EKS-TAR-00392
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00392
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR455.01.6E-136699956258
StatusUnreviewed
Ensembl ProteinENSTRUP00000044719
UniProt AccessionH2V685;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (2 of 2)
Gene Synonyms/Alias EGFR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000017446ENSTRUP00000044719ENSTRUT00000044870
ENSTRUG00000017446ENSTRUP00000044720ENSTRUT00000044871
OrganismTakifugu rubripes
Functional Description
Protein Length1185
Protein Sequence
(FASTA)
LEQRVVVEGQ SNQLTLLGTR ENHYDNMQRM FSNCSVVLEN LEVTYTLEHH SLSFLQSIEE 60
VGGYVLIAMN DATIIPLVNL RLIRGQSLYD GEFSLLVMSN YNRNLTSATR NYSSGLRQLQ 120
LSSLTEILRG GVKITHNPLL CNIETIQWWD IVDNTSDPRM VFKMDSFTRT CEKCDPSCVH 180
GSCWAEGPDH CQKITKLGCA EQCSRRCRGP KPSDCCNLHC AAGCTGPGAN QCLACREFND 240
DGSCKNSCPP QIFYDSKTHQ MVANPEAKFA FGAICVQACP HNYVVTGGWC VRACGTGMFE 300
VEENGIRHCQ QCDGPCPKAC DGIGVGRLTN TIAVNASNVE LFRNCTKING DVYFIGTSFT 360
GDPHYKIPPM DPAKLEYFRT VKEITGFLLI QSWPQNLSSL SVFENLHTIR GRTTLSSQHS 420
LVVVRTKHLR WLGLRSLKEV SAGKVMLKDN LQLCYTQPFQ WKRLFRSGQQ NFTISNNRPP 480
ELCEQQNQTC DPECTALGCW GPGPDMCVSC RHFIRRGHCV TSCNVLYGEP REAELNGSCA 540
ECHPECQRQT GVPTCHGPGP DQCSQCAHVQ DGPHCVAHCP QGMLGEGDVV IWKYPDSRGQ 600
CQPCHQNCTL GCSGPGRSGC TGLCPSSVTH SALAVCVVGG LIIVVVVSLA VVVLLRRKQI 660
TRRRTLRHLL QERELVEPLT PSGEAPNQAL LRIMKETEFK KIQVLGTGAF GTVYKGLWMP 720
EGENVRVSVA IKVLREATSS KANKEILDEA YVMASIDHPH VCRLLGICLT SSIQLVTQLM 780
PFGCLLDYVR LHRDRVGARR LLNWCVQIAK GMSYLEGRHL VHRDLAARNV LVKSPSHVKI 840
TDFGLAKLLT ANETAYHADG GKVPIKWMAL ESILESTYTH QSDVWSFGVT VWELTTFGLK 900
PYDGIPAGEI SSVLERGERL PHPPICTMDL YMIMVKCWMI DPSSRPTFGK LTAEFSMMAQ 960
DPSRFLIIQG DLPSPADHRF YSHLLSSEDM EDVIDAEEYL QPHKEFCHPG RSSCSHTVAA 1020
AALLARNRVC LRYITRPTQS LVDTEAVADH GRSAPSTNDL DLKGSLHMPD YMNDNMNGPS 1080
SAASGVLNPK YEDLGHVGLN ASASSSESFF QGPNRPEYQN TAQSSPPLVG PENRNNPDHE 1140
AGFLPQATTV STGNTRTSNG NRFFPAAENR EYLGLAPPSS SSSSS 1185
Nucleotide Sequence
(FASTA)
CTTGAGCAAC GTGTTGTCGT TGAGGGACAG AGTAATCAGC TGACCTTGTT GGGAACCCGG 60
GAGAATCACT ATGACAACAT GCAGAGGATG TTCTCCAATT GTTCGGTGGT CCTGGAGAAC 120
CTGGAGGTGA CCTACACGCT GGAGCATCAC AGCCTCTCGT TCCTCCAGTC CATAGAGGAA 180
GTGGGCGGTT ATGTCCTGAT CGCCATGAAC GACGCCACCA TCATCCCACT GGTCAACCTG 240
AGGCTGATCC GAGGACAGAG TTTGTACGAC GGGGAATTCT CCCTCCTGGT GATGTCGAAC 300
TACAACCGCA ACCTGACGTC AGCGACTCGA AACTACAGTA GTGGACTGAG ACAGCTGCAG 360
CTGAGCAGCC TGACAGAAAT CCTCAGGGGA GGGGTGAAGA TTACCCACAA TCCTTTACTC 420
TGCAACATCG AGACGATCCA GTGGTGGGAC ATCGTGGACA ACACCAGCGA CCCCAGGATG 480
GTTTTCAAGA TGGATTCCTT CACTCGAACA TGTGAGAAAT GTGACCCCTC GTGTGTTCAC 540
GGCTCGTGTT GGGCAGAAGG ACCAGATCAC TGCCAGAAAA TCACTAAACT AGGGTGTGCC 600
GAGCAGTGCA GCCGGAGGTG TCGTGGTCCA AAGCCCAGCG ACTGCTGTAA CCTTCACTGT 660
GCTGCAGGAT GTACCGGACC TGGCGCCAAC CAATGCCTGG CCTGCAGGGA ATTTAATGAT 720
GATGGATCCT GTAAGAACTC ATGTCCTCCT CAGATATTCT ACGACTCCAA AACCCACCAG 780
ATGGTCGCTA ACCCCGAGGC CAAGTTTGCC TTTGGTGCCA TATGTGTCCA GGCCTGCCCA 840
CATAATTACG TTGTGACGGG TGGCTGGTGT GTCCGAGCCT GCGGCACTGG GATGTTTGAG 900
GTGGAGGAAA ATGGAATCCG TCACTGTCAA CAATGTGACG GACCGTGTCC CAAAGCCTGC 960
GACGGCATCG GCGTGGGCAG GTTGACCAAC ACCATCGCTG TCAACGCCTC CAACGTGGAG 1020
CTGTTCAGGA ACTGCACCAA GATCAACGGG GACGTGTACT TCATCGGGAC CTCTTTCACG 1080
GGGGATCCCC ATTACAAAAT CCCACCAATG GACCCAGCAA AGCTGGAGTA CTTCAGGACA 1140
GTCAAAGAAA TCACAGGGTT TCTGCTGATC CAATCTTGGC CGCAGAATCT AAGCTCATTG 1200
TCTGTGTTTG AAAACCTGCA CACCATCCGA GGAAGAACCA CACTCTCCAG TCAGCACAGT 1260
TTGGTGGTTG TGAGGACCAA ACATCTACGC TGGCTTGGCC TCCGCTCTTT GAAGGAAGTG 1320
AGTGCAGGCA AGGTCATGCT AAAAGACAAC CTTCAACTCT GCTACACGCA ACCTTTTCAG 1380
TGGAAGCGCC TCTTCAGGTC CGGTCAACAA AATTTTACCA TCTCCAACAA CAGGCCTCCA 1440
GAGCTCTGTG AGCAGCAAAA CCAGACTTGT GACCCGGAGT GCACGGCGCT GGGCTGCTGG 1500
GGTCCTGGTC CTGACATGTG CGTCTCCTGC CGCCACTTTA TTCGCAGGGG TCACTGCGTG 1560
ACTTCCTGCA ACGTGCTGTA TGGAGAACCC AGAGAGGCGG AGCTGAACGG CAGCTGTGCT 1620
GAGTGTCACC CAGAGTGTCA GCGGCAGACC GGCGTTCCCA CCTGCCACGG ACCGGGTCCA 1680
GACCAGTGTT CCCAGTGTGC GCACGTTCAG GACGGTCCAC ATTGTGTGGC ACACTGCCCT 1740
CAAGGCATGC TGGGAGAAGG AGACGTGGTG ATCTGGAAGT ACCCTGACAG CAGGGGTCAG 1800
TGCCAGCCCT GCCACCAGAA CTGCACGCTG GGCTGTTCTG GTCCAGGACG CTCTGGATGC 1860
ACCGGTTTGT GCCCCAGTTC CGTCACACAC TCCGCTCTGG CCGTGTGTGT GGTTGGTGGC 1920
CTCATAATCG TTGTCGTTGT GTCACTGGCC GTGGTTGTGT TGCTGCGGAG GAAGCAGATC 1980
ACGAGGAGGA GGACTTTGCG CCACCTGCTG CAGGAGCGAG AGTTGGTGGA ACCACTGACT 2040
CCGAGTGGCG AAGCTCCCAA CCAGGCGTTG CTCAGGATAA TGAAGGAGAC AGAATTTAAG 2100
AAGATTCAAG TTCTCGGCAC CGGAGCATTT GGGACCGTCT ACAAGGGTCT CTGGATGCCT 2160
GAGGGGGAGA ATGTGAGGGT CTCAGTGGCC ATCAAGGTTC TCCGGGAAGC TACGTCATCT 2220
AAAGCCAACA AAGAAATCCT CGATGAAGCA TATGTCATGG CGAGCATCGA TCACCCTCAC 2280
GTGTGTCGTC TCCTGGGAAT CTGTCTGACG TCGTCCATCC AGCTGGTCAC TCAGCTGATG 2340
CCGTTCGGTT GCCTGCTCGA TTACGTCCGG CTCCACCGGG ATCGGGTCGG AGCCCGGCGG 2400
CTCTTGAACT GGTGCGTCCA GATCGCCAAG GGGATGAGTT ACCTGGAAGG ACGTCACCTG 2460
GTGCATCGGG ATCTGGCGGC GAGGAACGTT CTTGTGAAAA GTCCCTCTCA CGTCAAGATC 2520
ACAGATTTTG GACTGGCCAA GCTGCTGACG GCCAACGAGA CGGCGTACCA CGCCGACGGG 2580
GGCAAGGTCC CTATCAAGTG GATGGCTCTG GAGTCGATCC TGGAGTCGAC CTACACACAC 2640
CAGAGCGACG TCTGGAGCTT TGGTGTGACC GTCTGGGAGC TCACCACATT CGGATTAAAG 2700
CCGTACGACG GCATCCCAGC AGGGGAGATC TCCTCGGTTC TGGAACGAGG GGAGCGGCTG 2760
CCGCACCCCC CCATCTGCAC CATGGACCTC TACATGATCA TGGTCAAATG TTGGATGATC 2820
GATCCTTCCA GTCGTCCAAC GTTTGGAAAA CTGACGGCTG AATTCTCAAT GATGGCGCAG 2880
GATCCTTCTA GATTCTTGAT CATACAGGGT GACCTGCCAA GTCCTGCAGA CCACAGGTTT 2940
TACTCTCATC TGCTGAGCTC GGAGGACATG GAGGACGTGA TCGATGCAGA GGAATACCTA 3000
CAACCTCACA AGGAGTTTTG TCACCCCGGC AGAAGCTCCT GCAGCCACAC GGTAGCCGCA 3060
GCAGCTCTGC TAGCACGAAA CCGGGTCTGT CTGCGCTACA TCACTCGTCC CACTCAGAGT 3120
TTGGTGGATA CAGAAGCCGT GGCTGACCAC GGTAGGTCCG CACCATCAAC AAACGATCTG 3180
GATTTAAAGG GCTCTCTTCA CATGCCAGAT TATATGAACG ACAACATGAA TGGACCCAGT 3240
AGCGCCGCAT CCGGAGTTCT GAACCCCAAG TATGAGGACC TCGGCCACGT CGGGCTCAAC 3300
GCCTCGGCCT CATCCTCTGA ATCCTTCTTC CAAGGTCCCA ACAGACCTGA ATACCAGAAC 3360
ACTGCCCAAA GTTCTCCGCC ACTAGTTGGT CCTGAGAACC GGAACAACCC GGACCATGAG 3420
GCGGGCTTCC TGCCACAGGC AACAACTGTC TCCACTGGCA ACACTCGGAC ATCCAATGGG 3480
AACAGATTCT TCCCAGCTGC AGAGAACCGG GAATATTTAG GTCTCGCACC ACCTTCATCA 3540
TCATCATCAT CATCA 3555
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk++vlG+GafGtvykG+w+pegenv++ vaikvl+e+t++kanke+ldea+v+as+dh
Q: 699   FKKIQVLGTGAFGTVYKGLWMPEGENVRVSVAIKVLREATSSKANKEILDEAYVMASIDH  758
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+s++qlvtql+p+Gclldyvr h+d++G++ llnwcvqiakGmsyle +
Q: 759   PHVCRLLGICLTSSIQLVTQLMPFGCLLDYVRLHRDRVGARRLLNWCVQIAKGMSYLEGR  818
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvlvksp+hvkitdfGlakll+a+e+ ++a+ggkvpikw+alesil+ +y
Q: 819   HLVHRDLAARNVLVKSPSHVKITDFGLAKLLTANETAYHADGGKVPIKWMALESILESTY  878
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvws+Gvtvwel tfG kpydgipa ei+++le+Gerl+ ppict+d+ym++vkcw
Q: 879   THQSDVWSFGVTVWELTTFGLKPYDGIPAGEISSVLERGERLPHPPICTMDLYMIMVKCW  938
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srp+f +l++efs
Q: 939   MIDPSSRPTFGKLTAEFS  956
         ****************96
Domain Sequence
(FASTA)
FKKIQVLGTG AFGTVYKGLW MPEGENVRVS VAIKVLREAT SSKANKEILD EAYVMASIDH 60
PHVCRLLGIC LTSSIQLVTQ LMPFGCLLDY VRLHRDRVGA RRLLNWCVQI AKGMSYLEGR 120
HLVHRDLAAR NVLVKSPSHV KITDFGLAKL LTANETAYHA DGGKVPIKWM ALESILESTY 180
THQSDVWSFG VTVWELTTFG LKPYDGIPAG EISSVLERGE RLPHPPICTM DLYMIMVKCW 240
MIDPSSRPTF GKLTAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>
EKS-CAJ-00304
EKS-DRM-00152
EKS-GAA-00371
EKS-ORN-00388
EKS-ORL-00359
EKS-TEN-00388
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013