EKS-XET-00604

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00604

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	483.6	1.4E-145	9	270	262

Status

Reviewed

Ensembl Protein

ENSXETP00000013928

UniProt Accession

Q6P647;

Protein Name

Casein kinase I isoform delta

Protein Synonyms/Alias

CKI-delta; CKId;

Gene Name

csnk1d

Gene Synonyms/Alias

csnk1d; TEgg020f01.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000001288	ENSXETP00000013928	ENSXETT00000013928

Organism

Xenopus tropicalis

Functional Description

Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).

Protein Length

416

Protein Sequence
(FASTA)

MELRVGNRYR LGRKIGSGSF GDIYLEGTDI AAAEEVAIKL ECVKTKHPQL HIESKIYKMM 60

QGGVGIPTIK WCGAEGDYNV MVMELLGPSL EDLFNFCSRK FSLKTVLLLA DQMISRIEYI 120

HSKNFIHRDV KPDNFLMGLG KKGNLVYIID FGLAKKYRDA RTHQHIPYRE NKNLTGTARY 180

ASINTHLGIE QSRRDDLESL GYVLMYFNLG SLPWQGLKAA TKRQKYERIS EKKMSTPIEV 240

LCKGYPSEFA TYLNFCRSLR FDDKPDYSYL RQLFRNLFHR QGFSYDYVFD WNMLKFGANR 300

AAEDAERERR EREERLRHPR NPAARGLPST ASGRLRGTQE VTPSTPLTPT SHTANTSPRP 360

VSGMERERKV SMRLHRGAPV NVSSSDLTGR QETSRMSTSQ IPSRVASSGL PSTVHR 416

Nucleotide Sequence
(FASTA)

ATGGAGTTGA GAGTCGGAAA CAGGTATCGG TTGGGTCGAA AGATCGGCAG CGGCTCGTTC 60

GGTGACATAT ATTTGGAAGG CACTGATATT GCAGCGGCAG AAGAAGTTGC TATCAAACTA 120

GAATGTGTGA AAACCAAACA TCCTCAGCTT CATATTGAGA GCAAGATCTA TAAAATGATG 180

CAAGGAGGGG TGGGGATTCC AACAATAAAA TGGTGTGGCG CAGAAGGAGA TTACAACGTC 240

ATGGTCATGG AATTACTAGG ACCAAGTCTT GAAGACCTCT TTAATTTCTG CTCCAGGAAA 300

TTTAGTTTAA AAACTGTTCT TCTTCTTGCT GACCAGATGA TCAGCCGAAT TGAATACATT 360

CATTCCAAAA ACTTTATCCA TCGGGATGTG AAGCCTGACA ACTTTCTGAT GGGGCTTGGA 420

AAGAAAGGCA ACCTAGTGTA TATCATTGAT TTTGGGCTGG CCAAAAAATA CAGAGATGCT 480

CGCACACACC AGCATATACC ATATCGTGAA AACAAGAACT TAACTGGAAC AGCTCGCTAT 540

GCATCTATTA ACACCCACCT TGGAATAGAA CAATCACGGA GAGATGATTT AGAGTCTCTT 600

GGATATGTTC TTATGTACTT TAACCTTGGT TCCCTCCCAT GGCAAGGGTT AAAAGCTGCC 660

ACCAAAAGGC AAAAGTATGA ACGTATCAGT GAAAAGAAGA TGTCCACACC AATAGAAGTT 720

CTCTGTAAAG GCTATCCATC TGAGTTTGCT ACATACCTGA ATTTCTGTCG GTCCTTACGT 780

TTTGATGATA AGCCAGACTA TTCTTACTTA CGACAACTCT TCAGAAATCT CTTTCACAGA 840

CAGGGCTTCT CTTATGACTA CGTGTTTGAC TGGAACATGC TAAAATTCGG TGCAAATCGT 900

GCAGCTGAAG ATGCTGAACG TGAAAGGAGA GAAAGAGAAG AGAGACTTCG GCACCCACGG 960

AACCCTGCTG CAAGAGGCTT ACCCTCAACT GCTTCCGGCA GACTGCGAGG CACTCAGGAA 1020

GTAACGCCAT CCACTCCACT TACCCCAACT TCACACACTG CAAACACCTC TCCTCGACCC 1080

GTATCTGGAA TGGAACGTGA GAGAAAAGTC AGTATGAGAT TGCATCGGGG TGCTCCAGTT 1140

AATGTCTCTT CCTCTGATTT AACTGGCAGG CAAGAAACCT CACGCATGTC AACTTCTCAG 1200

ATACCAAGTC GAGTGGCTTC CAGTGGTCTT CCATCAACAG TACACCGATG A 1251

Domain Profile

S: 1     yrvvkkiGsGsfGdiyl.gknlasgeevaikleskkskapqlklesrvykilqggvgiPe  59

         yr+++kiGsGsfGdiyl g+++a+ eevaikle++k+k+pql++es++yk++qggvgiP+

Q: 9     YRLGRKIGSGSFGDIYLeGTDIAAAEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPT  68

         89*************95499****************************************

S: 60    vryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyr  119

         ++++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+r

Q: 69    IKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHR  128

         ************************************************************

S: 120   dikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlg  179

         d+kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg

Q: 129   DVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLG  188

         ************************************************************

S: 180   keqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPee  239

         +eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+e

Q: 189   IEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSE  248

         ************************************************************

S: 240   fatylkyvrklkfeekPdyeyl  261

         fatyl+++r+l+f++kPdy+yl

Q: 249   FATYLNFCRSLRFDDKPDYSYL  270

         ********************97

Domain Sequence
(FASTA)

YRLGRKIGSG SFGDIYLEGT DIAAAEEVAI KLECVKTKHP QLHIESKIYK MMQGGVGIPT 60

IKWCGAEGDY NVMVMELLGP SLEDLFNFCS RKFSLKTVLL LADQMISRIE YIHSKNFIHR 120

DVKPDNFLMG LGKKGNLVYI IDFGLAKKYR DARTHQHIPY RENKNLTGTA RYASINTHLG 180

IEQSRRDDLE SLGYVLMYFN LGSLPWQGLK AATKRQKYER ISEKKMSTPI EVLCKGYPSE 240

FATYLNFCRS LRFDDKPDYS YL 262

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

xtr:394689

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013