EKS-XET-00611
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00611
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK427.82.0E-12827313287
StatusUnreviewed
Ensembl ProteinENSXETP00000048167
UniProt AccessionF7A4Q7;
Protein Name
Protein Synonyms/Alias
Gene Namemapk12
Gene Synonyms/Alias mapk12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000000436ENSXETP00000048167ENSXETT00000048167
OrganismXenopus tropicalis
Functional Description
Protein Length365
Protein Sequence
(FASTA)
MSTSPLPKKG YYRQDVNKTV WEVKERYRDL VAVGSGAYGT VCSSLDTRTG TKVAIKKLYR 60
PFQSELFAKR AYRELRLLKH MQHENVIGLL DVFTPDSTLE NFNDFYLVMP FMGTDLGKIM 120
KHEKLSEDRI QFLVYQILRG LKYIHSAGII HRDLKPGNLA VNEDCELKIL DFGLARHTDS 180
EMTGYVVTRW YRAPEVILNW MHYTQTVDIW SVGCIMAEMY TGRPLFKGND HKDLDQLTEI 240
MKITGTPTQD FVQKLQSPDA KNYIKSLPKV QKKDFGSLLR YANPLAVNIL EKMLVLDAEK 300
RITATEALAH PYFEQFHDID DETEAEPYDD SFDNVNLPLE EWRRLTHKEL TSYKPLVADS 360
KETSV 365
Nucleotide Sequence
(FASTA)
ATGTCCACCT CCCCGTTGCC CAAGAAGGGA TACTATAGGC AGGACGTCAA TAAGACCGTC 60
TGGGAGGTGA AGGAGAGGTA CAGAGACCTG GTGGCTGTGG GATCAGGAGC CTATGGCACT 120
GTTTGCTCAT CTCTAGACAC TAGAACTGGA ACAAAAGTAG CTATCAAGAA ACTGTACCGT 180
CCTTTTCAAT CTGAACTCTT TGCAAAGCGA GCATATAGAG AGCTGAGGCT TTTGAAGCAC 240
ATGCAGCATG AAAACGTAAT TGGTCTATTG GACGTGTTTA CTCCAGACTC AACTTTGGAA 300
AATTTCAATG ATTTTTATTT GGTGATGCCA TTCATGGGTA CGGACCTTGG CAAGATAATG 360
AAACATGAAA AGCTATCTGA AGACCGAATC CAGTTCCTGG TTTATCAGAT CCTCAGGGGG 420
CTAAAGTACA TTCATTCAGC TGGAATCATC CACAGGGATT TAAAGCCTGG AAATCTTGCA 480
GTAAATGAAG ACTGTGAGTT AAAGATTCTG GATTTTGGCC TGGCAAGGCA CACAGATAGT 540
GAAATGACTG GTTACGTGGT GACCAGATGG TACAGAGCCC CAGAGGTTAT ACTCAATTGG 600
ATGCACTACA CTCAGACAGT GGATATCTGG TCTGTTGGAT GTATCATGGC AGAGATGTAC 660
ACTGGGAGGC CACTTTTCAA GGGAAATGAC CATAAAGATC TAGACCAGCT AACAGAAATA 720
ATGAAAATTA CTGGGACACC AACTCAGGAT TTTGTCCAGA AGCTCCAGAG TCCTGATGCT 780
AAAAACTATA TCAAGAGCCT TCCTAAAGTG CAGAAGAAAG ACTTTGGATC ATTGCTAAGA 840
TATGCAAACC CTCTTGCTGT AAATATCCTT GAGAAGATGT TGGTACTGGA TGCAGAAAAG 900
AGGATAACTG CGACAGAGGC TTTAGCACAT CCATACTTTG AACAGTTCCA TGATATTGAT 960
GATGAGACAG AAGCTGAACC CTATGATGAT TCATTCGACA ATGTAAATCT TCCTCTGGAG 1020
GAGTGGAGGC GTCTCACACA CAAGGAGCTT ACTAGCTATA AGCCATTGGT GGCTGATTCA 1080
AAGGAAACAT CGGTATAA 1098
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l  +g+Gayg+v+s+ d+rt+++vaikkl rpfq+e  akr++REl+llk+++heN+
Q: 27    YRDLVAVGSGAYGTVCSSLDTRTGTKVAIKKLYRPFQSELFAKRAYRELRLLKHMQHENV  86
         667889******************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i lldvftp+++le+++d+Ylv+ +m+tdL k++k++kls+++i++l+yqilrglky+Hs
Q: 87    IGLLDVFTPDSTLENFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQILRGLKYIHS  146
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKP+Nl+vnedcelkildFGlar++d+e    +t+yv+trwYraPe++l++++
Q: 147   AGIIHRDLKPGNLAVNEDCELKILDFGLARHTDSE----MTGYVVTRWYRAPEVILNWMH  202
         **********************************9....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkde..idqlekilevlgtpseeflkkieseearn  238
         yt++vDiWsvGCI+aE+ tg+plf+g+d+  +dql++i++++gtp+++f++k++s  a+n
Q: 203   YTQTVDIWSVGCIMAEMYTGRPLFKGNDHkdLDQLTEIMKITGTPTQDFVQKLQSPDAKN  262
         ***************************984468***************************
S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         yikslpk +kkdf +l+  a++ a+++lek+Lvld++kRi+++eaL+hpY+
Q: 263   YIKSLPKVQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEALAHPYF  313
         **************************************************6
Domain Sequence
(FASTA)
YRDLVAVGSG AYGTVCSSLD TRTGTKVAIK KLYRPFQSEL FAKRAYRELR LLKHMQHENV 60
IGLLDVFTPD STLENFNDFY LVMPFMGTDL GKIMKHEKLS EDRIQFLVYQ ILRGLKYIHS 120
AGIIHRDLKP GNLAVNEDCE LKILDFGLAR HTDSEMTGYV VTRWYRAPEV ILNWMHYTQT 180
VDIWSVGCIM AEMYTGRPLF KGNDHKDLDQ LTEIMKITGT PTQDFVQKLQ SPDAKNYIKS 240
LPKVQKKDFG SLLRYANPLA VNILEKMLVL DAEKRITATE ALAHPYF 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00430
EKS-ANC-00447
EKS-BOT-00461
EKS-CAJ-00471
EKS-CAF-00462
EKS-CAP-00495
EKS-DAR-00875
EKS-EQC-00455
EKS-GAM-00269
EKS-GAA-00569
EKS-HOS-00471
EKS-MAM-00460
EKS-MEG-00381
EKS-MUM-00492
EKS-MYL-00458
EKS-NOL-00419
EKS-ORN-00583
EKS-ORC-00436
EKS-ORL-00532
EKS-OTG-00468
EKS-PES-00404
EKS-POA-00454
EKS-RAN-00474
EKS-TAG-00528
EKS-TAR-00575
EKS-TEN-00575
EKS-TUT-00169
EKS-XIM-00575
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013