EKS-XET-00334

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00334

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	248.5	7.2E-74	52	315	264

Status

Unreviewed

Ensembl Protein

ENSXETP00000059427

UniProt Accession

F6PM85;

Protein Name

Protein Synonyms/Alias

Gene Name

stk11

Gene Synonyms/Alias

stk11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003285	ENSXETP00000007123	ENSXETT00000007123
ENSXETG00000003285	ENSXETP00000059427	ENSXETT00000062865

Organism

Xenopus tropicalis

Functional Description

Protein Length

435

Protein Sequence
(FASTA)

MLCPSSMDEG GSQEIGFLGD LSVGMDTFIH RIDSTEVIYQ PRRKRAKLVG KYLMGDLLGE 60

GSYGKVKEML DSDTLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH RNVIQLVDVL 120

YNEEKQKYCY TYMVMEYCVC GMQEMLDSVQ EKHFPVFQAH GYFCQLIDGL EYLHSQGIVH 180

KDIKPGNLLL TTDGTLKISD LGVAEALHPF AEGDTCRTSQ GSPAFQPPEI ANGLDTFSGF 240

KVDIWSAGVT LYNITTGLYP FEGDNIYKLF ENIGKGDYSI PEECGPLLSD LLRGMLEYDP 300

AKRFSIQQIR QHNWFRKKHP HMDPIVPIPP SPETKDRWRS LTVVPYLEDL HGYSEEEDLC 360

DLEDDIIYTQ DFTVPGQVAE DDYFAQTQST APSKQLCMNG TENQLKTERR VSSSSQRKAS 420

TAGSKVRKLS ACKQQ 435

Nucleotide Sequence
(FASTA)

ATGCTGTGTC CTTCAAGTAT GGATGAAGGG GGGTCACAAG AGATTGGCTT TTTGGGAGAC 60

CTGTCAGTAG GAATGGACAC TTTCATTCAC CGCATTGACT CCACTGAAGT GATTTATCAA 120

CCTCGCCGCA AGCGTGCCAA ATTGGTTGGA AAGTATCTGA TGGGGGACCT TCTGGGGGAG 180

GGTTCTTACG GGAAAGTAAA GGAAATGCTG GACTCTGACA CACTGTGCCG CCGTGCTGTC 240

AAAATCTTGA AAAAAAAGAA GCTGAGAAGG ATTCCCAATG GAGAGGCAAA TGTCAAGAAG 300

GAGATACAAC TACTGAGGCG CTTGAGGCAT CGGAATGTTA TCCAGCTAGT GGATGTGCTC 360

TACAATGAAG AAAAGCAAAA ATATTGCTAT ACGTATATGG TGATGGAATA TTGTGTTTGT 420

GGGATGCAGG AGATGCTGGA CAGTGTGCAG GAAAAACACT TTCCTGTATT TCAAGCCCAT 480

GGTTATTTTT GCCAACTCAT TGATGGTCTG GAGTACCTTC ACAGTCAGGG AATTGTTCAC 540

AAAGACATTA AACCAGGGAA TTTGCTGCTA ACAACAGATG GGACACTCAA AATCTCAGAC 600

TTGGGGGTGG CAGAGGCTTT GCACCCGTTT GCTGAAGGTG ATACTTGTAG GACCAGCCAA 660

GGATCTCCAG CTTTTCAGCC TCCAGAGATT GCCAATGGCC TGGATACCTT CTCAGGATTC 720

AAAGTGGACA TCTGGTCAGC AGGAGTAACG CTGTATAATA TTACCACAGG ACTGTATCCA 780

TTCGAGGGGG ACAATATATA TAAATTGTTT GAAAACATTG GAAAGGGAGA CTACTCCATC 840

CCAGAGGAAT GTGGACCCTT GCTGTCTGAC TTGTTAAGAG GCATGTTGGA GTACGACCCA 900

GCAAAGAGGT TCTCAATACA GCAGATCCGT CAGCACAACT GGTTCCGGAA GAAACACCCT 960

CATATGGATC CCATTGTCCC CATACCTCCA AGCCCAGAAA CAAAGGACCG CTGGAGAAGT 1020

CTAACAGTTG TGCCTTATCT GGAGGATCTG CACGGGTATA GTGAGGAGGA GGATCTGTGT 1080

GATCTAGAAG ATGATATAAT CTATACACAG GATTTCACAG TGCCAGGTCA GGTGGCTGAG 1140

GATGACTACT TTGCACAGAC ACAGAGCACT GCTCCCTCAA AGCAGCTGTG TATGAATGGC 1200

ACTGAGAACC AGCTCAAGAC AGAAAGAAGG GTCAGCTCTT CATCGCAGCG CAAGGCCAGT 1260

ACAGCTGGGA GTAAAGTACG AAAATTATCT GCCTGCAAAC AGCAGTGA 1308

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ +++t  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 52    YLMGDLLGEGSYGKVKEMLDSDTLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHR  111

         778999******************************965334567***************

S: 59    niikllevi..etkkk...lylvleyasgg..eLfdyieekgrlkekearklfkqlvsav  111

         n+i+l++v+  e+k+k   +y+v+ey+  g  e++d + ++++++  +a+ +f ql++++

Q: 112   NVIQLVDVLynEEKQKycyTYMVMEYCVCGmqEMLDSV-QEKHFPVFQAHGYFCQLIDGL  170

         ********9653333223369*****998888*****7.6789*****************

S: 112   kYlhskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPel  168

         +Ylhs+givH+D+Kp Nlll++++++ki+D+G+a+    f eg++++t++Gsp++++Pe+

Q: 171   EYLHSQGIVHKDIKPGNLLLTTDGTLKISDLGVAEalhPFAEGDTCRTSQGSPAFQPPEI  230

         **********************************966667888*****************

S: 169   lkg.kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskeles  227

          +g ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip+++ + l++

Q: 231   ANGlDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYSIPEECGPLLSD  290

         *99899******************************************************

S: 228   LlrklLvvdpekRatieeilkhewl  252

         Llr +L+ dp+kR++i++i++h+w+

Q: 291   LLRGMLEYDPAKRFSIQQIRQHNWF  315

         ************************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEMLD SDTLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHR 60

NVIQLVDVLY NEEKQKYCYT YMVMEYCVCG MQEMLDSVQE KHFPVFQAHG YFCQLIDGLE 120

YLHSQGIVHK DIKPGNLLLT TDGTLKISDL GVAEALHPFA EGDTCRTSQG SPAFQPPEIA 180

NGLDTFSGFK VDIWSAGVTL YNITTGLYPF EGDNIYKLFE NIGKGDYSIP EECGPLLSDL 240

LRGMLEYDPA KRFSIQQIRQ HNWF 264

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0097009	; P:energy homeostasis
GO:0060575	; P:intestinal epithelial cell differentiation

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013