EKS-XET-00608

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00608

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	476.9	2.1E-143	26	309	284

Status

Unreviewed

Ensembl Protein

ENSXETP00000004983

UniProt Accession

F7ETN4;

Protein Name

Protein Synonyms/Alias

Gene Name

pik3r4

Gene Synonyms/Alias

pik3r4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000002330	ENSXETP00000004982	ENSXETT00000004982
ENSXETG00000002330	ENSXETP00000004983	ENSXETT00000004983

Organism

Xenopus tropicalis

Functional Description

Protein Length

1025

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVDSYF SDIHEFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

SLPLTNYKQE LEELKIRLCS SQNCLPFQKF TLNEKAALLF RQFVRDNLYD RISTRPFLNN 120

IEKRWIAFQI LTAVDQAHKS GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TYLPEDNPAD 180

FNYFFDTSRR RTCYIAPERF VDGSTFSTEL ESIKDPSTPL VDLTNNNQRT RGDLKRAMDI 240

FSAGCVIAEL FTEGVPLFDL SQLLAYKKGQ FSPDQVMGKI EDSSIRQLVI QMICREPEKR 300

LAAEDYLKQQ RGNAFPEIFY TFLQPYMAQF AKETFHSADE RILVIRKDLD NIIHNLCGDD 360

QSEKVEGEIK ENGLLILVSV ITSCLQTLKY CDSKLAALEL ILHLAPRINV EILLDRITPY 420

LLHFCNDSVP RVKAEAVRTL TKVLALVKEV PRNDINIYPE YILPGIAHLA QDEATIVRLA 480

YAENIALLAE TALRFLELVQ LKNLNMENDP SSEELDEVSH PSESYDTELQ ALHEMVQQKV 540

VTLLSDPENI VKQTLMENGI TRLCVFFGRQ KANDVLLSHM ITFLNDKNDW HLRGAFFDSI 600

VGVAAYVGWQ SSSILKPLLQ QGLSDVEEFV IFKALNALTC MCQLGLLQKP HIYEFACDIA 660

PFLCHPNLWI RYGAVGFITT VAQQLNIADV YCKLMPYLHP FITQPIIQID KEIVLLSVLK 720

EPVSRSIFDY ALRSKDIASL FRHLHMRQKK RNGSLPECPP PEDPAITQLL KKLLSQGMTE 780

DEEDKLLALK DYMLKSNKAK ANVADQSHIH ESSLKGVIDL SALGLSGRQA DLIKTKQDTD 840

DKRARKHVKQ EYNVNEEWKS MFGAMEPVNV NQTVVRTAAD QEATKPVRSE SAAAVCAPLS 900

SSPQTSEGTG MQPRRPTMQI YTSISLPSTF QIRMTTCKSE LQQLIQQKRE QCNAERIAKH 960

MMESAEWESK PPPTGWHPKG LLVAHLHEHK GPVNRIRVSD EHSIFATCSN DGTVKIWNSQ 1020

KMEGK 1025

Nucleotide Sequence
(FASTA)

ATGGGAAACC AGTTAGCAGG AATTGCTCCA TCACAGATCC TGTCTGTAGA CAGTTATTTT 60

TCAGATATTC ATGAGTTTGA ATATGACAAG AGCCTGGGAA GTACTCGATT TTTTAAAGTT 120

GCACGAGCCA AACACAGGGA AGGTCTGGTA GTAGTTAAGG TATTTGCCAT TCAAGACCCA 180

TCATTGCCAC TCACAAACTA TAAGCAGGAA CTAGAGGAAC TGAAGATTCG TCTGTGTTCT 240

TCCCAGAATT GCCTTCCCTT TCAGAAGTTT ACCTTAAATG AAAAAGCAGC CTTATTATTC 300

AGGCAGTTTG TTAGGGACAA CCTCTATGAC AGGATCAGTA CCCGTCCTTT CCTGAACAAC 360

ATTGAGAAGC GCTGGATTGC CTTTCAGATA CTAACTGCTG TGGATCAGGC ACACAAGTCT 420

GGCGTACGCC ATGGAGATAT TAAGACAGAA AATGTCATGG TGACAAGTTG GAACTGGGTC 480

CTTCTTACAG ACTTTGCAAG TTTCAAACCC ACATACCTTC CAGAAGACAA CCCAGCAGAT 540

TTCAATTATT TCTTTGACAC TTCTCGTAGG AGAACCTGTT ACATTGCCCC GGAGAGGTTT 600

GTGGATGGAA GCACATTTTC AACAGAACTT GAGTCCATCA AGGACCCATC TACTCCACTG 660

GTTGACTTGA CTAATAACAA CCAACGAACA AGAGGGGATC TTAAGCGTGC AATGGACATC 720

TTTTCTGCAG GATGTGTAAT AGCAGAACTG TTTACAGAAG GAGTGCCATT ATTCGACTTG 780

TCCCAGCTCT TAGCATACAA AAAAGGACAA TTTTCACCAG ATCAAGTGAT GGGTAAAATT 840

GAAGATAGCT CAATAAGACA ACTGGTTATT CAGATGATAT GTCGTGAACC AGAGAAACGG 900

CTGGCAGCAG AAGACTACTT AAAACAACAG CGGGGAAATG CATTCCCTGA AATATTTTAC 960

ACCTTTTTGC AGCCATATAT GGCACAGTTT GCTAAAGAAA CATTTCACTC TGCTGATGAA 1020

CGTATTCTTG TTATCCGCAA GGATTTAGAC AACATCATTC ATAATTTATG TGGAGATGAT 1080

CAGAGTGAAA AAGTAGAAGG TGAAATTAAG GAGAATGGGC TGCTTATTCT TGTTTCTGTG 1140

ATAACGTCCT GTTTGCAAAC CTTGAAGTAC TGCGACTCGA AACTTGCTGC ATTGGAGCTT 1200

ATACTTCACC TAGCTCCACG TATAAATGTT GAAATTTTAT TGGATCGAAT CACCCCATAC 1260

TTGCTTCATT TCTGCAATGA TTCTGTTCCC AGAGTTAAGG CTGAAGCTGT AAGGACCCTG 1320

ACTAAGGTTC TTGCTCTTGT CAAGGAGGTA CCTCGGAATG ACATCAACAT TTACCCAGAG 1380

TACATTTTAC CTGGTATTGC ACATTTAGCT CAAGACGAAG CCACAATAGT AAGACTGGCT 1440

TATGCAGAGA ACATAGCGTT GCTGGCAGAA ACTGCTCTGA GGTTTCTGGA GTTGGTGCAG 1500

CTAAAAAACT TAAACATGGA AAATGATCCT AGCAGTGAAG AACTGGATGA GGTGTCACAT 1560

CCTAGTGAGA GCTATGACAC AGAGTTGCAG GCCTTGCATG AGATGGTCCA ACAAAAAGTT 1620

GTAACACTTC TAAGTGACCC TGAAAACATT GTGAAGCAAA CCTTAATGGA GAACGGGATA 1680

ACGAGACTGT GTGTTTTCTT TGGTCGGCAA AAAGCCAATG ATGTGCTTCT CTCCCACATG 1740

ATCACATTCT TGAATGACAA GAATGATTGG CATCTCCGTG GGGCTTTTTT TGACAGCATT 1800

GTTGGTGTTG CAGCATATGT TGGGTGGCAA AGCTCTTCCA TCCTAAAACC CCTTCTCCAG 1860

CAGGGCCTCA GTGATGTGGA AGAATTTGTA ATCTTTAAAG CTCTCAATGC CCTTACTTGC 1920

ATGTGTCAAC TCGGTCTTCT ACAGAAACCA CACATCTATG AATTTGCTTG TGACATTGCA 1980

CCTTTTCTGT GCCACCCAAA CCTGTGGATA CGTTATGGAG CTGTGGGATT TATTACTACT 2040

GTAGCTCAGC AGCTAAATAT TGCAGATGTA TATTGTAAGC TTATGCCTTA CCTTCATCCC 2100

TTTATTACCC AGCCAATCAT ACAGATTGAT AAGGAAATTG TCCTTCTCAG TGTCTTAAAA 2160

GAACCAGTCA GCCGCTCCAT ATTTGACTAT GCCCTAAGAT CCAAAGATAT TGCAAGCCTC 2220

TTCAGACATC TTCATATGCG TCAGAAGAAA AGGAATGGCT CTCTCCCAGA ATGCCCTCCC 2280

CCTGAAGATC CAGCAATAAC TCAGCTCTTA AAGAAACTTT TGTCACAGGG CATGACAGAA 2340

GATGAAGAAG ATAAACTTTT AGCATTAAAA GATTACATGC TGAAGTCTAA CAAAGCCAAA 2400

GCTAATGTAG CCGATCAGAG TCATATACAT GAAAGTTCCC TGAAAGGCGT GATTGATTTG 2460

TCTGCTTTGG GCCTTTCTGG AAGGCAGGCA GATCTTATTA AAACAAAGCA GGATACAGAT 2520

GATAAACGTG CAAGAAAGCA TGTCAAGCAG GAATATAATG TGAATGAAGA GTGGAAAAGC 2580

ATGTTTGGGG CAATGGAGCC TGTAAATGTT AACCAAACAG TAGTGAGAAC AGCTGCTGAC 2640

CAAGAGGCCA CAAAACCTGT TCGCTCTGAG TCTGCAGCTG CTGTATGTGC TCCTCTCTCA 2700

TCTTCACCTC AGACATCTGA AGGGACAGGG ATGCAGCCAA GAAGGCCCAC CATGCAAATA 2760

TATACCAGCA TTTCCCTCCC TTCAACCTTC CAGATTCGCA TGACCACATG CAAGAGTGAG 2820

CTTCAACAGC TTATACAGCA GAAAAGGGAA CAGTGCAATG CAGAAAGAAT AGCTAAACAT 2880

ATGATGGAGA GTGCAGAATG GGAGAGCAAA CCACCACCAA CAGGATGGCA CCCAAAAGGC 2940

CTTCTGGTGG CACATCTGCA TGAACACAAG GGTCCAGTAA ATCGTATACG AGTCTCTGAT 3000

GAACATTCCA TTTTTGCTAC TTGCTCAAAT GATGGGACAG TAAAAATATG GAACAGTCAA 3060

AAAATGGAAG GAAAA 3075

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdp+l+l+++kq+leelk++l ++qncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPSLPLTNYKQELEELKIRLCSSQNCL  85

         68**********************************************************

S: 61    pfqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhG  120

         pfqk +++ekaa+l+rq+v+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+hG

Q: 86    PFQKFTLNEKAALLFRQFVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHG  145

         ************************************************************

S: 121   diktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsala  180

         diktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++ +

Q: 146   DIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGST  205

         ************************************************************

S: 181   sdekl...rdgstelvdl.dsiqrlrgelkkamdifsaGcvilelftegrplfelsqlla  236

         + ++l   +d+st+lvdl +++qr+rg+lk+amdifsaGcvi+elfteg+plf+lsqlla

Q: 206   FSTELesiKDPSTPLVDLtNNNQRTRGDLKRAMDIFSAGCVIAELFTEGVPLFDLSQLLA  265

         **9998889*******963789**************************************

S: 237   yrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         y++g+f +++v+ kied+++r+lv+q+i +epekr+ aed+lk+

Q: 266   YKKGQFSPDQVMGKIEDSSIRQLVIQMICREPEKRLAAEDYLKQ  309

         ******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPSLPLT NYKQELEELK IRLCSSQNCL 60

PFQKFTLNEK AALLFRQFVR DNLYDRISTR PFLNNIEKRW IAFQILTAVD QAHKSGVRHG 120

DIKTENVMVT SWNWVLLTDF ASFKPTYLPE DNPADFNYFF DTSRRRTCYI APERFVDGST 180

FSTELESIKD PSTPLVDLTN NNQRTRGDLK RAMDIFSAGC VIAELFTEGV PLFDLSQLLA 240

YKKGQFSPDQ VMGKIEDSSI RQLVIQMICR EPEKRLAAED YLKQ 284

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 2.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 1.

Prints

Created Date

20-Feb-2013