EKS-XET-00343

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00343

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	453.0	6.4E-136	190	518	329

Status

Unreviewed

Ensembl Protein

ENSXETP00000003569

UniProt Accession

F6T404;

Protein Name

Protein Synonyms/Alias

Gene Name

hipk1

Gene Synonyms/Alias

hipk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000001698	ENSXETP00000059258	ENSXETT00000063100
ENSXETG00000001698	ENSXETP00000003569	ENSXETT00000003569

Organism

Xenopus tropicalis

Functional Description

Protein Length

1172

Protein Sequence
(FASTA)

MASQLQVFSP SSVSSSAFCS AKKLKVEPSG WDVTGQGSSN KYYTHTKNLP VAQGHASSSH 60

QVAGFSLPAY EPNLLIPAAA AEHIVVTAAD STDSGPTTSF QNSQILTHRS NVPLLDPYQK 120

CGLKRKSEEV DSNGSVQIID ERPPLMLQNR TVVGAAATTT TVTTKSSSSN GEGDYQLVQH 180

EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240

LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300

TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360

PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420

KTSRFFNRDP DLGYPLWRLK APDEHEMETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480

MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHPFVTM THLLDFPHSN HVKSCFQNME 540

ICKRRSNMYD TVNQIKSPFT THVAPNTSTN LTMSFNNQLN SVHNQASVLA SSSTAAATLS 600

LANSDVSLLN YQSALYPPAA GPVTGVTQQS VSLQPGTTQL CTQTDPFQQT FIVCPPAFQA 660

AGLQATTKHS GFPVRMDNSV PIVPQAPAAQ PLQIQSGVLT QAWPGGTQQI LLPSTWQQLP 720

GVALHNSVQP TAMIPETIGN NQQLTDWRNA HSHGNQYSTL MQQPSLLANH VTLAAAQPLN 780

VGVAHVVRQQ QNSNTSTKKN KQQASQSSSK ALSSLDVIPS QVYSLVGSSP LQASSSYNPL 840

LPLQEQRQPI VIPDTPSPPV SVITIRSDTD EEEDSKYKPT NSGMKLRSNV ISYVTVNDSP 900

DSDSSVSSPY LADRHTSVNG VTGVFDMSNS RTAHSQSLNS RTIIVPPLKS QMNDCPLDTQ 960

LTGVLSGAAK ITKSCTATNG QSSSCITQTG CRSHRMLNGV QPLNLSQNQQ SAMMGTQERS 1020

MNPGSRRQQA YVAPLPSISQ APFTFQHSSP LHSTVHPHLA AAATATSHLT SQPHMYTYAP 1080

TTAASLGSTT SIAHLFSPQG SSRHTTFATH PSTLVHQVPV SVGPSLLTSA NVASAQYPHQ 1140

FAAQSYIGAS RGSAIYTGYP LSPTNINQYS YL 1172

Nucleotide Sequence
(FASTA)

ATGGCATCAC AGCTGCAGGT GTTCTCCCCT TCTTCAGTAT CGTCCAGTGC CTTTTGCAGT 60

GCAAAGAAAC TCAAAGTTGA GCCTTCTGGC TGGGATGTTA CGGGACAGGG TAGCAGCAAC 120

AAGTATTACA CACACACCAA AAACCTCCCA GTTGCTCAAG GACACGCAAG TTCATCTCAC 180

CAGGTAGCTG GTTTCAGTCT ACCTGCCTAC GAACCCAATC TCCTAATCCC TGCAGCAGCT 240

GCAGAGCACA TTGTGGTAAC AGCTGCAGAC AGCACAGACA GTGGGCCCAC CACTTCCTTC 300

CAGAACAGCC AAATCCTTAC CCACAGAAGC AACGTTCCTT TACTGGACCC TTACCAAAAA 360

TGTGGACTGA AAAGAAAAAG TGAGGAGGTA GACAGCAACG GTAGTGTACA GATCATTGAT 420

GAACGGCCAC CTCTGATGCT GCAAAACAGA ACTGTGGTGG GTGCTGCTGC CACGACCACC 480

ACTGTAACCA CTAAAAGTAG CAGTTCCAAT GGTGAAGGAG ACTATCAGCT TGTCCAACAT 540

GAAATTCTTT GTTCCATGAC AAACAGCTAT GAGGTTTTAG AATTTCTGGG AAGAGGTACG 600

TTTGGGCAGG TGGCAAAATG CTGGAAGCGG AGTACCAAGG AGATTGTAGC CATTAAGATC 660

TTAAAAAATC ACCCTTCCTA CGCCAGGCAA GGACAGATTG AAGTGAGCAT CCTGTCTCGC 720

TTGAGCAGTG AAAATGCTGA TGAGTACAAT TTTGTGCGTT CATATGAGTG CTTCCAGCAC 780

AAGAATCACA CTTGCCTTGT TTTTGAGATG CTGGAGCAGA ATCTTTATGA CTTTCTGAAG 840

CAGAACAAGT TCAGTCCGCT ACCACTGAAA TATATCCGAC CCATCCTTCA GCAGGTAGCC 900

ACTGCTTTAA TGAAGCTTAA GAGCTTGGGC CTAATTCATG CTGATTTGAA ACCTGAAAAC 960

ATTATGCTTG TGGACCCAGT GCGTCAACCA TACAGGGTGA AGGTTATAGA CTTTGGATCT 1020

GCAAGCCATG TATCTAAAGC AGTGTGTTCC ACTTACTTGC AGTCTCGTTA CTACAGAGCT 1080

CCTGAAATCA TACTTGGTTT ACCATTCTGT GAAGCGATTG ATATGTGGTC GTTGGGCTGT 1140

GTCATAGCAG AATTGTTTCT TGGATGGCCC CTGTACCCAG GAGCATCAGA ATATGATCAG 1200

ATTCGATACA TATCCCAGAC TCAGGGCCTT CCTGCTGAAT ACCTTCTGAG TGCGGGAACA 1260

AAGACCTCCA GATTTTTCAA CAGAGATCCA GACCTGGGCT ACCCTCTATG GAGGCTAAAG 1320

GCACCAGATG AACATGAAAT GGAAACAGGA ATAAAATCGA AAGAGGCGCG AAAGTATATC 1380

TTTAATTGCT TGGATGACAT GGCTCAGGTG AATATGTCTA CAGATTTAGA GGGCACAGAT 1440

ATGTTGGCAG AGAAAGCAGA TAGGAGGGAA TATATTGACT TGTTGAAGAA AATGTTAACC 1500

ATTGATGCTG ATAAAAGGAT AACTCCACTG AAAACATTAA ACCATCCATT TGTCACTATG 1560

ACACACCTAC TGGATTTCCC ACATAGCAAC CATGTGAAGT CTTGTTTTCA GAATATGGAG 1620

ATTTGTAAGA GAAGAAGTAA TATGTATGAT ACCGTGAATC AGATCAAGAG TCCATTTACC 1680

ACACATGTTG CTCCTAACAC AAGCACAAAC TTGACTATGA GCTTCAACAA CCAGCTTAAC 1740

AGTGTGCACA ATCAGGCTAG TGTTCTGGCT TCAAGCTCGA CGGCTGCAGC TACTCTTTCC 1800

CTTGCCAACT CTGATGTTTC GCTGCTTAAC TATCAGTCGG CATTGTACCC ACCAGCTGCT 1860

GGTCCAGTTA CAGGAGTTAC ACAGCAAAGT GTCTCTCTGC AGCCTGGAAC AACTCAGCTC 1920

TGCACTCAAA CTGATCCATT CCAGCAGACG TTCATTGTCT GCCCCCCAGC ATTTCAAGCT 1980

GCTGGACTTC AAGCAACAAC CAAGCATTCC GGGTTTCCAG TTCGAATGGA CAATAGTGTT 2040

CCCATTGTTC CACAAGCTCC AGCTGCTCAG CCCCTCCAGA TCCAATCTGG AGTTCTAACA 2100

CAGGCATGGC CTGGCGGAAC GCAGCAGATA TTGCTGCCAT CTACTTGGCA GCAGCTTCCT 2160

GGTGTAGCGC TCCACAATTC TGTTCAGCCA ACCGCCATGA TTCCAGAGAC TATTGGGAAT 2220

AACCAGCAGC TTACTGATTG GAGAAATGCA CATTCCCATG GGAACCAGTA TAGCACACTG 2280

ATGCAGCAAC CTTCTTTATT GGCCAACCAT GTGACTTTGG CAGCAGCCCA GCCTTTGAAT 2340

GTTGGAGTGG CTCATGTAGT TCGTCAGCAA CAGAATAGCA ACACATCAAC AAAGAAAAAC 2400

AAGCAACAGG CATCCCAAAG CAGTTCAAAG GCTCTCTCGT CCTTGGATGT TATTCCATCA 2460

CAAGTTTATT CACTGGTTGG AAGCAGCCCA CTTCAGGCGT CTTCGTCATA CAACCCACTT 2520

CTCCCACTCC AAGAACAACG TCAGCCTATT GTTATTCCAG ATACACCCAG CCCTCCAGTG 2580

AGTGTTATAA CCATCCGAAG CGATACCGAT GAAGAGGAAG ATAGCAAGTA TAAACCAACA 2640

AACTCTGGAA TGAAGCTGCG ATCCAATGTT ATCAGCTATG TCACAGTAAA TGACTCTCCT 2700

GATTCTGATT CGTCTGTGAG CAGCCCTTAC CTGGCAGATC GCCACACTTC AGTTAATGGA 2760

GTGACTGGGG TTTTTGATAT GTCAAATAGC CGAACAGCTC ACAGCCAGAG TTTGAACTCG 2820

CGTACAATCA TTGTCCCACC ACTGAAAAGT CAAATGAATG ACTGCCCATT GGATACCCAG 2880

CTAACAGGTG TTCTAAGCGG TGCTGCCAAG ATAACTAAAA GTTGTACTGC TACAAACGGA 2940

CAATCAAGCA GCTGCATCAC ACAAACGGGG TGTCGCTCAC ATCGCATGCT GAATGGAGTA 3000

CAGCCGCTCA ACCTCAGCCA GAACCAGCAG TCAGCCATGA TGGGAACCCA GGAGAGAAGC 3060

ATGAACCCAG GTTCTCGAAG ACAACAGGCT TATGTGGCTC CTCTCCCTTC AATATCTCAG 3120

GCACCATTCA CCTTCCAGCA CAGCAGCCCC TTACATTCCA CTGTGCACCC TCATCTTGCA 3180

GCAGCTGCAA CAGCCACCAG CCATCTGACA AGCCAGCCTC ACATGTACAC CTATGCCCCT 3240

ACCACTGCTG CATCTCTGGG GTCAACTACA TCAATAGCTC ATCTGTTCTC CCCTCAGGGT 3300

TCCTCAAGGC ATACAACGTT TGCTACTCAC CCTAGCACTC TGGTCCACCA AGTCCCTGTC 3360

AGTGTTGGGC CCAGCCTGCT GACCTCTGCC AACGTGGCTT CTGCACAATA CCCTCACCAA 3420

TTTGCGGCTC AGTCTTATAT TGGTGCCTCC AGGGGTTCTG CAATATACAC TGGATATCCT 3480

CTTAGTCCAA CCAACATCAA CCAGTACTCC TATCTATAG 3519

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+

Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 309   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff

Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFnr  428

         **********************************************************55

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

           + ++p ++lk           ks++++k+++n+ +++++++++++ e +++l+ek+d+

Q: 429   dPDLGYPLWRLKAPdehemetgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488

         5456778888877799*******************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + ++dllk+ml++d++kRitp ++l+hpfv

Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHPFV  518

         99***************************7

Domain Sequence
(FASTA)

YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60

NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTSRFFNRD 240

PDLGYPLWRL KAPDEHEMET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300

EYIDLLKKML TIDADKRITP LKTLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013