EPS-XET-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XET-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	284.8	8.5E-85	23	293	271

Status

Unreviewed

Ensembl Protein

ENSXETP00000036930

UniProt Accession

F6RTH1;

Protein Name

Protein Synonyms/Alias

Gene Name

ppm1b

Gene Synonyms/Alias

ppm1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000002746	ENSXETP00000005985	ENSXETT00000005985
ENSXETG00000002746	ENSXETP00000036930	ENSXETT00000036930

Organism

Xenopus tropicalis

Functional Description

Protein Length

387

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPRGL DDWSFFAVYD 60

GHAGSRVANY CSSHLLEHIT DNEDFRATET PGSALEPTVE NVKSGIRTGF LKIDEYMRNF 120

ADLRNGMDRS GSTAVAVLLS PSHVYFINCG DSRAVLYRSG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIV RADEDEFIIL 240

ACDGIWDVMS NEELCEFVKY RLELTDDLEK VCNSVVDTCL HKGSRDNMSI VLVCFPNAPK 300

VSEEAIKKDA DLDKHLESRV EEIMTNAGEE GMPDLAHVMR ILAAENVPHL PPGGGLAAKR 360

SVIEEVYNRL NPHRESDGGS GDLEDPW 387

Nucleotide Sequence
(FASTA)

ATGGGGGCAT TTTTGGACAA ACCGAAAACA GAGAAACACA ATGCACACGG TGCCGGAAAT 60

GGCTTGCGTT ATGGACTCAG CAGCATGCAG GGCTGGAGAG TGGAGATGGA GGATGCGCAC 120

ACAGCCGTGG TTGGGATCCC TCGTGGCTTG GATGATTGGT CGTTTTTTGC AGTTTACGAT 180

GGCCATGCAG GATCACGCGT TGCAAATTAT TGCTCTTCCC ACTTACTAGA GCACATCACA 240

GACAATGAAG ATTTCAGGGC AACAGAAACA CCGGGATCCG CTCTGGAGCC AACAGTAGAA 300

AATGTTAAAA GTGGCATTAG AACTGGGTTT TTAAAAATTG ACGAGTACAT GCGCAACTTT 360

GCCGATTTAA GAAATGGAAT GGATAGAAGT GGTTCTACCG CAGTAGCGGT CTTACTTTCA 420

CCCAGTCACG TGTATTTTAT TAACTGCGGG GATTCTCGGG CTGTTTTGTA TAGGAGCGGA 480

CAAGTTTGTT TTTCAACGCA GGATCACAAA CCTTGCAACC CAAGGGAGAA GGAGAGAATT 540

CAAAACGCCG GCGGCAGCGT CATGATACAG CGCGTCAATG GATCGCTGGC AGTTTCCCGT 600

GCACTTGGAG ACTATGATTA CAAGTGCGTC GATGGCAAGG GCCCTACGGA GCAGCTTGTT 660

TCACCTGAGC CTGAAGTATA TGAAATCGTG AGAGCTGATG AAGATGAGTT TATCATTTTG 720

GCTTGTGATG GCATTTGGGA TGTCATGAGC AACGAGGAGC TTTGTGAATT TGTGAAATAT 780

AGGCTTGAGC TAACGGATGA CCTTGAAAAA GTGTGCAATT CAGTAGTGGA CACCTGTTTA 840

CATAAGGGAA GCCGTGATAA CATGAGCATT GTTCTAGTTT GTTTTCCAAA TGCCCCCAAG 900

GTCTCTGAAG AGGCAATAAA GAAAGATGCT GATTTGGATA AACATTTAGA GTCCAGGGTT 960

GAAGAAATCA TGACCAACGC TGGGGAGGAA GGAATGCCAG ATCTTGCCCA TGTAATGCGC 1020

ATCTTAGCTG CAGAGAACGT CCCGCATTTA CCGCCAGGTG GAGGCTTGGC AGCAAAACGC 1080

AGTGTTATTG AAGAGGTATA TAATAGGTTG AATCCACACA GAGAGAGCGA TGGGGGTTCT 1140

GGCGATCTAG AAGACCCCTG GTAG 1164

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ +  +    ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPRGLD---DWSFFAVYDGHAGSRVANYCSSHLLEHI  79

         69****************98666655544...4***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         + + +         + e++ ++vk+ ++++Fl++de ++++ + ++ +d+sGstav +l+

Q: 80    TDNEDfratetpgsALEPTVENVKSGIRTGFLKIDEYMRNFADLRNGMDRSGSTAVAVLL  139

         ***99*********99********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         ++s++y++n+GdSravL r+g+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPSHVYFINCGDSRAVLYRSGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ +  edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRADEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+ +le +++++++++++v+++l++gs+dn+s+++v

Q: 257   FVKYRLELTDDLEKVCNSVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPRGLDD WSFFAVYDGH AGSRVANYCS SHLLEHITDN 60

EDFRATETPG SALEPTVENV KSGIRTGFLK IDEYMRNFAD LRNGMDRSGS TAVAVLLSPS 120

HVYFINCGDS RAVLYRSGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEIVRA DEDEFIILAC DGIWDVMSNE ELCEFVKYRL 240

ELTDDLEKVC NSVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013