EKS-XET-00097

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00097

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	354.0	5.6E-106	40	312	273

Status

Unreviewed

Ensembl Protein

ENSXETP00000008037

UniProt Accession

F6VAY9;

Protein Name

Protein Synonyms/Alias

Gene Name

gak

Gene Synonyms/Alias

gak;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003718	ENSXETP00000008037	ENSXETT00000008037

Organism

Xenopus tropicalis

Functional Description

Protein Length

1322

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA GRDQHDFVGQ TVEMGDMKMR VKRVIAEGGF AFVYEAQDVG 60

SGKDYALKRL LSNEEEKNKS IIQEICFMKK LSGHPNIVQF CSAASIGKEE SDTGQGEFLL 120

LTELCRGQLV EFLNKAECKG PLSCDTVLKI FYQTCRAVQH MHKQKPPIIH RDLKVENLLV 180

SNQGTVKLCD FGSSTTIAHY PDYNWTAQQR ATVEDEVTRN TTPMYRTPEI IDLYSNFPIG 240

EKQDIWALGC ILYLLCFKQH PFEDGAKLRI VNGKYSVPQN DTKYTVFHGL INSMIKVNPE 300

ERLSITEVVS QLQEIAAARN VNPKSPITEL LEQNGGYGNT VIQRSSSGAP QNSKPLAHPG 360

LTLTDDDQTS GGFFDILKGG TERILSNIKD TSSKVIQSVT NYAKGDLDLS YITSRIAVMS 420

FPAEGVESAI KNNIEDVRLF LDSKHPGHYA VYNLCLRKYR PSKFHNRVSE CGWAGRRAPN 480

LMNLYSICKN MHLWLKQDPK NVCIVHCTDG RAASAVVLCS FLCFCRLFTT AEAAVYMFSM 540

KRCPPGIWPS HKRYIEYMCD MMAEEPIIPH SKPILIRAIT MTPVPLFSKQ RNGCRPFCEV 600

YVGDERVATT SQEYDKMRDF RNEDGKAEIP LNVTVQGDVL IVIYHARSTL GGRLQAKMTS 660

MKMFQIQFHT GFVPRNATTV KFAKYDLDAC DIQEKYPDLF QVNLEVEVSS RDKQATSSPP 720

WENINTKRLN PKILFSSREE QQEMLSKFGK PELPRQPGST AQYEGDINME KPSPDLSDSE 780

TLQKNNFFQT LDWQDQSGVR NAQIGDQENV AKEDYENEYL SDSKSEASDE EFYSFPQGNR 840

GIRCEENGPA VGTDDSVARE VLFEANKDSQ STEQGPPVEE EVDLLGLNPA TNKVDTNTMP 900

SEIKNSSSNI ALLDDLFSDS LSGTADNVKT DFIGHDLLGN RGDFYFIGPP QTSVESSSNS 960

FDIPFSSSDP FDPFAMSTSE NKSSGPDLFE GLVSPNSAST PNVYPSVQSA APPTSNIDFL 1020

NLDNLPTRQS KIVSSASNPD LLGGWSSWEE TSKSSNVFLP KLNKPAFEGP AYSSTSHLST 1080

SSSSSFSQTK SSGFDPFADL DNLSSSLQGS STQFPSQSTE KSAQKVSNSW QSVKQPAKPQ 1140

TGGNPWQSQA KPATQSKPNY TANFSVIGGR EERGIRAPGF GLKPKVSESD FGDLLSNHGF 1200

SAKTDRGGPK TIAEMRRHEL TKDTDPLKLK ILDWIEGKER NIRALISTLH TVLWEGESRW 1260

KPVNMAELVT PDQVKKYYRK AVLVVHPDKA TGQPYEQYAK MIFMELNDAW SEFENQGSRS 1320

LF 1322

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TTCAGTCAGC TTTGGATTTT CTAGCTGGTC CGGGGTCCCT CGGAGGTGCA 60

GGCCGGGACC AACATGACTT CGTGGGACAG ACGGTGGAGA TGGGAGATAT GAAGATGCGG 120

GTCAAGCGAG TTATTGCTGA GGGTGGTTTT GCATTTGTGT ACGAAGCCCA AGATGTAGGA 180

AGTGGAAAAG ACTATGCATT AAAGAGATTG CTGTCCAACG AAGAAGAGAA GAACAAGTCC 240

ATTATTCAAG AAATCTGTTT CATGAAAAAA TTATCTGGCC ATCCCAACAT AGTTCAGTTC 300

TGTTCAGCGG CATCCATTGG AAAAGAAGAA TCCGACACTG GCCAAGGAGA ATTTCTCCTC 360

CTTACAGAAC TGTGTAGAGG ACAACTTGTG GAATTCTTAA ATAAGGCTGA ATGTAAAGGT 420

CCACTGTCCT GTGATACAGT TCTGAAGATT TTTTACCAAA CATGTCGGGC AGTTCAGCAT 480

ATGCATAAAC AAAAACCACC AATAATCCAT AGGGACCTCA AGGTAGAAAA CTTACTTGTT 540

AGTAATCAAG GCACTGTTAA ATTATGCGAT TTTGGCAGTT CAACTACTAT TGCTCATTAT 600

CCTGATTACA ATTGGACAGC CCAACAGAGA GCAACAGTTG AAGATGAAGT TACAAGAAAT 660

ACAACGCCAA TGTATAGAAC TCCAGAAATA ATAGACTTAT ATTCCAACTT TCCCATTGGA 720

GAGAAACAAG ATATATGGGC ACTTGGGTGT ATCTTGTACT TACTGTGCTT TAAACAGCAT 780

CCCTTTGAAG ATGGAGCAAA ACTTCGCATA GTGAATGGAA AATATTCAGT TCCTCAAAAT 840

GACACCAAAT ACACTGTCTT TCATGGCCTT ATCAATTCCA TGATAAAGGT CAATCCAGAG 900

GAAAGGCTGT CTATTACAGA AGTTGTCAGC CAGCTTCAAG AAATTGCGGC AGCTAGGAAT 960

GTTAACCCTA AATCTCCTAT TACTGAGCTC TTGGAGCAAA ATGGTGGTTA TGGGAATACT 1020

GTGATACAAA GGTCATCTTC TGGTGCTCCA CAGAACTCCA AGCCTCTAGC ACATCCTGGC 1080

CTTACACTTA CTGATGATGA TCAGACATCT GGGGGATTCT TTGACATCCT GAAAGGAGGA 1140

ACTGAACGAA TCTTAAGTAA CATTAAAGAT ACATCGTCAA AAGTTATCCA ATCTGTGACC 1200

AATTATGCAA AAGGAGATTT GGATTTATCA TACATAACAT CAAGGATTGC TGTTATGTCA 1260

TTTCCAGCAG AAGGTGTGGA ATCTGCCATT AAAAATAATA TTGAGGATGT TCGCCTGTTT 1320

CTGGACTCAA AACATCCAGG ACATTATGCT GTCTATAACC TGTGTTTAAG AAAATATAGG 1380

CCTTCAAAGT TTCATAACAG GGTTTCAGAA TGTGGCTGGG CTGGAAGACG TGCTCCAAAT 1440

CTTATGAACC TTTACAGCAT TTGCAAAAAT ATGCATTTGT GGTTGAAACA AGATCCGAAG 1500

AACGTCTGCA TTGTTCACTG CACAGATGGA AGAGCCGCAT CAGCAGTTGT GTTGTGTTCC 1560

TTTCTTTGTT TCTGCCGTCT GTTTACCACT GCTGAAGCTG CAGTTTATAT GTTCAGCATG 1620

AAACGGTGCC CGCCAGGTAT ATGGCCTTCT CACAAAAGGT ATATAGAGTA CATGTGTGAC 1680

ATGATGGCAG AGGAGCCAAT CATTCCCCAC AGCAAGCCTA TCCTTATTAG GGCTATAACC 1740

ATGACACCAG TACCTCTGTT CAGCAAACAA CGCAATGGTT GCAGACCATT TTGTGAAGTT 1800

TATGTGGGGG ATGAGAGAGT AGCAACAACA TCTCAAGAGT ATGATAAAAT GAGAGACTTT 1860

AGAAATGAAG ATGGCAAAGC TGAAATTCCT TTAAATGTTA CTGTGCAAGG GGATGTCCTG 1920

ATTGTTATCT ATCATGCACG GTCTACACTT GGCGGCAGAT TGCAAGCAAA GATGACCTCA 1980

ATGAAAATGT TCCAGATTCA GTTCCATACA GGGTTTGTGC CACGAAATGC TACAACAGTA 2040

AAGTTTGCAA AGTATGATCT AGATGCTTGT GACATCCAAG AAAAATATCC TGATCTTTTC 2100

CAAGTAAACC TAGAGGTTGA GGTTTCTTCC CGTGATAAAC AAGCAACCAG CAGCCCTCCA 2160

TGGGAGAATA TAAACACAAA GCGTTTAAAT CCCAAGATCC TTTTTTCCAG CAGAGAGGAA 2220

CAACAGGAAA TGCTGTCTAA ATTTGGCAAA CCTGAACTAC CCAGGCAACC AGGATCAACA 2280

GCACAATATG AAGGAGACAT AAACATGGAG AAACCTTCCC CAGACCTGTC AGACTCTGAA 2340

ACACTCCAGA AAAATAACTT TTTTCAAACA CTCGACTGGC AAGATCAATC GGGAGTAAGA 2400

AATGCTCAGA TTGGTGACCA AGAAAATGTG GCTAAGGAGG ATTATGAAAA TGAATACTTA 2460

AGTGATTCGA AAAGTGAGGC ATCTGATGAA GAATTTTACT CATTTCCTCA AGGAAACAGG 2520

GGAATAAGAT GTGAAGAAAA TGGGCCTGCT GTCGGGACAG ATGATTCAGT AGCCAGAGAG 2580

GTACTGTTTG AGGCCAATAA GGATTCTCAG TCTACAGAAC AGGGACCTCC TGTTGAAGAG 2640

GAAGTTGATT TACTTGGACT TAATCCAGCA ACAAATAAAG TAGACACTAA TACCATGCCC 2700

TCCGAAATAA AGAATTCCTC CAGTAACATA GCATTATTAG ACGATCTTTT TTCAGATAGC 2760

TTGTCTGGCA CTGCTGACAA TGTAAAAACA GACTTTATAG GACATGACTT GCTAGGAAAT 2820

AGAGGGGACT TCTACTTCAT TGGACCTCCT CAAACCTCTG TAGAATCATC AAGCAACTCA 2880

TTTGACATTC CATTTTCTTC TTCTGATCCT TTTGACCCAT TTGCAATGTC TACGTCAGAA 2940

AATAAATCAA GTGGCCCTGA TCTTTTCGAA GGACTTGTCA GCCCAAACTC TGCATCAACT 3000

CCAAATGTAT ATCCTTCAGT ACAAAGTGCA GCACCTCCTA CCTCAAATAT TGATTTCCTA 3060

AACTTGGATA ATCTACCAAC ACGTCAATCA AAAATAGTTT CTTCTGCAAG CAATCCAGAT 3120

CTATTAGGTG GTTGGTCTTC TTGGGAAGAA ACATCTAAGA GCAGCAATGT TTTTCTTCCC 3180

AAACTTAATA AACCAGCTTT TGAAGGTCCT GCATATTCTT CTACCAGTCA CTTAAGTACA 3240

TCTTCAAGTT CATCTTTCAG CCAGACAAAG TCTTCAGGTT TTGACCCTTT TGCTGATCTT 3300

GATAATCTCA GTTCATCCCT GCAAGGCTCC TCAACACAAT TCCCTTCTCA ATCCACTGAA 3360

AAATCTGCAC AGAAAGTCAG TAATTCATGG CAGTCTGTAA AACAACCAGC TAAACCACAG 3420

ACTGGTGGTA ATCCATGGCA ATCACAGGCT AAGCCTGCTA CACAGTCAAA ACCTAACTAC 3480

ACTGCAAACT TTAGTGTGAT CGGAGGGAGA GAAGAAAGAG GTATCAGAGC TCCAGGTTTT 3540

GGACTAAAGC CAAAAGTTTC TGAAAGTGAT TTTGGGGATT TGTTATCCAA TCATGGGTTT 3600

TCAGCAAAAA CAGATAGGGG AGGGCCAAAA ACCATTGCAG AAATGAGAAG ACACGAGCTG 3660

ACAAAGGACA CAGATCCTCT GAAATTAAAG ATTTTAGATT GGATTGAAGG CAAAGAAAGA 3720

AATATAAGGG CACTGATATC CACACTTCAC ACTGTTTTAT GGGAAGGGGA ATCTAGATGG 3780

AAACCTGTCA ACATGGCTGA ATTAGTCACT CCTGATCAAG TAAAGAAATA TTACCGGAAA 3840

GCAGTGCTTG TGGTCCATCC AGACAAGGCT ACTGGGCAGC CCTATGAACA ATATGCCAAA 3900

ATGATCTTCA TGGAACTAAA TGATGCCTGG TCAGAATTTG AAAATCAAGG ATCAAGATCC 3960

CTTTTTTAG 3969

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++v+aeGGfa+vy a+d+ +g+ yalKr+l+neee++++i++Ei++mkklsgh+niv+

Q: 40    RVKRVIAEGGFAFVYEAQDVGSGKDYALKRLLSNEEEKNKSIIQEICFMKKLSGHPNIVQ  99

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g+ e+lll+e+c+ g+lv++lnk + kg ls++++lki+++++rav

Q: 100   FCsaASIGKEESDTGQGEFLLLTELCR-GQLVEFLNKAECKGPLSCDTVLKIFYQTCRAV  158

         **777888999***************9.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+l+s++g+++lcD+GS tt+ + ++   ++q+++++++e++

Q: 159   QHMHKQKPPIIHRDLKVENLLVSNQGTVKLCDFGSSTTIAHYPDynwTAQQRATVEDEVT  218

         *******************************************999999***********

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf ++Pfe+++kl+i+ngkys+P

Q: 219   RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFKQHPFEDGAKLRIVNGKYSVP  278

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +n++ ++ ++ li++m++v+peeR++i++v+++l

Q: 279   QNDTKYTVFHGLINSMIKVNPEERLSITEVVSQL  312

         ******************************9875

Domain Sequence
(FASTA)

RVKRVIAEGG FAFVYEAQDV GSGKDYALKR LLSNEEEKNK SIIQEICFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQGEFL LLTELCRGQL VEFLNKAECK GPLSCDTVLK IFYQTCRAVQ 120

HMHKQKPPII HRDLKVENLL VSNQGTVKLC DFGSSTTIAH YPDYNWTAQQ RATVEDEVTR 180

NTTPMYRTPE IIDLYSNFPI GEKQDIWALG CILYLLCFKQ HPFEDGAKLR IVNGKYSVPQ 240

NDTKYTVFHG LINSMIKVNP EERLSITEVV SQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013