EKS-TAR-00191

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00191

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	551.3	7.5E-166	390	666	277

Status

Unreviewed

Ensembl Protein

ENSTRUP00000045147

UniProt Accession

H2V7F4;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017610	ENSTRUP00000045145	ENSTRUT00000045297
ENSTRUG00000017610	ENSTRUP00000045146	ENSTRUT00000045298
ENSTRUG00000017610	ENSTRUP00000045143	ENSTRUT00000045295
ENSTRUG00000017610	ENSTRUP00000045144	ENSTRUT00000045296
ENSTRUG00000017610	ENSTRUP00000045148	ENSTRUT00000045300
ENSTRUG00000017610	ENSTRUP00000045147	ENSTRUT00000045299

Organism

Takifugu rubripes

Functional Description

Protein Length

730

Protein Sequence
(FASTA)

MSSWAWLLAA VLVSLLTASV ARPPLTAAKE EEATQRPEDA ISSGDDEDDT ERSEDSGADG 60

EQPTLGAPYW ISSAKMEKKL HAVPAANTVK FRCAAGGNPE PKLRWLKNNR PFRQEDRMGG 120

YKVRNQHWTL IMESVVPSDK GNYTCLVENE FGSINHTYTL DVVERSPHRP ILQAGLPANT 180

TVHVGEDARF VCKVYSDAQP HIQWLKHIAQ NGSRFGPDGN PYVRVLKTAG VNTTDKEIEV 240

LYLPNVTFED AGEYTCLAGN SIGISFHTAW LTVLPAIEES HGPLSPHYVE IAIYCAGVFL 300

IACMVGIVVV CRMRNTTKKP DFGGQPAVHK LSKQIPLRRQ VTVSADSSSS MNSNTPLVRI 360

TTRRSSAHDE PIPEYDLPED PRWEFTRDRL TLGKPLGEGC FGQVVMAEAL GVDKDKPKEA 420

VTVAVKMLKD DATEKELSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN 480

LREYLRARRP PGMEYSYDIA RVSDEQLTFK DLVSCTYQVA RGMEYLASQK CIHRDLAARN 540

VLVTESNIMK IADFGLARDV HNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV 600

LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPGNCTNE LYMMMKDCWH AISSQRPTFK 660

QLVEDLDRIL TLSSNEEYLD LCIPSEQYSP SFPDTRSSCS SGDDSVFSHD PLPDEPCLPK 720

YQHINGNVKT 730

Nucleotide Sequence
(FASTA)

ATGTCCTCCT GGGCCTGGCT GCTGGCTGCC GTCTTGGTCT CCCTACTGAC TGCCAGTGTG 60

GCACGGCCAC CACTAACTGC CGCCAAGGAA GAGGAGGCCA CTCAGCGACC CGAAGATGCC 120

ATCTCGTCGG GGGATGATGA GGACGATACA GAGCGTTCTG AGGACTCTGG GGCCGATGGA 180

GAGCAGCCGA CATTAGGTGC TCCATACTGG ATCTCATCGG CAAAGATGGA AAAGAAACTG 240

CACGCCGTGC CAGCTGCCAA CACAGTCAAG TTCCGCTGTG CAGCGGGAGG CAACCCCGAG 300

CCCAAGTTAC GCTGGCTTAA AAACAACAGA CCTTTCCGCC AAGAGGACCG CATGGGAGGC 360

TATAAGGTTC GTAACCAGCA TTGGACCCTG ATCATGGAGA GTGTGGTGCC TTCAGACAAG 420

GGCAACTACA CTTGCCTGGT GGAGAATGAG TTTGGATCCA TCAACCACAC GTACACCTTG 480

GATGTAGTGG AACGCTCCCC TCACCGACCA ATTCTGCAGG CTGGTCTCCC AGCTAACACA 540

ACTGTACACG TAGGTGAAGA TGCTCGCTTT GTCTGCAAAG TCTATAGCGA TGCCCAGCCA 600

CACATCCAGT GGCTAAAACA CATCGCTCAA AATGGCAGCC GTTTTGGGCC CGACGGGAAC 660

CCTTATGTCC GAGTGTTAAA GACCGCAGGT GTTAACACTA CAGATAAGGA GATTGAAGTT 720

CTCTACTTGC CCAATGTTAC TTTTGAAGAT GCTGGCGAGT ATACGTGCTT GGCGGGTAAT 780

TCTATTGGGA TCTCCTTTCA CACTGCTTGG TTGACGGTGC TCCCAGCCAT TGAAGAATCC 840

CATGGTCCCC TTTCGCCACA CTACGTGGAG ATCGCCATAT ACTGTGCAGG AGTCTTCCTC 900

ATTGCCTGCA TGGTGGGCAT TGTGGTGGTG TGCCGGATGA GGAACACAAC AAAAAAACCC 960

GACTTCGGGG GCCAGCCGGC TGTCCACAAA CTGAGCAAAC AGATCCCGCT GCGGCGCCAG 1020

GTAACAGTGT CAGCGGACTC GAGTTCTTCA ATGAACTCCA ACACACCTCT CGTGCGAATT 1080

ACAACGCGGC GGAGCTCTGC ACACGATGAG CCAATCCCCG AATACGACCT TCCTGAGGAT 1140

CCACGATGGG AGTTTACTCG AGACAGATTG ACCCTGGGCA AACCCCTGGG TGAAGGTTGC 1200

TTTGGCCAAG TTGTAATGGC AGAGGCTCTG GGCGTTGATA AAGACAAACC CAAGGAAGCT 1260

GTGACTGTTG CCGTCAAAAT GCTGAAAGAT GATGCCACGG AGAAAGAGCT GTCTGACCTG 1320

GTATCAGAGA TGGAAATGAT GAAGATGATT GGTAAACATA AGAACATCAT TAATCTTCTT 1380

GGAGCCTGTA CGCAAGATGG TCCCCTTTAT GTGATAGTAG AATACGCCTC CAAAGGCAAC 1440

CTTAGGGAGT ACCTCCGAGC CCGGAGGCCA CCTGGCATGG AATACTCTTA TGATATCGCC 1500

AGAGTCTCAG ATGAACAACT TACATTCAAA GATTTAGTGT CCTGCACCTA CCAAGTAGCA 1560

AGGGGTATGG AGTACCTTGC ATCACAGAAG TGTATACACA GAGACCTTGC AGCCAGGAAC 1620

GTCCTGGTCA CAGAGAGCAA CATTATGAAG ATCGCAGACT TTGGCCTTGC CAGAGATGTC 1680

CACAATATTG ACTATTATAA AAAGACAACA AATGGTCGTC TCCCGGTGAA ATGGATGGCG 1740

CCAGAGGCGT TGTTCGACCG GGTCTACACA CACCAAAGTG ATGTCTGGTC ATTTGGGGTG 1800

CTGATGTGGG AGATCTTCAC CTTAGGGGGC TCCCCGTACC CCGGCATTCC CGTTGAAGAG 1860

CTCTTTAAAT TGCTCAAAGA GGGACATCGC ATGGACAAGC CTGGCAACTG CACCAATGAG 1920

CTGTACATGA TGATGAAAGA CTGCTGGCAC GCCATCTCAT CCCAGAGACC CACCTTCAAG 1980

CAGCTAGTCG AAGATCTGGA TCGCATCCTT ACCCTCAGCA GCAATGAGGA GTATCTGGAC 2040

CTTTGCATCC CATCAGAGCA GTATTCTCCC AGCTTCCCCG ACACCCGCAG CTCCTGCTCC 2100

TCCGGTGATG ACTCTGTGTT TTCCCATGAC CCGTTACCAG ACGAGCCCTG CCTCCCCAAA 2160

TACCAGCACA TCAATGGCAA TGTTAAAACA TGA 2193

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+k+l+dlvseme++k+

Q: 390   LTLGKPLGEGCFGQVVMAEALGVDKDKPKEAVTVAVKMLKDDATEKELSDLVSEMEMMKM  449

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d +++s+eqlt+

Q: 450   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEQLTF  509

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yqvarGmeylas+kcihrdlaarnvlvte n++kiadfGlardvh+idyykkt

Q: 510   KDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNIMKIADFGLARDVHNIDYYKKT  569

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 570   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  629

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp +ct+ely++m++cwha +s+rptfkqlvedl

Q: 630   RMDKPGNCTNELYMMMKDCWHAISSQRPTFKQLVEDL  666

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGVDKDKPKE AVTVAVKMLK DDATEKELSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEQLTF 120

KDLVSCTYQV ARGMEYLASQ KCIHRDLAAR NVLVTESNIM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPGNCTN ELYMMMKDCW HAISSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013