EKS-XET-00433

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00433

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	351.4	4.1E-105	608	1009	402

Status

Unreviewed

Ensembl Protein

ENSXETP00000058997

UniProt Accession

F7BH85;

Protein Name

Protein Synonyms/Alias

Gene Name

eif2ak4

Gene Synonyms/Alias

eif2ak4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000002204	ENSXETP00000014386	ENSXETT00000014386
ENSXETG00000002204	ENSXETP00000058997	ENSXETT00000066083
ENSXETG00000002204	ENSXETP00000004685	ENSXETT00000004685

Organism

Xenopus tropicalis

Functional Description

Protein Length

1661

Protein Sequence
(FASTA)

MAGGRGNALL PIELSPQGGL RPTPPACDPP ETYSHRQENE LEVLESIYSG DFADLRKNSA 60

WKVQQPPEVI IALRPQGNEV HVKVDLWVKC PQNYPDVPPE IKLKNIQGLS NENVNSLTSS 120

LEDLAKQLCG EVMIYQLADH VQCFLTEYNH PPPKSFHEEM LKNLQKQQEK LALEEERRMQ 180

EIKMKEEQTR REILNEIVAK QVSRIRDKEF LPTVLQKERI ENANLMCQEN VNKINNTGKT 240

TTAASDGSLP DHGGTNRNRP HSAGRSKRDR QYSVCLTDDS TPFEVLTFDI GCSGQIVVHR 300

GKCLGKDELL GKSVYNGLET ASGHFVVIYE WVLQWQKKMG KFLTNQEKEK IEKCKKQIQG 360

TETEFSSLIK LSHPNIVHYL AMRIKEKEDS ISVGIIAEHV NGTKLSSYLE QGVPVPLDQL 420

RHYTAQLLSA LDYLHSNSVV HKVMCASSVL VTADGKVKLT DYSLSKRLAD ICKEDVFEQT 480

KVRFSEDALP SKSGKKGDIW KLGLLLLSLS QGNIAKEYPV KVPSDLPADF QDFLQKCVCL 540

EDKERWTTQQ LLSHSFLNPP PEKSPVTEEC SDDYPGDCTE TVIPRSSVSN STFHIESQRQ 600

FSRYFNEFEE LQMLGKGAFG AVIKVQNKLD GCYYAVKRVQ INPASKQFRR IKGEVTLLSR 660

LNHENIVRYY NAWIEKHEHP TISPKCEAHE EKKVTVKPEQ IVKNDLGLLD DIEENAPAPI 720

LTSSVEWSTS CERSSSAHCT NGDQDSKEGV FSPSFLPGTD SDSEIIFENE DDISPDQDEE 780

YDKNNVEDRK AGANEIVTQA VHYLYIQMEY CEKSTLRDTI DQGLYMDVGR LWRLFREILD 840

GLTYIHEQGM IHRDLKPVNI FLDSEDHVKI GDFGLATDHP ASYTESAQGE EDQAHSDLVK 900

VDPEGKLTGM VGTALYVSPE VQGNTKASYN QKVDLYSLGI ILFEMSYRPM DTSSERISVL 960

SRLRQQALIV FPSDFENPEN EKQKKVITWL LNHDPASRPT AMELLKCDLL PPPQLEESEL 1020

HEVLHHTLAN IDGKAYRTMM SQIFAQRISP AMDYTYDSDI LKGIFSVRSA RLHHHVCEAV 1080

CRIFKRHGAV KLHAPLLMPR GKAGFDNSES ACFMDHSGML VTLPYNLRIS FARFVARNNI 1140

TSLKRYSIER VFRPRKLNRC HPKELTECAF DIITSAANCY LPIAETIYTI YEIIQEFPVL 1200

QERNYSIYVN HTSLLKAILL HCGVPEDKLT QVYNILYDAM IEKLTKREVE AKFCNLSLSE 1260

NSFQLSRLYR FIEQKGDLPD LEAMMVPLTK QKTGVGVLAK QGLKDLEGVI GLVKRLGIKL 1320

QIVVNFGLVY KMQQHSGIVF QFVAFIKRRQ RTVPEILAAG GRYDHLISQF RGPQTGAMGL 1380

PCAVGVSIAI DKISAALSTA EEHVMISSCD LLVVSAGQMS LNRAIGITQK LWAAGITAEI 1440

MYEWSESQDE LQDYCKCSGI SYAAIISDKE GNHIKLKTFE KERQSEKRIL ESDLVDLLVQ 1500

KLRIRVLEER NNSMAEGNSG GPFPRGASSS SKVVSAFHIN QDITIPSFCP PQSPKEVELH 1560

SLDPQVLTKL QTLITNFQQR NGEIEILAVD LPKETIQNLL ALEQCADEQV FNASVKMLMS 1620

RLPKQRYLKS VFDEIYTIKI EKRVPVLVLY SYKDDYYKIL F 1661

Nucleotide Sequence
(FASTA)

ATGGCAGGCG GCCGGGGAAA TGCACTTCTT CCTATTGAGC TCAGCCCGCA AGGGGGTCTG 60

CGCCCTACTC CGCCTGCCTG TGACCCCCCT GAAACTTATT CCCACCGGCA GGAGAATGAG 120

CTGGAGGTCC TGGAATCCAT CTATAGTGGG GATTTCGCGG ATCTGCGCAA GAACTCTGCC 180

TGGAAGGTAC AGCAGCCTCC AGAAGTCATC ATTGCCTTAC GTCCTCAGGG AAATGAGGTT 240

CATGTCAAGG TGGATTTATG GGTAAAATGC CCTCAGAACT ATCCTGATGT TCCTCCTGAA 300

ATAAAGCTGA AGAACATCCA GGGGTTGTCC AATGAAAATG TGAACTCTCT GACATCAAGC 360

TTGGAAGATT TAGCAAAACA GCTTTGTGGA GAGGTAATGA TATACCAGCT TGCGGATCAT 420

GTGCAGTGTT TTCTTACAGA GTATAACCAT CCACCTCCTA AATCCTTTCA TGAGGAGATG 480

TTAAAAAACC TTCAGAAGCA GCAGGAGAAG CTTGCTCTTG AAGAAGAGAG ACGAATGCAA 540

GAGATAAAGA TGAAAGAAGA GCAGACGAGA CGGGAAATCC TTAATGAAAT CGTAGCAAAA 600

CAGGTATCAA GGATACGCGA CAAGGAATTT TTACCCACTG TACTGCAAAA GGAACGGATT 660

GAAAACGCTA ATCTAATGTG CCAAGAGAAT GTAAATAAGA TTAATAATAC AGGCAAGACA 720

ACAACAGCTG CCTCGGATGG GTCACTTCCT GATCATGGAG GAACCAACAG AAATCGGCCA 780

CATTCAGCAG GACGCTCAAA GCGGGACCGA CAGTATTCGG TGTGCCTCAC TGATGACTCA 840

ACCCCATTTG AAGTGTTAAC CTTTGATATT GGATGCAGTG GGCAAATTGT TGTTCACAGA 900

GGAAAGTGCC TGGGGAAAGA TGAGCTGCTG GGTAAATCTG TTTACAATGG CTTGGAAACT 960

GCTTCAGGAC ATTTTGTTGT AATCTATGAA TGGGTTCTCC AGTGGCAGAA AAAGATGGGC 1020

AAGTTTCTTA CTAATCAAGA AAAAGAAAAG ATTGAAAAGT GTAAAAAACA GATTCAGGGA 1080

ACAGAAACCG AGTTCAGTTC TCTTATCAAA CTGAGCCATC CAAACATTGT GCACTACCTC 1140

GCTATGCGAA TAAAAGAGAA AGAAGATTCC ATTTCTGTCG GGATCATAGC TGAACATGTT 1200

AATGGTACAA AGCTTTCCAG TTACCTTGAG CAGGGTGTAC CTGTTCCACT GGATCAACTA 1260

CGGCACTATA CTGCCCAGCT GCTATCGGCA CTGGACTATT TGCATTCTAA TTCTGTGGTA 1320

CATAAAGTCA TGTGCGCCTC CAGTGTTTTG GTGACAGCTG ACGGGAAAGT AAAACTGACA 1380

GACTATAGCC TTTCCAAACG CCTTGCTGAC ATCTGCAAAG AGGACGTGTT TGAGCAAACA 1440

AAAGTTCGAT TCAGTGAGGA TGCTCTGCCT AGCAAGAGTG GCAAGAAAGG AGATATATGG 1500

AAGCTCGGTC TCTTGCTACT TTCGCTGTCA CAAGGCAACA TAGCCAAAGA GTATCCTGTA 1560

AAAGTGCCCA GTGACCTGCC TGCAGATTTC CAAGATTTCC TGCAAAAGTG TGTTTGCTTG 1620

GAAGACAAGG AACGCTGGAC TACACAGCAG TTACTAAGTC ACAGTTTCCT TAACCCTCCA 1680

CCTGAGAAGA GTCCTGTAAC AGAGGAATGC TCAGATGATT ATCCGGGTGA CTGTACTGAG 1740

ACTGTCATTC CCAGATCTTC AGTATCTAAT TCCACATTCC ATATTGAGTC ACAGAGACAG 1800

TTTTCTCGCT ACTTCAATGA GTTTGAAGAA TTACAGATGC TTGGGAAAGG GGCATTTGGT 1860

GCTGTCATTA AGGTTCAGAA CAAACTGGAT GGCTGCTATT ACGCTGTAAA ACGGGTACAA 1920

ATCAATCCTG CAAGTAAACA GTTCCGCAGA ATTAAGGGGG AGGTAACATT GTTATCTCGG 1980

CTCAACCATG AAAACATTGT AAGGTACTAT AATGCATGGA TTGAGAAACA CGAGCATCCT 2040

ACTATTTCTC CTAAATGTGA AGCACATGAG GAAAAGAAAG TGACTGTGAA GCCAGAACAA 2100

ATAGTAAAGA ATGATTTGGG ATTGTTGGAT GATATTGAGG AAAACGCACC AGCACCCATA 2160

TTAACCAGCT CTGTAGAATG GAGTACATCT TGCGAGCGAT CATCCAGTGC GCACTGTACT 2220

AATGGGGATC AAGATTCAAA AGAGGGAGTG TTTTCACCTT CGTTCCTGCC TGGGACAGAT 2280

TCTGACAGTG AGATCATATT TGAGAATGAA GATGACATTA GTCCAGATCA GGATGAAGAA 2340

TATGACAAGA ACAATGTAGA AGACCGCAAA GCTGGAGCCA ATGAGATTGT GACTCAGGCA 2400

GTGCATTATT TATATATTCA GATGGAATAT TGTGAGAAAA GCACCTTACG GGACACGATA 2460

GACCAAGGAC TGTATATGGA TGTTGGCCGC CTCTGGAGGC TGTTTCGTGA AATTTTGGAT 2520

GGATTGACCT ATATACATGA GCAGGGAATG ATCCACAGAG ACCTAAAGCC AGTCAATATC 2580

TTTTTAGATT CAGAAGATCA TGTCAAAATA GGAGATTTTG GACTAGCTAC AGATCACCCA 2640

GCATCTTATA CTGAATCAGC ACAAGGGGAA GAGGATCAGG CGCATTCTGA CTTGGTTAAA 2700

GTCGACCCTG AAGGAAAACT CACTGGCATG GTTGGCACTG CCTTGTATGT AAGCCCTGAA 2760

GTCCAAGGAA ACACCAAAGC TTCATATAAC CAGAAAGTGG ACCTTTACAG CCTGGGTATA 2820

ATATTGTTTG AGATGTCCTA CCGGCCCATG GACACAAGTT CTGAACGTAT CTCTGTCTTA 2880

AGCAGGCTTA GACAGCAGGC CTTGATTGTG TTCCCAAGTG ATTTTGAAAA CCCAGAAAAT 2940

GAAAAACAGA AAAAAGTGAT TACTTGGCTC CTGAACCATG ACCCAGCATC CCGCCCCACC 3000

GCTATGGAGT TGCTTAAGTG CGATCTCTTA CCCCCACCAC AACTAGAGGA GTCTGAACTC 3060

CATGAAGTCC TGCACCACAC CTTGGCCAAT ATCGATGGGA AAGCGTACCG CACAATGATG 3120

AGTCAAATCT TTGCCCAGCG CATTTCACCT GCTATGGATT ATACATATGA CAGTGATATA 3180

TTGAAGGGTA TTTTCTCAGT CCGTTCTGCC AGACTACATC ATCATGTTTG TGAGGCAGTC 3240

TGCAGGATAT TTAAAAGACA CGGGGCTGTG AAGTTACATG CCCCACTGCT GATGCCACGA 3300

GGTAAAGCTG GGTTTGATAA CAGTGAATCT GCATGTTTTA TGGATCACAG TGGCATGCTG 3360

GTCACCCTTC CTTATAACCT CAGGATATCA TTTGCGCGGT TTGTTGCAAG GAATAATATA 3420

ACTAGTTTGA AAAGGTATAG CATTGAGAGA GTGTTTAGAC CACGCAAACT GAACCGCTGC 3480

CATCCAAAGG AACTCACTGA GTGTGCATTT GATATAATCA CTTCTGCTGC AAACTGTTAC 3540

CTGCCCATTG CAGAAACAAT ATACACCATA TATGAAATTA TCCAGGAATT TCCAGTACTG 3600

CAGGAAAGGA ATTACAGTAT TTATGTGAAC CACACCTCGT TGTTGAAAGC CATTCTCCTT 3660

CACTGTGGCG TGCCCGAGGA TAAACTCACT CAGGTGTATA ACATTCTGTA TGATGCAATG 3720

ATTGAGAAGC TGACAAAAAG AGAAGTGGAA GCCAAATTTT GTAATCTCTC CCTTTCAGAG 3780

AACAGTTTCC AATTGAGTCG CCTTTACCGG TTTATTGAGC AGAAAGGAGA CCTCCCAGAT 3840

TTGGAGGCAA TGATGGTCCC ACTCACAAAG CAAAAAACAG GGGTCGGTGT GCTGGCAAAG 3900

CAAGGTTTGA AAGACTTGGA AGGAGTCATT GGATTAGTGA AGAGGCTGGG CATTAAATTA 3960

CAGATTGTGG TTAACTTTGG ACTTGTCTAC AAGATGCAGC AGCACAGTGG CATAGTCTTC 4020

CAGTTTGTGG CTTTTATCAA GCGGAGACAG AGGACTGTGC CTGAAATACT TGCAGCTGGA 4080

GGCAGATATG ACCATTTGAT TTCCCAGTTT AGGGGACCTC AGACTGGAGC TATGGGATTA 4140

CCCTGTGCTG TAGGCGTTAG TATAGCAATA GACAAGATAT CTGCTGCGCT TTCCACTGCA 4200

GAGGAACATG TCATGATCAG CAGCTGTGAT TTATTAGTCG TAAGCGCTGG GCAGATGTCT 4260

CTGAATAGAG CCATTGGGAT AACACAGAAG CTGTGGGCTG CTGGCATTAC TGCAGAGATC 4320

ATGTATGAGT GGTCTGAGTC TCAGGATGAA CTGCAGGATT ATTGCAAGTG TTCGGGGATT 4380

TCGTATGCTG CAATTATTTC TGACAAAGAA GGAAATCACA TTAAGCTGAA AACATTTGAG 4440

AAGGAAAGAC AGAGTGAGAA GAGAATATTG GAATCTGATC TAGTGGATCT CCTGGTGCAG 4500

AAACTTCGGA TCAGAGTCCT TGAAGAAAGA AATAACAGTA TGGCAGAGGG CAATTCAGGG 4560

GGCCCCTTTC CCAGGGGGGC TTCCAGCTCC TCCAAGGTAG TCTCGGCCTT CCACATCAAC 4620

CAAGACATAA CCATTCCATC ATTCTGTCCT CCGCAATCTC CCAAGGAGGT GGAACTACAC 4680

TCACTCGACC CACAGGTGCT AACAAAGCTT CAGACACTCA TTACAAACTT CCAGCAGAGA 4740

AATGGTGAAA TTGAAATTTT AGCAGTTGAT CTGCCAAAAG AAACAATACA GAACTTGTTA 4800

GCTTTAGAGC AGTGCGCAGA TGAACAAGTC TTCAATGCAT CAGTGAAAAT GCTAATGTCT 4860

CGGCTGCCAA AACAGAGATA CCTGAAATCA GTGTTTGATG AAATATACAC CATTAAAATC 4920

GAAAAGCGGG TTCCTGTGCT GGTACTATAC AGTTATAAAG ATGATTATTA CAAGATCCTT 4980

TTTTAG 4986

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kr+++n a+k++++++ ev++L++l+h+niv

Q: 608   FEELQMLGKGAFGAVIKVQNKLDGCYYAVKRVQINPASKQFRRIKGEVTLLSRLNHENIV  667

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e++

Q: 668   RYYNAWIEKHEHPTispkceaheekkvtvkpeqivkndlgllddieenapapiltssvew  727

         ***********9997888888888888888888888877666666666666655555555

S: 75    ...............................tdsseveaeaeleesesseesdtk.....  98

                                        t                      +

Q: 728   stscersssahctngdqdskegvfspsflpgT----------------------Dsdsei  765

         55555555555555555555555555555551......................055555

S: 99    .....................................llyiqmelceketLkdwiderkl  121

                                              +lyiqme+cek+tL+d+id+  l

Q: 766   ifeneddispdqdeeydknnvedrkaganeivtqavhYLYIQMEYCEKSTLRDTIDQG-L  824

         5555555555555555555788888899999999999*********************.9

S: 122   lesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaeal  181

         + +  +l+ rlf+++l+gl y+H++g+iHrdLkp+niFlds+d+vKigDFgLat+   +

Q: 825   YMDVGRLW-RLFREILDGLTYIHEQGMIHRDLKPVNIFLDSEDHVKIGDFGLATDHPASY  883

         ********.**********************************************88887

S: 182   kedvkqdaqske.........akhtgqvgtklymsPeql..eksqYnkkvDifsLGlilf  230

         +e+++ ++++++         +k tg+vgt+ly+sPe++  +k++Yn+kvD++sLG+ilf

Q: 884   TESAQGEEDQAHsdlvkvdpeGKLTGMVGTALYVSPEVQgnTKASYNQKVDLYSLGIILF  943

         7766665555556787777766*****************999******************

S: 231   eLly.pfstemervetltelrd...gkipedfdd.kvpkekkllqkllsrdpkeRpsase  285

         e++y p++t++er+++l  lr+   + +p+df++ + +k+kk++ +ll++dp+ Rp+a+e

Q: 944   EMSYrPMDTSSERISVLSRLRQqalIVFPSDFENpENEKQKKVITWLLNHDPASRPTAME  1003

         **********************99999*******9*************************

S: 286   llksel  291

         llk +l

Q: 1004  LLKCDL  1009

         **9766

Domain Sequence
(FASTA)

FEELQMLGKG AFGAVIKVQN KLDGCYYAVK RVQINPASKQ FRRIKGEVTL LSRLNHENIV 60

RYYNAWIEKH EHPTISPKCE AHEEKKVTVK PEQIVKNDLG LLDDIEENAP APILTSSVEW 120

STSCERSSSA HCTNGDQDSK EGVFSPSFLP GTDSDSEIIF ENEDDISPDQ DEEYDKNNVE 180

DRKAGANEIV TQAVHYLYIQ MEYCEKSTLR DTIDQGLYMD VGRLWRLFRE ILDGLTYIHE 240

QGMIHRDLKP VNIFLDSEDH VKIGDFGLAT DHPASYTESA QGEEDQAHSD LVKVDPEGKL 300

TGMVGTALYV SPEVQGNTKA SYNQKVDLYS LGIILFEMSY RPMDTSSERI SVLSRLRQQA 360

LIVFPSDFEN PENEKQKKVI TWLLNHDPAS RPTAMELLKC DL 402

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0006446	; P:regulation of translational initiation

KEGG

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013