EKS-XET-00064

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00064

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	349.3	1.6E-104	4	282	279

Status

Unreviewed

Ensembl Protein

ENSXETP00000060092

UniProt Accession

Q28FA6;

Protein Name

Protein Synonyms/Alias

Cell division cycle 2, G1 to S and G2 to M;

Gene Name

cdc2

Gene Synonyms/Alias

cdc2; TEgg081h12.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003123	ENSXETP00000006772	ENSXETT00000006772
ENSXETG00000003123	ENSXETP00000060092	ENSXETT00000060706

Organism

Xenopus tropicalis

Functional Description

Protein Length

297

Protein Sequence
(FASTA)

MDEYTKIEKI GEGTYGVVYK GRHKATGQVV AMKKIRLENE EEGVPSTAIR EISLLKELQH 60

PNIVCLLDVL MQDSRLYLIF EFLSMDLKKY LDSIPSGQYI DTMLVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDSKG VIKLADFGLA RAFGIPVRVY THEVVTLWYR APEVLLGSVR 180

YSTPVDVWSI GTIFAEIATK KPLFHGDSEI DQLFRIFRYL SISYLVSYPS NHALNTFTLW 240

ARTHLNAIKT PSESQKPLIA AIKSSGNAQQ ISARKALLHP YFDDLDKSSL PANQIRN 297

Nucleotide Sequence
(FASTA)

ATGGACGAGT ACACTAAAAT AGAAAAGATC GGAGAGGGCA CATACGGGGT TGTGTACAAG 60

GGTCGCCATA AAGCAACAGG CCAGGTGGTT GCAATGAAGA AAATTCGGTT GGAAAACGAA 120

GAGGAGGGCG TCCCAAGCAC AGCGATTAGA GAAATATCAC TACTGAAAGA ACTTCAGCAC 180

CCCAACATAG TTTGCCTTCT AGATGTCCTG ATGCAAGACT CAAGGTTGTA CCTCATCTTT 240

GAGTTTCTCT CCATGGATCT GAAGAAGTAT TTAGACTCAA TACCCAGCGG CCAGTATATA 300

GATACAATGC TTGTTAAGAG TTACCTCTAC CAGATCCTAC AAGGGATTGT ATTTTGCCAC 360

TCCAGAAGAG TGTTACACAG GGATCTGAAG CCTCAAAACC TGCTGATCGA CAGCAAAGGA 420

GTGATAAAGT TGGCAGATTT TGGCCTTGCC AGAGCTTTTG GCATTCCGGT TCGGGTTTAC 480

ACACACGAGG TAGTGACGTT ATGGTACAGA GCCCCAGAAG TGCTGTTGGG GTCAGTCCGA 540

TATTCCACAC CGGTCGACGT ATGGAGCATA GGAACCATTT TCGCTGAGAT TGCCACAAAG 600

AAACCCCTCT TCCATGGCGA CTCTGAAATT GACCAGCTCT TCAGGATATT CAGGTACCTT 660

TCTATCAGCT ATCTGGTCAG TTACCCTAGC AACCATGCAC TGAATACTTT CACCCTCTGG 720

GCCAGGACCC ATCTAAATGC AATAAAAACC CCTTCAGAAT CACAGAAACC CCTAATTGCT 780

GCAATTAAAA GCTCTGGGAA CGCCCAACAA ATTTCTGCGC GTAAAGCGTT GCTGCACCCC 840

TACTTTGATG ACTTGGATAA GTCCAGCCTT CCTGCCAATC AGATTAGAAA TTAA 894

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v Ll+v++ ++++lyL+fefl++dLkk+l++ ++  ++++  vks+l+q+l+g+ ++Hs+

Q: 64    VCLLDVLM-QDSRLYLIFEFLSMDLKKYLDSIPSGqYIDTMLVKSYLYQILQGIVFCHSR  122

         ********.99********************98765999*********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p++ yt+evvTlwYraPe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vD+Ws+g i+ae++t+kplf+g+seidql+rif+ l      ++p+ + l++++

Q: 183   TPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRYLSISYLVSYPSNHALNTFT----  238

         ************************************************99999876....

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          +++++l+    + +e+   l+  + +  +++ isa++al h+yf

Q: 239   LWARTHLNAIK-TPSESQKPLIAAIKSSGNAQQISARKALLHPYF  282

         45555555443.445567899999999999**************8

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KATGQVVAMK KIRLENEEEG VPSTAIREIS LLKELQHPNI 60

VCLLDVLMQD SRLYLIFEFL SMDLKKYLDS IPSGQYIDTM LVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDSKGVIK LADFGLARAF GIPVRVYTHE VVTLWYRAPE VLLGSVRYST 180

PVDVWSIGTI FAEIATKKPL FHGDSEIDQL FRIFRYLSIS YLVSYPSNHA LNTFTLWART 240

HLNAIKTPSE SQKPLIAAIK SSGNAQQISA RKALLHPYF 279

Keyword

ATP-binding; Cell cycle; Cell division; Nucleotide-binding.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013