EKS-XET-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.1	6.8E-116	64	315	252

Status

Unreviewed

Ensembl Protein

ENSXETP00000005827

UniProt Accession

F6WG24;

Protein Name

Protein Synonyms/Alias

Gene Name

mark2

Gene Synonyms/Alias

mark2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000002704	ENSXETP00000005827	ENSXETT00000005827

Organism

Xenopus tropicalis

Functional Description

Protein Length

785

Protein Sequence
(FASTA)

MLEDIAAKHR DHPDSCTNPL LAHEPALGHA DQKTSSSGSS KPNMLRCRTS IATTADEQPH 60

IGNYRLLKTI GKGNFAKVKL ARHVLTGKEV AVKIIDKTQL NSSSLQKLFR EVRIMKVLNH 120

PNIVKLFEVI ETEKTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK 180

LIVHRDLKAE NLLLDSDMNI KIADFGFSNE FTFGNKLDTF CGSPPYAAPE LFQGKKYDGP 240

EVDVWSLGVI LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKKFLILNP 300

AKRGTLEQIM RDRWMNVGHE EDELKPYVEP IPDYKDPKRT ETELMITMGY TREEISDSLV 360

NQKYNEVMAT YLLLGYKSSE TDNDNLTLKP RPPPDVTNSI APSPAHKVQR SVSANPKQRR 420

LSDQAGPAIP NSNSYSKKTQ SNNAENRRSE DDKESGRKSS STVRVPPSPL SGLDRKKTTP 480

TPSTNSVLST GTNRSRNSPM LDRASLVPGS VQNGKDSFST PGSRASTASA PATSARIRQH 540

QKSMSTSVHP SKPAPSLDGN CEVQRPSTAP QRVPVASPSA HNISSAATER TNFPRGVSSR 600

STFHAGQVRQ ARDQQNLGFG SVSPASPSGN SQGRRGATGS IFSKFTSKFV RRNPNEPEGK 660

DRVESTRPHL TVLDKEKDKE DHRDSKPRSL RFTWSMKTTS SMEPNEMMSE IRKVLDANNC 720

QHESQEKYML LCVHGTPGHD NYVQWEMEVC KLPRLSLNGV RFKRISGTSI AFKNIASKIA 780

NELKL 785

Nucleotide Sequence
(FASTA)

ATGTTGGAGG ATATAGCAGC AAAGCATCGT GATCACCCGG ACTCCTGCAC TAACCCCCTG 60

CTCGCTCATG AGCCAGCACT GGGTCATGCG GATCAAAAAA CAAGCAGCAG TGGCAGCAGC 120

AAACCTAACA TGCTGCGATG CCGCACATCT ATCGCCACAA CAGCTGATGA ACAGCCACAC 180

ATTGGAAACT ACCGGCTCCT CAAAACCATT GGCAAAGGCA ACTTTGCTAA AGTTAAACTT 240

GCACGGCATG TACTGACTGG CAAAGAGGTT GCGGTAAAAA TTATAGATAA AACACAACTT 300

AACTCCTCTA GTCTACAGAA GCTTTTCAGA GAAGTGAGGA TCATGAAAGT TTTAAATCAT 360

CCTAACATAG TTAAGTTATT TGAGGTTATT GAAACTGAGA AGACGCTGTA TCTAGTTATG 420

GAGTATGCTA GTGGAGGAGA AGTGTTTGAT TACCTTGTTG CACATGGACG TATGAAAGAG 480

AAAGAAGCCC GTGCCAAATT CCGGCAGATT GTATCCGCTG TACAGTATTG CCATCAAAAG 540

TTAATTGTGC ATAGAGACTT GAAGGCCGAG AATTTGCTGC TAGACTCAGA CATGAACATT 600

AAAATTGCTG ACTTTGGCTT CAGCAATGAA TTCACGTTTG GGAACAAGCT AGACACATTT 660

TGTGGAAGCC CCCCCTATGC AGCACCGGAA CTTTTTCAGG GCAAGAAGTA TGATGGTCCT 720

GAGGTTGATG TATGGAGTTT GGGTGTTATT CTCTATACAC TGGTTAGCGG TTCTCTTCCT 780

TTTGATGGAC AAAACTTAAA GGAGTTGCGT GAGCGAGTAT TACGAGGCAA ATATCGTATT 840

CCTTTTTATA TGTCTACGGA TTGTGAAAAC CTGCTAAAGA AATTTCTCAT ATTAAACCCC 900

GCAAAGAGGG GTACACTAGA GCAAATAATG AGGGATCGCT GGATGAATGT TGGACATGAA 960

GAAGATGAGC TAAAGCCCTA TGTGGAGCCT ATTCCAGATT ACAAGGACCC CAAAAGAACA 1020

GAAACAGAGT TAATGATAAC CATGGGTTAT ACCCGAGAAG AAATCAGCGA CTCTCTAGTT 1080

AACCAGAAAT ATAATGAGGT CATGGCTACT TATCTACTGC TGGGTTACAA GTCATCTGAG 1140

ACGGATAATG ACAACTTAAC TCTGAAGCCC AGACCCCCAC CAGACGTCAC TAATAGCATA 1200

GCCCCGTCAC CTGCTCACAA AGTGCAGCGC AGTGTTTCAG CCAATCCCAA ACAGAGAAGA 1260

CTCAGTGACC AAGCTGGACC AGCCATCCCC AACTCCAATT CCTACTCCAA GAAGACCCAA 1320

AGCAACAATG CTGAAAACAG GCGATCTGAG GATGACAAAG AAAGTGGGCG CAAGTCCAGC 1380

AGTACTGTCC GAGTTCCACC AAGTCCTCTT TCTGGGCTTG ACAGAAAGAA GACAACACCA 1440

ACCCCATCTA CGAACAGTGT ACTTTCTACT GGCACTAATC GCAGTCGCAA CTCGCCAATG 1500

CTGGACAGAG CCTCACTTGT GCCTGGATCT GTACAGAATG GAAAGGATAG CTTCTCTACA 1560

CCTGGGTCCC GTGCCTCCAC CGCTTCTGCC CCAGCCACCT CTGCTCGGAT CCGACAGCAC 1620

CAGAAATCCA TGTCCACTTC TGTGCACCCT TCCAAACCCG CTCCTTCCCT GGATGGAAAC 1680

TGTGAAGTTC AAAGGCCAAG CACAGCCCCC CAGAGAGTGC CTGTAGCATC CCCCTCAGCT 1740

CACAACATAA GTAGTGCCGC AACAGAGCGG ACCAACTTCC CTCGTGGTGT TTCCAGCCGC 1800

AGCACATTTC ATGCTGGCCA GGTCCGCCAA GCTCGGGACC AACAGAACCT GGGATTTGGA 1860

AGCGTCTCAC CTGCTTCTCC TTCTGGGAAC AGCCAGGGGC GGAGGGGGGC TACTGGGAGC 1920

ATATTTAGCA AATTCACATC CAAATTTGTG CGCAGGAATC CAAATGAACC AGAAGGGAAA 1980

GACCGAGTGG AGAGTACAAG GCCTCACCTC ACAGTGCTAG ACAAGGAGAA GGATAAAGAA 2040

GACCATCGGG ACTCCAAGCC TCGCTCTCTG CGCTTCACCT GGAGCATGAA AACCACCAGC 2100

TCAATGGAGC CCAATGAGAT GATGAGCGAG ATCCGCAAAG TCCTGGATGC AAACAACTGC 2160

CAACATGAAT CACAGGAAAA ATATATGCTG CTCTGCGTCC ACGGGACTCC TGGTCACGAC 2220

AACTACGTGC AGTGGGAAAT GGAGGTGTGC AAGCTTCCGC GTCTCTCTCT CAACGGTGTA 2280

CGCTTCAAGC GCATCTCTGG CACCTCCATC GCATTTAAGA ACATTGCTTC CAAAATAGCC 2340

AATGAGCTGA AACTTTAA 2358

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 64    YRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  123

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 124   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIV  183

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 184   HRDLKAENLLLDSDMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  243

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 244   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKR  303

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i++++w+

Q: 304   GTLEQIMRDRWM  315

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKLIV 120

HRDLKAENLL LDSDMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPAKR 240

GTLEQIMRDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013