EKS-TAR-00553

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00553

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	445.0	2.2E-133	78	340	263

Status

Unreviewed

Ensembl Protein

ENSTRUP00000046625

UniProt Accession

H2VBN4;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2 (2 of 2)

Gene Synonyms/Alias

ROCK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000018218	ENSTRUP00000046623	ENSTRUT00000046781
ENSTRUG00000018218	ENSTRUP00000046624	ENSTRUT00000046782
ENSTRUG00000018218	ENSTRUP00000046625	ENSTRUT00000046783
ENSTRUG00000018218	ENSTRUP00000046626	ENSTRUT00000046784

Organism

Takifugu rubripes

Functional Description

Protein Length

1380

Protein Sequence
(FASTA)

IMPGAESRQE SRLAKLEALM RNPQSALNLE TLLDSISALA RDLNYPALRK NKNIDAFLNR 60

YEKAASQLQE LQVKLSDFDK VKLIGRGAYG EVQLVRHKAS QKVYAMKQLN KFEMIKRSDS 120

AFFWEERHIM AFSNSPWVVQ LCCAFQDDRH LYMVMEFMPG GDLVTLTMNY DIPEKWARFY 180

TAEVVLALDA IHSMGFIHRD VKPDNMLLDQ HGHLKLADFG TCMKMDSTGM VHCDTAVGTP 240

DYISPEVLQS QGGDGYYGRE CDWWSVGVFI YELLVGETPF YAESLVGTYG KIMNHKNSLI 300

FPEDVEMSQD AKDLICAFLS DRKVRLGRNG VDDIKRHAFF QNNQWTFDII RETVAPVVPE 360

LSSDIDTSNF DDIENDKGNA ETFPPPRAFV GNQLPFVGFT YFKEDHSLLS EKIQRTVRKT 420

ARIRSRTPTQ RCREQLQKKL HQLEEQLDCE MQAKDELEQK CKNATNRLEK LVKELDKEMS 480

GRQKVEASLR QLERERALLQ HQSVENLRKV ELETDRKRSL ENELNNLRDQ LEDLRKKNQN 540

SQISNEKNIQ LQKQLDDTNA GLQAEQEAAA RLKKSQAEAQ KQAQSLEASL GETKERCSQL 600

EKDRMELEKQ LTALQAELDE ERRDGNLRTE TIADLQGRVG RLKEEVKEVK SSHSEVLSEK 660

KKLQEQLGIL EKEKSNQEID LMFKLRTLQQ SMELEELEHK ATKAKLVDQN KIDHSIEEAT 720

SETLKEVELT LQEERSLKMQ VEGKLLQLKK EHSMLDCDYK QAKQKLDELQ TQKEKLSEEV 780

KNLSLRLEQE SHRRSLSQSE LKMQTQQVSV LRSSEKQLKQ ELNHLLDMKQ TLDKQNQELR 840

REKQEVGGQL KELKDQLEAE QYFTTLYKTQ VRELKDESDK KSKQCKELQR RLAEYKEERE 900

SLTAQLEASL TKVDAEQLAR SIAEEQYSDL EKEKIMKELE IKDMMARHKQ ELGDKESTIS 960

SLEESNRTLT VDVANLAGEK EELNNQLKEM QQKLQKAKEA EKQMNSHKVS FERMLQNERT 1020

LKIQAINKLA EVMNRRVPVR GGTEVHRREK ENRKLQLELR AEKEKLNSTL IKYQREMTDM 1080

QALLAEENQV RLELQMALDS KESDIEQLRC QISTLSVHSL DSTSISSGND LDTSEGYPDS 1140

RLEGWISLPT KNTKRFGWDK KYLVVSSKKI LFYNSELDRE QGNPFMTLDI DKLFHVRPVT 1200

HTDVYRADPK EIPRIFQILY ANEGEVKRDQ EVVMEPTPFG ERLSYISHKG HEFILTLYHF 1260

PSSCEVCTRP LWHVFKPPPA LECRRCHTKC HKDHLDKKEE VIVPCKVNYD MSTAKELLLL 1320

TNSQEEQQRW VSHLYKRIPR KHPTLGPAAS LSTSPEAPPR SSPRVSPRPS PRSSPHMSPH 1380

Nucleotide Sequence
(FASTA)

ATCATGCCGG GAGCGGAGAG CAGACAGGAA AGCCGCTTGG CGAAGCTGGA GGCTCTTATG 60

AGGAACCCCC AGTCGGCACT AAACTTGGAA ACCCTACTGG ACTCCATCAG CGCACTGGCG 120

CGTGATCTGA ATTATCCCGC TCTACGGAAA AACAAAAACA TAGACGCCTT CCTCAACCGA 180

TATGAGAAGG CGGCCAGTCA GCTGCAGGAG CTGCAGGTGA AGCTCTCCGA CTTTGACAAA 240

GTGAAGCTGA TCGGCCGCGG GGCCTACGGG GAGGTGCAGC TGGTCCGTCA CAAGGCCTCT 300

CAGAAGGTCT ACGCCATGAA GCAGCTCAAC AAGTTTGAGA TGATCAAGCG GTCGGACTCG 360

GCCTTCTTTT GGGAGGAGCG GCACATCATG GCTTTCTCCA ACAGTCCCTG GGTGGTGCAG 420

CTGTGCTGCG CCTTCCAAGA TGACCGCCAC CTCTACATGG TGATGGAGTT CATGCCCGGC 480

GGCGACCTGG TCACGCTCAC CATGAACTAC GACATACCCG AGAAGTGGGC TCGCTTCTAC 540

ACGGCCGAGG TGGTGCTGGC GCTGGACGCC ATCCACTCCA TGGGCTTCAT CCACCGCGAC 600

GTCAAACCGG ACAACATGCT GCTCGACCAG CATGGCCACC TGAAGCTGGC GGACTTCGGC 660

ACCTGCATGA AGATGGACTC GACAGGCATG GTTCACTGCG ACACAGCTGT AGGTACGCCT 720

GATTACATCT CCCCAGAGGT GCTCCAGTCT CAGGGTGGTG ACGGTTACTA CGGCCGGGAA 780

TGTGACTGGT GGTCTGTGGG AGTCTTTATC TATGAGTTAC TGGTTGGTGA AACCCCCTTC 840

TATGCCGAGT CTCTCGTTGG AACTTACGGG AAGATCATGA ACCACAAGAA TTCCCTAATC 900

TTCCCAGAAG ATGTGGAAAT GTCTCAGGAT GCCAAAGACC TCATCTGTGC CTTTCTTTCT 960

GACAGGAAAG TTCGGCTGGG ACGCAATGGA GTGGATGACA TCAAGCGGCA CGCGTTTTTC 1020

CAGAACAACC AGTGGACCTT CGACATCATC CGAGAGACGG TGGCTCCAGT CGTGCCAGAG 1080

CTGAGCAGTG ACATCGACAC CAGCAACTTT GACGACATAG AGAATGACAA AGGCAACGCT 1140

GAGACCTTCC CTCCACCCAG AGCGTTCGTG GGCAACCAGC TGCCGTTTGT TGGCTTCACT 1200

TACTTCAAGG AGGACCACTC GCTGCTTTCT GAAAAGATTC AAAGGACGGT GAGGAAAACA 1260

GCGAGAATAA GGAGTCGGAC ACCAACACAG AGATGCCGTG AGCAGCTTCA GAAAAAGCTT 1320

CATCAGCTGG AGGAGCAGCT CGACTGTGAG ATGCAGGCCA AAGATGAGCT GGAGCAGAAG 1380

TGCAAAAATG CCACCAACCG TTTAGAAAAG CTTGTGAAAG AGCTGGACAA GGAGATGAGC 1440

GGCAGACAGA AAGTGGAGGC CTCGCTCCGT CAGCTGGAGA GAGAACGAGC TCTGCTGCAG 1500

CACCAGAGCG TCGAGAACCT GCGCAAGGTG GAGCTCGAGA CTGACAGGAA GCGGAGCCTG 1560

GAGAACGAAT TGAACAACCT GAGGGATCAG CTGGAGGATC TTCGGAAAAA GAACCAGAAT 1620

TCCCAAATCT CCAACGAGAA GAATATCCAA CTGCAGAAAC AACTCGACGA CACCAACGCT 1680

GGGCTGCAGG CGGAACAGGA GGCGGCAGCC AGGCTGAAGA AGAGTCAGGC AGAGGCGCAG 1740

AAACAGGCTC AGAGCCTGGA GGCCAGCCTG GGGGAGACGA AGGAGAGGTG TAGCCAGCTG 1800

GAAAAGGACA GGATGGAGCT GGAGAAGCAG CTGACGGCGC TGCAGGCCGA GCTGGACGAG 1860

GAGAGGAGAG ATGGAAACCT CAGGACCGAA ACCATCGCTG ACCTGCAGGG ACGTGTTGGG 1920

AGACTGAAGG AGGAGGTGAA AGAAGTGAAA TCCTCCCACT CTGAAGTCCT GTCTGAAAAG 1980

AAGAAGCTTC AGGAGCAGTT GGGCATCCTT GAAAAGGAGA AGAGCAACCA GGAGATAGAC 2040

TTGATGTTCA AGCTGAGGAC TCTGCAGCAG AGTATGGAGC TGGAGGAGCT GGAGCACAAG 2100

GCCACCAAAG CCAAGCTGGT GGATCAAAAT AAGATCGACC ATTCCATCGA GGAGGCCACC 2160

TCTGAGACCC TGAAAGAGGT GGAATTGACG CTGCAGGAGG AGCGCAGCCT GAAGATGCAG 2220

GTGGAGGGGA AGCTGCTGCA GCTGAAGAAG GAGCACTCCA TGCTGGACTG TGACTACAAG 2280

CAGGCCAAGC AAAAGCTGGA TGAGCTGCAG ACCCAAAAGG AGAAACTCTC CGAAGAGGTA 2340

AAGAACCTGA GCCTGCGGCT GGAGCAGGAG AGCCACAGGC GAAGTCTGAG CCAGAGCGAG 2400

CTGAAGATGC AGACCCAGCA GGTGTCGGTG CTCCGCTCTT CAGAGAAACA GCTCAAGCAG 2460

GAGCTCAACC ACCTGCTGGA CATGAAGCAG ACCCTGGACA AGCAGAACCA GGAACTGCGC 2520

AGGGAGAAGC AGGAGGTGGG TGGCCAGCTG AAGGAACTGA AAGACCAGCT GGAGGCAGAA 2580

CAGTATTTCA CGACCCTGTA CAAGACGCAG GTCCGTGAGC TGAAGGACGA GAGCGACAAG 2640

AAGAGCAAAC AGTGCAAAGA GCTGCAGCGG CGGCTGGCAG AGTACAAGGA GGAGAGGGAG 2700

TCACTGACGG CCCAGCTGGA AGCCAGTTTA ACCAAGGTGG ACGCTGAGCA GCTGGCCCGC 2760

TCCATCGCCG AGGAGCAGTA CTCTGACCTG GAGAAGGAGA AGATCATGAA GGAGCTGGAG 2820

ATCAAAGACA TGATGGCGAG ACACAAGCAG GAACTCGGCG ACAAGGAGTC CACCATCAGC 2880

TCGCTGGAGG AGTCCAACCG CACGCTGACG GTGGACGTAG CCAACCTGGC CGGAGAGAAG 2940

GAGGAGCTCA ACAACCAGCT GAAAGAAATG CAGCAAAAGT TGCAGAAAGC CAAAGAAGCG 3000

GAGAAGCAGA TGAACTCGCA CAAAGTGTCT TTCGAAAGGA TGCTGCAGAA CGAACGCACG 3060

CTGAAAATCC AGGCCATCAA CAAGCTGGCC GAGGTGATGA ACAGAAGGGT GCCGGTGCGG 3120

GGGGGCACGG AGGTTCACAG GAGGGAGAAG GAGAACAGGA AGCTGCAACT GGAGCTGCGG 3180

GCAGAGAAGG AGAAACTCAA CAGCACCCTC ATCAAGTACC AGAGGGAAAT GACAGATATG 3240

CAGGCGCTGT TGGCGGAGGA GAACCAGGTT CGCCTGGAGC TTCAGATGGC GCTGGACAGC 3300

AAAGAGAGCG ACATCGAGCA GCTGCGTTGC CAGATTTCCA CCCTCAGCGT TCACTCACTG 3360

GACTCCACCA GCATCAGCAG CGGCAACGAC CTGGACACGA GCGAGGGATA CCCAGACTCC 3420

AGGCTGGAGG GCTGGATCTC ACTTCCCACC AAGAACACAA AGCGCTTTGG ATGGGACAAA 3480

AAATATCTAG TTGTTAGCAG TAAGAAGATC CTTTTCTATA ACAGCGAGCT GGACCGGGAA 3540

CAGGGCAATC CTTTCATGAC ACTGGACATT GATAAACTGT TTCATGTCCG ACCAGTCACT 3600

CACACCGATG TGTACCGAGC AGATCCCAAA GAAATCCCAA GGATATTCCA GATTCTATAC 3660

GCTAACGAAG GCGAGGTTAA ACGCGACCAG GAGGTCGTGA TGGAGCCCAC GCCGTTTGGA 3720

GAACGACTCT CGTACATCAG CCACAAGGGC CACGAGTTCA TCCTCACCCT CTACCACTTC 3780

CCGTCCAGCT GCGAGGTCTG CACCCGCCCC CTGTGGCACG TCTTCAAGCC CCCTCCTGCC 3840

CTCGAGTGCC GCCGCTGCCA CACCAAGTGC CACAAGGACC ACCTGGACAA GAAGGAGGAA 3900

GTTATTGTTC CCTGCAAGGT GAATTATGAC ATGTCCACGG CCAAAGAGCT GCTTCTGCTG 3960

ACCAACTCTC AGGAGGAGCA GCAGCGCTGG GTCAGTCACC TCTACAAACG CATCCCGAGG 4020

AAGCATCCCA CGTTGGGTCC CGCCGCCTCA CTGAGCACGT CTCCCGAGGC GCCGCCGCGT 4080

TCCTCTCCGC GAGTGTCCCC CAGGCCGTCG CCCAGGAGTT CTCCTCACAT GTCGCCTCAC 4140

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+ +k+iGrGa+gev++vr+ka++kvyamk l+k+e++kr++saff+eer+++++++s+w

Q: 78    FDKVKLIGRGAYGEVQLVRHKASQKVYAMKQLNKFEMIKRSDSAFFWEERHIMAFSNSPW  137

         7789********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql +afqd+++ly+vme+++GGdl+tl  +y+  +pe++arfy+ae+vlald++h++g

Q: 138   VVQLCCAFQDDRHLYMVMEFMPGGDLVTLTMNYD--IPEKWARFYTAEVVLALDAIHSMG  195

         **********************************..************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lld++Gh+kladfG+c+k++++g+v++++avGtpdyispevl++++ g+

Q: 196   FIHRDVKPDNMLLDQHGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLQSQG-GD  254

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv++yellvgetpfyaeslv ty+ki+nhk+sl fped+++s++akdl

Q: 255   GYYGRECDWWSVGVFIYELLVGETPFYAESLVGTYGKIMNHKNSLIFPEDVEMSQDAKDL  314

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++l++r+ rlgr+g++d+k+h+ff

Q: 315   ICAFLSDRKVRLGRNGVDDIKRHAFF  340

         *************************9

Domain Sequence
(FASTA)

FDKVKLIGRG AYGEVQLVRH KASQKVYAMK QLNKFEMIKR SDSAFFWEER HIMAFSNSPW 60

VVQLCCAFQD DRHLYMVMEF MPGGDLVTLT MNYDIPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDQHGHLKLA DFGTCMKMDS TGMVHCDTAV GTPDYISPEV LQSQGGDGYY 180

GRECDWWSVG VFIYELLVGE TPFYAESLVG TYGKIMNHKN SLIFPEDVEM SQDAKDLICA 240

FLSDRKVRLG RNGVDDIKRH AFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013