EKS-XET-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	417.5	2.2E-125	36	297	262

Status

Unreviewed

Ensembl Protein

ENSXETP00000000141

UniProt Accession

Q0IHL7;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase-activated protein kinase 3;

Gene Name

mapkapk3

Gene Synonyms/Alias

mapkapk3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000000076	ENSXETP00000000141	ENSXETT00000000141

Organism

Xenopus tropicalis

Functional Description

Protein Length

375

Protein Sequence
(FASTA)

MEENANVQET GDQETLPPAQ PVKLEIKRHA ITDDYKVSKQ VLGLGINGKV LECYRRDTGQ 60

KCALKILYDS PKARREVDCH IRASEGPHIV HVLDVYENIH RSKRCLLIVM ECMQGGELFT 120

RIQKRGDQAF TEREASEIMR DIGMAIQHLH GMNIAHRDVK PENLLYTHKD SNAELKITDF 180

GFSKETTVQN ALQTPCYTPY YVAPEVLGPE KYDKSCDMWS LGVIMYILLC GYPPFYSNTG 240

QAISPGMKKR IRMGQYEFPA PEWNDVSQEA QQMIQHLLKT DPTERMSITQ FMNHPWINQS 300

MVVPQTPLHT ARVLQEDKEH WDEVKEEMTS ALATMRVDYD QVKIKDLNSS TNKLLNKRRK 360

KQSDGNPNTT GCNNQ 375

Nucleotide Sequence
(FASTA)

ATGGAGGAGA ATGCCAATGT CCAGGAGACG GGGGACCAGG AAACCCTCCC ACCAGCCCAA 60

CCTGTTAAGC TGGAGATTAA GCGACATGCC ATCACCGATG ATTACAAGGT GTCAAAGCAG 120

GTGCTGGGTC TGGGGATCAA TGGCAAAGTG CTGGAATGTT ACCGCAGGGA CACCGGGCAG 180

AAGTGTGCAC TCAAGATCCT GTATGATAGC CCCAAAGCTC GGCGAGAGGT GGATTGTCAC 240

ATCAGAGCAT CTGAAGGACC ACACATTGTA CACGTGCTAG ATGTCTATGA AAATATACAT 300

CGTTCAAAGA GATGCCTGCT CATTGTCATG GAGTGCATGC AGGGTGGGGA GCTGTTCACT 360

CGCATCCAGA AGAGAGGCGA CCAAGCATTC ACTGAAAGAG AGGCATCAGA GATCATGCGG 420

GACATAGGAA TGGCCATACA GCATCTCCAT GGAATGAATA TCGCTCACAG GGATGTCAAG 480

CCAGAAAATC TCCTCTACAC CCACAAGGAC AGCAACGCAG AGCTCAAGAT CACAGATTTT 540

GGCTTTTCCA AAGAAACAAC AGTTCAGAAT GCACTCCAGA CCCCATGCTA TACACCATAT 600

TATGTGGCTC CAGAAGTGTT GGGTCCAGAA AAGTATGATA AGTCATGCGA CATGTGGTCA 660

CTGGGAGTCA TCATGTATAT ACTTCTCTGT GGGTATCCTC CTTTCTATTC TAACACAGGT 720

CAGGCCATCT CCCCGGGTAT GAAAAAACGA ATCCGTATGG GACAGTATGA GTTTCCAGCA 780

CCTGAGTGGA ATGATGTGTC ACAGGAAGCT CAGCAGATGA TCCAACACTT GCTGAAGACT 840

GACCCAACTG AGAGGATGTC TATTACCCAG TTCATGAACC ACCCATGGAT AAATCAATCT 900

ATGGTGGTGC CTCAGACTCC TCTGCACACA GCTCGAGTTT TGCAGGAGGA CAAGGAGCAC 960

TGGGATGAGG TGAAGGAAGA GATGACGAGT GCTTTGGCCA CAATGAGAGT AGATTATGAC 1020

CAAGTAAAGA TCAAAGATCT CAACTCCTCC ACCAATAAAC TCCTCAACAA ACGGCGCAAA 1080

AAACAAAGTG ATGGAAACCC GAATACTACC GGCTGTAACA ACCAATAG 1128

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         k++++vlG Gi+gkvlec+++ tg+k+alkil+d++k+rrev+ h++as+ ++iv+++dv

Q: 36    KVSKQVLGLGINGKVLECYRRDTGQKCALKILYDSPKARREVDCHIRASEGPHIVHVLDV  95

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en+++ +++ll+v+e+++GGel++riq+r  +afte+ease+++di++a+++lh +nia

Q: 96    YENIHRSKRCLLIVMECMQGGELFTRIQKRgdQAFTEREASEIMRDIGMAIQHLHGMNIA  155

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy++k++na +k++Dfg++ket+ +++l+tpc+t++yvaPevl++ek

Q: 156   HRDVKPENLLYTHKDSNAELKITDFGFSKETTVQNALQTPCYTPYYVAPEVLGPEK----  211

         ********************************************************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcGypPfys++g+ais+++k+ri++g+yefP +eW++vs+ea

Q: 212   -YDKSCDMWSLGVIMYILLCGYPPFYSNTGQAISPGMKKRIRMGQYEFPAPEWNDVSQEA  270

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         +++i++lLk+dp+er++i++++nhpw+

Q: 271   QQMIQHLLKTDPTERMSITQFMNHPWI  297

         **************************8

Domain Sequence
(FASTA)

KVSKQVLGLG INGKVLECYR RDTGQKCALK ILYDSPKARR EVDCHIRASE GPHIVHVLDV 60

YENIHRSKRC LLIVMECMQG GELFTRIQKR GDQAFTEREA SEIMRDIGMA IQHLHGMNIA 120

HRDVKPENLL YTHKDSNAEL KITDFGFSKE TTVQNALQTP CYTPYYVAPE VLGPEKYDKS 180

CDMWSLGVIM YILLCGYPPF YSNTGQAISP GMKKRIRMGQ YEFPAPEWND VSQEAQQMIQ 240

HLLKTDPTER MSITQFMNHP WI 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:780323

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013