EKS-XET-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	336.5	9.8E-101	1	227	227

Status

Unreviewed

Ensembl Protein

ENSXETP00000008141

UniProt Accession

F7AAR0;

Protein Name

Protein Synonyms/Alias

Gene Name

sik3

Gene Synonyms/Alias

sik3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003762	ENSXETP00000008141	ENSXETT00000008141

Organism

Xenopus tropicalis

Functional Description

Protein Length

1190

Protein Sequence
(FASTA)

QVAIKIIDKT KLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI 60

FDHLVAHGRM AEKEARKKFK QIVAAVHFCH CRNIVHRDLK AENLLLDANL NIKIADFGFS 120

NRFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN 180

LRARVLSGKF RIPFFMSTEC EHLIRHMLVL EPSKRLSMEQ ICKHKWMCQG EQDLEFERLI 240

AECQHVKLER QRDPLNEQVL LTMVEMGLDR ERTLQSLRTD AYDHYSAIYS LLCDRLKRHK 300

TLRLPTQPSA PRTVSYSTPS VQADAASNTV SINVPQVQLI NPENQIVETN GTMTLDSDEA 360

EEPSPEALAR YLSMRRHTVG VPDTHNESGT DELQKIFPGF PRVTQQIPFL PVTQNTNVLH 420

TLLPMPPSAH LEYKEQSLLQ PPTLQLLNGM GPLGRRASDG GANIQMHAQL LLKRPRGPSP 480

LVTMATTVTA VTPVDEESSD GEPDQEAVQS SMYKDSNTLH LPAERFSPVR RFSDGAATIQ 540

AFKAHLEKMG NQNSSIKQLQ QECEQLQKMY GVHMDERTLE HTQQQHVMYQ HEHQHHLLQQ 600

QIQDCIRPAQ PSPPLQSSSM TPASENQPAL LTHQLQRLRI QPSSPPPNPA SNHLFRQPNS 660

SPPPSSSAML QTHGATSSSQ YPGMPTHSSI YQPSSTGSPP PSMALPRMSI QQQQSQQQSP 720

QQVTIQVQEA SDLPGASRGM PIIPCANHIQ MQQRASLMSS MGNYSHRPLS KQLSADNAEV 780

HSLNMAHFSP STNYDQTHLH PHVFAEQPRP PPAVYTSTGS GYGPSGGTAA YSQALKVPQM 840

EQYPGFSTTS QQNYPSSSLQ QALLSPTPGT YTRHHQQLPH MLQGLLSPRH SLTGHTDVRL 900

PPADFMQLIK QHQQQQQELN ELFNQQLSQG DPGNLPYQSA SEPYHHLLQI HPASAATPDS 960

RYHPIMLHSE SMEEDFSGEG QKESEGETVR SLCKPCQETR HGDTESLLGT LALKEQELGV 1020

QQYKTQTSYN RTKSASRAEP GPTANCMDRA SPPHVMDVPD HNGIPYPPRP SSSEHARSRM 1080

LQRHHTIQTS DDAYVQLDSL TGMSLVAGKA LSSARMADAV LSRSSLMGSQ QLQDGESEDC 1140

KADYVENPEE SDLSLLGDSG QHLPTSCFPS TMLLGYKHTD LNFSMEQAGV 1190

Nucleotide Sequence
(FASTA)

CAGGTTGCAA TAAAGATCAT TGATAAAACT AAGCTGGATG AAGAGAACCT AAAGAAAATT 60

TTCAGAGAGG TCCAGATTAT GAAGATGTTG TGTCATCCCC ACATTATCCG CCTTTACCAG 120

GTAATGGAGA CAGAACGAAT GATCTATCTG GTTACTGAGT ATGCAAGCGG AGGCGAGATA 180

TTTGACCACT TAGTGGCTCA TGGACGCATG GCAGAGAAGG AAGCCCGAAA AAAGTTTAAG 240

CAGATTGTGG CTGCTGTCCA TTTCTGTCAC TGTAGGAATA TTGTGCATCG AGACCTGAAG 300

GCTGAAAACC TGCTGCTGGA TGCAAACCTC AACATTAAAA TTGCAGATTT TGGATTTAGT 360

AACCGTTTTA CTCCTGGACA ACTGCTGAAG ACTTGGTGTG GGAGTCCTCC TTATGCAGCG 420

CCAGAATTGT TTGAAGGCAA GGAGTATGAT GGACCAAAGG TTGACATTTG GAGCCTGGGA 480

GTTGTACTAT ATGTTCTGGT TTGTGGAGCC CTCCCATTTG ATGGAAGTAC TTTGCAGAAC 540

CTGCGTGCAC GTGTCCTTAG TGGAAAGTTC CGAATACCCT TTTTCATGTC CACAGAATGC 600

GAACACCTGA TAAGACACAT GCTAGTTCTG GAGCCCAGTA AACGCCTGTC TATGGAGCAG 660

ATTTGCAAAC ATAAGTGGAT GTGCCAAGGA GAGCAGGATC TGGAGTTTGA AAGGTTGATA 720

GCAGAGTGCC AGCACGTGAA GTTAGAGCGG CAGAGGGATC CCCTCAATGA ACAGGTTTTG 780

TTGACAATGG TTGAAATGGG TTTGGACAGA GAACGTACCC TGCAGTCTCT CAGAACAGAT 840

GCCTATGATC ACTATAGTGC TATCTATAGT TTACTCTGCG ATCGTCTGAA GAGGCATAAA 900

ACTCTTCGGC TCCCAACTCA GCCAAGTGCA CCTCGAACTG TTTCCTATTC CACTCCTTCG 960

GTCCAGGCTG ATGCTGCAAG CAATACAGTC AGTATAAATG TACCTCAGGT TCAGCTTATC 1020

AACCCTGAGA ACCAGATAGT TGAGACAAAT GGAACCATGA CTCTGGATAG TGATGAAGCA 1080

GAGGAGCCAT CACCTGAGGC ACTGGCTCGA TACCTGTCTA TGAGGAGACA CACAGTGGGA 1140

GTTCCAGACA CACACAATGA AAGTGGCACT GATGAGCTGC AGAAGATATT TCCTGGTTTT 1200

CCAAGGGTCA CTCAGCAGAT TCCATTTCTA CCAGTGACAC AGAATACCAA TGTTCTGCAC 1260

ACCCTACTGC CCATGCCACC TAGCGCACAC CTCGAGTACA AGGAGCAGTC TCTTCTTCAG 1320

CCCCCTACCC TACAGCTGCT GAATGGAATG GGGCCTCTTG GACGCAGAGC CTCAGATGGA 1380

GGCGCCAACA TTCAAATGCA TGCGCAGCTA CTTCTCAAAC GACCACGTGG ACCTTCTCCG 1440

CTAGTCACCA TGGCAACAAC TGTGACAGCT GTTACACCAG TGGATGAGGA GAGTTCAGAT 1500

GGAGAACCTG ATCAGGAGGC AGTTCAGAGC TCCATGTACA AAGACTCCAA CACACTTCAT 1560

CTTCCTGCTG AGCGTTTCTC TCCAGTTCGG AGATTCTCAG ATGGAGCAGC CACAATCCAG 1620

GCTTTCAAAG CTCACCTAGA GAAGATGGGA AACCAGAATA GCAGCATCAA ACAGCTGCAA 1680

CAGGAATGTG AGCAGCTTCA AAAGATGTAC GGTGTACACA TGGATGAAAG AACTCTGGAG 1740

CATACACAAC AGCAGCATGT CATGTACCAG CACGAGCATC AGCACCATCT CCTCCAGCAG 1800

CAGATTCAGG ATTGTATACG ACCTGCACAA CCTTCCCCTC CTCTTCAGTC ATCTTCTATG 1860

ACACCAGCCT CTGAAAATCA GCCAGCCCTG CTAACACACC AACTACAGAG GTTGCGAATT 1920

CAGCCTTCTA GTCCACCCCC AAACCCAGCC AGCAACCACC TCTTCCGACA GCCAAATAGT 1980

AGTCCCCCTC CATCATCGAG TGCCATGCTC CAGACACATG GGGCCACTTC CTCATCTCAG 2040

TATCCAGGAA TGCCAACCCA CAGTTCAATC TACCAGCCTT CTAGTACTGG ATCACCCCCT 2100

CCCAGCATGG CTTTGCCACG CATGAGCATC CAGCAACAGC AAAGCCAGCA GCAATCACCG 2160

CAGCAAGTCA CCATTCAGGT GCAAGAGGCA TCAGACCTAC CAGGAGCCTC TCGTGGTATG 2220

CCAATTATTC CCTGTGCCAA CCACATTCAG ATGCAGCAGA GGGCGTCATT AATGTCTTCT 2280

ATGGGCAACT ACAGCCACAG ACCCCTTTCT AAGCAGCTGA GTGCTGACAA TGCTGAAGTG 2340

CACAGTTTGA ATATGGCCCA CTTCTCTCCA TCTACAAACT ATGACCAGAC TCACTTGCAC 2400

CCTCATGTAT TTGCTGAGCA GCCAAGGCCT CCTCCAGCTG TTTACACATC CACAGGCTCT 2460

GGATACGGCC CATCTGGCGG CACCGCAGCT TATTCACAGG CTTTAAAGGT TCCTCAGATG 2520

GAGCAATACC CAGGATTCTC CACAACTTCT CAACAGAACT ATCCATCCTC ATCTTTGCAG 2580

CAGGCCTTGC TCTCCCCTAC ACCAGGCACT TACACAAGGC ATCACCAGCA GCTGCCCCAC 2640

ATGCTGCAGG GGCTTCTCTC CCCACGCCAT TCCCTCACTG GCCACACAGA TGTACGTCTA 2700

CCCCCAGCTG ACTTTATGCA GCTCATTAAA CAGCACCAGC AACAGCAGCA GGAGCTCAAT 2760

GAACTCTTTA ACCAGCAGCT GAGCCAAGGT GACCCAGGTA ACCTTCCCTA CCAGAGTGCT 2820

TCTGAGCCCT ACCATCACCT TCTCCAGATC CACCCAGCAT CAGCGGCCAC CCCTGATTCC 2880

AGGTATCACC CAATCATGCT GCATTCAGAG AGCATGGAGG AGGACTTCTC TGGAGAGGGA 2940

CAAAAGGAAT CTGAGGGAGA GACTGTAAGA AGCCTGTGCA AACCATGCCA GGAGACTAGG 3000

CATGGGGACA CAGAGTCTTT GCTTGGAACA CTGGCACTTA AAGAGCAGGA ACTGGGGGTA 3060

CAGCAGTACA AGACACAGAC TTCATATAAC CGGACCAAGT CTGCCAGCAG AGCAGAGCCA 3120

GGGCCTACAG CAAATTGCAT GGACAGAGCC TCCCCACCCC ATGTAATGGA TGTCCCTGAC 3180

CACAACGGTA TTCCCTATCC TCCAAGACCC TCTTCCAGTG AGCATGCCCG ATCGAGGATG 3240

CTTCAAAGGC ACCACACCAT CCAGACAAGT GATGATGCCT ATGTACAGCT AGATAGTCTA 3300

ACCGGGATGA GTTTAGTGGC TGGAAAAGCT CTTAGCTCTG CTCGCATGGC TGATGCAGTT 3360

TTGAGCCGCT CTTCACTTAT GGGAAGTCAG CAACTTCAAG ATGGAGAGAG TGAAGACTGT 3420

AAGGCAGACT ATGTGGAAAA TCCAGAAGAA TCAGATTTAT CTTTACTCGG TGACAGTGGT 3480

CAACATCTGC CAACCTCCTG CTTTCCTTCC ACTATGTTAT TGGGTTACAA GCACACAGAT 3540

CTGAACTTCA GCATGGAGCA GGCAGGAGTT TGA 3573

Domain Profile

S: 26    kvavKiikkkklseeslekikrEieilkklkhpniikllevietkkklylvleyasggeL  85

         +va+Kii+k+kl+ee+l+ki+rE++i+k+l hp+ii+l++v+et++++ylv+eyasgge+

Q: 1     QVAIKIIDKTKLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  60

         69**********************************************************

S: 86    fdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGla  145

         fd+++++gr+ ekeark fkq+v+av+++h ++ivHrDlK+eNllld++ nikiaDFG++

Q: 61    FDHLVAHGRMAEKEARKKFKQIVAAVHFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  120

         ************************************************************

S: 146   nlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlke  205

         n f++g+ll+t+cGsppYaaPel++gk+Y+gpkvD+WslGvvLy+lv+g+lPfd+++l++

Q: 121   NRFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  180

         ************************************************************

S: 206   llekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         l++++l+gk++ip+ +s+e+e+L+r++Lv +p+kR+++e+i kh+w+

Q: 181   LRARVLSGKFRIPFFMSTECEHLIRHMLVLEPSKRLSMEQICKHKWM  227

         **********************************************8

Domain Sequence
(FASTA)

QVAIKIIDKT KLDEENLKKI FREVQIMKML CHPHIIRLYQ VMETERMIYL VTEYASGGEI 60

FDHLVAHGRM AEKEARKKFK QIVAAVHFCH CRNIVHRDLK AENLLLDANL NIKIADFGFS 120

NRFTPGQLLK TWCGSPPYAA PELFEGKEYD GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN 180

LRARVLSGKF RIPFFMSTEC EHLIRHMLVL EPSKRLSMEQ ICKHKWM 227

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013