EKS-TAR-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	375.5	3.0E-112	43	328	286

Status

Unreviewed

Ensembl Protein

ENSTRUP00000045256

UniProt Accession

H2V7R4;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000017658	ENSTRUP00000045256	ENSTRUT00000045408
ENSTRUG00000017658	ENSTRUP00000045255	ENSTRUT00000045407
ENSTRUG00000017658	ENSTRUP00000045254	ENSTRUT00000045406
ENSTRUG00000017658	ENSTRUP00000045253	ENSTRUT00000045405
ENSTRUG00000017658	ENSTRUP00000045252	ENSTRUT00000045404
ENSTRUG00000017658	ENSTRUP00000045257	ENSTRUT00000045409

Organism

Takifugu rubripes

Functional Description

Protein Length

417

Protein Sequence
(FASTA)

FQNNPNGFEK SQPVNIPDAV KKKKKKRIRA SDSSTGTFED LYKLTDEVLG QGAYAKVQGC 60

INLQNRQEYA VKKIIEKSAG HSRSRVFREV ETLYQCQGNR NILELIEFFE DSSCFYLVFE 120

KLCGGSILTH IQNRKHFDEL EASRVVRDIA QALHFLHTKG IAHRDLKLEN ILCENTDQVS 180

PVKICDFDLG SGVKLSSACT PITTPELTTP CGSAEYMAPE VVEVFTDEAS FYDKRCDLWS 240

LGVILYILLS GSPPFIGHCG SDCGWDRGET CRTCQSQLFE SIQQGKYEFP DKDWAHITGG 300

AKDLISKLLV RDATLRLSAA QVLKHPWVQG NAPERGLPTP HVLQRNSSTK DLTQFAAEAI 360

AFNRQLSQHD EQQGDAGAIV CTMRLSPPSN SRLARRRALS NARRIGEFAP SPDDLRA 417

Nucleotide Sequence
(FASTA)

TTCCAAAATA ATCCTAACGG ATTTGAGAAA AGTCAGCCGG TGAACATCCC AGATGCTGTA 60

AAAAAGAAAA AGAAGAAAAG AATCAGGGCC AGTGACAGCT CAACTGGGAC ATTTGAGGAT 120

CTCTACAAAC TGACAGATGA AGTGCTTGGA CAGGGGGCAT ATGCAAAAGT TCAGGGATGT 180

ATAAATCTGC AAAACAGACA GGAATATGCT GTAAAGAAGA TCATCGAAAA GAGCGCAGGA 240

CACAGTCGCA GCAGAGTCTT TCGTGAAGTG GAGACTCTCT ACCAGTGCCA GGGAAATAGG 300

AACATTTTGG AATTGATTGA GTTCTTTGAA GACAGCTCCT GCTTTTATTT GGTGTTTGAA 360

AAGCTCTGTG GGGGGTCCAT TCTCACACAT ATCCAGAACC GGAAGCACTT TGATGAGCTG 420

GAGGCCAGTA GGGTTGTCAG GGACATTGCT CAAGCGCTCC ATTTCCTGCA CACGAAGGGG 480

ATTGCTCACC GAGATCTTAA ACTGGAGAAC ATCCTTTGTG AAAACACCGA TCAGGTGTCC 540

CCTGTTAAGA TCTGTGATTT TGACCTGGGA AGTGGAGTGA AGCTCAGCAG CGCCTGCACC 600

CCCATAACCA CTCCAGAACT CACCACACCA TGTGGCTCAG CTGAATACAT GGCTCCAGAG 660

GTTGTGGAGG TCTTCACTGA TGAAGCCTCG TTCTATGACA AGCGATGTGA TCTTTGGAGC 720

CTGGGGGTCA TCCTCTACAT CCTGCTGAGT GGCAGCCCCC CTTTCATAGG CCACTGTGGG 780

AGTGACTGTG GCTGGGACCG TGGAGAAACT TGCAGAACCT GCCAGAGTCA ATTGTTTGAG 840

AGTATCCAGC AAGGGAAGTA TGAGTTTCCA GACAAGGACT GGGCTCACAT CACAGGGGGG 900

GCCAAAGATC TCATCTCCAA GCTGCTGGTT CGAGATGCGA CGCTGCGCCT CAGCGCTGCA 960

CAAGTCCTCA AGCATCCTTG GGTGCAGGGG AATGCCCCAG AGAGAGGTCT TCCAACTCCT 1020

CATGTCCTAC AAAGGAACAG CAGCACCAAA GACCTGACTC AGTTTGCAGC CGAGGCCATC 1080

GCCTTTAACC GGCAGCTGTC CCAGCACGAC GAGCAGCAGG GCGACGCGGG GGCCATCGTC 1140

TGCACCATGA GACTCTCTCC TCCGTCCAAC TCCAGACTTG CCCGCCGACG GGCACTGTCC 1200

AACGCTCGGC GCATCGGGGA ATTTGCACCC TCACCAGATG ACCTCAGAGC CTGA 1254

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil......kdrkkvrrevelhvqasghkni  54

         klt+evlG+G+++kv+ c++ ++ ++ya+k +      ++r++v+reve+++q++g++ni

Q: 43    KLTDEVLGQGAYAKVQGCINLQNRQEYAVKKIieksagHSRSRVFREVETLYQCQGNRNI  102

         5799*************************8777***************************

S: 55    velidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhs  114

         +eli++fe    d+++++lv+ekl GG++l++iq+rk+f e eas+vv+dia+al+flh+

Q: 103   LELIEFFE----DSSCFYLVFEKLCGGSILTHIQNRKHFDELEASRVVRDIAQALHFLHT  158

         ********....************************************************

S: 115   kniahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyva  166

         k+iahrDlk en+L+e++++++pvk+cDf+l+++++ +        +el+tpc++aey+a

Q: 159   KGIAHRDLKLENILCENTDQVSPVKICDFDLGSGVKLSsactpittPELTTPCGSAEYMA  218

         *********************************9954456888888**************

S: 167   PevleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskkl  215

         Pev+e++++ea++ydk+CDlWslGvilyill+G pPf +++g           r+++ +l

Q: 219   PEVVEVFTDEASFYDKRCDLWSLGVILYILLSGSPPFIGHCGsdcgwdrgetcRTCQSQL  278

         *****************************************99*****************

S: 216   keriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +e+iq+gkyefP+++W++++  akdli+klL+rd++ rl++++vl+hpwv

Q: 279   FESIQQGKYEFPDKDWAHITGGAKDLISKLLVRDATLRLSAAQVLKHPWV  328

         *************************************************8

Domain Sequence
(FASTA)

KLTDEVLGQG AYAKVQGCIN LQNRQEYAVK KIIEKSAGHS RSRVFREVET LYQCQGNRNI 60

LELIEFFEDS SCFYLVFEKL CGGSILTHIQ NRKHFDELEA SRVVRDIAQA LHFLHTKGIA 120

HRDLKLENIL CENTDQVSPV KICDFDLGSG VKLSSACTPI TTPELTTPCG SAEYMAPEVV 180

EVFTDEASFY DKRCDLWSLG VILYILLSGS PPFIGHCGSD CGWDRGETCR TCQSQLFESI 240

QQGKYEFPDK DWAHITGGAK DLISKLLVRD ATLRLSAAQV LKHPWV 286

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013