EKS-XET-00135
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00135
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.12.4E-167488764277
StatusUnreviewed
Ensembl ProteinENSXETP00000005103
UniProt AccessionF6V1T7;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene Namefgfr3
Gene Synonyms/Alias fgfr3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000002396ENSXETP00000005103ENSXETT00000005103
OrganismXenopus tropicalis
Functional Description
Protein Length828
Protein Sequence
(FASTA)
MSKAGGGCGI ALYQGIHMGM VTLFCTLCLF LVAVNCVPAA RLPVTLPGED RASRKASDYI 60
TVEQPPFDEL MFTIGETIEL SCAAEDASTT TKWFKDGIAI VPNNRTNTRQ GLLKIINISY 120
DDSGIYSCRL WHSTEILRNF TIRVTDLPSS GDDEDDDDEE TEDREPPRWT QPEKMDKKLT 180
AVPAANTIRF RCPAAGNPTP TIHWLKNGKE FRGEHRIGGI KLRHQQWSLV MESVVPSDKG 240
NYTCVVENKY GSIRQTYQLD VLERSSHRPI LQAGLPANQT VVIGSDVEFH CKVYSDAQPH 300
IQWLKHVEVN GSKYGPDGDP YVTVLQPTGV YSSDKDLEVL VLRNVSFEDA GEYTCLAGNS 360
IGYSHHTAWL TVLPAEPVEK PTTTSSSSTT VLIVVSVITG FILLVIIFVT YRVKVPSKKA 420
MSAPPVHKVS KFPLKRQQVS LESNSSMNSN TPLVRITHLS SSDGTMLANV SELGLPLDPK 480
WELLRTRLTL GKPLGEGCFG QVVMAEAIGI EKERPNKPVT VAVKMLKDDA TDKDLSDLVS 540
EMEMMKMIGK HKNIINLLGA CTQDGPLYVL VEYASKGNLR EYLKARRPPG MDYSFDTCKI 600
PAEQLTFKDL VSCAYQVARG MEYLASQKCI HRDLAARNVL VTDDNVMKIA DFGLARDIHN 660
IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSYGVLL WETFTLGGSP YPGIPVEELF 720
KLLKEGHRMD KPANCTHELY MIMRECWHAV PSQRPTFKQL VEDLDRVLTV TSTDEYLDLS 780
VPFEQYSPAC QDSHSTCSSG DDSVFAHDIL PDEPCLPKHQ QYNGAIRT 828
Nucleotide Sequence
(FASTA)
ATGTCTAAGG CTGGAGGGGG CTGCGGAATT GCCCTTTATC AAGGGATCCA TATGGGAATG 60
GTCACCCTGT TCTGCACTCT CTGCTTGTTT CTGGTCGCTG TGAACTGTGT CCCGGCCGCC 120
CGGCTGCCAG TTACGCTCCC TGGGGAGGAC AGAGCGAGCA GAAAAGCATC AGATTATATC 180
ACGGTGGAAC AGCCCCCATT CGATGAGCTC ATGTTTACAA TTGGAGAAAC CATTGAGTTG 240
TCCTGTGCAG CGGAAGATGC TTCCACGACT ACCAAATGGT TTAAGGATGG TATCGCCATT 300
GTTCCAAACA ACAGAACAAA CACAAGGCAG GGCCTATTAA AGATTATCAA CATCTCCTAC 360
GATGACTCTG GGATATACAG CTGCAGACTT TGGCATTCTA CTGAGATTCT GCGCAATTTC 420
ACCATCAGAG TAACAGACTT GCCATCATCT GGTGACGACG AGGATGATGA TGATGAGGAA 480
ACCGAAGACA GAGAACCTCC TCGCTGGACC CAGCCTGAGA AGATGGATAA GAAACTAACT 540
GCAGTCCCTG CTGCTAACAC GATCCGCTTC CGGTGCCCAG CCGCAGGGAA TCCCACCCCT 600
ACCATCCACT GGCTCAAGAA CGGAAAGGAG TTCCGGGGGG AGCATCGTAT TGGTGGCATC 660
AAACTCCGAC ATCAGCAGTG GAGCCTTGTT ATGGAGAGCG TGGTCCCATC GGATAAAGGC 720
AACTACACGT GTGTGGTGGA GAACAAGTAT GGAAGCATCC GTCAAACCTA TCAACTTGAC 780
GTCCTGGAGC GGTCCTCTCA TCGGCCTATC CTTCAGGCCG GGTTACCTGC TAACCAAACA 840
GTTGTGATTG GGAGCGACGT AGAATTCCAC TGCAAAGTGT ACAGTGATGC CCAGCCTCAT 900
ATTCAGTGGC TGAAACACGT GGAAGTAAAT GGCAGCAAGT ACGGCCCAGA CGGAGATCCT 960
TACGTCACCG TGCTGCAACC TACTGGTGTT TACTCTTCGG ATAAGGATCT TGAGGTGCTG 1020
GTTTTACGCA ATGTGTCCTT TGAGGATGCT GGGGAATATA CTTGTCTGGC TGGGAATTCT 1080
ATTGGCTATT CACATCACAC TGCTTGGCTG ACGGTTCTCC CAGCAGAACC TGTGGAGAAG 1140
CCAACAACAA CTTCTTCAAG CTCCACGACC GTCCTTATCG TGGTTTCGGT CATCACTGGG 1200
TTCATACTGT TGGTTATCAT CTTCGTCACC TACCGCGTAA AGGTCCCTTC GAAAAAGGCA 1260
ATGAGTGCCC CGCCGGTGCA TAAAGTCTCC AAGTTTCCCC TTAAACGGCA GCAGGTGTCT 1320
CTAGAGTCCA ACTCTTCCAT GAATTCCAAC ACCCCGTTGG TGAGGATCAC TCATCTGTCC 1380
TCCAGCGACG GAACCATGCT GGCTAATGTG TCGGAACTGG GCCTACCGCT GGATCCTAAG 1440
TGGGAGCTGT TGCGAACACG GCTGACTTTA GGAAAGCCCC TCGGGGAAGG CTGCTTCGGT 1500
CAGGTGGTGA TGGCAGAAGC AATCGGCATT GAAAAGGAAC GGCCAAATAA GCCTGTAACT 1560
GTAGCTGTAA AGATGCTTAA AGATGATGCC ACAGATAAAG ATCTCTCAGA TCTGGTCTCA 1620
GAGATGGAGA TGATGAAAAT GATCGGAAAG CACAAAAATA TCATCAATCT GCTAGGAGCC 1680
TGCACTCAGG ATGGACCGCT GTACGTTCTG GTGGAATACG CATCCAAAGG GAACCTCAGG 1740
GAGTATTTAA AGGCACGGCG CCCCCCAGGA ATGGATTATT CTTTTGACAC CTGCAAAATT 1800
CCAGCTGAGC AGTTGACTTT CAAGGACCTA GTTTCTTGCG CCTACCAGGT AGCCCGTGGC 1860
ATGGAGTACC TGGCATCACA AAAATGCATT CACAGAGATC TGGCAGCCAG AAATGTGTTA 1920
GTAACAGATG ACAACGTAAT GAAGATTGCT GATTTCGGCT TGGCCAGGGA CATCCACAAC 1980
ATAGATTATT ACAAGAAAAC AACAAATGGT CGGCTGCCTG TGAAATGGAT GGCTCCGGAA 2040
GCTTTGTTTG ACCGTATCTA CACTCATCAA AGTGATGTAT GGTCGTACGG AGTGCTGCTG 2100
TGGGAGACAT TTACGCTGGG GGGCTCGCCC TACCCAGGGA TCCCAGTAGA GGAACTCTTT 2160
AAGCTATTGA AAGAAGGCCA CCGAATGGAC AAGCCAGCAA ACTGCACACA TGAACTGTAT 2220
ATGATCATGA GAGAGTGCTG GCACGCTGTC CCGTCGCAAA GACCAACCTT CAAGCAACTG 2280
GTTGAAGACC TTGACCGCGT TCTTACTGTA ACATCTACTG ATGAGTACCT GGACCTGTCG 2340
GTACCATTCG AGCAGTACTC CCCGGCGTGC CAGGACAGTC ACAGCACCTG CTCCTCGGGG 2400
GACGACTCGG TCTTTGCTCA TGACATTTTG CCAGATGAAC CGTGTCTTCC CAAGCACCAG 2460
CAGTACAACG GCGCCATCCG GACATGA 2487
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig++k++++k vtvavkmlk+datdkdl+dlvseme++k+
Q: 488   LTLGKPLGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  547
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlre+l+arrp+g+++s d++k+++eqlt+
Q: 548   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARRPPGMDYSFDTCKIPAEQLTF  607
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvt+dnv+kiadfGlard+h+idyykkt
Q: 608   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNIDYYKKT  667
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvws+Gvllwe +tlGgspypgi+veelfkllkeGh
Q: 668   TNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGH  727
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mrecwha++s+rptfkqlvedl
Q: 728   RMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDL  764
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIEKERPNK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLKARR PPGMDYSFDT CKIPAEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTDDNVM KIADFGLARD IHNIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSYG VLLWETFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH ELYMIMRECW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAF-00155
EKS-CAP-00149
EKS-DRM-00072
EKS-EQC-00146
EKS-GAG-00124
EKS-GAA-00177
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00080
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XIM-00175
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013