EKS-TAR-00612

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00612

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/CCK4	432.5	1.4E-129	647	912	266

Status

Unreviewed

Ensembl Protein

ENSTRUP00000044893

UniProt Accession

H2V6Q1;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK7

Gene Synonyms/Alias

PTK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017511	ENSTRUP00000044895	ENSTRUT00000045046
ENSTRUG00000017511	ENSTRUP00000044894	ENSTRUT00000045045
ENSTRUG00000017511	ENSTRUP00000044892	ENSTRUT00000045043
ENSTRUG00000017511	ENSTRUP00000044893	ENSTRUT00000045044
ENSTRUG00000017511	ENSTRUP00000044890	ENSTRUT00000045041
ENSTRUG00000017511	ENSTRUP00000044891	ENSTRUT00000045042
ENSTRUG00000017511	ENSTRUP00000044887	ENSTRUT00000045038
ENSTRUG00000017511	ENSTRUP00000044888	ENSTRUT00000045039
ENSTRUG00000017511	ENSTRUP00000044889	ENSTRUT00000045040

Organism

Takifugu rubripes

Functional Description

Protein Length

921

Protein Sequence
(FASTA)

LFLSPVLFGQ TLAIQFTKEP KSQDALHGRS AMLRCEVSNP TNISYRWLHN GQRLENSDRR 60

FQEGSNLKFM AVDRQLDAGS FECVAQNPVT GEIRQSTNAS FNIKWLESGS VTLKEPNSEE 120

GIESSAPVTL HCQIDGHPRP TCQWFKDGVK LTEKSHQINS KERTLTVKNA SPDDNGLYYC 180

CAKNAAGHVC SSSNFSLNII DKSFPRPVVS PEDVLVLRNE EAMFHCQFTA VPAPTFEWYH 240

ENELLTNKSR NAEERIMHVR IVFLLSNGTL LITQVKPRNT GTYKCVSRGI RGPPVILEAS 300

LLIAEIDDMV PKLWRVFTAD SLQRVACEPP LGRPEPEVWW ERGGQRVPTE GRVFQDGLYL 360

VFSPTKEEDS GTYTCVAQNK AGRRTQEVIF TVANGGQLPP HLGQRNGLLH FSKVTRGDAG 420

NYTCIASNSL QGEIRAVVSL TAAVYIRFKV EPENTTVYQG HTAILHCQAT GDPEPHIHWM 480

VKDKTLDSSK NRSSRVQKMP NGSLLITDVT SDDTGRYTCV TGNSCSIKDR VAQLYVVDKP 540

VHFFEDGDRA PYKMIQTIGL SVGAAVAYII IVLGLMFYCK KRRNAKRLQK GQDREEPEME 600

CLNGGALQQN GHTTAEIQEE VALTNMGTTA TTEKRNSDKI QFARANLQTI TVLGKGEFGE 660

VLLCKAKGIE QSKEEMVVLV KSLQTRDEQL QLDFRREAEM FAKLSQPNIV RLLGLCREAE 720

PHYIILEYYD LGDLKQFLRI SKSKDDKVKS QPISTKTKVS ICAQVAHGME HVSNHRFVHK 780

DLAARNCLIN SQRHVKISSL SLSKDVYNSE YYYYRQAWIP LRWLPSESVF EDDFSTKSDV 840

WAFGVLMWEV FSYGELPHSK LNDDEILAAL KAGKLKLPVP DGCPSRIYKL MVRCWALSLK 900

ERPSFTEIVQ ALGELPSNSK V 921

Nucleotide Sequence
(FASTA)

CTCTTTCTTT CTCCAGTTTT GTTTGGTCAG ACTCTCGCCA TCCAGTTTAC CAAGGAGCCG 60

AAATCTCAGG ATGCTTTGCA CGGCCGCAGT GCCATGTTAC GGTGTGAGGT CAGCAATCCA 120

ACCAACATCA GTTACAGGTG GCTACACAAT GGCCAGCGCC TGGAAAACAG CGACAGGCGC 180

TTTCAGGAGG GCAGCAACCT CAAGTTTATG GCTGTGGATC GGCAGCTGGA TGCAGGCAGC 240

TTTGAGTGCG TCGCACAAAA CCCAGTAACG GGAGAAATAC GCCAGTCCAC TAATGCCTCC 300

TTCAATATCA AGTGGTTAGA AAGTGGCAGT GTGACTTTAA AGGAACCTAA CTCAGAAGAG 360

GGCATCGAGA GTTCAGCACC AGTCACATTA CACTGTCAGA TTGATGGACA CCCACGACCA 420

ACATGCCAGT GGTTCAAGGA TGGGGTGAAG CTGACTGAGA AGAGCCATCA GATTAACAGC 480

AAAGAGAGGA CACTAACTGT CAAGAATGCC AGTCCAGATG ACAATGGACT GTACTACTGT 540

TGTGCCAAGA ATGCAGCAGG TCATGTCTGC AGCAGCAGCA ACTTCAGCCT CAACATTATA 600

GATAAGAGTT TCCCACGACC GGTGGTCTCT CCTGAGGATG TGCTGGTGCT GAGGAATGAG 660

GAGGCCATGT TCCACTGCCA GTTCACTGCT GTGCCAGCCC CCACATTTGA GTGGTACCAC 720

GAGAATGAGC TTTTGACAAA CAAGTCTCGG AATGCAGAGG AAAGGATAAT GCATGTCAGA 780

ATTGTGTTCC TACTCTCCAA TGGCACACTG TTGATCACCC AGGTCAAGCC CCGGAACACT 840

GGGACCTACA AGTGCGTCAG CCGTGGAATT AGAGGGCCCC CGGTTATATT GGAGGCATCC 900

CTCCTCATAG CAGAGATAGA TGACATGGTG CCAAAGCTGT GGAGGGTCTT CACAGCAGAC 960

TCTCTACAGC GGGTCGCATG TGAACCCCCA CTTGGAAGAC CTGAGCCTGA GGTGTGGTGG 1020

GAGAGAGGAG GGCAGCGGGT ACCTACAGAG GGCAGAGTCT TCCAAGATGG CCTGTATCTG 1080

GTGTTTAGCC CCACCAAGGA AGAAGACTCC GGCACCTACA CCTGTGTGGC TCAGAATAAG 1140

GCGGGTCGCA GGACACAGGA GGTCATCTTT ACTGTGGCCA ATGGAGGACA GCTGCCGCCT 1200

CACTTGGGGC AGAGGAACGG CCTTCTTCAC TTCAGCAAAG TGACCCGCGG TGATGCCGGA 1260

AACTATACAT GTATTGCTTC AAACAGCCTT CAGGGGGAGA TTCGAGCTGT GGTGTCCCTC 1320

ACTGCGGCTG TGTACATTCG TTTTAAGGTG GAGCCAGAAA ATACAACTGT GTACCAAGGC 1380

CACACAGCCA TCCTCCACTG TCAGGCTACC GGCGACCCCG AGCCTCACAT TCACTGGATG 1440

GTCAAAGACA AGACACTGGA CAGCAGTAAG AACAGAAGTT CCAGGGTCCA GAAAATGCCC 1500

AACGGCTCCT TGCTCATCAC AGATGTCACC TCGGATGATA CTGGCAGATA TACATGTGTA 1560

ACAGGCAACA GCTGCAGCAT CAAAGACCGT GTGGCTCAGC TGTATGTAGT GGACAAACCT 1620

GTGCATTTCT TTGAAGATGG GGACAGGGCT CCTTACAAGA TGATCCAAAC CATTGGTCTT 1680

TCCGTGGGGG CCGCTGTGGC TTATATCATC ATAGTACTAG GACTCATGTT CTACTGTAAA 1740

AAGAGGCGCA ATGCTAAAAG ACTGCAGAAG GGCCAGGATA GAGAGGAGCC AGAGATGGAA 1800

TGTCTCAATG GAGGGGCACT GCAACAGAAT GGCCACACCA CGGCAGAGAT CCAGGAAGAG 1860

GTTGCACTCA CCAACATGGG TACAACAGCA ACAACAGAGA AACGCAATAG CGATAAGATC 1920

CAGTTTGCTC GGGCAAACCT CCAAACCATC ACAGTCTTAG GTAAAGGAGA GTTTGGTGAG 1980

GTGCTGCTCT GCAAAGCTAA GGGTATTGAG CAGAGCAAGG AGGAGATGGT GGTCTTGGTG 2040

AAAAGTCTAC AGACCAGAGA CGAACAGCTT CAACTCGACT TCCGCCGTGA AGCTGAAATG 2100

TTTGCTAAGC TTAGCCAGCC CAATATCGTC CGCCTGTTGG GTCTGTGTCG GGAGGCGGAG 2160

CCTCACTACA TTATCCTGGA GTACTATGAC TTGGGAGACC TAAAGCAGTT TCTAAGAATT 2220

TCCAAAAGCA AAGATGACAA GGTCAAATCC CAGCCAATCA GCACCAAAAC CAAAGTTTCG 2280

ATTTGTGCCC AAGTGGCTCA TGGGATGGAG CATGTCTCAA ATCACAGATT TGTTCATAAA 2340

GACCTAGCTG CTCGAAACTG CCTGATCAAC AGTCAGAGGC ATGTAAAGAT CTCGTCACTG 2400

AGCCTCAGCA AGGACGTCTA CAACAGTGAG TATTACTACT ACAGGCAGGC TTGGATCCCA 2460

CTGCGCTGGC TCCCATCTGA GTCAGTGTTT GAGGATGACT TCTCCACCAA GTCGGACGTG 2520

TGGGCCTTTG GAGTCTTAAT GTGGGAGGTG TTTAGTTATG GGGAACTTCC ACATTCTAAA 2580

CTGAACGATG ATGAGATCCT GGCGGCCCTG AAGGCTGGAA AACTGAAACT GCCTGTTCCA 2640

GATGGATGTC CATCCAGAAT CTACAAGCTA ATGGTGCGCT GCTGGGCACT CAGCCTCAAA 2700

GAACGGCCCT CTTTCACTGA AATCGTGCAG GCATTGGGAG AGCTGCCTTC AAACAGCAAA 2760

GTCTGA 2766

Domain Profile

S: 1     lqelitlgksefgevflaklkgleegatetlvlvkslqkkdeqaqldfrrelellgklnh  60

         lq ++ lgk+efgev+l+k+kg+e++  e +vlvkslq++deq qldfrre e++ kl+

Q: 647   LQTITVLGKGEFGEVLLCKAKGIEQSKEEMVVLVKSLQTRDEQLQLDFRREAEMFAKLSQ  706

         799*********************************************************

S: 61    anvvrllglcreaephymvleyvdlgdlkqflkiskakdeklksqplstkqkvalasqva  120

          n+vrllglcreaephy++ley dlgdlkqfl+isk+kd+k+ksqp+stk kv++++qva

Q: 707   PNIVRLLGLCREAEPHYIILEYYDLGDLKQFLRISKSKDDKVKSQPISTKTKVSICAQVA  766

         ************************************************************

S: 121   lgmealsrarfvhkdlaarnclisaerqvkvsalalskdvynseyykfrqalvplrwlsp  180

          gme++s+ rfvhkdlaarncli ++r vk+s l+lskdvynseyy +rqa++plrwl

Q: 767   HGMEHVSNHRFVHKDLAARNCLINSQRHVKISSLSLSKDVYNSEYYYYRQAWIPLRWLPS  826

         ************************************************************

S: 181   eaileddfstksdvfafgvlvwevftqaelpheeladdevladlqagklrlsqaeatpsk  240

         e++ eddfstksdv+afgvl+wevf+ +elph +l dde+la l+agkl+l++++++ps+

Q: 827   ESVFEDDFSTKSDVWAFGVLMWEVFSYGELPHSKLNDDEILAALKAGKLKLPVPDGCPSR  886

         ************************************************************

S: 241   lyrlllrcwasnpkdrpsfselasal  266

         +y+l+ rcwa++ k+rpsf+e+  al

Q: 887   IYKLMVRCWALSLKERPSFTEIVQAL  912

         **********************9886

Domain Sequence
(FASTA)

LQTITVLGKG EFGEVLLCKA KGIEQSKEEM VVLVKSLQTR DEQLQLDFRR EAEMFAKLSQ 60

PNIVRLLGLC REAEPHYIIL EYYDLGDLKQ FLRISKSKDD KVKSQPISTK TKVSICAQVA 120

HGMEHVSNHR FVHKDLAARN CLINSQRHVK ISSLSLSKDV YNSEYYYYRQ AWIPLRWLPS 180

ESVFEDDFST KSDVWAFGVL MWEVFSYGEL PHSKLNDDEI LAALKAGKLK LPVPDGCPSR 240

IYKLMVRCWA LSLKERPSFT EIVQAL 266

Keyword

Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 5.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 6.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013