EKS-XET-00502

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00502

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	353.0	1.3E-105	683	939	257

Status

Unreviewed

Ensembl Protein

ENSXETP00000005271

UniProt Accession

F7A415;

Protein Name

Protein Synonyms/Alias

Gene Name

map3k5

Gene Synonyms/Alias

map3k5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000002476	ENSXETP00000005271	ENSXETT00000005271

Organism

Xenopus tropicalis

Functional Description

Protein Length

1377

Protein Sequence
(FASTA)

MQVMSDSSEG ISFSVPCSRL PGSSCCAHED TGGLTLQENA TICGGTRIPE AGSFWREDYL 60

RASAVGSGKD APCYGKWVNP PPTASGGISL RRITVVYVIN EVSPELHACE AAALYSLQEA 120

CENHGALLET LDFGKLDFGE TSVLDTFYNA DIAVVEMNDA FRQPSLFYHL GVRESFSMAN 180

NIILYCDTNS DSLQSLKEII GQKNTMCTGN YTFIPYMITP QNKVFCCESI FMRGMTELMP 240

SNFELLLGPI CLPLVDRFVQ ILKVAQATSC QYFREAILND IRRARNQYTG KDLAAELIRI 300

RQRVDSIELL SPDIIINLLL SYRDIQDYDS VVTLVEILEK LPTFNLSSNH HIKFHYAFAL 360

NRRNHPGDRV KALEIMLPLV QLEDQVASDI YCIVGRIYKD MFLDSNFMDT ESRDNAIHWY 420

RKAFESEPTL HSGINYAVLL LAAGHQFETS LELRKIGVKL SSLLGKKGNL EKLQSYWDVG 480

FYLGACILAN DSSKVIHAAE KLFKLKTPAW FLNSVVETIL IYQHFKTPNQ EQHVTNHELV 540

DFWMDFLVES TSSNVSVLRF PVLILEPTKI YQPSYLSINS EAEVQTISIW HVLPGDKKGI 600

HEWNFPADSI RGVSISKFEE RCCFLYVLNN SDDFQIYFCT ELHCKKFFDK VNRIKEENGK 660

NTEEGECDGD LMEFDYEYDE NGDRVVLGKG KHGVVYAGRD LSNQVRIAIK EVPERDGRCS 720

QPLHEEIALH KRLKHKNIVQ YLGSFSKGGF IKIFMEQVPG GSLSALLRSK WGPLKDNEQT 780

IGFYTKQILE GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL AGINPNTETF 840

TGTLQYMAPE IIDKGPRGYG KPADIWSLGC TVIEMATGKP PFYELGEPQA AMFKVGMFKI 900

HPDIPESMSS EAKAFLLRCF EPDPVKRATA TELITDEFLK VSSRKRKSQL KLTTLSSGSN 960

EYLRSISLPV SVMVEDTSSS SEYSSVSPDS DLRSDPFTFK TRARSCIEKD VKLNRSLFLG 1020

IPDENFEDSS APPSPEERDS GFFMLKKDSE RRATLYHILT EDQDKVARNL MDALVQGSEI 1080

KLKWDHITAI VDSLKEFVRS TDRKIISTTL SKLKLELDFD SHAISQVQMV LFGFQDAVNK 1140

VLRNHNIKPH WMFALDNIIR KAVQTAITIL VPDIFKELRP HFSITSESDQ ADQEDIEVEE 1200

RSNKQPTEQT IHREVNEDNV QTSGVSTLSS TLSHNSQNAD RSLNVQLERL RLESNRLLEE 1260

LLLKEREFQV LLRQAIEVKD REIKRLQCTS EPIKIIPGTS VSSTRSTISG SEDLNLVYWL 1320

HKCRVDEDTI SKFLAEDYQL EDILCHVTRD DLKSLNLRGG VLCTIWKEIT DYREKQA 1377

Nucleotide Sequence
(FASTA)

ATGCAAGTAA TGAGTGACAG CAGCGAAGGA ATCAGTTTCT CTGTACCATG CTCACGGCTG 60

CCTGGCTCAA GCTGCTGTGC TCATGAAGAC ACAGGAGGGC TTACGCTACA GGAAAATGCC 120

ACCATATGCG GTGGAACCAG GATCCCTGAA GCTGGAAGCT TCTGGCGTGA AGATTACCTC 180

CGTGCTTCAG CGGTTGGAAG TGGTAAAGAT GCCCCATGCT ATGGAAAGTG GGTTAACCCC 240

CCTCCTACAG CTAGCGGAGG TATTAGCCTT CGTAGGATTA CTGTGGTATA TGTTATCAAT 300

GAAGTAAGTC CGGAGTTGCA TGCTTGTGAG GCTGCTGCAT TATACAGTTT GCAGGAGGCA 360

TGTGAGAACC ATGGGGCACT GCTTGAGACC CTGGATTTCG GCAAACTGGA CTTTGGCGAG 420

ACGTCAGTGC TAGACACCTT CTACAATGCA GATATTGCAG TGGTTGAGAT GAATGACGCT 480

TTTCGACAGC CTTCTTTGTT CTACCATCTG GGAGTAAGAG AAAGCTTTAG CATGGCAAAC 540

AACATAATTC TTTACTGTGA CACAAATTCA GACTCCCTGC AGTCACTGAA GGAAATTATC 600

GGGCAAAAGA ATACTATGTG CACAGGTAAT TACACATTTA TTCCTTACAT GATCACGCCA 660

CAAAACAAAG TGTTTTGCTG TGAGAGTATT TTCATGAGAG GAATGACTGA ACTAATGCCG 720

TCAAACTTTG AGTTACTTCT TGGTCCGATC TGCCTGCCCC TAGTGGATCG CTTTGTTCAG 780

ATTCTGAAGG TGGCACAGGC CACGTCATGC CAATATTTTC GAGAGGCAAT ACTAAATGAT 840

ATTAGAAGGG CTCGGAACCA ATACACTGGG AAGGATCTGG CTGCTGAGCT AATAAGGATC 900

CGCCAGCGCG TAGACAGCAT CGAGTTGTTA TCACCTGACA TCATTATCAA TCTGCTTTTG 960

TCATACAGAG ATATCCAGGA CTACGATTCA GTTGTGACGT TGGTGGAAAT ATTGGAGAAA 1020

CTTCCAACCT TTAATTTATC TTCCAATCAC CATATAAAAT TTCATTATGC ATTTGCATTA 1080

AACAGGAGAA ATCATCCAGG TGACAGAGTA AAAGCCCTTG AAATAATGTT GCCTTTGGTG 1140

CAACTTGAAG ATCAAGTAGC TTCAGACATA TACTGCATTG TGGGAAGGAT CTACAAAGAT 1200

ATGTTCTTAG ATTCTAACTT CATGGATACC GAAAGTCGTG ATAATGCTAT ACATTGGTAC 1260

AGGAAGGCCT TTGAATCTGA ACCAACACTT CATTCTGGAA TCAATTATGC GGTGCTACTT 1320

CTAGCTGCTG GTCATCAATT TGAGACTTCT TTGGAACTCC GGAAAATCGG AGTTAAACTC 1380

AGTAGCCTGT TGGGTAAAAA AGGAAATCTC GAAAAACTCC AAAGTTATTG GGATGTTGGA 1440

TTTTATTTGG GGGCATGTAT ACTGGCCAAT GACTCATCAA AAGTTATCCA TGCAGCAGAA 1500

AAGCTTTTCA AGCTCAAAAC CCCAGCATGG TTCTTGAATT CAGTTGTGGA GACCATTTTG 1560

ATTTATCAGC ATTTTAAAAC GCCAAACCAA GAACAACATG TAACAAACCA TGAGCTGGTT 1620

GATTTTTGGA TGGATTTTCT TGTTGAGTCT ACAAGTAGCA ATGTGTCTGT ATTACGGTTT 1680

CCTGTCTTAA TACTAGAGCC AACAAAAATC TACCAGCCTT CCTACCTATC AATCAATAGT 1740

GAAGCTGAAG TTCAGACAAT ATCTATTTGG CACGTTCTAC CTGGCGATAA GAAAGGAATC 1800

CATGAATGGA ATTTCCCTGC AGATTCTATC AGAGGTGTAA GCATTTCAAA GTTTGAAGAA 1860

AGGTGCTGTT TTCTGTATGT TCTGAACAAC TCTGACGATT TTCAAATATA TTTCTGCACA 1920

GAGCTCCACT GCAAAAAATT CTTTGATAAA GTAAACCGTA TCAAAGAAGA GAATGGAAAG 1980

AACACAGAAG AAGGGGAGTG TGATGGAGAT TTAATGGAGT TCGACTATGA GTATGATGAA 2040

AATGGGGACA GAGTGGTTCT CGGTAAAGGG AAACATGGAG TGGTATATGC AGGAAGAGAC 2100

TTGAGTAACC AGGTCAGAAT TGCAATTAAA GAAGTTCCAG AGAGAGATGG TCGATGCTCT 2160

CAACCACTTC ATGAAGAGAT TGCTTTGCAT AAACGTCTAA AGCATAAAAA CATTGTTCAG 2220

TATTTGGGAT CATTCAGTAA AGGTGGTTTC ATTAAAATAT TTATGGAACA AGTACCTGGA 2280

GGAAGCCTCT CCGCACTTCT AAGGTCAAAA TGGGGACCCT TGAAAGACAA TGAGCAGACA 2340

ATCGGATTTT ATACCAAACA GATCCTTGAA GGTTTGAAAT ATCTCCATGA TAACCAGATA 2400

GTTCATAGAG ATATCAAGGG TGATAATGTT CTTATAAACA CATACAGTGG TGTTCTGAAA 2460

ATCTCTGATT TTGGCACTTC AAAGAGACTT GCTGGAATCA ACCCAAATAC AGAAACCTTC 2520

ACTGGCACTC TACAATATAT GGCACCAGAA ATTATAGACA AAGGACCAAG AGGATATGGA 2580

AAGCCAGCAG ACATTTGGTC TCTGGGATGC ACAGTTATAG AAATGGCAAC AGGAAAACCA 2640

CCATTTTATG AGCTTGGAGA ACCACAAGCT GCCATGTTTA AAGTGGGCAT GTTTAAAATT 2700

CATCCAGATA TCCCAGAATC TATGTCGTCT GAAGCTAAGG CATTTTTGTT GCGGTGCTTT 2760

GAACCAGATC CTGTGAAACG CGCTACTGCT ACTGAACTTA TAACGGATGA ATTCTTGAAG 2820

GTGTCCTCTA GGAAACGCAA GTCCCAGCTT AAGCTTACAA CTCTTTCCTC TGGCTCAAAT 2880

GAATATCTCC GTAGCATATC TTTGCCGGTG TCAGTGATGG TGGAAGATAC AAGCAGCAGC 2940

AGTGAATACA GTTCCGTTTC TCCAGATTCA GACTTAAGAT CGGACCCATT TACTTTTAAA 3000

ACAAGAGCCA GATCATGTAT AGAAAAGGAT GTCAAGCTTA ACAGAAGTTT ATTTCTAGGA 3060

ATTCCAGACG AGAATTTTGA AGACAGTAGT GCTCCTCCTT CTCCTGAAGA ACGAGACTCT 3120

GGATTTTTCA TGCTGAAGAA AGATAGTGAA AGGAGGGCTA CACTTTATCA TATTCTTACA 3180

GAGGATCAGG ACAAGGTGGC TAGAAACTTA ATGGATGCTT TAGTCCAGGG ATCAGAAATA 3240

AAATTGAAAT GGGACCACAT CACTGCTATT GTTGACAGCC TAAAAGAGTT TGTAAGATCT 3300

ACTGACAGGA AAATCATTTC AACAACACTA TCAAAACTCA AACTTGAGTT AGACTTTGAT 3360

AGTCATGCTA TCAGTCAAGT CCAGATGGTG CTGTTTGGCT TTCAAGATGC GGTAAATAAA 3420

GTGCTACGAA ATCATAACAT AAAGCCTCAC TGGATGTTTG CCTTAGATAA TATAATTCGA 3480

AAGGCCGTGC AGACAGCTAT CACTATCCTG GTACCTGATA TATTCAAAGA GCTGAGGCCA 3540

CATTTTAGCA TTACATCAGA AAGTGACCAA GCAGATCAGG AGGACATAGA AGTAGAGGAA 3600

AGAAGTAATA AACAACCCAC AGAACAAACC ATTCACAGAG AAGTCAATGA GGACAACGTG 3660

CAAACCTCAG GAGTGAGCAC ACTCAGTTCA ACTTTGTCCC ACAACTCTCA GAATGCCGAC 3720

AGGTCCCTGA ATGTGCAACT TGAAAGACTT AGGTTAGAGT CAAACAGGCT TTTGGAAGAA 3780

TTGTTACTTA AAGAGAGAGA ATTCCAAGTC CTTCTACGCC AAGCTATTGA AGTGAAGGAC 3840

AGGGAAATCA AACGCCTGCA GTGCACGTCT GAGCCAATAA AGATAATCCC AGGCACTTCC 3900

GTATCCAGCA CAAGGTCAAC TATCTCAGGC AGTGAAGACT TGAATCTTGT TTACTGGCTA 3960

CACAAGTGCA GAGTAGATGA AGATACAATA AGCAAGTTTT TGGCAGAAGA CTATCAGCTT 4020

GAAGATATTC TTTGTCATGT CACACGAGAT GATTTAAAAT CTCTGAATCT GAGGGGAGGA 4080

GTACTATGCA CAATATGGAA AGAAATCACT GACTACAGAG AAAAACAAGC C 4131

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Kev   pe++   + +++l+eEi+l+k+lkH+n

Q: 683   DRVVLGKGKHGVVYAGRDLSNQVRIAIKEV---PERDG--RCSQPLHEEIALHKRLKHKN  737

         5789**************************...77766..499*****************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ ++ + +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 738   IVQYLGSFSKGGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  797

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 798   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPN---TETFTGTLQYMAPEIIDK  854

         ************************************999...9*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg+ aDiWslgc+viem+tgk+Pf el+e++a+mfkvg+ k++P+ipe++s+e+k+

Q: 855   GPRGYGKPADIWSLGCTVIEMATGKPPFYELGEPQAAMFKVGMFKIHPDIPESMSSEAKA  914

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +c+e dp kr++a+eL+++efl

Q: 915   FLLRCFEPDPVKRATATELITDEFL  939

         **********************996

Domain Sequence
(FASTA)

DRVVLGKGKH GVVYAGRDLS NQVRIAIKEV PERDGRCSQP LHEEIALHKR LKHKNIVQYL 60

GSFSKGGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPNTETFTG TLQYMAPEII DKGPRGYGKP 180

ADIWSLGCTV IEMATGKPPF YELGEPQAAM FKVGMFKIHP DIPESMSSEA KAFLLRCFEP 240

DPVKRATATE LITDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013