTKSITCAA LQAEASSDYA EAVKLYNEAL NTEQWSDGEP AECERDFWEM 3000

AAMEAYSHLT DWKSLQYCST VYIDEASPPD LQRMWSEPVY QEMYLPHMIR SMLKQLQVGE 3060

RDQSLLSFTD EAMSVEERKD LLESQYSQEL GLLYILQEDY DRASYYTNYA FELFIQNYSS 3120

VDSLMTQSRL TMLKSVQALT EIQEFLLFVK GGGNQVSVSS VKQLIGRWTE RYPDPTVDPM 3180

SLWDDIVTSR CFFLDQIKRR MRPQAPSDSM EAQAPSDSME AQAPSDSMEV DGPDGTPAPL 3240

DTLINECKFS MKLQMADSAW KQNNFAVATK LLKELQREAR RERGRLLRWV HSFCGYAHKR 3300

SRTQGPVEQI GAMLRTVALL EDLQTESWAV PAVSRCQQLL QGTSFTILVA AVSKSPSVLG 3360

SIEANKAESV ANLAGVSWPT RNLKEVEAGL RKKAWNFLSE ASRKADEEVQ SCPQDCVDTS 3420

SITQTYMALA NFCDGALREH EQGDAGVCGG VSVGDPMWAT PISGSGSRPF WVLSDKLDYD 3480

GNIGPTFLVF LAVQLPEVNR LAVQHCLEQI ANSFPQALAY ALMISSESFQ FQDSVRGHKQ 3540

REFVSRLRGL LDQGGAVKNF VDALMQLANP EMIFKDWWDS LKNEMGKQSF TEETMSDLYK 3600

DLFSSLGHHT SGQGTFHKKF LQRFAKEVEK LLGPNGLTLF QKRRDKSLVR RVDELAASMR 3660

NFQKEPGNLK EYSPRLSGFK ADTLGNELEV PGQYDGRSKP LPEYHAKITG FDERVKVMSS 3720

IRRPKRLIIR GDDERDHPVL VKSGEDLRQD QRIEQLFSVM NILLSNDAAC AQRGLQLRTY 3780

QVIPLTTRIG LIEWMENTCT LREFLCATMT AEEQRTAARC PEVYNAWLAT FAPKNTTGAP 3840

LYGHAYRKAG RADAVNNFVK VVQRVPSDLL KRAFLKMSSS PEAFLSLRSH FARSHALLCV 3900

SHWLLGIGDR HLSNFMVNTE SGGIIGIDFG HAFGSATQFL PVPELMPFRL TQQFVNLMQP 3960

LRESGLIQSV MVHSLRAYGA DPDLLLNTMD VFVKEPLLDW KNFELKQLKK GGTWTEEVNT 4020

RDINWYPLQK VAFARRKLQG ANPAAITSDE LKLGFENDGA FAGMQAVALG SREHNVRATL 4080

PPSGLSVEDQ VRCLLDQAMD PNVLGRVWAG WDPWM 4115

Nucleotide Sequence
(FASTA)

TTGAGTGGTA GTTTGGTGGT AGTTTGGTGG TTTATCATGT CCTCCTCTGG CGGGATCCAC 60

GCGCACCTCC TCAAACTGCA CCAGTCTCTT TCTGATGAAG ACCCGCGAGC TGCGGCGCTG 120

AAGAGCCACG ACATCGTCGG TGATTTGTTC CAGGAATGTT TGGAAACGAC CACCGAGAAC 180

AAACTTGCGT TCCAGACGTC CCTCCTGTTC TCGAAGGAGT TGGGACTGCT GAGCTTCCTC 240

AGGAAGTCCC TGGGGAGGGA GGAGCTCAGG GAAACTCGAG TGGAGGTCTT GTGTTTTTTG 300

GAGAAGTTCT TGGATCGAGT CTCGCCGAGA GTCAAAGGAT GGGACCAGAC TTACGCCGCC 360

GACATAACGG ACACGTGCAC GTCTCTGTAT TCAAAGGAGA AGGGCGCCAA ATGTCGGGCG 420

GCGGTGCTGG AGCTCCTCCT GAAGATTCTC CACAAGACAA AAGCATCAAG TGTCGCTGCC 480

GACCTCCGAA TCGGCGAAAT GTTCAACCGC TACTATGGCG AGCTGTGCCA GGGGAGCAAG 540

CTCCAAGATT CTGTTCTGGG TAAAGTCTAT GAGTTGCTGG GGGTTCTGGC GGAGGTTCAC 600

CCCAGCGACA TGGTCAACCA CTCTGACAAG CTGTACCGAG CGTATTTGGG GGCGCTGAAG 660

GAGCAGATGA CGTCTGCGAC CAAGGAGCCG AAGCTGCTGG TGGTGGCCGG GTGTTTGAGG 720

GGACTCTCCG CTCTCATGGT CAACTTCCCC AAAACGAAGG AGGAAGATCC CACGTCGGTG 780

AAGGAAATCT TCCACTACGC TCTAAAAACC ATCAGGCCGC AGATGGAGAT GAACCGCTAC 840

GCAGTGACGT TCGCTGGGCT CCAGTTACTG GCCAAACATG CGTCCCAGTT CAGCAGCTTC 900

TTCATGGACC ACTACAGGAA CATGTTTGAG GTCATGTCTA AGCTGTGTGG CCACGTCAAC 960

CCTGAGATGA GGAAGACCAG TTCCTTCGCC CTCGAGGCCT TCCTGAAGCA GATCGCACTG 1020

CAGGTCGCAG CTGATGTTGA GGAGCACAAG AGCGTCTTGA AGTTCTTCAT GCATACCTTC 1080

TGTGGCATCA TCAAGACCAT GGACTCCACC TATAAGGAGC TCTCCATCGC CATAAGAGGA 1140

TACGGATTTT TTGCAGCTCC TTGCAAGAAG GTTTGTCCAC AGGATGTAGA CCTGATGTAT 1200

ACGGAGCTGA TCCAGCGCTG CAAGATCATG TACCTGACTG AGTCTGATGG GGATGAAGAC 1260

GGGTACTTCC AGCTGCCCAG CTTCCTGGAC TCCATAGCCA GCATCTTGAT TCACCTGGAC 1320

AAGGTTCCAG AGGTGTACAC GCCCACTCTG GAGCGCCTCC TTGTGGTGCA GGTTGAAAGT 1380

TTTCCTCAGT ACAGCGAGAA GATGCAGAGC GCCTGTTGCA AATCTATACT GAAGGTGCTG 1440

GTGGCCATGG CCTCTAAAGG ACCCGTGATG TGGGGCTTCA TTAGCTCAGT GGTGTACCAA 1500

GGGTTAATCC GCGTGTGTTC AAAGCCCATC GTGCTTGAGG TGAGCTGGGT CACTTGTGTT 1560

GCCACCTATT CATGCAAATC CTCAGAAGTC CGTATTGGGA AGTGGAAAGT TCCCTCTAGT 1620

CACAACTACC TTCCTCTTTA TAAAACCCTG CTGAGCTGTG ACCGGCTGAA GGATTCCGGG 1680

TTTTTGGATG GATCGTTTGA AAGTCTAAAT AGCGGCCTGT TCCCTTTGAG CCGGCTGGTT 1740

TACGACATGT TTGTGAAGTC CGTTCTCCAA ATCGTGTCCA AACTGGACCT GTCGGTGCAG 1800

AAAGTGAGCG GAGAGGAGCA TTCATGTCAG AGTCCAGGTG ACGCCGACCA CGTCCTGCCC 1860

TCCTCTGACC CCACGGCGCA TCTGTTGCCG AATAAGACCA AAGATTTTAC TGCTTTCATA 1920

AACCTGGTGG ACTTTTGCAG CGAGCTGTTG CTGAAAGAAC AGCTGGAATA CTTCCGGTCC 1980

TGGTTGTACC CCCTCAGCCA CGAACTCGTC TTCTACTCCA TACGAAGTCC TCTCGTCAGC 2040

GGCTTCTACA AGCTGCTCTC AGCTGCAATG ACGATTGCAA AGAAAATCAA GTACTTCCAG 2100

GGAGTGGACC GGAAAGGAGT CACATCTCCA CAGACCGATC CTGTGAGAGA TGCCTGTCTG 2160

GCTCTCTTCT CCAAGTTTGG CAAAGAGGTG TGCGCCAAAA TGAAGCAGTA CAAAGACGAG 2220

CTGCTGGCTT CCTGCCTGAC GTTTGTTCTG TCGCTGCACC ACAGCATCAT AGCCGCAGAC 2280

ATCAAGGCCT ACTGTCCCGC TCTGGAGGTG GCGTTGAAAC TGGGCCTGAG CCACGTTCCT 2340

CTGGCCGACG CCGCCCTCGA CGCTCTGGAG AGCTGGTCCG CCAACATTCC CCCGGAGACG 2400

ATGCAGCCGT GCTTCTCCTC CGTCCTCCCT CTTCTGGACG GATACCTGAA GTCACACCTG 2460

AACCACAACA AAGATGACGG CGTTTGGGAG GTGATGTCTT CCGTGTCCTC AACAAGCCAC 2520

AGAGGATACA ACCGAGTGAT GACGAAACTG CTGAAGAAGT CCAGCCAGCT TGTTACGGAA 2580

GAGGCTCCCT TTGTCATGGT GAGGATGAGG GTGGTGAAGC TGCTGGGACG CCTCGGCGGG 2640

AAGATCAACA GGAACCTGGT GACCGGCAGG GAGACGCAGC AGGAAATGAT GAAGAAGTTT 2700

GTGGCCTGGG ACTCTGAGAG GAGGCTCAGC TTTGCTGTGC CCTTCGCTGA CATGAAGCCG 2760

CTCATCTACC TGGACCCGTT CCTCCCGCGC ATCTGCGAGC TAGCTTTGTC AACCACCGAC 2820

CGCCAGACCA AAGTCGTAGC GTGCGAGCTG CTGCACAGCC TGGTTATCTA CACGGTTGGG 2880

AAGAACGCTC AGATCGTGGA GGGAGAAAAC ACCTTACCGC CAATGTACAA ACTACACAAG 2940

AGGCTGTTTC CCGTGCTGCT GCGCCTTGCG TGTGACGTGG ATCAGGTCAC CAGGCAGCTC 3000

TTCGAGCCAC TGGTCATGCA GCTCATTCAC TGGTTCACCA ACAACAAGAA GTTTGAGAGC 3060

CAAGACACGG TGGCTGTCCT GGAGGCTATA ATGGACGGCC TGGTCGACCC GGTCGACAGC 3120

ACGCTCCGAG ACTTCTCTGG CCGCTGCATC GAAGAGTTCG TGAAGTGGTC GATCAAGCAG 3180

ACGACGCCGA AGCAGCAGGA GAGGAGCCCC ACCAATATGA AGTCCTTGTT TAAGCGCATC 3240

TACAGCCTGG CGCTCCATCC AAACGGGTTC AGGAGACTGG GAGCAGCTCT GGCGTTCAAC 3300

AGCGTCTACC GGCTCTTCAG GGAGGAAAGT TCCTTAGTGG ACCAGTTTGT CTTTGAAGTT 3360

CTTGTCATAT TTGTTGAAAG TCTGGCTCTC GCTCACTCTG ACGAGCAATC GCTGGGAACG 3420

GTGCAGCAGT GCGGCGGCGC CATCGATCAT CTCCAGAGAA TCGTTCAGCA CAAATGTGCC 3480

AGTCTCAATC AGCCCAGCGC TCAAAGACGC CGTCCAAGGA GCTTCCCAGC GGAGGGGGCG 3540

GTGTGCCTCT CCGACGTGGT TTTATGGCTC CTGGAACAAT GTGGTCGCCC CCAGACGGAG 3600

TGCCGCCACA AGTGCATGCA GCTTTTCTAC GAGTTTGCTC CCCTCCTCCC AGGGAGGAAG 3660

TCTTTACCGC AGTGGTTCGA CGGCATGCTG AAGAGTCGCG GCGGAACCTT CCTGACGTCG 3720

GGGTTTGAAG GCGGGGGCCT CCTCTCCCAG CCTACTCTTC GGGATCGGAA GGGTCCGTTC 3780

AGCGTCCGGG CCACCCTCCA GTGGATGGAC CTGCTGCTGG CTTCCCTGGA CTGTTACACC 3840

ACCTTCATCA ATCTGCACAT CCTCAAGCCT CCTCACATGA TCAGCTTGGG AGAGAGCTCC 3900

CGTTTTCTGA AAGCTGTTCA CTTCTTTTTG ACCGAACTGG CGACTCGCGA CCTGTCGGCA 3960

GCAGAGCGGC GCTTCCAGCT GGGGAAGGGG ACGTCTCACT TCAGTCCCAG AGAGATGGAC 4020

CAGTACAACT TCAGCAAATG TACCATCACC GTTCGCCTGC TGGAGTTTTC CACCATGGTT 4080

CTCACCAGGA GCGACCAGGA CTTGCTGAAG CTTCTGGAAA AAGACGTGTT TATCCCGGCT 4140

TTTTTCGAGC TGGTAGCGGC CGTGGTGTGT GAGCCTTCCA CCGTGGGCTT CAACATGGCA 4200

GATGTTGTGG TCATGAAGAA CCTTCCAGAT GTTTGCGTTG CTGCTCTGAA GGCCCTGCTC 4260

ACCTCACCGT ATCACACACT GATGGAGAGC AGCATCAGGG AGAAAATCTC CCAGAGCAGT 4320

GTAGAGAAGC TGTGTGCTGC TGACCTCAAC GGTTCCGACT CAGCGATCCA GCTGGACCAG 4380

CTGGAGCCGG TTCTTTCTGC CTGTCGGCAG ATCCATAAAG CCGGCTACCT GAGCTCCATT 4440

TTAAACAGCC AGGATGCCTC CTACGCTGTG TCTCTGGGGT CTGGACTTCT CATGATGGTC 4500

TTTAAAGGTA TAGCCCCTGG TCAGGACAGG GAGGCGCTCC CTTCCTTGGA CTCGAGCACC 4560

AAAAGGTTGG CAGATGGTTT GCTTCAGCTC GCCTTCTCCT TAAATCAGCA GGGTGAACAG 4620

CTGGTGGACC TGTTGTTGAA CACCATGACG GTTCCTGGAG GTCAGCCCCT CTCACATGGC 4680

GAATACTTCT ACAGCCTCTT TAAGAGCACC ATCAACACGG AGCTCCTGAA GAACCTTGAG 4740

ATCACCGTGC CACTGATCAT GAAGGCTTCC TCTGGAAACT CCACCATGGT CAGCATGTTG 4800

CTGAACGGCC TGCTGGACTA CAGCTTCAGA GAACGTTCTG TCAGGGCGAC CCGAGAGAAG 4860

AAGCTGGTAA AGGAAATATT AGGAGGTTGG GAATGTTTCA GGTCCTGGTG GGATGGCCCC 4920

TCGGCGACTC CAGAGACCAA GACTGCCACT ATTCTGCTCC TTTCCAAGCT GCTGCAGATT 4980

GACTCGTCTG CCTGCTCCAA CATCAACCAC TCGGCCTTCA GGCCGGTGTT TTCCACGTTC 5040

ACCGGCTTGT TGGTTGACAA GAGCTTTCAA CTGAATCTCA AGAGTCAGGC GTTGTTGGTG 5100

TTGCCCTTTT TCACGATGCT TCCAGAGGAG CTGCTGGCGG AGCTGCAAAG CTGCTTGGAC 5160

ACCCTGGTAG TTTCCCACTT CCCCATCCAA TCCGATGAGT TCGCCAAGGG CTCGCTCCAC 5220

CGCAACAACT ACATGGACTG CATCCGGAAG TTGCTGGACG CCCTGGAGCT CTCCCAGAGC 5280

CCCCTCCTGC TCCGGCTGAT GGCTGGCGTC CTGTGTCGGG ATCGAAGGCA CATAATGGAG 5340

GAGCAGTTTC AAAACTCTTT CCAGAAAATT GCTAAAAGAG CGAGCGCCGA CCAGCAGCTG 5400

CGGCTCCTGG AAGCAGCTTA CCAGGTGGTC CAGACGGGCC AGGTGCCTCT GAGCTCGCTG 5460

CTGCAGGCCA TGGAGCGAGT GGTGCTGCCC CTAGCCAAGC ACTGCAGCTC CACGGCCATC 5520

AGCCTCTTCT TTGTGTCCAA CATATGTGAC ATTAGCGCCG TGCTGCTCGG GCGCTTCACC 5580

AAGACAAACG TAGCAGAATT TGAGGTCCAG ATACTGAAGA AGATCGGCTG CTACAAGCTG 5640

ATGGAGCTGA TGTATTCTCG GCTTCCCAAA GAGGAGGTTT ACTCCAAGGA GTCCTGCATC 5700

AACAGAGCCT ACTGCCGCAC AGACACGGCA GAGGGGAACG AGCTGTCCAA GAGTTTGATC 5760

AAGATCCTGT TTGAAGCCTT CACTGAAAAT ATGAGCGGAG AGACTCAGCT CCTGGAGCTC 5820

AGGAGGCTTT ATCATTGTGC TGCCTACAAC TGTGCCGTCG CTGCCATCAG CTGCAGCTTC 5880

AGTGAGCCCA GGTTCTTCAC TGGCTTCCTC TTCAGTGAGA AACCAGAGAA GAATCAGTTA 5940

ATTCTAGAAA ATCTCATTGA TGTTAAAAGG ACCTACAACT TCCCAGTGGA AATTGAGGTC 6000

CCACTTGAGA GATCAAAGAA ATATGTTGCC ATTCGAAAAG CAGCCACTGA TGAGAATGAA 6060

GGTATTTCCA ACAAACCTGA TGCTCCCGTG TACCTGTCGT CCCAGTCGTT CATGTCTGAC 6120

AGCAGTCTGA GTGAGGAAAT GAGTCAGTTT GATTTCTCCA CTGGAGTCCA GAGTTTTTCC 6180

TTCAGCTCCC AAAAGGTCGA CGGGCAGAGA CGCAATGTTG CAAAAAAAGA ACCAGGAGAG 6240

GAGACGATTC CCTCTCAAGA TGCAGTTGTG GACCTTGAGA TGGACGAGCT GAACCAGCAC 6300

GAGTGCATGG CCACCCTGAC GGGCCTCATC GGCCACATGC ACAGGAACAA CATCACCCCC 6360

AAAACGGACC AGGAAAACGC CCCTGCAGAA CTTCCACCGT GGATGAAGTA CCTGCACACC 6420

AAGCTGTCCA ACCCAACAAC ACACCTCAAC ATCCGGCTCT TCATCGCAAA GATGATCATC 6480

AACACCGAGG AGGTTTTTCG ACCGTATGCA AAATACTTTC TGGGGCCGCT GATCCAGCTC 6540

GTCGTCTGTG GGGACAACGG AGGAGACGGC ATCCACTTCA TGGTGGTGGA CATTGTGGTC 6600

ACGGTTCTGT CCTGGACGGG TGTGGCCAAG CCCAAGGGTA ACCCCCGAGA CGAAGTCCTG 6660

GCCAACCGCC TGCTGGAGTT CCTGATGAAG CACAGCTTCC ACTCCAACAG AGCCGTCTTC 6720

CGTCACAACC TGCAGATCAT TCGCACGCTG GTGGAGTGTT GGAAGGACTG TCTGCACGTC 6780

CCCTACAGAC TCATTTATGA GCGCTTCTGT GGCACCGACG GCAACAAAAA AGACAATTCT 6840

GTCGGGCTTC AGCTGCTGGG AATCATCTTG GCCAACAACC TGGCTGCCTA CGACCCTTCC 6900

TGTGGAGTCG CTTATACCAG GTATATACAG GCTCTCACCA ACAACGTGAC CTTTGTGCGG 6960

TACAAAGATC TGTACGCTGC TGCTGCAGAG ATCATCGGCC TCATGCTGAA GAACCTGACC 7020

CACACGCCTG AGCTTCATCA GGAACTCCTC AGCATGGCTG TAAACAAGAT AGGAAACCTG 7080

AAGAGAATGA GCATGGATGA CAAGTTCATA ATATGCTTGA ATAAAGTCTC CAAACACTTT 7140

CCTCCATTTA TGGATCGGTT CGTCAACCAC CTGTTTTTCC TCCTACCGAA GTCTCACGGG 7200

TTCCTAAAGA CCAGCTGCTT GGAGTGTGTG CTCGGCCGGG CCGAAGTCAT CCCCGACGTC 7260

TTCCTGCAGC TGAAGACCTC CGGTTTCATC CAGACGATGG GCCACAGGGA GGAGATGAAG 7320

CAGAGAGTGT GTCTCGATAT CGTCCACAAG ATTGTCGCCC TGCTGACCCC AGAGGAGCTG 7380

CAGGAGGTCC TGGGACCTGT GACGGCTTTC ATCTCCCACC CGTCACCTGT GTGCAGAGAG 7440

AGAATGTACG ATATTCTCAT GTGGATCCTG GACAACTACA GTGATGAAGA GAGCATGGAA 7500

GACAGCACCT CAGTCAGGAT CTTGGACGTT GCTAAAGAGT CACTCCTTCA GGGATTGTCT 7560

GAGGAAAACC AAGGCTTGCA GCTCTATGTT CGCAACTTCT GGAGTCAGGA GAAGCGTCTT 7620

CCCGCTGCCA CTCTGGAGCG AATGTTGGCG GTGTTGCAGT CTCTCTACTC CAGCAAGACG 7680

GAGAAGTGCT TCTTGAGTCT GGCTACGGAC CTCCTGCTGG AAATGACCAG CCAGAGTCCC 7740

GACTTCCAGC GCCACATGTT TGAGTATCCG CTATCGGAGT GCACCTTCCA GGACTATCGG 7800

ATTGATTCAA ACTGGCGCGT CAGGAGCACA GTGATGACTC CCATGTTTGT GGAGACCCTG 7860

AACTCTCAGG CTCAGGAGAG CGTGGCATCT CAACCTGGTA CCATGAAAGG GAAGCTGCGA 7920

GCCACCCAGA CCTCCCTGGA GTTCTCCCAG ACCCAAACAG GGCATCGCAC AACATATAAC 7980

TGGCTGACAG GCAGAAGCAT GGGCACCTTA GCCGAGTACT CGCTCGGCTC CGAGTCCGCG 8040

TCCTCGTCCT CACTGATGGT GTTTGATAAA GATGAGAGAC GGATCAAAGC ACGGAAGCCA 8100

GTAGGAGAAG GATTTGGCAC AAAGCTTCTG AGTGGATCCA GTGAGCAGGG CGGAGGTCCC 8160

ACCACAGCAA ACGAGCAGCG CAGCAACATC CTGGCGCTGC GGCGCAGATT CCTCAAGGAT 8220

CGGAGGAACG CCAGCCTGGC TTACGCACAG AAGGAGATCC AACAGCAGCG GCGGAAAAAG 8280

GAAGAAGCAG CTGATAAAAG GCTGCAAAAA GAGGTTCAGG TGACTCTCTA TCGGAACTAC 8340

CGGGTGGGAG ACTTTCCTGA TATTCAGATT TCATACAGCA GTCTCATTAC TCCTCTTCAA 8400

GCTCTCGCCC AGAGAGATCC TGTTGTAGCC AAGCAGCTGT TCAGCTCCCT GTTTGCTGGA 8460

ATACTGGAAG AGATGGAAAA GCAGAAACCA AGAAAGGAAG TTGTGAAGAT TAAAGAGGAG 8520

CTGCAGCAGA ACATGTGTGC TCTGCTGAGC AGGAGCACCC TCTGCTTCCC TCCCTTTGTA 8580

GCATGTGTGC AGGACATGTG CTACCACCAT AAGGACCTGC AGCAGCTGAA TCCAGCCCTG 8640

GTCAGCTCCA CCTCCCTGCT CAGCCTCCAG CAGCCTCTGG GGGTCCTCCT GCTGGAGGAG 8700

AGCTTGGTGC ACCATGGCGG CCTGGAGGAA CCCCCATCCA AACGCTCTCG GGGCCATAAG 8760

GAAATACCTC CAGACACCAA TAAATTGTGG TCCAGGCTCT ACAGATCCAT GGAGGATTAC 8820

GACGTTGTTC GTGGGATTTT TGGTGGCAAG GTTGGGACCA AGTCCATCAC CTGTGCGGCG 8880

CTTCAGGCTG AAGCCAGTTC AGACTACGCA GAAGCTGTGA AACTTTACAA TGAGGCTCTA 8940

AACACGGAGC AGTGGAGCGA TGGCGAGCCT GCTGAATGTG AGAGGGACTT CTGGGAAATG 9000

GCTGCGATGG AGGCGTACAG CCACCTGACT GACTGGAAGT CTCTTCAGTA CTGCTCCACC 9060

GTCTACATCG ATGAGGCCTC CCCCCCCGAC CTGCAGAGGA TGTGGTCAGA GCCAGTCTAC 9120

CAGGAGATGT ACCTGCCGCA CATGATCCGC AGCATGCTGA AGCAGCTGCA GGTGGGGGAG 9180

CGGGACCAAA GCCTCCTCAG CTTCACCGAT GAAGCCATGT CGGTGGAGGA GCGCAAGGAT 9240

CTGCTGGAGA GCCAGTACAG CCAGGAGCTG GGCCTGCTCT ACATCCTCCA GGAGGATTAC 9300

GACCGCGCCA GCTACTACAC CAACTACGCC TTTGAGCTCT TCATACAGAA TTATTCCAGC 9360

GTGGACTCGC TGATGACCCA AAGCCGACTG ACCATGCTGA AGTCGGTGCA GGCGCTGACG 9420

GAGATCCAGG AGTTTCTGCT GTTCGTTAAA GGAGGCGGTA ACCAGGTTTC CGTGAGCTCC 9480

GTCAAGCAGC TGATTGGACG ATGGACGGAG CGCTATCCTG ACCCCACGGT GGATCCCATG 9540

AGCCTGTGGG ACGACATCGT CACCTCCCGC TGTTTCTTTT TGGACCAAAT CAAGAGAAGG 9600

ATGAGGCCCC AGGCTCCCAG CGACAGCATG GAGGCCCAGG CTCCCAGCGA CAGCATGGAG 9660

GCCCAGGCTC CCAGCGACAG CATGGAGGTG GACGGTCCAG ACGGCACGCC GGCACCGCTG 9720

GACACCTTAA TAAATGAGTG CAAGTTTAGC ATGAAGCTGC AGATGGCCGA CAGCGCCTGG 9780

AAGCAGAATA ATTTTGCCGT GGCCACCAAA CTCCTGAAGG AGCTCCAGCG GGAGGCCAGA 9840

CGAGAGCGCG GCCGGCTGCT GCGCTGGGTG CACAGTTTCT GTGGCTACGC CCACAAACGC 9900

AGCCGGACGC AGGGACCCGT GGAGCAAATC GGCGCCATGC TGAGGACTGT GGCGCTCCTG 9960

GAGGACCTCC AGACGGAGAG CTGGGCTGTT CCAGCTGTGT CCAGATGTCA ACAGCTCCTT 10020

CAGGGTACTT CCTTCACTAT CCTGGTAGCA GCCGTGAGTA AAAGCCCCTC GGTGCTGGGA 10080

AGTATCGAAG CCAACAAAGC AGAAAGTGTT GCTAATCTGG CCGGAGTGTC CTGGCCCACT 10140

CGGAATCTCA AGGAAGTGGA GGCGGGGCTA CGGAAAAAAG CGTGGAATTT TCTGTCTGAA 10200

GCCTCCAGGA AGGCTGATGA GGAAGTGCAG TCGTGTCCTC AGGACTGTGT GGACACGAGC 10260

AGCATCACCC AGACCTACAT GGCTCTGGCC AACTTCTGTG ACGGAGCGCT GCGAGAGCAC 10320

GAGCAGGGCG ACGCAGGGGT CTGTGGGGGT GTTAGTGTGG GCGACCCTAT GTGGGCGACA 10380

CCAATCTCCG GCAGCGGCTC CAGACCTTTC TGGGTTTTGA GTGATAAACT GGATTATGAT 10440

GGAAATATTG GACCAACATT TCTGGTATTT CTCGCTGTCC AACTGCCTGA AGTGAATCGC 10500

CTGGCGGTCC AGCACTGCCT GGAGCAGATC GCCAACAGCT TCCCCCAGGC GCTGGCGTAC 10560

GCGCTGATGA TCAGCAGCGA GAGCTTCCAG TTCCAGGACT CGGTCAGAGG ACACAAGCAG 10620

CGGGAATTTG TTAGCAGGCT CAGAGGCCTG CTGGATCAGG GAGGGGCTGT GAAGAACTTT 10680

GTGGACGCAC TGATGCAGCT TGCAAACCCA GAGATGATTT TCAAGGACTG GTGGGACTCT 10740

CTGAAAAATG AGATGGGAAA GCAGAGCTTC ACCGAGGAGA CGATGAGCGA CCTCTATAAG 10800

GACCTGTTCT CCTCTCTGGG CCACCACACC AGCGGGCAGG GAACGTTCCA CAAGAAGTTT 10860

CTCCAAAGAT TTGCTAAAGA GGTGGAGAAG CTGCTGGGGC CCAACGGCCT CACGCTGTTC 10920

CAGAAGAGAC GGGACAAAAG CTTGGTGCGG CGGGTGGACG AGCTCGCTGC GTCCATGCGT 10980

AACTTCCAGA AGGAGCCGGG GAACCTGAAG GAATACTCGC CGCGGCTCAG TGGCTTTAAA 11040

GCCGACACGC TGGGCAACGA GCTGGAGGTG CCAGGACAAT ACGACGGAAG ATCAAAGCCG 11100

CTGCCCGAGT ATCACGCCAA GATCACGGGC TTTGATGAGC GGGTGAAGGT CATGTCCTCC 11160

ATCCGGCGGC CCAAACGCCT CATCATCCGA GGGGACGACG AACGCGACCA CCCGGTTCTG 11220

GTGAAGAGCG GCGAGGACCT CCGACAGGAC CAGAGGATTG AGCAGCTCTT TTCTGTCATG 11280

AACATTTTGC TGAGTAACGA CGCCGCCTGT GCACAGAGAG GCCTGCAGCT GCGCACGTAC 11340

CAAGTCATCC CATTAACCAC CAGAATCGGT CTCATTGAGT GGATGGAGAA CACGTGCACG 11400

CTGAGGGAGT TCCTGTGCGC CACAATGACT GCAGAGGAGC AGCGCACGGC AGCACGGTGT 11460

CCTGAAGTCT ACAACGCCTG GCTCGCCACC TTCGCTCCCA AGAACACGAC GGGCGCGCCG 11520

CTGTACGGCC ACGCCTACAG GAAAGCCGGA CGGGCCGATG CCGTCAACAA CTTTGTGAAG 11580

GTGGTGCAGC GGGTGCCCAG CGACCTCCTG AAGAGAGCCT TCCTGAAGAT GAGCAGCAGT 11640

CCCGAGGCGT TCCTCTCCCT GCGCTCCCAC TTCGCCCGCT CCCACGCGCT GCTGTGTGTG 11700

AGCCACTGGC TCCTGGGCAT CGGCGACCGC CACCTCTCCA ACTTCATGGT CAACACGGAA 11760

AGCGGCGGCA TCATTGGCAT CGACTTCGGT CACGCCTTTG GCTCGGCGAC GCAGTTCCTC 11820

CCCGTGCCGG AGCTCATGCC CTTCCGGCTG ACGCAGCAGT TTGTCAACCT GATGCAGCCG 11880

CTGAGGGAGT CCGGTCTGAT CCAGAGCGTC ATGGTCCACT CGCTCCGGGC GTACGGCGCC 11940

GACCCAGACC TGCTGCTCAA CACCATGGAC GTGTTTGTCA AGGAGCCCCT GCTGGACTGG 12000

AAGAACTTTG AGCTGAAGCA GCTGAAGAAG GGAGGAACCT GGACAGAGGA GGTGAACACC 12060

AGAGACATCA ACTGGTACCC CCTCCAGAAA GTGGCCTTTG CCAGGAGGAA ACTACAAGGA 12120

GCAAATCCTG CTGCCATCAC CAGCGATGAG CTCAAACTGG GCTTTGAGAA CGACGGCGCC 12180

TTCGCTGGGA TGCAGGCGGT GGCCTTGGGT TCGAGGGAAC ACAACGTCCG AGCTACGCTT 12240

CCGCCCTCTG GCCTTTCCGT GGAGGATCAG GTCCGGTGTC TCCTTGACCA AGCCATGGAT 12300

CCAAATGTCC TCGGGAGAGT CTGGGCGGGA TGGGACCCTT GGATGTGA 12348

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gfderv++++s ++pk+l++rG d++ +p Lvk  eDlrqd+r++qlfs++N lL +d

Q: 3708  ITGFDERVKVMSSIRRPKRLIIRGDDERDHPVLVKSGEDLRQDQRIEQLFSVMNILLSND  3767

         789*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++ +r L++rty+V+pl+tr+gliew+ent +L+e+l  ++  ++   + + +  y+ +

Q: 3768  AACAQRGLQLRTYQVIPLTTRIGLIEWMENTCTLREFLCATMTAEEQRTAARCPEVYNAW  3827

         **************************************9998888877777788889988

S: 121   stvqar.....kpklkhlkls......levfkevlenlvpkdllkklllekfpspeewfe  169

          +  a      +p + h   +      ++ f +v++  vp dllk+++l+++ spe++++

Q: 3828  LATFAPknttgAPLYGHAYRKagradaVNNFVKVVQR-VPSDLLKRAFLKMSSSPEAFLS  3886

         877776344443334444444888899*********9.**********************

S: 170   lrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekv  229

         lr++++rs+A+ +++++ Lg+gdrhl+n++++ e+g ++ idfg+af++a+++l+vpe +

Q: 3887  LRSHFARSHALLCVSHWLLGIGDRHLSNFMVNTESGGIIGIDFGHAFGSATQFLPVPELM  3946

         ************************************************************

S: 230   PFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk....  285

         PFRLT+++vn+++++ ++G++++ +++ lr+   +++ ll++++vf+++pl+dwk+

Q: 3947  PFRLTQQFVNLMQPLRESGLIQSVMVHSLRAYGADPDLLLNTMDVFVKEPLLDWKNfelk  4006

         ************************************************************

S: 286   ..kkktsketeeelaekakaealkikkllskvekaenavatrdlll  329

           kk++++ +e +  + ++++ +k+  + +k+++a++a +t d+l

Q: 4007  qlKKGGTWTEEVNTRDINWYPLQKVAFARRKLQGANPAAITSDELK  4052

         *999************************************998875

Domain Sequence
(FASTA)

ITGFDERVKV MSSIRRPKRL IIRGDDERDH PVLVKSGEDL RQDQRIEQLF SVMNILLSND 60

AACAQRGLQL RTYQVIPLTT RIGLIEWMEN TCTLREFLCA TMTAEEQRTA ARCPEVYNAW 120

LATFAPKNTT GAPLYGHAYR KAGRADAVNN FVKVVQRVPS DLLKRAFLKM SSSPEAFLSL 180

RSHFARSHAL LCVSHWLLGI GDRHLSNFMV NTESGGIIGI DFGHAFGSAT QFLPVPELMP 240

FRLTQQFVNL MQPLRESGLI QSVMVHSLRA YGADPDLLLN TMDVFVKEPL LDWKNFELKQ 300

LKKGGTWTEE VNTRDINWYP LQKVAFARRK LQGANPAAIT SDELK 345

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006303	; P:double-strand break repair via nonhomologous end joining

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013