EKS-XET-00349

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00349

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	455.4	8.6E-137	232	519	288

Status

Unreviewed

Ensembl Protein

ENSXETP00000001261

UniProt Accession

F7ESG8;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr1b

Gene Synonyms/Alias

acvr1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000000572	ENSXETP00000001261	ENSXETT00000001261

Organism

Xenopus tropicalis

Functional Description

Protein Length

530

Protein Sequence
(FASTA)

LWLEASCGRA PGIRLSVWVV RGRAGCGRCA AITMAELPAF FIAFSLLLFG GGPSFAFELK 60

CMCSNCIQSN FTCVTDGACM VSISNVKGKE YHLRACIGHE DLVPPGKPFY CLSSEDIRNT 120

HCCYSDYCNK IDLGVPTGQI IVDTPSGWGP VELVAVIAIP VFLICVILIV VVLFHCHQRV 180

YHNRQRLDLE DPSCEMYLAK DKTLPDLVYD LSTSGSGSGL PLFVQRTVAR TIVLQEIIGK 240

GRFGEVWRGK WRGGDVAVKI FSSREERSWF REAEIYQTVM LRHENILGFI AADNKDNGTW 300

TQLWLVSDYH EHGSLFDYLN RYTVTIEGMI KLSLSAASGL AHLHMEIVGT QGKPGIAHRD 360

LKSKNILVKK NGMCAIADLG LAVRHDSATD TIDIAPNQRV GTKRYMAPEV LDETINMKHF 420

DSFKCADIYA LGLVYWEIAR RCSAGGFHEE YQLPFYDLVP SDPSIEEMRK VVCDQKLRPN 480

IPNWWQSYEA LRVMGKMMRE CWYANGAARL TALRIKKTLS QLSIQEDVKI 530

Nucleotide Sequence
(FASTA)

CTCTGGCTGG AGGCGTCGTG CGGACGCGCT CCCGGAATAC GCTTGTCTGT CTGGGTCGTT 60

CGTGGTCGCG CAGGTTGTGG GCGCTGTGCG GCTATTACTA TGGCGGAGCT ACCGGCCTTC 120

TTTATCGCCT TCAGCCTCCT TCTCTTTGGA GGGGGCCCCA GCTTTGCGTT TGAGCTTAAA 180

TGTATGTGCT CTAACTGCAT TCAGTCAAAC TTCACCTGTG TTACGGATGG TGCCTGCATG 240

GTTTCTATCT CCAATGTCAA GGGTAAAGAA TATCATTTGC GAGCTTGCAT TGGTCATGAG 300

GATCTCGTAC CTCCCGGAAA ACCATTTTAT TGTCTTAGCT CAGAGGATAT TCGCAACACC 360

CACTGCTGTT ACTCAGATTA CTGCAACAAA ATCGATTTAG GAGTGCCAAC TGGACAAATT 420

ATAGTTGATA CTCCTTCAGG ATGGGGTCCG GTGGAGCTGG TAGCTGTTAT CGCTATCCCG 480

GTATTTCTCA TTTGTGTCAT CCTCATTGTC GTAGTCTTGT TTCACTGTCA CCAGAGAGTT 540

TATCACAACC GCCAGAGACT TGACTTGGAG GATCCATCAT GTGAAATGTA TCTTGCAAAA 600

GATAAAACCC TGCCAGACTT GGTCTATGAT CTCTCCACAT CTGGTTCTGG CTCAGGACTA 660

CCACTTTTTG TGCAGCGAAC TGTGGCGAGA ACTATTGTTT TGCAAGAGAT AATTGGGAAG 720

GGACGTTTTG GTGAAGTTTG GCGTGGGAAG TGGAGGGGCG GTGATGTTGC AGTAAAAATT 780

TTCTCCTCTC GAGAAGAACG TTCTTGGTTT AGAGAAGCAG AAATCTACCA AACCGTTATG 840

CTGAGGCATG AAAATATCCT AGGATTTATT GCTGCAGACA ACAAAGACAA TGGAACCTGG 900

ACCCAGTTGT GGCTTGTTTC TGACTATCAC GAACATGGCT CCCTGTTCGA CTATCTCAAC 960

CGATATACAG TTACTATCGA AGGGATGATA AAGCTATCTC TTTCTGCAGC TAGTGGTCTT 1020

GCCCATTTAC ATATGGAAAT TGTTGGCACT CAAGGAAAGC CTGGAATTGC TCACAGAGAT 1080

CTAAAGTCCA AGAATATTTT GGTGAAAAAG AATGGAATGT GTGCTATTGC AGACTTGGGT 1140

CTTGCTGTAA GACATGATTC TGCCACTGAC ACTATTGACA TTGCTCCAAA CCAGAGAGTC 1200

GGGACCAAAA GGTATATGGC CCCTGAAGTC TTGGATGAGA CCATAAACAT GAAACATTTT 1260

GATTCCTTCA AATGTGCTGA CATTTACGCT CTGGGGTTGG TTTATTGGGA AATTGCCCGC 1320

AGATGCAGTG CAGGAGGTTT TCATGAGGAA TATCAGCTTC CCTTTTATGA CCTTGTTCCC 1380

TCGGATCCAT CTATTGAAGA AATGAGGAAA GTAGTGTGTG ACCAGAAGTT GCGGCCAAAC 1440

ATACCTAATT GGTGGCAAAG TTATGAGGCT CTTCGAGTTA TGGGGAAGAT GATGAGGGAG 1500

TGCTGGTACG CCAATGGTGC AGCCAGATTG ACTGCTCTGC GCATTAAAAA AACACTGTCA 1560

CAGCTCAGTA TACAAGAAGA TGTGAAAATA TGA 1593

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++k+rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 232   IVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  291

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++l ls+asGlahLH+eivgt+

Q: 292   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLSLSAASGLAHLHMEIVGTQ  351

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 352   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDSATDTIDIAPNQRVGTKRYMAPE  409

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++ +eey+lpf++ v+sdPs+eem

Q: 410   VLDETINMKHFDSFKCADIYALGLVYWEIARRCSA-GGFHEEYQLPFYDLVPSDPSIEEM  468

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 469   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  519

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LSLSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDSATDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CSAGGFHEEY QLPFYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013