EKS-TAR-00194
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00194
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR514.71.1E-154375651277
StatusUnreviewed
Ensembl ProteinENSTRUP00000047713
UniProt AccessionH2VER7;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (2 of 2)
Gene Synonyms/Alias FGFR1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000018627ENSTRUP00000047713ENSTRUT00000047875
ENSTRUG00000018627ENSTRUP00000047712ENSTRUT00000047874
OrganismTakifugu rubripes
Functional Description
Protein Length683
Protein Sequence
(FASTA)
PVKCLPKADV VKSSEDEDDD ESSSEENKLS SELSTSNEKL NCKPPLPFRW VMPEKMEKQL 60
HAVPVGKTVK LRCQAIGSPV PSLRWYKNGK EFRKDQRIGG FKVRGQTWTL IMESVIPSDK 120
GNYTCVVENE YGRLQHTYVL DVVERSPHRP FLQFGLPANQ TAVIGSDVAF VCRVFSDAQP 180
HIQWLKHITV NGSTVGPDGL PHIRVLKTAG LNTTDKDMEV LTLRNVSLND SGEYTCLAGN 240
SIGVSHHSAW LTVVDGLAPD APPSVLPSQT YLEIFIYCLG FFLVMILTAT AVLCRLCCAP 300
KKSDFSSQIA VQKLAKSIPL KRQVTVSVES SSSLQSGACL IRQSRLPSAA TTILMGVSEC 360
ELPYDPIWEL PRERLTLGKP LGEGCFGQVV LAEAVGLDKN KPTRLTKVAV KMLKADATEK 420
DRADLISEME MMKMIGKHKN IINLLGACTQ DGPLYVLVEY ASKGNLRDYL RARRPAGLEY 480
WSSSRPVSLA SLEIMELVSA AYQVARGMAY LASKKCIHRD LAARNVLVTE DNVMKIADFG 540
LARDVHHIDY YKKTTNGRLP VKWMAPEALF DRIYTHQSDV WSFGVLLWEI FTLGGSPYPG 600
VPVEELFKLL KEGHRMEKPA TSTQELYLMM RDCWHAVPSR RPTFQQLVED LDRMLSLMAN 660
QEYLDLAVPM VQYSEQRPDV RNS 683
Nucleotide Sequence
(FASTA)
CCGGTTAAAT GTCTGCCAAA GGCTGATGTA GTTAAATCCT CGGAAGATGA AGACGACGAT 60
GAGTCATCCT CGGAGGAAAA TAAATTATCC AGCGAGCTGT CGACCAGCAA TGAAAAGCTC 120
AACTGTAAGC CTCCGTTGCC TTTTCGGTGG GTGATGCCGG AAAAGATGGA AAAGCAACTC 180
CACGCCGTTC CTGTCGGTAA GACCGTAAAA TTAAGATGCC AGGCCATCGG AAGCCCCGTC 240
CCCTCTCTGC GCTGGTACAA GAATGGAAAA GAGTTCAGGA AGGACCAGAG AATTGGAGGT 300
TTCAAGGTCA GAGGCCAAAC TTGGACTCTA ATAATGGAGT CAGTGATTCC TTCTGATAAA 360
GGGAACTACA CCTGCGTGGT GGAGAATGAG TACGGGAGAC TGCAGCACAC CTACGTGCTG 420
GACGTAGTCG AGCGCTCTCC TCACAGGCCG TTCCTGCAGT TCGGTCTGCC CGCCAACCAA 480
ACCGCAGTCA TTGGCAGCGA TGTGGCGTTT GTGTGCCGCG TGTTCAGCGA CGCGCAGCCG 540
CACATCCAGT GGCTCAAACA CATCACGGTC AACGGCAGCA CAGTGGGACC AGACGGACTC 600
CCACATATCC GTGTTCTCAA GACGGCAGGC TTGAACACCA CAGACAAAGA CATGGAAGTA 660
TTGACGCTGA GGAACGTGTC TCTGAACGAT TCCGGGGAGT ACACCTGCCT GGCTGGGAAC 720
TCCATCGGAG TCTCTCATCA TTCTGCCTGG CTCACCGTGG TCGACGGTCT TGCCCCAGAT 780
GCTCCGCCCT CTGTGCTGCC CTCTCAGACA TACTTGGAGA TCTTCATCTA CTGCCTTGGC 840
TTTTTCCTTG TGATGATCCT CACAGCCACA GCTGTCCTCT GCAGACTCTG TTGTGCCCCA 900
AAGAAGAGTG ACTTTAGCAG TCAGATCGCT GTGCAGAAGC TAGCTAAGAG TATTCCTCTA 960
AAGAGACAGG TAACCGTGTC AGTTGAGTCC TCTTCCTCTC TTCAGTCTGG GGCGTGTTTG 1020
ATTCGCCAGT CTCGTCTTCC CAGTGCAGCC ACCACCATCC TGATGGGAGT GTCTGAGTGC 1080
GAACTTCCCT ACGATCCGAT TTGGGAGCTG CCACGTGAAA GGCTGACGCT GGGGAAGCCT 1140
CTCGGGGAAG GGTGCTTCGG CCAGGTGGTT CTGGCCGAGG CTGTTGGGCT CGACAAAAAC 1200
AAACCCACAC GTCTCACAAA GGTGGCTGTA AAAATGCTCA AAGCGGATGC CACAGAGAAG 1260
GACCGGGCTG ACCTCATCTC TGAAATGGAA ATGATGAAGA TGATCGGCAA ACATAAGAAC 1320
ATCATTAACC TGCTGGGAGC GTGCACACAG GATGGGCCCC TGTATGTGCT TGTGGAGTAC 1380
GCCTCAAAGG GGAACCTGCG GGATTACCTC CGCGCTCGTA GACCAGCCGG GCTGGAGTAC 1440
TGGAGCAGCT CCAGGCCAGT TTCTCTGGCC AGTTTGGAGA TCATGGAGCT GGTTTCTGCT 1500
GCTTACCAGG TGGCCAGAGG AATGGCTTAC CTAGCATCAA AGAAGTGCAT CCACAGAGAC 1560
CTGGCAGCCA GGAACGTGCT GGTCACAGAA GATAATGTGA TGAAGATCGC CGACTTCGGT 1620
CTGGCCCGGG ATGTCCACCA CATCGACTAC TACAAGAAGA CCACAAATGG TCGTCTGCCT 1680
GTGAAGTGGA TGGCACCAGA AGCTTTATTC GACCGCATCT ACACCCACCA GAGTGATGTA 1740
TGGTCATTTG GGGTTTTGCT GTGGGAGATC TTTACCCTTG GGGGGTCCCC ATACCCCGGA 1800
GTCCCTGTGG AGGAACTGTT CAAGCTGCTA AAAGAGGGAC ATCGCATGGA AAAACCTGCC 1860
ACCTCCACTC AGGAATTGTA CCTGATGATG AGGGACTGCT GGCATGCTGT TCCATCCCGC 1920
AGACCAACGT TCCAGCAGCT GGTTGAAGAT TTAGACCGCA TGCTTTCTCT CATGGCTAAC 1980
CAGGAGTACC TGGACCTGGC CGTTCCCATG GTTCAGTACT CGGAGCAACG GCCTGATGTT 2040
AGAAACAGC 2049
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv aea+gldk+k+++ ++vavkmlk dat+kd adl+seme++k+
Q: 375   LTLGKPLGEGCFGQVVLAEAVGLDKNKPTRLTKVAVKMLKADATEKDRADLISEMEMMKM  434
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlr++lrarrp g e+ + ++ +s  +l  
Q: 435   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRPAGLEYWSSSRPVSLASLEI  494
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
          +lvs ayqvarGm ylaskkcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt
Q: 495   MELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKT  554
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 555   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  614
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rmekpa+ t+ely +mr+cwha++s rptf+qlvedl
Q: 615   RMEKPATSTQELYLMMRDCWHAVPSRRPTFQQLVEDL  651
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVLAEA VGLDKNKPTR LTKVAVKMLK ADATEKDRAD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLRDYLRARR PAGLEYWSSS RPVSLASLEI 120
MELVSAAYQV ARGMAYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMEKPATSTQ ELYLMMRDCW HAVPSRRPTF QQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona savignyi"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CIS-00182
EKS-GAA-00176
EKS-ORN-00185
EKS-ORL-00173
EKS-TEN-00187
EKS-XIM-00179
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013