EKS-XET-00095

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00095

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	335.4	2.2E-100	225	479	255

Status

Unreviewed

Ensembl Protein

ENSXETP00000056943

UniProt Accession

F6TV41;

Protein Name

Protein Synonyms/Alias

Gene Name

mylk

Gene Synonyms/Alias

mylk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003217	ENSXETP00000056943	ENSXETT00000056943

Organism

Xenopus tropicalis

Functional Description

Protein Length

655

Protein Sequence
(FASTA)

DQIKARVGDK VELHCGIRGT TPIAATWLRN KKQVTEGPRI SVHTSDMESR LVIDQVCEDD 60

SGCYTLYVQD RTGNVQHHTS LTVVEHPSPP SGKPLVSATQ PSSLTLSWSG PCYDGGSAVV 120

SYWIEMKCTK KEEDGWKLLT DSCVNTSYRV EEGLEPGGQY QFRVRAANAH GVSEPGEESD 180

IVAMLCAGGE LIKPHINHEE TEGEGSNGYT NVSVNTTEHF NDFYIQLEKL GMGKFGQVYK 240

LKERSTGKIC AGKFFKARTQ KEIQGARVEV ELMNKLHHPQ LVRCLSAFQE PGRVVMVLEY 300

IAGGELFERI VADDFEHTEV MCVEYICQIL NGVAYMHHQS IVHLDLKPEN IICLNTVSNQ 360

VKIIDFGLAR ELDPHVPMKV LQGTAEFVAP EVIAFEPVGF TTDMWSLGVI CYILLSGDSP 420

FQGNNDMETM QNITSACWDF DDETNALLSE TAKDFVKRLL QKNMRSRLTA VQALDHPWVQ 480

HKCVSKTKTL SKERIKKFLA RQKWQKTGKA VLALNRMALL SAKSDNNTTS THTDGSHDCQ 540

QVSMHLQEQL QAAPVFSTLL KDQVEVVGST ARFQCHIEGF PDPEVLWFHA GSPVQECRRL 600

QIEYEDTGSC ALIISDVLLT DSGVYTCRAS NTQGETESSA KLTVHSLLAE RRAKE 655

Nucleotide Sequence
(FASTA)

GACCAGATAA AAGCACGGGT GGGGGACAAG GTAGAGCTGC ACTGTGGAAT TCGAGGCACA 60

ACACCAATAG CTGCCACCTG GCTAAGAAAC AAGAAACAGG TCACAGAAGG CCCAAGAATA 120

TCAGTTCACA CATCTGACAT GGAGAGCCGA CTGGTTATCG ACCAGGTTTG TGAGGATGAT 180

TCTGGCTGTT ATACACTTTA TGTACAAGAC CGGACCGGAA ACGTTCAGCA CCACACTAGC 240

CTCACTGTTG TAGAGCACCC CTCTCCACCC TCAGGAAAGC CACTTGTGTC AGCCACGCAA 300

CCTTCCTCTT TGACTCTCTC ATGGTCGGGG CCATGTTATG ATGGTGGCAG TGCTGTGGTC 360

AGCTACTGGA TTGAAATGAA ATGCACTAAG AAGGAGGAAG ATGGTTGGAA ACTGCTCACA 420

GACTCCTGTG TTAACACTTC CTATCGAGTA GAAGAAGGCT TGGAACCCGG AGGCCAATAC 480

CAGTTCCGTG TGCGAGCAGC TAATGCCCAT GGAGTGAGTG AGCCAGGGGA GGAGTCAGAC 540

ATCGTTGCCA TGTTGTGTGC TGGCGGTGAG CTCATAAAAC CTCATATTAA CCATGAGGAA 600

ACCGAGGGTG AAGGATCAAA TGGATACACT AATGTCTCCG TCAACACAAC AGAGCACTTT 660

AATGACTTCT ACATACAGCT GGAGAAGTTG GGAATGGGTA AGTTTGGGCA GGTGTACAAG 720

CTGAAGGAGA GATCTACCGG TAAGATCTGT GCAGGGAAGT TCTTTAAGGC ACGGACTCAG 780

AAGGAGATAC AGGGTGCACG TGTAGAGGTG GAACTGATGA ACAAACTTCA CCACCCTCAA 840

CTGGTGCGCT GCTTGTCTGC TTTCCAGGAA CCTGGGCGTG TGGTCATGGT GCTGGAATAT 900

ATTGCAGGAG GAGAGTTGTT TGAACGTATT GTGGCAGATG ACTTTGAGCA CACGGAGGTC 960

ATGTGTGTTG AATACATATG CCAAATTCTG AATGGGGTGG CATATATGCA CCACCAGAGC 1020

ATCGTTCATT TGGACCTCAA ACCTGAGAAT ATTATCTGCC TTAACACAGT CAGCAACCAG 1080

GTCAAAATCA TTGACTTTGG TTTGGCAAGA GAGCTGGATC CCCATGTCCC AATGAAAGTG 1140

CTACAGGGCA CGGCTGAGTT TGTGGCTCCA GAGGTCATTG CCTTTGAACC AGTTGGGTTT 1200

ACTACAGACA TGTGGAGCCT TGGTGTCATC TGTTATATCC TGCTAAGTGG GGACTCCCCA 1260

TTCCAGGGTA ACAACGACAT GGAGACTATG CAAAATATCA CATCTGCTTG TTGGGATTTT 1320

GATGATGAAA CGAATGCTCT TTTGTCTGAA ACAGCCAAGG ACTTTGTAAA GCGACTGTTG 1380

CAGAAGAACA TGAGGTCCCG ACTCACTGCA GTTCAGGCCC TGGACCACCC TTGGGTTCAG 1440

CACAAATGTG TTTCCAAGAC CAAGACCCTA TCAAAAGAAC GCATCAAGAA GTTTCTGGCA 1500

AGGCAGAAGT GGCAGAAAAC GGGCAAAGCT GTGCTGGCTC TGAACCGGAT GGCGCTGCTT 1560

AGTGCCAAGT CTGACAACAA TACAACCTCA ACACACACAG ACGGTAGCCA TGACTGCCAG 1620

CAAGTCTCTA TGCATCTCCA AGAGCAACTC CAGGCTGCCC CAGTCTTTTC TACTCTATTA 1680

AAGGACCAGG TGGAGGTAGT TGGCAGCACA GCGCGTTTCC AGTGCCACAT CGAGGGATTC 1740

CCAGACCCAG AAGTGCTGTG GTTTCATGCT GGGAGCCCAG TTCAAGAATG CAGACGTCTG 1800

CAGATTGAGT ATGAAGATAC CGGTAGCTGT GCTCTCATTA TATCAGACGT TCTCCTGACA 1860

GATTCTGGTG TTTACACCTG CCGAGCCTCA AACACCCAGG GGGAGACTGA AAGCTCTGCC 1920

AAATTAACTG TTCACTCCCT GTTGGCAGAA CGGCGGGCAA AAGAA 1965

Domain Profile

S: 2     sikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliql  61

          + e+lg Gkfg+v+k  e+stgk  a+k++k+r++k+ + ++ E+e +n+l+H++l+++

Q: 225   IQLEKLGMGKFGQVYKLKERSTGKICAGKFFKARTQKEIQGARVEVELMNKLHHPQLVRC  284

         56799*******************************************************

S: 62    ydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHl  121

          +af++  ++v+vlE+++ggelferiv++d+e tE ++v++++q+l++++y+H+++ivHl

Q: 285   LSAFQEPGRVVMVLEYIAGGELFERIVADDFEHTEVMCVEYICQILNGVAYMHHQSIVHL  344

         ************************************************************

S: 122   dlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDm  181

         dlkpeni++ ++ s+q+K+idFGlar l+++  +kvl gt+efvaPEv+  epv+++tDm

Q: 345   DLKPENIICLNTVSNQVKIIDFGLARELDPHVPMKVLQGTAEFVAPEVIAFEPVGFTTDM  404

         ************************************************************

S: 182   WsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkek  241

         Ws+Gvi+y+LlsG sPF g+nd et++n++sa +dfd+e+   +se akdF+++ll k++

Q: 405   WSLGVICYILLSGDSPFQGNNDMETMQNITSACWDFDDETNALLSETAKDFVKRLLQKNM  464

         ************************************************************

S: 242   kkRmsaeeaLkhkwl  256

         ++R++a +aL+h+w+

Q: 465   RSRLTAVQALDHPWV  479

         **************6

Domain Sequence
(FASTA)

IQLEKLGMGK FGQVYKLKER STGKICAGKF FKARTQKEIQ GARVEVELMN KLHHPQLVRC 60

LSAFQEPGRV VMVLEYIAGG ELFERIVADD FEHTEVMCVE YICQILNGVA YMHHQSIVHL 120

DLKPENIICL NTVSNQVKII DFGLARELDP HVPMKVLQGT AEFVAPEVIA FEPVGFTTDM 180

WSLGVICYIL LSGDSPFQGN NDMETMQNIT SACWDFDDET NALLSETAKD FVKRLLQKNM 240

RSRLTAVQAL DHPWV 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00060	; FN3; 1.
SM00408	; IGc2; 2.
SM00220	; S_TKc; 1.

Prosites

PS50853	; FN3; 1.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013