EKS-XET-00374
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00374
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk508.54.3E-1537621031270
StatusUnreviewed
Ensembl ProteinENSXETP00000000090
UniProt AccessionF6UBP5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLTK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000000055ENSXETP00000000090ENSXETT00000000090
OrganismXenopus tropicalis
Functional Description
Protein Length1160
Protein Sequence
(FASTA)
SNWKMLSAEI AGVNEPFQIS LDYIHCVQTA DHPIVLESLT LRHCSADICY QDSVMPTCVG 60
ENSFFCDNGD CINYVNLCDF SNDCPTGEDE GALCEIILPS GSYCSFDDGT CGWTPYDGND 120
TTWLYTDATQ IEDTSPSDLK LVKVTGHFLY LSVQSKRSDG SATIYSAVFP KVVTNNVCQL 180
SFKFLISGIY NGSLGIYGLE DGKGMGSSVK LWVKQGASGN FWNPGTLQIP QFQNRFRLLV 240
VATWGWNSLA HIALDNVTFS VDCFHAGLRP FLVQSGISIL DLDPNPEPQP SGSQYLPCCN 300
WFTSCGASGP HGPTQTQCDN AYRSSNISVV VGKEGPLRGV QLWKVPFTSV YQISAYGAAG 360
GKGAKNHNNP AHGVFISAIF PLQKDEILYI LVGQQGEDAC PGKNELTKEI CMGKSSIIED 420
NYDDQNRFSE WAGGGGGGGG ASYVFKEVNG EFIPLLVAAG GGGKAYLEDQ EDPLDFIHPE 480
RFENNTAVPG PNGMSGAAGG GGGWNDITEL PVAGKSLLFG AEGGQTCYKA ITKLQWHTSG 540
GFGGGGGPCT SGGGGGGYQG GNASELDDIF TDGQYGVSFF HPSVKIFLHP LAAMESHGEV 600
QIKLFVNCSH CYTDNCKRDP INRSVVCLCE VGTVLASDNT TCVGILMKNC FFTLYSLTHC 660
YFVLLLVPKW PLAEKQLPLS LILAVLIATV ILGIIFACGS LSFVYHRKKK QLEGARVRLQ 720
STEYKLSKIR SSIIMTDYNP NYCFAGKGAS LSELKEVPRK NITLLRALGH GAFGEVYEGM 780
VVGISGDPNP LQVAIKTLPE ICSEQDEMDF LMEALIISKF SHQNIVRCIG VSLQTLPRFI 840
LLELMSGGDM KSFLRQNRPW INQPSTLSML DLLNMARDIA CGCKYLEENH FIHRDIAARN 900
CLLTYSGTGR VAKIGDFGMA RDIYRASYYR KGGRAMLPVK WMPPEAFLEG VFTSKTDTWS 960
FGVLLWEIFS LGYMPYPCKT NQEVLEFVTS GGRMDPPKNC PGPVYRIMTQ CWQHTPEHRP 1020
NFSTILERIS YCTQDPDVIN TPLPVESGPA PEDEGSTSIR PNSCNGLNPI MSSQPIAPLL 1080
DTQSTEQKLG DVPQELLVEN LAGWNIKTPG LQTVAESTEG SWFQSNLSTT TEPKLQTTHK 1140
LKNKSKNLWN PTYGSWVMES 1160
Nucleotide Sequence
(FASTA)
TCAAACTGGA AGATGCTGAG TGCAGAAATT GCAGGAGTGA ATGAGCCATT TCAGATATCT 60
TTGGATTATA TACATTGTGT GCAGACGGCA GATCATCCTA TAGTCCTGGA GTCGCTAACC 120
CTTAGACACT GTTCTGCTGA TATATGTTAC CAAGACAGTG TTATGCCTAC ATGTGTAGGG 180
GAGAATTCCT TCTTTTGTGA CAATGGAGAC TGCATCAATT ATGTCAATCT TTGTGACTTT 240
AGTAATGATT GCCCCACAGG CGAAGATGAA GGTGCTTTAT GTGAAATCAT CCTTCCCTCT 300
GGAAGCTACT GTTCCTTTGA TGATGGAACT TGTGGTTGGA CTCCATATGA TGGAAATGAC 360
ACAACGTGGC TATACACTGA CGCTACACAA ATAGAGGACA CATCCCCCTC CGACCTCAAA 420
TTGGTGAAAG TCACAGGACA TTTTCTGTAT CTGTCTGTAC AGAGTAAGCG CAGCGATGGT 480
AGCGCAACTA TTTACAGTGC CGTGTTTCCA AAAGTGGTCA CTAATAATGT CTGCCAGCTT 540
AGTTTCAAGT TCCTGATCTC TGGGATCTAC AACGGCTCCC TTGGAATATA TGGCCTGGAG 600
GACGGGAAAG GAATGGGGAG TTCAGTAAAA CTCTGGGTAA AGCAAGGGGC ATCAGGCAAC 660
TTTTGGAATC CAGGAACACT ACAGATTCCC CAGTTTCAAA ACAGATTCCG CTTACTTGTA 720
GTGGCAACTT GGGGTTGGAA TTCCCTTGCA CACATTGCTT TAGATAATGT CACCTTTTCA 780
GTGGATTGCT TTCATGCAGG TTTGAGACCC TTTTTAGTCC AGTCGGGCAT ATCCATACTT 840
GACCTGGACC CGAACCCTGA ACCACAACCC AGTGGGTCAC AATACCTTCC CTGCTGTAAC 900
TGGTTCACTT CGTGCGGTGC CAGTGGACCT CATGGACCGA CCCAGACACA ATGTGACAAT 960
GCTTACCGCA GCAGCAACAT ATCTGTAGTC GTGGGGAAGG AGGGTCCACT TAGGGGAGTA 1020
CAGCTGTGGA AGGTCCCTTT TACCAGCGTG TACCAAATTT CAGCATATGG AGCGGCTGGA 1080
GGCAAAGGAG CAAAGAACCA CAACAATCCT GCTCATGGGG TCTTCATTTC TGCCATCTTC 1140
CCTCTACAGA AGGATGAGAT TCTATATATC TTGGTGGGCC AGCAAGGAGA AGATGCCTGC 1200
CCAGGGAAAA ATGAATTGAC CAAAGAAATA TGCATGGGCA AGTCCTCCAT TATTGAAGAC 1260
AATTATGATG ACCAGAATAG GTTCTCAGAA TGGGCAGGTG GCGGAGGAGG AGGAGGTGGA 1320
GCATCTTATG TCTTCAAGGA GGTAAATGGT GAATTTATAC CACTGCTGGT AGCAGCTGGA 1380
GGTGGAGGGA AAGCCTACCT AGAAGATCAA GAAGATCCCT TAGACTTTAT TCACCCAGAG 1440
AGGTTTGAAA ACAATACAGC TGTACCTGGC CCCAATGGCA TGTCTGGAGC GGCAGGTGGA 1500
GGGGGTGGAT GGAATGACAT CACAGAGTTG CCGGTGGCTG GAAAATCCTT ATTATTTGGG 1560
GCAGAAGGAG GGCAGACCTG CTACAAAGCA ATAACAAAAC TACAGTGGCA TACATCTGGT 1620
GGATTTGGTG GTGGAGGAGG TCCCTGCACC TCTGGTGGTG GAGGAGGAGG CTACCAAGGT 1680
GGTAACGCCT CTGAACTGGA TGACATTTTT ACTGATGGAC AATATGGCGT CTCATTTTTT 1740
CACCCATCTG TTAAAATCTT CCTGCATCCT TTGGCTGCTA TGGAGAGTCA CGGAGAAGTG 1800
CAAATTAAAC TGTTTGTAAA CTGTAGCCAC TGTTATACTG ACAATTGTAA AAGAGACCCA 1860
ATCAACAGGA GCGTTGTGTG TCTTTGCGAG GTTGGTACTG TGCTCGCCAG CGATAACACA 1920
ACCTGTGTAG GAATTCTCAT GAAAAATTGT TTCTTCACCT TATATTCTCT CACTCATTGT 1980
TACTTTGTTT TACTTTTAGT TCCAAAGTGG CCATTAGCCG AGAAGCAACT CCCACTCTCA 2040
CTCATTCTCG CTGTCCTTAT AGCGACGGTT ATTCTTGGTA TCATCTTTGC CTGTGGAAGC 2100
CTGTCATTTG TTTACCACCG TAAGAAGAAA CAGCTGGAAG GAGCACGAGT GCGACTGCAG 2160
AGCACAGAGT ACAAACTGAG CAAGATCCGT AGTTCTATCA TCATGACAGA CTACAACCCT 2220
AACTACTGTT TTGCAGGGAA GGGAGCCAGC CTGAGTGAGC TGAAGGAAGT ACCTCGCAAG 2280
AACATTACTC TGCTTAGAGC CCTGGGTCAT GGCGCTTTTG GTGAGGTTTA TGAAGGGATG 2340
GTTGTTGGGA TTTCTGGAGA TCCGAACCCA CTCCAAGTAG CTATAAAGAC ACTACCAGAA 2400
ATCTGCTCTG AACAAGATGA AATGGACTTT CTCATGGAAG CTCTGATAAT CAGTAAATTC 2460
AGCCACCAGA ACATTGTGCG CTGTATTGGA GTGAGTCTTC AAACCCTTCC TCGTTTTATC 2520
CTGCTGGAAC TGATGTCTGG TGGGGACATG AAGAGCTTCC TCCGGCAGAA TCGTCCATGG 2580
ATTAACCAAC CTTCTACCCT ATCCATGCTA GATCTGCTGA ATATGGCCAG GGATATAGCT 2640
TGTGGCTGCA AATACCTGGA GGAGAACCAC TTCATCCACA GGGACATAGC GGCCAGAAAC 2700
TGCCTTCTAA CGTACAGTGG GACAGGACGT GTGGCCAAAA TCGGTGACTT TGGAATGGCG 2760
CGGGACATTT ATAGAGCCAG CTACTATCGC AAAGGAGGGA GAGCCATGCT TCCAGTCAAG 2820
TGGATGCCAC CAGAGGCTTT CCTAGAGGGA GTCTTCACTT CGAAAACAGA CACTTGGTCA 2880
TTTGGAGTAT TGCTCTGGGA AATCTTCTCT TTGGGCTACA TGCCATACCC ATGCAAAACT 2940
AACCAGGAAG TGCTGGAATT TGTAACCAGT GGTGGGCGCA TGGATCCCCC CAAAAATTGC 3000
CCAGGGCCAG TATATCGTAT AATGACTCAG TGCTGGCAGC ATACACCGGA GCATAGACCC 3060
AACTTCTCCA CTATTCTAGA AAGGATCAGT TACTGTACGC AGGATCCTGA TGTAATTAAT 3120
ACACCTTTGC CTGTGGAAAG TGGACCAGCA CCTGAAGATG AAGGAAGCAC AAGTATACGG 3180
CCAAACAGCT GCAATGGGCT CAACCCAATT ATGAGCAGCC AACCAATTGC TCCTTTGCTG 3240
GATACGCAGT CCACAGAACA AAAGCTCGGA GATGTCCCTC AGGAATTATT AGTAGAGAAT 3300
CTTGCTGGCT GGAATATCAA GACCCCAGGT TTGCAAACTG TTGCCGAATC AACTGAGGGC 3360
TCATGGTTCC AATCAAACCT CAGCACTACA ACAGAGCCAA AACTCCAGAC AACACACAAA 3420
CTAAAAAATA AGTCAAAAAA CCTCTGGAAC CCAACTTATG GTTCTTGGGT TATGGAGAGC 3480
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i+l+ralG+GafGevyeg v g++gd+ +l+va+ktlpe +seqde+dfl+ealiiskf+
Q: 762   ITLLRALGHGAFGEVYEGMVVGISGDPNPLQVAIKTLPEICSEQDEMDFLMEALIISKFS  821
         799*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr+iGvsl++lpr+illel++GGd+ksflr++rp  +q+s+l+m dll++a+d+a+
Q: 822   HQNIVRCIGVSLQTLPRFILLELMSGGDMKSFLRQNRPWINQPSTLSMLDLLNMARDIAC  881
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gckyleen+fihrdiaarn+ll+ +G++rvaki+dfGmardiyra+yyrkggra+lpvkw
Q: 882   GCKYLEENHFIHRDIAARNCLLTYSGTGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  941
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeafleG+ftsktd+wsfGvllwe+fslG++pyp k+nqevle+v++Ggr+d+pk++p
Q: 942   MPPEAFLEGVFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCP  1001
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h+pe+rp+f +iler+ +
Q: 1002  GPVYRIMTQCWQHTPEHRPNFSTILERISY  1031
         ***************************975
Domain Sequence
(FASTA)
ITLLRALGHG AFGEVYEGMV VGISGDPNPL QVAIKTLPEI CSEQDEMDFL MEALIISKFS 60
HQNIVRCIGV SLQTLPRFIL LELMSGGDMK SFLRQNRPWI NQPSTLSMLD LLNMARDIAC 120
GCKYLEENHF IHRDIAARNC LLTYSGTGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFLEGV FTSKTDTWSF GVLLWEIFSL GYMPYPCKTN QEVLEFVTSG GRMDPPKNCP 240
GPVYRIMTQC WQHTPEHRPN FSTILERISY 270
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00050
EKS-ANC-00293
EKS-CAE-00256
EKS-DAR-00653
EKS-DRM-00153
EKS-GAG-00254
EKS-GAA-00375
EKS-LAC-00314
EKS-MAE-00034
EKS-MEG-00249
EKS-ORN-00393
EKS-ORL-00363
EKS-PAT-00291
EKS-PES-00269
EKS-PEM-00167
EKS-PTV-00067
EKS-SAH-00288
EKS-TAG-00317
EKS-TAR-00396
EKS-TEN-00398
EKS-XIM-00391
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048066; P:developmental pigmentation
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR023415; LDLR_class-A_CS.
IPR002172; LDrepeatLR_classA_rpt.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS01209; LDLRA_1; 1.
PS50068; LDLRA_2; 1.
PS50060; MAM_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013