EKS-TAR-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	312.4	6.4E-93	513	778	266

Status

Unreviewed

Ensembl Protein

ENSTRUP00000047488

UniProt Accession

H2VE41;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000018544	ENSTRUP00000047485	ENSTRUT00000047646
ENSTRUG00000018544	ENSTRUP00000047484	ENSTRUT00000047645
ENSTRUG00000018544	ENSTRUP00000047483	ENSTRUT00000047644
ENSTRUG00000018544	ENSTRUP00000047489	ENSTRUT00000047650
ENSTRUG00000018544	ENSTRUP00000047488	ENSTRUT00000047649
ENSTRUG00000018544	ENSTRUP00000047487	ENSTRUT00000047648
ENSTRUG00000018544	ENSTRUP00000047486	ENSTRUT00000047647

Organism

Takifugu rubripes

Functional Description

Protein Length

1098

Protein Sequence
(FASTA)

MRKSGRRAHL SSPPSITFGL EIHFYTPIVH QLEFLSGCYT AEELCVKAAK KCSISPLCHN 60

LFGLYDEKAG MWYPPSYEFT VTDEISLKLH YRMRFYLRNW HGNTEVWRHC ISKLRGSLSL 120

EKMPEGTPLL DAASLDYLFY QGQHSFHKGL VPLRKSHSDA EQHEIENECL GMAVLAITHT 180

TNMSVPGSHD ISYKRFIPES LNRSIKQRSF MTRIRINNVF KKFLSEFHQR TIRDSNITPY 240

DLKIKYLATL EGLTSGLGSE TSVVSKDKPK SKKSKVDGKQ QSDKKKEENE GWAVFCDFHE 300

ITHAVIKEKT TVTIYRQDNM RMELQMASRA ESLSFVALVD GYFRLTVDAH HYLCKEVAPE 360

SVVRNIRNSC HGPISPSTEY AVHKLRQEGN EEGTYILRWS CTDFQYIIIT VVCTEETRPV 420

RQYKNFQIEE SPDGFRLYGT DTFRPTLAEL LKHLESQSLR TDNLHFQLRR CCPPQPREIS 480

NLLVVTKDRV LTHPSPMPDS QLSFHRILKE DIEQEEHLGR GTRTNIYSGT LRVKSEEDED 540

AGYSSFQEVK VVLKLLSYGH RDISLAFFET ASMMRQVSHK HIVLLYGVCV HHQENIMVEE 600

FVQLGPLDVY MRRQQSPLSI PWKFQVAKQL ASALSYLEDK KLVHGFVCAK NILLARDGLG 660

IDEGGPFIKL SDPGIPITVL TREECVHRIP WIAPECVKNM SSLSVAADKW GFGTTLWEIC 720

YDGEVPLKEK KLTEKERFYE TKCQLATPDC KELAELMTHC MNYDPKKRPF FRAIVRDIDM 780

LGEKSKLEFS SLRKPPSLLV THSCGCNPSI KPKPTAEVDP TIFEKRFLTK YRALGEGHFG 840

KVELCRYDPR GDKTGELVAV KSLKPEKQEE QGTNLSREID ILKALFHENI VRYKGICQEE 900

GGQAYKLIME YVPLGSLKDY LPRHKKDTSL ATLLSYSVQI CKGMEYLGSK NYIHRDLAAR 960

NVLVENERTV KIGDFGLTKC IKDNEGYYTV KDENDSPVFW YAPECLTQCK FYLASDVWSF 1020

GVTLYELITY CDSSKSPMTC FLDMIGSTHG QMTVMRLVKM LNEGRRLPQP DGCPEAVYEL 1080

MRKCWDQKPE RRITFTAL 1098

Nucleotide Sequence
(FASTA)

ATGAGGAAGT CAGGTAGAAG GGCTCATCTT TCCTCTCCTC CATCCATCAC CTTTGGGCTG 60

GAGATCCACT TTTACACGCC GATTGTGCAC CAGCTTGAGT TCCTGAGCGG CTGCTACACT 120

GCAGAGGAGC TCTGCGTGAA AGCTGCCAAG AAATGCTCTA TCTCTCCTTT GTGCCATAAC 180

CTGTTTGGGT TGTATGATGA GAAAGCAGGC ATGTGGTACC CACCCAGCTA CGAGTTCACA 240

GTCACGGACG AAATAAGTCT GAAGCTGCAT TATCGCATGA GATTTTATCT CAGAAATTGG 300

CATGGCAACA CTGAAGTTTG GAGACACTGC ATCAGTAAAC TCAGAGGGAG CCTCAGCCTT 360

GAGAAGATGC CAGAGGGAAC ACCTCTGTTG GATGCTGCTT CTCTTGACTA CTTGTTTTAC 420

CAGGGCCAAC ACAGCTTTCA TAAAGGTTTG GTTCCACTGA GGAAGTCTCA TTCAGATGCA 480

GAGCAACATG AAATAGAAAA TGAGTGTTTG GGGATGGCTG TGCTTGCTAT CACTCATACA 540

ACAAACATGA GTGTACCAGG CTCACATGAT ATCAGTTACA AACGTTTCAT CCCAGAGTCG 600

CTGAACCGCA GCATTAAGCA GCGCAGTTTT ATGACACGCA TCCGCATCAA CAACGTCTTC 660

AAGAAGTTCC TGAGTGAATT CCATCAGCGC ACCATCAGGG ACAGCAACAT CACACCATAC 720

GACCTGAAGA TCAAGTATCT GGCCACACTG GAGGGGCTGA CCAGCGGCTT GGGCAGTGAG 780

ACATCGGTGG TCTCTAAGGA CAAGCCCAAG TCAAAGAAGA GCAAGGTTGA CGGGAAGCAG 840

CAAAGCGACA AAAAAAAAGA GGAGAATGAA GGATGGGCGG TGTTCTGCGA CTTCCATGAG 900

ATCACCCACG CCGTAATCAA AGAAAAGACA ACTGTCACCA TCTACAGACA GGACAACATG 960

AGGATGGAGT TGCAAATGGC TTCCAGGGCC GAGTCTTTGT CCTTTGTAGC TCTTGTTGAT 1020

GGGTATTTCC GGCTGACAGT GGACGCCCAT CACTACTTGT GCAAAGAAGT GGCCCCTGAA 1080

TCAGTGGTGC GCAACATCCG TAACAGCTGC CATGGACCCA TCAGCCCAAG CACTGAGTAC 1140

GCTGTTCACA AGCTCCGTCA GGAGGGCAAT GAAGAGGGTA CCTACATCTT GCGCTGGAGC 1200

TGCACTGACT TCCAGTACAT CATCATTACA GTGGTCTGCA CTGAGGAAAC TCGGCCCGTT 1260

CGACAATACA AGAACTTCCA GATTGAAGAG TCCCCTGATG GTTTCCGACT GTATGGCACG 1320

GACACATTTC GGCCCACATT GGCAGAGCTA CTTAAACACC TGGAGAGCCA AAGCCTCCGC 1380

ACTGATAACC TCCACTTCCA GTTGCGCCGC TGCTGCCCTC CACAGCCGAG AGAGATCTCT 1440

AACCTGCTGG TGGTCACTAA AGACAGAGTG CTTACTCATC CATCGCCGAT GCCAGATAGT 1500

CAGCTCAGCT TCCATCGCAT TCTCAAGGAG GACATTGAAC AGGAGGAGCA CCTTGGCCGA 1560

GGGACAAGAA CCAATATTTA CTCTGGAACA CTGAGGGTAA AAAGTGAAGA GGATGAAGAT 1620

GCAGGCTACT CTTCTTTCCA GGAGGTCAAG GTGGTTCTGA AATTGCTGAG TTATGGACAC 1680

AGGGACATCT CTTTGGCTTT CTTTGAAACA GCCAGCATGA TGCGACAGGT GTCCCACAAA 1740

CACATAGTGC TGTTGTACGG AGTTTGCGTC CACCATCAGG AGAATATCAT GGTTGAGGAG 1800

TTTGTCCAAC TAGGACCACT TGATGTATAT ATGAGGAGGC AACAGAGCCC CCTGAGCATC 1860

CCGTGGAAGT TTCAGGTGGC CAAGCAGCTG GCTTCAGCTC TCAGCTATTT GGAGGACAAA 1920

AAGCTGGTCC ACGGCTTTGT TTGTGCGAAG AATATTCTGT TGGCCAGAGA TGGGCTGGGC 1980

ATCGATGAAG GTGGGCCTTT CATCAAGCTC AGTGACCCAG GCATTCCAAT TACAGTCCTC 2040

ACAAGGGAGG AGTGTGTGCA TCGCATCCCT TGGATCGCTC CAGAGTGTGT GAAGAATATG 2100

TCGTCGCTTA GCGTCGCAGC TGACAAGTGG GGATTTGGTA CCACCCTGTG GGAGATCTGC 2160

TATGATGGAG AGGTCCCACT CAAAGAGAAG AAACTTACAG AGAAGGAGAG GTTTTATGAA 2220

ACTAAGTGCC AACTTGCCAC ACCGGACTGC AAAGAGCTGG CTGAACTGAT GACCCACTGC 2280

ATGAACTATG ACCCCAAGAA GAGACCTTTC TTCAGGGCTA TTGTCCGAGA CATAGACATG 2340

CTTGGAGAAA AGAGTAAGTT GGAATTTTCT TCCTTAAGAA AACCGCCAAG TCTTCTTGTA 2400

ACACATTCAT GTGGTTGTAA TCCATCCATC AAACCCAAAC CCACTGCAGA GGTGGATCCG 2460

ACTATATTTG AAAAAAGATT CCTCACGAAA TATCGAGCTC TGGGAGAGGG GCACTTTGGG 2520

AAGGTGGAGC TGTGCCGTTA CGACCCTCGA GGAGATAAGA CAGGCGAGCT GGTGGCGGTG 2580

AAGTCACTGA AGCCTGAGAA ACAGGAGGAG CAGGGCACCA ACCTCTCACG TGAGATAGAC 2640

ATCCTGAAGG CGCTCTTCCA CGAAAACATC GTCAGGTACA AGGGCATCTG CCAAGAAGAA 2700

GGCGGTCAGG CGTACAAGCT GATCATGGAG TATGTCCCAT TGGGCAGTTT GAAGGACTAT 2760

CTCCCCAGGC ATAAGAAAGA CACCAGTCTG GCTACTCTAC TCAGCTACTC TGTTCAGATC 2820

TGCAAGGGAA TGGAATATCT GGGCTCTAAG AACTACATCC ATCGGGACTT GGCCGCTCGG 2880

AACGTGCTGG TGGAAAATGA GAGAACGGTG AAGATCGGAG ACTTTGGCCT CACCAAGTGC 2940

ATCAAAGACA ATGAGGGCTA TTACACCGTC AAAGACGAGA ACGACAGCCC CGTTTTCTGG 3000

TACGCGCCGG AGTGTCTGAC GCAGTGCAAG TTCTATCTGG CTTCAGATGT CTGGTCTTTT 3060

GGAGTGACGC TGTATGAACT CATCACCTAC TGTGACTCCT CCAAGAGTCC CATGACGTGT 3120

TTCCTGGACA TGATCGGCAG CACTCACGGC CAGATGACAG TCATGCGTTT GGTGAAGATG 3180

TTGAATGAAG GGAGGAGGTT GCCCCAGCCC GACGGCTGTC CCGAGGCTGT TTACGAGCTG 3240

ATGCGCAAGT GCTGGGACCA AAAGCCTGAG AGGAGAATTA CCTTCACAGC CCTG 3294

Domain Profile

S: 2     kqiesLgkgtftkvfevre........d.aegdsteeevalkvLkesgedisrdfkreae  52

         +q+e+Lg+gt+t+++++++        d  ++  +e +v+lk L  +++dis +f+++a+

Q: 513   EQEEHLGRGTRTNIYSGTLrvkseedeDaGYSSFQEVKVVLKLLSYGHRDISLAFFETAS  572

         789***************97776553213344456667**********************

S: 53    ilsqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlak  112

         +++q+sh+hiv l+gvcv+ +en++V+e+v+ G+Ld+y+r+++  ls++++++vakqla+

Q: 573   MMRQVSHKHIVLLYGVCVHHQENIMVEEFVQLGPLDVYMRRQQSPLSIPWKFQVAKQLAS  632

         ************************************************************

S: 113   ameYLedkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerd  170

         a++YLedkklvh+ v+a+n+L++r++   ++++pf+klsdpg+  +v      l+ree+

Q: 633   ALSYLEDKKLVHGFVCAKNILLARDGLgiDEGGPFIKLSDPGIPITV------LTREECV  686

         **************************9999*****************......*******

S: 171   sripwlapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleeker  230

          ripw+apec+++  +ls+a+d+W+Fg+tl+e+  c++ge pl++++l++k++++e+k++

Q: 687   HRIPWIAPECVKNMSSLSVAADKWGFGTTLWEI--CYDGEVPLKEKKLTEKERFYETKCQ  744

         *********************************..*************************

S: 231   lpkpkcpaelaelmtnclsyepsqrpsFrailedl  265

         l +p+c+ elaelmt+c++y+p++rp+Frai++d+

Q: 745   LATPDCK-ELAELMTHCMNYDPKKRPFFRAIVRDI  778

         *******.************************996

Domain Sequence
(FASTA)

EQEEHLGRGT RTNIYSGTLR VKSEEDEDAG YSSFQEVKVV LKLLSYGHRD ISLAFFETAS 60

MMRQVSHKHI VLLYGVCVHH QENIMVEEFV QLGPLDVYMR RQQSPLSIPW KFQVAKQLAS 120

ALSYLEDKKL VHGFVCAKNI LLARDGLGID EGGPFIKLSD PGIPITVLTR EECVHRIPWI 180

APECVKNMSS LSVAADKWGF GTTLWEICYD GEVPLKEKKL TEKERFYETK CQLATPDCKE 240

LAELMTHCMN YDPKKRPFFR AIVRDI 266

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013