EKS-XET-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	495.5	3.4E-149	529	786	258

Status

Unreviewed

Ensembl Protein

ENSXETP00000000921

UniProt Accession

F6ZD16;

Protein Name

Protein Synonyms/Alias

Gene Name

erbb4

Gene Synonyms/Alias

erbb4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000000413	ENSXETP00000000921	ENSXETT00000000921

Organism

Xenopus tropicalis

Functional Description

Protein Length

1120

Protein Sequence
(FASTA)

GRCPKSCMGR CWGPSDQHCQ RLTKTVCAEQ CDGRCYGSYV SDCCHRECAG GCTGPKDTDC 60

FSCMKFNDSG SCVTQCPQPN IYNPTAFQLE QNPKAKYTYG AFCVNKCPHN FVVDDSSCVR 120

ACPSNKMEVE ENGIKMCKPC AGICPKVCDG IGTGSLQSAQ TVDSSNIDKF INCTKINGNL 180

HFLVTGIDGD PYHNIAALEP QKLNIFFTVR EITGFLNIQS WPRNMTDLSV FSNLVNIGGR 240

VLYSGISLLI LKQQSLNSLQ FQSLKEISAG NVYITDNRNL CYYHTVNWTS LFRTSNQRTT 300

IRENKKPENC TAEGMVCDPL CSNAGCWGPG ANQCLSCRYF SRGKSCVRSC NLYKGESREF 360

VNGSVCVMCD SQCEKMEDSI VTCYGPGPDH CTKCSNFKDG PNCVEKCPEG LQGANSFIFK 420

YADEDKECHP CHPNCTDGCN NPTSHDCLWN DPLTLPQHAR TPLIAASVIG GLFIIVIMAL 480

TFAVYIRRKS IKKKRALRRF LETELVEPLT PSGTAPNQAQ LRILKETELK RIKILGSGAF 540

GTVYKGIWVP EGETVKIPVA IKILNETTGP KANAEFMDEA LIMASMDHPH LVRLLGVSLS 600

PTIQLVTQLM PHGCLLDYVH EHKDNIGSQL LLNWCVQIAK GMMYLEERRL VHRDLAARNV 660

LVKSPNHVKI TDFGLARLLE GDEKEYNADG GKMPIKWMAL ECIHYRKFTH QSDVWSYGVT 720

VWELMTFGGK PYDGIPTREI PDLLEKGERL PQPPVCTIDV YMVMVKCWMI DADSRPKFKE 780

LAAEFSRMAR DPQRYLVIQG DDRMKLPSPN DSKFFQNLLD EEDLGDMMDA EEYLVPQAFN 840

IPPPIYTSRT RIDSNRSEIG HSPPPAYTPM SGNQFVYRDG GYTTQEAVNL PFRPTACPIT 900

ELSTAQGATA EVFDDVCCNG TLCKQVVSER IPEESSLQRY SADPTAFVPE RNPRGVVGED 960

GYMTPMKEKP KSDYLNPVEE NPFVSRRKNG DVQAVEKPEY NNGPSTQSKS EDEYVKERLY 1020

LNSFAKPKEN AEYLKNNGLT VPEKSKKAFD NPEYWNHSLP PRSTIHHPDY LHEYSTKYFY 1080

KQNGRIRPVV AENPEYLTEF TLKPGTVLPP PPYRHRNTVV 1120

Nucleotide Sequence
(FASTA)

GGGAGGTGCC CTAAGTCATG CATGGGACGC TGCTGGGGAC CATCGGATCA ACACTGCCAG 60

AGATTGACGA AGACTGTGTG CGCAGAACAA TGTGATGGCC GATGCTATGG TTCCTATGTT 120

AGTGATTGCT GTCACCGAGA ATGTGCTGGA GGCTGCACAG GACCAAAAGA CACTGACTGC 180

TTTTCCTGTA TGAAATTTAA CGACAGCGGT TCCTGTGTCA CCCAGTGTCC TCAGCCTAAT 240

ATTTACAATC CGACTGCTTT CCAGCTGGAG CAAAACCCAA AGGCCAAGTA TACCTATGGA 300

GCTTTTTGTG TCAACAAGTG CCCACATAAC TTTGTCGTGG ATGACAGCTC CTGTGTACGA 360

GCCTGCCCAA GCAACAAGAT GGAAGTGGAA GAAAATGGAA TCAAGATGTG CAAGCCTTGT 420

GCGGGCATCT GTCCAAAAGT GTGTGACGGG ATTGGGACTG GGTCCTTGCA GTCAGCACAG 480

ACGGTAGATT CCAGCAACAT AGACAAATTC ATTAACTGTA CCAAGATCAA TGGCAATCTG 540

CATTTCCTGG TCACGGGCAT TGACGGGGAT CCCTACCACA ACATAGCTGC ACTAGAACCT 600

CAGAAACTAA ACATCTTTTT CACAGTTCGA GAGATCACAG GATTCCTAAA TATTCAGTCT 660

TGGCCAAGAA ATATGACGGA CCTCAGTGTC TTTTCCAACC TGGTGAATAT AGGAGGCAGA 720

GTGCTCTACA GTGGAATTTC CCTGCTGATT CTAAAGCAGC AGAGCCTCAA CTCCCTACAG 780

TTTCAGTCAC TCAAAGAGAT CAGTGCTGGG AATGTATATA TCACTGATAA CCGTAACCTG 840

TGCTATTACC ATACCGTCAA CTGGACATCT CTCTTCCGGA CATCCAACCA GAGAACCACT 900

ATCCGAGAGA ACAAGAAGCC AGAAAACTGC ACTGCAGAAG GAATGGTTTG TGACCCTCTC 960

TGTTCCAATG CTGGGTGCTG GGGTCCAGGG GCCAATCAGT GCCTGTCCTG TCGATACTTC 1020

AGCCGAGGGA AGTCATGTGT CAGATCCTGC AACCTTTATA AAGGAGAATC CCGTGAATTT 1080

GTCAATGGCT CTGTCTGTGT AATGTGTGAC TCTCAATGCG AGAAGATGGA AGACAGCATA 1140

GTCACCTGCT ATGGGCCGGG CCCAGATCAC TGCACAAAAT GCTCAAACTT TAAGGATGGG 1200

CCCAACTGCG TGGAAAAATG TCCAGAAGGT CTTCAAGGGG CAAACAGCTT CATCTTTAAA 1260

TACGCAGATG AGGACAAAGA ATGCCATCCT TGCCACCCTA ACTGTACAGA TGGGTGTAAC 1320

AACCCTACCT CCCATGACTG CTTGTGGAAC GACCCTCTCA CCCTACCTCA ACATGCTAGG 1380

ACTCCTCTCA TCGCAGCCAG TGTTATTGGA GGGCTCTTCA TAATAGTTAT CATGGCATTG 1440

ACCTTTGCCG TTTACATTAG AAGGAAAAGC ATCAAAAAGA AGAGAGCTTT ACGCAGATTC 1500

CTTGAAACAG AGTTGGTAGA ACCACTGACA CCCAGTGGCA CAGCCCCAAA TCAGGCCCAG 1560

CTGAGGATTC TAAAGGAAAC AGAACTAAAA AGGATAAAAA TCTTGGGATC TGGTGCTTTT 1620

GGGACTGTCT ACAAGGGCAT CTGGGTTCCT GAAGGAGAAA CTGTGAAGAT CCCTGTGGCA 1680

ATTAAGATAC TAAATGAGAC AACTGGACCT AAAGCAAATG CTGAGTTCAT GGACGAGGCT 1740

TTGATTATGG CCAGCATGGA CCATCCACAC CTGGTTCGAC TTCTGGGCGT CTCTTTAAGT 1800

CCCACAATTC AACTTGTTAC ACAGCTAATG CCCCATGGAT GCCTGTTGGA CTATGTGCAT 1860

GAACATAAGG ATAACATCGG GTCACAACTC CTTCTTAACT GGTGCGTCCA GATAGCAAAG 1920

GGCATGATGT ATTTGGAAGA AAGGCGTCTT GTTCACAGAG ATCTGGCAGC TCGGAATGTT 1980

CTGGTCAAGT CTCCCAATCA TGTGAAGATC ACCGACTTTG GACTGGCACG ACTTCTGGAA 2040

GGAGATGAAA AAGAATATAA TGCAGATGGT GGCAAGATGC CCATTAAATG GATGGCCCTA 2100

GAGTGTATCC ATTACAGAAA GTTTACCCAT CAGAGTGATG TCTGGAGCTA TGGTGTCACT 2160

GTCTGGGAGC TTATGACATT TGGTGGAAAA CCCTATGATG GTATCCCAAC ACGGGAAATC 2220

CCTGACTTAC TGGAGAAAGG AGAAAGACTT CCTCAGCCAC CAGTCTGCAC AATTGATGTC 2280

TACATGGTCA TGGTGAAATG CTGGATGATT GACGCAGATA GTCGCCCTAA GTTTAAAGAA 2340

CTAGCTGCTG AATTTTCCAG GATGGCAAGA GACCCTCAGA GATATCTTGT CATACAGGGA 2400

GATGACCGTA TGAAACTCCC CAGCCCCAAT GACAGCAAGT TCTTCCAAAA CCTTTTGGAT 2460

GAAGAAGACC TTGGAGATAT GATGGATGCA GAGGAATACC TAGTGCCACA GGCCTTTAAC 2520

ATCCCACCTC CCATCTACAC ATCCCGGACG AGAATCGACT CCAATAGAAG TGAAATTGGA 2580

CACAGCCCTC CTCCTGCCTA CACCCCTATG TCAGGAAACC AGTTTGTTTA TAGAGATGGG 2640

GGCTACACCA CTCAAGAAGC AGTAAATCTT CCCTTCAGAC CCACTGCCTG CCCAATAACA 2700

GAACTCTCAA CAGCACAGGG GGCTACAGCT GAAGTCTTTG ATGATGTTTG TTGCAATGGC 2760

ACACTTTGTA AACAGGTGGT ATCAGAGCGA ATACCAGAGG AGAGCAGCCT GCAGAGATAT 2820

AGTGCTGACC CCACTGCATT TGTGCCGGAA CGCAACCCCA GAGGAGTTGT CGGGGAAGAT 2880

GGCTATATGA CTCCCATGAA GGAAAAACCG AAGTCTGATT ATTTAAACCC AGTTGAAGAG 2940

AATCCCTTTG TATCTCGAAG GAAAAATGGG GATGTCCAAG CTGTGGAGAA ACCAGAGTAT 3000

AATAATGGGC CCAGCACACA GTCTAAGTCA GAAGATGAAT ATGTCAAAGA GCGTTTGTAT 3060

TTGAACTCTT TTGCTAAACC CAAGGAAAAT GCTGAGTACC TGAAAAATAA TGGACTTACT 3120

GTGCCAGAGA AATCCAAGAA GGCATTTGAT AATCCAGAAT ACTGGAATCA CAGTCTGCCA 3180

CCAAGGAGCA CCATCCATCA TCCAGATTAC CTGCATGAAT ACAGCACAAA ATACTTTTAT 3240

AAGCAAAATG GACGGATCAG GCCAGTGGTA GCAGAAAATC CAGAATACCT GACAGAATTT 3300

ACTCTGAAAC CAGGCACTGT TCTCCCCCCT CCTCCCTATA GGCACCGGAA CACTGTTGTG 3360

TAG 3363

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 529   LKRIKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANAEFMDEALIMASMDH  588

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+ ls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 589   PHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  648

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 649   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  708

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG kpydgip++eipdllekGerl+qpp+ctidvymv+vkcw

Q: 709   THQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCW  768

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 769   MIDADSRPKFKELAAEFS  786

         ****************96

Domain Sequence
(FASTA)

LKRIKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANAEFMD EALIMASMDH 60

PHLVRLLGVS LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTVWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPVCTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013