EKS-XET-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	492.4	3.3E-148	4	287	284

Status

Unreviewed

Ensembl Protein

ENSXETP00000000704

UniProt Accession

F6WHM3;

Protein Name

Protein Synonyms/Alias

Gene Name

cdkl2

Gene Synonyms/Alias

cdkl2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000000335	ENSXETP00000000704	ENSXETT00000000704

Organism

Xenopus tropicalis

Functional Description

Protein Length

563

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKENGRIV AVKKFLESED DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDRTVLDD LEQFPNGLDF SKVRKYLFQI IRGIGFCHSH 120

NIIHRDIKPE NILVSHSGIV KLCDFGFART LAGPGEDYTD YVATRWYRAP ELLVGDIKYG 180

KAVDVWAIGC IVTEMLTAQP LFPGDSDIDQ LHHIVKCQGN LTPRHQELFY RNPMFAGFSL 240

PDMKEAESLE WRYPKLSPIM LDLAKSCLHI DPDKRPACMT LLLHELFTKD SFSERFSQEI 300

RAKLQNLPKD NSLQSKKLKN HKKEKEDYAI ENKTTAFQEC NFDSKIKEIK PTKVKIIKTD 360

MEKSEKSDAF SNSFYSSSTN QNKIASHVAL KETSNSLDLH KSAGIIPLIN YNLTAISPYM 420

NSNASTVSGI GHGNFRGEDK SKLYSNSLKK SGKPATGSHY NQNLAPLVDK SPLQRSKKRW 480

DFSKAEMRLP ELHYSHLPEL KGTDCGTLFC ELTKKDSRPV HEPRIPSLAI SEPYNASMAL 540

PQVLGNSLQE TPDANFPPVE HYH 563

Nucleotide Sequence
(FASTA)

ATGGAGAAAT ATGAAAATCT GGGGCTTGTA GGAGAGGGGA GCTATGGAAT GGTTATGAAG 60

TGCAGAAACA AGGAGAATGG GAGAATTGTG GCTGTCAAGA AATTTCTTGA AAGTGAAGAT 120

GACAAGATGG TTAAAAAGAT TGCAATGAGG GAGATCAAAT TGCTCAAGCA ACTACGACAT 180

GAAAACCTGG TAAATCTCCT GGAGGTGTGC AAGAAGAAGA AGCGCTGGTA TCTAGTGTTT 240

GAATTTGTTG ATCGCACTGT ATTGGATGAC CTGGAACAAT TCCCTAATGG GCTAGACTTC 300

AGCAAAGTGC GAAAGTATTT ATTTCAGATC ATAAGAGGAA TAGGGTTTTG CCACAGTCAC 360

AATATTATCC ATCGTGACAT AAAGCCTGAA AACATTTTAG TATCACACTC TGGGATTGTA 420

AAGCTATGTG ATTTCGGATT TGCACGAACC TTGGCTGGAC CTGGTGAAGA TTACACAGAT 480

TATGTGGCAA CAAGATGGTA CAGGGCACCA GAGCTCTTGG TGGGAGACAT CAAGTATGGC 540

AAAGCAGTTG ATGTATGGGC TATTGGCTGC ATAGTGACTG AAATGCTTAC AGCACAACCA 600

CTTTTTCCCG GTGATTCTGA TATTGATCAA TTACACCATA TTGTTAAGTG TCAAGGTAAC 660

CTAACACCAA GGCATCAGGA GTTGTTCTAC AGAAACCCTA TGTTTGCAGG TTTTTCTTTG 720

CCAGACATGA AAGAAGCTGA ATCCCTTGAA TGGAGATATC CAAAACTCTC TCCAATAATG 780

TTAGATTTAG CTAAGAGCTG CTTGCATATT GATCCAGACA AGCGGCCGGC CTGCATGACC 840

CTGTTACTGC ATGAACTTTT TACAAAAGAC AGTTTCTCTG AAAGATTCTC CCAGGAAATC 900

AGAGCAAAAT TGCAAAACCT TCCCAAAGAC AACTCTTTGC AATCCAAAAA ACTAAAAAAC 960

CACAAAAAGG AAAAAGAAGA TTATGCAATA GAAAATAAGA CTACAGCATT CCAGGAATGC 1020

AACTTTGACT CGAAAATAAA AGAGATAAAA CCCACAAAAG TGAAAATAAT AAAAACTGAT 1080

ATGGAGAAGA GTGAGAAGAG CGACGCATTT TCCAACAGCT TTTACAGTAG CAGCACGAAC 1140

CAGAATAAAA TTGCATCGCA CGTTGCATTA AAAGAGACTA GTAACAGTCT GGATCTTCAC 1200

AAAAGTGCTG GGATAATTCC GCTAATTAAC TACAACTTAA CTGCCATATC CCCATATATG 1260

AACTCCAATG CAAGCACTGT CTCTGGCATA GGGCATGGTA ATTTCAGGGG AGAAGATAAA 1320

AGTAAACTGT ATAGCAATTC CTTAAAGAAA AGTGGAAAAC CTGCCACAGG AAGTCATTAT 1380

AATCAGAATT TAGCACCTCT GGTTGACAAG AGTCCTCTAC AAAGAAGCAA GAAAAGATGG 1440

GACTTTTCTA AGGCTGAGAT GCGGTTACCA GAGCTTCACT ACAGTCATTT ACCAGAACTA 1500

AAAGGCACAG ATTGTGGGAC ACTTTTTTGT GAGCTGACAA AGAAGGATAG CAGGCCAGTA 1560

CACGAACCCC GAATTCCATC TCTTGCCATA AGTGAGCCTT ACAATGCAAG CATGGCCTTG 1620

CCACAGGTTT TAGGAAACTC ATTGCAAGAG ACGCCAGATG CAAATTTCCC TCCAGTGGAG 1680

CACTATCAT 1689

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnk+ g+iva+kkfleseddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKENGRIVAVKKFLESEDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+tvld+le++pnG++ ++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDRTVLDDLEQFPNGLDFSKVRKYLFQIIRGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sg+vklcdfGfar+la+pg+ ytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSHSGIVKLCDFGFARTLAGPGEDYTDYVATRWYRAPELLVGDIKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc+++e+lt +plfpg+sd+dql++i+k+ G+l+prhq++f++n++faG +lp++

Q: 184   DVWAIGCIVTEMLTAQPLFPGDSDIDQLHHIVKCQGNLTPRHQELFYRNPMFAGFSLPDM  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++esle +ypkl++++ldl+k+cl++dp++r +c  ll he+f

Q: 244   KEAESLEWRYPKLSPIMLDLAKSCLHIDPDKRPACMTLLLHELF  287

         *****************************************988

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KENGRIVAVK KFLESEDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DRTVLDDLEQ FPNGLDFSKV RKYLFQIIRG IGFCHSHNII 120

HRDIKPENIL VSHSGIVKLC DFGFARTLAG PGEDYTDYVA TRWYRAPELL VGDIKYGKAV 180

DVWAIGCIVT EMLTAQPLFP GDSDIDQLHH IVKCQGNLTP RHQELFYRNP MFAGFSLPDM 240

KEAESLEWRY PKLSPIMLDL AKSCLHIDPD KRPACMTLLL HELF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013