EPS-XET-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XET-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	179.9	8.7E-53	79	332	254

Status

Unreviewed

Ensembl Protein

ENSXETP00000002455

UniProt Accession

F6YNL0;

Protein Name

Protein Synonyms/Alias

Gene Name

ppm1e

Gene Synonyms/Alias

ppm1e;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000001119	ENSXETP00000002455	ENSXETT00000002455

Organism

Xenopus tropicalis

Functional Description

Protein Length

593

Protein Sequence
(FASTA)

NCPSFLAAAL ARATADEILQ SDLSVYYSPK HVDGTEGIIQ LEAIKLARGV FSKLHEICCS 60

WVKDFPLQRK PHMYYDISIH AIKNMRRKME DKHVCIPDFN ILFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNLVRQ EIFPQDPAEA LCRAFRITDE SFVQKAAREN LRCGTTGVVT 180

FIRGNMLHIA WLGDSQVMLV RRGQAVELMK PHKPDREDEK HRIEALGGCV VWFGAWRVNG 240

SLSVSRAIAG DAEHKPYICG DADSVSTVLD GSEDYLILAC DGFYDTVNPD EAVKVVSDHL 300

KENNGDSSMV AHKLVASARD AGSSDNITVI VVFLRDLNTT TATEQENKQT ENSFDGGQED 360

NGDDKENQGD CKGSWPLHQC SAPADLGGYD GRDSFTDRTS LSLGPEVKVL EEQDYLNPLQ 420

GGDGKPRSAK CLPCSQVTSA SSPKRASGRK ELLEGSSFYL EKGFREGVSS SQGLGCIDIL 480

MPRKEGSLCP SWDLKDKCLE AMMKAPFHLA PLHFRKRRGG TKAKPKFSQL RSSQKPCYKV 540

QNVPMQSVVK NRVSMHSSVR CRKGSHQDTL VNRALLRESN CIALADLHRS YKM 593

Nucleotide Sequence
(FASTA)

AATTGCCCGT CTTTCCTGGC TGCTGCATTG GCAAGGGCAA CAGCAGATGA AATCCTGCAA 60

AGCGACCTGT CCGTGTACTA CTCGCCAAAG CATGTGGATG GCACAGAGGG GATCATACAA 120

CTTGAGGCCA TAAAACTTGC CCGCGGAGTG TTTAGCAAAC TGCATGAAAT CTGCTGCAGC 180

TGGGTAAAAG ACTTCCCCCT GCAACGCAAA CCACACATGT ATTATGACAT CTCTATCCAC 240

GCAATCAAGA ACATGCGGAG AAAGATGGAG GACAAGCATG TCTGTATCCC AGACTTTAAT 300

ATCCTATTTA ATCTGGAGGA TCAAGAAGAG CAAGCTTACT TTGCTGTGTT TGATGGTCAT 360

GGAGGAGTAG ATGCTGCTAT TTATGCCTCT ATCCATCTAC ATGTGAACTT AGTACGACAA 420

GAAATATTCC CACAGGATCC AGCTGAAGCA CTCTGCAGAG CATTTCGTAT TACAGATGAG 480

AGCTTTGTGC AGAAAGCAGC TAGGGAGAAT CTTCGATGTG GAACAACAGG CGTGGTGACC 540

TTTATCCGAG GGAACATGCT ACATATTGCC TGGCTAGGAG ACTCACAGGT GATGTTAGTA 600

CGAAGAGGTC AAGCTGTGGA GCTAATGAAG CCACATAAAC CAGACAGAGA GGATGAAAAG 660

CATCGAATCG AGGCCCTGGG AGGCTGTGTT GTCTGGTTTG GGGCATGGAG GGTTAACGGA 720

AGCCTTTCTG TCTCCAGAGC CATTGCAGGG GATGCAGAGC ACAAGCCATA TATTTGTGGA 780

GATGCTGATT CTGTCTCCAC TGTCCTTGAT GGCTCTGAAG ATTACCTCAT TCTGGCATGT 840

GATGGATTCT ATGATACAGT CAACCCTGAT GAAGCTGTAA AAGTGGTGTC TGACCATCTG 900

AAAGAGAACA ACGGAGATAG TAGCATGGTT GCCCATAAGT TGGTGGCATC TGCTCGTGAT 960

GCTGGCTCAA GTGATAACAT CACCGTGATT GTGGTATTTC TCAGGGACCT GAACACGACA 1020

ACTGCAACTG AGCAAGAAAA TAAGCAAACT GAGAACTCTT TTGACGGTGG TCAAGAAGAC 1080

AATGGAGATG ATAAAGAGAA CCAAGGAGAT TGTAAAGGAT CGTGGCCTCT TCACCAGTGC 1140

TCAGCGCCGG CTGATCTTGG AGGCTATGAT GGGCGCGATT CCTTCACAGA CAGAACTAGC 1200

TTGAGTCTTG GCCCTGAAGT AAAAGTTCTA GAAGAGCAAG ACTATCTAAA CCCATTGCAG 1260

GGGGGTGATG GCAAACCGCG TAGTGCCAAA TGTTTACCAT GCTCCCAAGT GACCAGTGCT 1320

AGCTCACCAA AGAGAGCCAG TGGAAGGAAA GAGCTTTTAG AAGGGTCTTC ATTTTATTTA 1380

GAAAAAGGCT TTCGTGAAGG CGTTTCCAGC AGTCAAGGAT TGGGATGTAT TGATATTTTA 1440

ATGCCCAGAA AGGAGGGTTC ACTTTGTCCT TCTTGGGATT TAAAAGATAA ATGTTTGGAA 1500

GCCATGATGA AGGCCCCCTT TCATTTAGCT CCCTTACATT TCAGAAAGAG GAGAGGAGGG 1560

ACTAAGGCAA AACCAAAGTT TTCACAGCTT CGCTCTTCCC AAAAGCCTTG TTACAAAGTT 1620

CAAAATGTGC CCATGCAAAG TGTTGTTAAA AATAGGGTAT CAATGCATAG CTCTGTAAGA 1680

TGTAGGAAAG GTAGTCATCA AGATACTCTG GTGAATAGAG CATTGTTAAG AGAGAGCAAC 1740

TGTATAGCAC TGGCAGATCT ACATAGAAGC TATAAAATGT AA 1782

Domain Profile

S: 5     vvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheila  62

         + +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 79    IHAIKNMRRKMEDKHVCIPDFNILFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNLV  138

         67899**************99765554444449***********************9999

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvanv  122

         ++        ++  +al +aF  tde +  ++++  ++ ++G+t vv  i+++ l++a +

Q: 139   RQEI----FPQDPAEALCRAFRITDESF--VQKAARENLRCGTTGVVTFIRGNMLHIAWL  192

         9944....678888899***********..7777778888********************

S: 123   GdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRal.Gd  180

         GdS+++L r g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+ Gd

Q: 193   GDSQVMLVRRGQAVELMKPHKPDREDEKHRIEALGGCVV-WFGAwRVNGSLSVSRAIaGD  251

         ************************************999.55899***********999*

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + + +s+ l+ ++++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 252   AEHKPYICGDADSVSTVLDGSEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  311

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 312   HKLVASARDAGSSDNITVIVV  332

         *****************9997

Domain Sequence
(FASTA)

IHAIKNMRRK MEDKHVCIPD FNILFNLEDQ EEQAYFAVFD GHGGVDAAIY ASIHLHVNLV 60

RQEIFPQDPA EALCRAFRIT DESFVQKAAR ENLRCGTTGV VTFIRGNMLH IAWLGDSQVM 120

LVRRGQAVEL MKPHKPDRED EKHRIEALGG CVVWFGAWRV NGSLSVSRAI AGDAEHKPYI 180

CGDADSVSTV LDGSEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013