EKS-XET-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.5	1.1E-110	94	378	285

Status

Reviewed

Ensembl Protein

ENSXETP00000007502

UniProt Accession

A4IIW7;

Protein Name

Cyclin-dependent kinase 14

Protein Synonyms/Alias

Cell division protein kinase 14;

Gene Name

cdk14

Gene Synonyms/Alias

cdk14; pftk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003466	ENSXETP00000007502	ENSXETT00000007502

Organism

Xenopus tropicalis

Functional Description

Serine/threonine-protein kinase involved in the controlof the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity).

Protein Length

428

Protein Sequence
(FASTA)

ICVTKMSTRN CQGIDSVIKP LDTIPEDKKV RVQRTQSSFD PFEKTSNQVK RVHSENNACI 60

NFKSASVGKE SPKVRRHSSP SSPTSPKFGK ADSYEKLEKL GEGSYATVYK GKSKVNGKLV 120

ALKVIRLQEE EGTPFTAIRE ASLLKGLKHA NIVLLHDIIH TKETLTLVFE YVHTDLCQYM 180

DKHPGGLNPE NVKLFLFQLL RGLSYIHQGH ILHRDLKPQN LLISDTGELK LADFGLARAK 240

SVPSHTYSNE VVTLWYRPPD VLLGSTDYST CLDMWGVGCI FVEMIQGVAA FPGMKDIQDQ 300

LERIFLILGT PNEETWPGVH SLPHFKLERF TQYGPKNLRQ AWNKLSYVNH AEDLASKLLQ 360

CFPKNRLSAQ AALNHDYFSD LPPRLWELSD MSSIFTVPNV KLQPEAGESM RVFGKNNSFS 420

KSLSNSKH 428

Nucleotide Sequence
(FASTA)

ATATGTGTCA CCAAGATGTC GACACGGAAC TGCCAAGGAA TAGACTCGGT CATAAAGCCT 60

CTCGACACCA TTCCTGAAGA CAAGAAGGTC AGGGTGCAGA GGACACAGAG CAGTTTTGAC 120

CCCTTTGAAA AAACATCAAA CCAGGTGAAG AGAGTGCATT CAGAAAACAA TGCATGCATT 180

AACTTTAAGA GCGCATCCGT GGGAAAGGAA TCTCCCAAAG TCAGACGCCA TTCAAGCCCC 240

AGCTCGCCAA CAAGTCCAAA ATTTGGAAAG GCAGACTCTT ATGAAAAACT GGAAAAATTA 300

GGAGAAGGCT CATATGCTAC AGTCTATAAA GGAAAAAGCA AAGTTAATGG GAAGCTGGTG 360

GCACTGAAGG TGATAAGACT GCAAGAAGAA GAAGGCACTC CATTTACTGC AATCAGGGAA 420

GCTTCACTTC TGAAGGGATT GAAGCACGCT AACATTGTGC TGTTGCATGA TATTATTCAT 480

ACGAAGGAGA CTTTGACCCT CGTCTTTGAA TATGTGCACA CGGATTTATG TCAGTATATG 540

GATAAACACC CAGGGGGGCT GAATCCAGAG AATGTGAAGT TATTTTTATT TCAGTTGCTG 600

CGTGGTTTGT CCTATATCCA CCAAGGCCAT ATTTTACACA GGGATCTGAA GCCACAAAAC 660

CTTCTCATCA GCGATACAGG GGAACTGAAG CTGGCCGACT TTGGGCTTGC AAGAGCCAAG 720

TCTGTACCAA GCCACACGTA CTCCAATGAA GTAGTGACTC TCTGGTACAG ACCTCCAGAT 780

GTCCTTCTGG GCTCCACAGA CTATTCCACC TGCCTTGACA TGTGGGGTGT TGGGTGCATA 840

TTTGTGGAAA TGATCCAGGG AGTCGCTGCA TTTCCAGGAA TGAAAGATAT CCAAGACCAA 900

TTGGAACGGA TATTTTTGAT CCTCGGGACG CCTAATGAAG AAACATGGCC TGGGGTCCAT 960

TCTTTACCAC ATTTCAAGCT AGAACGATTT ACGCAATACG GCCCTAAGAA TCTAAGACAA 1020

GCTTGGAATA AGCTGAGCTA TGTGAATCAT GCAGAAGATC TAGCTTCCAA GCTGCTCCAG 1080

TGTTTCCCAA AGAACAGACT GTCGGCGCAA GCTGCTCTGA ACCATGATTA TTTCAGTGAT 1140

CTCCCTCCCC GGCTCTGGGA GCTAAGTGAC ATGTCTTCCA TTTTTACGGT ACCGAATGTG 1200

AAGTTACAAC CTGAAGCTGG AGAAAGTATG AGAGTATTTG GGAAAAACAA TAGTTTCAGC 1260

AAAAGTCTTT CAAACAGCAA GCACTGA 1287

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 94    YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  152

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++e+vk +l+qll+gl+y+H+ +

Q: 153   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLNPENVKLFLFQLLRGLSYIHQGH  210

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg+++Yst

Q: 211   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTDYST  270

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f

Q: 271   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLILGTPNEETWPGVHSLPHFKlERF  330

         ************************99679***************************99**

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         +++ +k+l++ ++kl+  ++a dl +kll++ pk+R+sa++al+h+yf

Q: 331   TQYGPKNLRQAWNKLSyvNHAEDLASKLLQCFPKNRLSAQAALNHDYF  378

         ************99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLNPENVK LFLFQLLRGL SYIHQGHILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTDYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLILGTPNE ETWPGVHSLP HFKLERFTQY 240

GPKNLRQAWN KLSYVNHAED LASKLLQCFP KNRLSAQAAL NHDYF 285

Keyword

ATP-binding; Cell cycle; Cell division; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0051301	; P:cell division
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

xtr:100125075

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013