EKS-XET-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	330.9	7.0E-99	846	1117	272

Status

Unreviewed

Ensembl Protein

ENSXETP00000001294

UniProt Accession

A0JM01;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

jak2

Gene Synonyms/Alias

jak2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000000586	ENSXETP00000001294	ENSXETT00000001294

Organism

Xenopus tropicalis

Functional Description

Protein Length

1129

Protein Sequence
(FASTA)

MACLMMTEID GTTTPPIHSI RDVNLNSDFP KRSEQGLHIY LYHISEETDG DYLVLPPEKY 60

VAEEICIMAS KACGVTPVYY SLFALMDEQD RIWYPPNHTF HVEETTRQKL IFRIRFYLPH 120

WYCNGTNRAF RYGVAKGAES PVLDDVVMAY LFAQWRDDFV NGRITVPITH EAQEECLGMA 180

VLDMMRMASE KGQSPLAVYN SVSYKKFLPK CIRAKIQDYH ILTRKRIRYR FRKFIQQFGQ 240

CKATARDLKL KYLINLETLQ SAFYSECFEV REPSRDNSGG ENFATIVVTG NSGIQFSKGK 300

PKERESLADM DLQTYCDFTE IIDISIKQAN KDDSTESRVV TINKQDNKIL EVEFSTLKEA 360

LSFGSLIDGY CRLTTDAHHY LCKEVVPPRV LEGIQSYCHG PVSMEFAINK LKKAGNQRGL 420

FILRCSPKEF NKYFLTFSIE RDGVTQYKHC LITKNDNGDY NLSGAKKSFA TLKDLLNCYQ 480

KETVRSDGII FQFRRCCPPR PKEKSNLIIF RSNEDSEVSS SPTLQRNNNV NQMVFHKIRS 540

EDLHFLENLG QGTFTKIFKG KREELGDYNK IHVTEVLLKV LDKTHRSFSE SFFEAASMMS 600

QLSYKHLILN YGVCVCGDES ILVQEYAKYG SLDTYLKRNK NAINIMWKLE VSKQLAWAMH 660

FLEDRNLVHG NVCSKNILLI REEDRKTGNP PFIKLSDPGI SITVLPKEIL LERIPWVPPE 720

CIDNSKHLTQ ASDKWSFGTT LWEIYSGGDK PLTALDSQRK LQFYEDRHQL PAPKWIELAN 780

LINSCMDYEP DFRPSFRAII RDLNSLFTPD YELLAETDFL QNMRIGAFGF SGGFEDRDPP 840

FEERHLKFLQ QLGKGNFGSV ELCRYDPLQD NTGEVVAVKK LQHTTEEYLR DFEREIEILK 900

SLQHDNIVRY KGVCYSAGRR NLRLIMEYLP YGSLRDYLQK HKDRLDFKKL LQYSSQICKG 960

MEYLTIKRYI HRDLATRNIL VENENRVKIG DFGLTKVLPQ DKEYYKVKEP GESPIFWYAP 1020

ESLTESKFSV ASDVWSFGVV LYELFTYSEK SKSPPSEFMR MIGNDKQGQM IVFHLIELLK 1080

NKGRLPQPEG CPDEIYRIMN ECWNNSISQR PSFKELTIQV EKAKEIMGA 1129

Nucleotide Sequence
(FASTA)

ATGGCTTGCC TCATGATGAC TGAAATCGAT GGAACCACAA CTCCTCCTAT TCACTCAATT 60

CGGGATGTGA ATTTAAATTC AGATTTCCCA AAACGAAGTG AGCAAGGATT ACACATATAC 120

TTGTACCATA TTTCAGAGGA GACTGATGGG GATTACTTGG TATTACCACC AGAAAAGTAT 180

GTCGCTGAAG AGATATGTAT CATGGCTTCA AAAGCTTGTG GGGTGACACC TGTTTACTAC 240

AGCTTATTTG CATTAATGGA TGAGCAGGAC AGAATATGGT ATCCCCCAAA TCATACTTTC 300

CATGTTGAGG AAACAACAAG GCAAAAATTA ATTTTTCGAA TAAGGTTTTA TTTACCTCAT 360

TGGTATTGCA ATGGAACCAA CAGAGCATTT CGATATGGAG TTGCAAAAGG TGCAGAGAGT 420

CCTGTCCTTG ATGACGTTGT AATGGCATAT TTGTTTGCTC AATGGCGAGA TGATTTTGTT 480

AATGGACGAA TTACCGTACC TATTACACAT GAAGCCCAAG AAGAATGCCT GGGGATGGCA 540

GTTCTTGACA TGATGCGTAT GGCCAGTGAA AAGGGGCAAA GTCCACTGGC TGTTTACAAT 600

TCTGTTAGCT ACAAGAAATT TTTGCCAAAG TGTATTCGAG CAAAAATTCA AGACTACCAC 660

ATTTTGACAA GAAAGAGAAT AAGATACAGA TTTCGCAAAT TTATTCAACA GTTTGGCCAG 720

TGTAAAGCTA CTGCCAGAGA CTTAAAACTT AAGTACTTGA TAAATCTCGA GACCCTACAG 780

TCAGCTTTCT ACTCTGAATG CTTTGAAGTA AGGGAGCCAA GCAGGGATAA TTCAGGAGGA 840

GAAAATTTTG CAACCATCGT GGTTACTGGA AATAGTGGCA TTCAATTTTC AAAAGGAAAG 900

CCTAAAGAAA GAGAATCATT AGCTGACATG GATTTACAGA CGTACTGTGA TTTTACTGAA 960

ATAATTGACA TCAGTATTAA ACAAGCAAAT AAAGATGATT CTACAGAGAG CAGGGTTGTC 1020

ACAATCAACA AACAAGACAA CAAAATTCTG GAGGTAGAAT TTTCCACCTT AAAAGAAGCT 1080

CTTTCATTTG GGTCACTTAT TGATGGATAC TGTAGGCTAA CAACAGATGC ACACCATTAT 1140

CTTTGCAAAG AAGTTGTGCC TCCAAGGGTA TTGGAAGGAA TTCAGAGCTA TTGTCATGGA 1200

CCAGTTTCGA TGGAATTCGC CATTAATAAG CTAAAAAAAG CAGGGAACCA GAGAGGCCTT 1260

TTCATTCTTC GATGCAGTCC AAAAGAGTTT AACAAATATT TCCTTACATT TTCCATAGAG 1320

CGTGATGGTG TAACACAATA CAAGCATTGC TTAATTACAA AAAATGACAA TGGAGACTAC 1380

AACTTAAGTG GAGCCAAGAA AAGTTTTGCC ACTCTTAAAG ACTTATTAAA CTGTTATCAG 1440

AAAGAAACCG TCCGCTCTGA TGGAATAATA TTTCAGTTCC GCCGATGCTG CCCGCCAAGG 1500

CCCAAAGAAA AATCAAACCT GATCATCTTC AGGAGCAATG AAGATTCAGA GGTCTCCTCC 1560

TCGCCCACGT TGCAGAGGAA CAATAATGTA AATCAGATGG TGTTCCACAA AATCAGAAGT 1620

GAAGATTTGC ATTTTCTGGA GAATCTTGGC CAGGGCACAT TTACCAAGAT ATTTAAAGGT 1680

AAACGTGAAG AACTGGGAGA CTATAATAAG ATTCATGTAA CTGAAGTCCT TCTCAAGGTT 1740

TTGGACAAAA CGCACAGAAG TTTTTCAGAG TCCTTTTTTG AGGCAGCAAG TATGATGAGT 1800

CAACTGTCTT ACAAGCATTT GATTTTAAAT TATGGGGTCT GTGTGTGTGG GGATGAGAGC 1860

ATTCTGGTTC AAGAATATGC AAAATATGGG TCACTTGACA CATACTTGAA GAGAAACAAA 1920

AATGCAATAA ATATCATGTG GAAACTAGAA GTTTCAAAAC AGTTGGCATG GGCAATGCAC 1980

TTTCTCGAAG ATAGAAATCT TGTGCATGGA AATGTGTGTT CAAAAAACAT CCTGCTGATC 2040

AGAGAAGAAG ATAGGAAGAC TGGTAACCCA CCCTTTATTA AACTTAGTGA TCCTGGAATA 2100

AGCATTACGG TCTTACCTAA AGAAATTCTT TTGGAGAGAA TTCCTTGGGT TCCACCTGAG 2160

TGCATTGATA ATTCAAAGCA CCTCACTCAA GCATCAGATA AGTGGAGTTT TGGCACCACC 2220

TTATGGGAAA TATACAGTGG TGGTGATAAA CCACTTACTG CTCTTGATAG CCAAAGAAAA 2280

TTACAGTTTT ATGAAGATAG ACATCAACTT CCAGCACCAA AATGGATAGA ACTCGCAAAT 2340

TTAATTAACA GCTGTATGGA CTATGAACCA GATTTTCGGC CTTCATTCAG GGCGATAATA 2400

AGGGACCTTA ATAGCTTGTT TACTCCAGAC TATGAGTTAC TGGCAGAAAC TGACTTTCTC 2460

CAAAATATGA GAATTGGGGC TTTTGGTTTC TCTGGAGGCT TTGAAGACCG AGATCCTCCT 2520

TTTGAAGAAA GACATCTTAA ATTCTTGCAG CAACTTGGCA AGGGTAATTT TGGAAGTGTT 2580

GAATTGTGCC GCTATGACCC ACTACAAGAC AATACTGGTG AAGTTGTGGC AGTAAAAAAG 2640

CTGCAGCATA CCACTGAGGA GTACCTGAGG GACTTTGAAC GAGAAATTGA AATCCTTAAA 2700

TCACTCCAAC ATGATAACAT AGTGAGATAC AAGGGAGTGT GTTACAGCGC AGGTCGTCGA 2760

AATCTTAGAT TGATTATGGA ATACTTGCCC TATGGAAGCT TACGAGACTA TTTACAAAAG 2820

CATAAAGACC GATTGGACTT CAAAAAGCTT TTACAATATT CAAGCCAAAT ATGCAAGGGA 2880

ATGGAATATC TTACCATTAA AAGGTACATT CACAGAGATT TGGCAACGAG AAATATTTTA 2940

GTCGAGAATG AAAACAGGGT AAAAATAGGG GATTTTGGAT TGACTAAAGT ACTGCCGCAA 3000

GACAAAGAAT ATTACAAAGT CAAAGAACCT GGTGAAAGTC CAATATTCTG GTATGCTCCT 3060

GAATCTCTGA CAGAAAGCAA ATTTTCTGTA GCATCAGATG TGTGGAGTTT TGGAGTTGTT 3120

CTCTATGAGT TGTTCACCTA CAGTGAGAAG AGCAAAAGCC CACCTTCGGA GTTCATGAGA 3180

ATGATTGGAA ATGATAAACA AGGACAGATG ATTGTATTTC ATTTGATAGA ACTGCTAAAA 3240

AATAAAGGAA GACTGCCACA ACCTGAAGGC TGCCCTGATG AGATTTATAG GATAATGAAT 3300

GAATGCTGGA ACAACAGCAT CAGTCAGCGT CCCTCATTTA AAGAGCTCAC CATTCAAGTT 3360

GAGAAGGCAA AGGAAATCAT GGGAGCATGA 3390

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++ +e++ rdf+re+eil++l+h+

Q: 846   LKFLQQLGKGNFGSVELCRYDPLQDNTGEVVAVKKLQHTTEEYLRDFEREIEILKSLQHD  905

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +iv +kgvc++ g++  rl+mey+++GsL++yL+k+k++l++++ll++++q++k+meYL

Q: 906   NIVRYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKDRLDFKKLLQYSSQICKGMEYLT  965

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

          k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 966   IKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1019

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t  +k++sp    +r+++++        +++el

Q: 1020  PESLTESK-FSVASDVWSFGVVLYELFTySEKSKSPpsefMRMIGNDkqgqmivfHLIEL  1078

         ********.*******************88889999****999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l++k rlp+p+ cp+e++ +m++c++++ sqrpsF+++

Q: 1079  LKNKGRLPQPEgCPDEIYRIMNECWNNSISQRPSFKELT  1117

         ***********************************9985

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVELCRY DPLQDNTGEV VAVKKLQHTT EEYLRDFERE IEILKSLQHD 60

NIVRYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKDRL DFKKLLQYSS QICKGMEYLT 120

IKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYSEKSKSPP SEFMRMIGND KQGQMIVFHL IELLKNKGRL 240

PQPEGCPDEI YRIMNECWNN SISQRPSFKE LT 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

xtr:100036599

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013