EKS-XET-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	402.0	1.1E-120	469	723	255

Status

Unreviewed

Ensembl Protein

ENSXETP00000008450

UniProt Accession

F6TN72;

Protein Name

Protein Synonyms/Alias

Gene Name

mylk3

Gene Synonyms/Alias

mylk3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000003892	ENSXETP00000008450	ENSXETT00000008450

Organism

Xenopus tropicalis

Functional Description

Protein Length

772

Protein Sequence
(FASTA)

VSNMDKKLNL LNEKMDKILH FQEDVMGKLE YVHHNMDMLE KGMDMLAALR GPSQQILHEN 60

VDISQSPGHN SCSNLIRLLK LIHEDSVIHR EKLDSLERMV STMDKVVAFV GSTLRNSKIV 120

DFILKGTVPW KKESKDEGFE EAKDKSEEKE VKTKQGLNRG EGQVEAQRLN EVLIRKEVKN 180

YQIISLLLNT FLHKTDIYKI NKKPKHGMHF IIHFNVPDSR KSSAQEERTE KENIRVAQHN 240

QAATNQVPEQ STRQKDHNSG TKEENHSSVS ISKSGSMLKL KQSSKEQVLR YFLTPEYIIF 300

RTNTSEQLII KKTELMTPGK DTVKQTSAFH GIDISQEVVA EDKQPSLSVK LGKVQPSFNK 360

TTKCIKRQES CDKKSVGQQR TSDTDRVQLT EDHGKGAEEH QIDIVGLPSL KVGKWHKAAG 420

LENTLVNRIR NSQSCIVICL DDCPPPPAPF NHRIVSIKQA ILSSCYSVSQ HEVLGGGRFG 480

QVHKCIEKAT GLQLAAKIIK VKGAKDRDEV KNEINVMNQL NHVNLIQLYD AFECKNDLTL 540

IMEYLDGGEL FDRITDENYS LTELDAIMFT KQICEGIYYL HQQYILHLDL KPENILCVNR 600

TGNQIKIIDF GLARRYKPRE KLKVNFGTPE FLAPEVVNYD FVSFPTDMWS VGVITYMLLS 660

GLSPFLGESD AETMNYIVNC NWDFESESFE QVSEEAKDFI SKLLIKERSC RLSAGQCLKH 720

DWLVNLPLKA MKYKVRLKSQ ILLQKYMAQK KWKKHFYVVA AANRLKKFQA LS 772

Nucleotide Sequence
(FASTA)

GTCAGCAATA TGGACAAAAA GCTGAATCTG CTGAATGAGA AAATGGACAA GATTTTACAC 60

TTTCAAGAAG ATGTTATGGG AAAACTGGAA TATGTGCATC ACAACATGGA CATGTTGGAA 120

AAAGGAATGG ACATGCTGGC AGCTTTACGT GGGCCCAGTC AACAGATTCT TCATGAAAAT 180

GTTGATATTA GTCAGAGTCC TGGACACAAT TCTTGCTCAA ATTTAATAAG ACTGCTAAAG 240

TTGATACATG AGGATTCTGT GATCCACAGA GAGAAGTTAG ACAGTCTAGA AAGGATGGTG 300

TCAACAATGG ACAAGGTGGT GGCATTTGTG GGAAGTACTC TAAGGAACTC TAAAATTGTA 360

GACTTTATCC TAAAGGGTAC AGTGCCATGG AAAAAGGAGT CAAAAGATGA GGGTTTTGAA 420

GAGGCTAAAG ACAAATCTGA AGAGAAAGAA GTCAAAACAA AGCAGGGACT TAACAGAGGA 480

GAGGGGCAGG TGGAGGCACA GAGATTAAAT GAAGTGCTTA TAAGAAAAGA GGTTAAAAAC 540

TACCAGATAA TCTCATTGTT ATTAAATACC TTCCTACATA AGACAGACAT TTACAAAATC 600

AATAAAAAAC CTAAACATGG TATGCATTTT ATAATACATT TTAATGTTCC AGACAGCAGA 660

AAAAGCAGTG CACAGGAAGA AAGGACAGAG AAGGAAAATA TTCGGGTGGC CCAGCACAAC 720

CAGGCTGCGA CCAATCAAGT CCCAGAGCAG AGCACCAGGC AGAAGGACCA TAATTCAGGA 780

ACTAAGGAGG AAAATCATAG TTCCGTGTCC ATCAGCAAAT CTGGATCAAT GTTGAAACTC 840

AAACAATCAA GTAAAGAACA AGTTCTAAGA TATTTTCTTA CTCCTGAATA TATAATATTC 900

AGGACAAATA CTTCTGAGCA ACTTATAATA AAAAAAACAG AATTAATGAC TCCAGGAAAA 960

GACACAGTGA AGCAAACATC TGCCTTTCAT GGCATTGATA TTTCCCAGGA AGTTGTAGCG 1020

GAAGACAAAC AACCCTCTCT AAGTGTAAAA CTTGGAAAGG TTCAGCCATC ATTTAATAAA 1080

ACCACAAAGT GCATCAAAAG GCAGGAGAGC TGTGATAAAA AATCTGTCGG ACAGCAAAGG 1140

ACTAGTGACA CAGACCGTGT ACAGCTAACA GAAGACCATG GAAAAGGAGC AGAAGAACAT 1200

CAAATAGATA TAGTTGGACT ACCTTCATTA AAAGTGGGCA AATGGCATAA GGCAGCAGGG 1260

CTAGAGAATA CTCTAGTGAA CAGAATCAGG AACAGCCAGA GCTGTATAGT CATATGTTTA 1320

GATGACTGCC CTCCGCCTCC TGCACCATTC AACCATCGGA TAGTGAGCAT TAAGCAAGCA 1380

ATCTTGTCGT CATGTTATTC TGTGAGCCAA CATGAGGTCT TAGGAGGGGG GCGCTTTGGC 1440

CAAGTTCACA AGTGTATAGA AAAAGCAACT GGGCTTCAGC TAGCAGCAAA AATAATCAAA 1500

GTCAAAGGAG CAAAGGACAG GGATGAAGTG AAAAATGAAA TCAATGTCAT GAACCAACTA 1560

AATCACGTGA ACCTGATACA GCTCTATGAT GCATTTGAAT GCAAGAATGA CCTGACCTTG 1620

ATAATGGAAT ATCTGGATGG TGGAGAACTA TTTGACCGCA TCACGGATGA AAACTACAGT 1680

CTGACAGAGC TGGATGCAAT AATGTTCACC AAACAGATCT GTGAAGGAAT ATACTATCTT 1740

CACCAACAGT ATATACTGCA TCTAGATCTA AAACCAGAAA ATATTTTATG TGTCAATCGA 1800

ACTGGCAACC AAATCAAAAT TATTGACTTT GGATTGGCAA GAAGGTACAA GCCACGTGAG 1860

AAGTTGAAGG TGAATTTTGG CACTCCGGAA TTTCTGGCCC CTGAAGTAGT GAATTATGAT 1920

TTTGTGTCTT TTCCAACAGA CATGTGGAGT GTGGGAGTCA TTACGTACAT GCTGCTCAGT 1980

GGTTTGTCCC CGTTCCTGGG GGAGAGTGAT GCTGAGACAA TGAATTACAT TGTAAACTGC 2040

AACTGGGACT TTGAGTCTGA ATCATTTGAG CAGGTGTCAG AGGAGGCCAA AGACTTTATT 2100

TCCAAACTCT TGATAAAAGA AAGGAGCTGT AGACTTAGTG CAGGACAGTG TCTTAAGCAT 2160

GATTGGCTTG TCAACCTGCC ACTAAAAGCC ATGAAATACA AAGTGCGCTT GAAGTCCCAG 2220

ATCCTCCTTC AGAAATACAT GGCACAAAAG AAATGGAAAA AACACTTCTA CGTGGTTGCT 2280

GCAGCTAATC GCCTCAAGAA GTTTCAGGCC CTCTCT 2316

Domain Profile

S: 2     sikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliql  61

         s++e lg G+fg+v+k++ek+tg +laaki+kv+ +kd++evk+Ei+++nql+H +liql

Q: 469   SQHEVLGGGRFGQVHKCIEKATGLQLAAKIIKVKGAKDRDEVKNEINVMNQLNHVNLIQL  528

         67899*******************************************************

S: 62    ydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHl  121

         ydafe k++++l++E+++ggelf+ri++e+y+ltE + ++f++q++e++ ylH+++i+Hl

Q: 529   YDAFECKNDLTLIMEYLDGGELFDRITDENYSLTELDAIMFTKQICEGIYYLHQQYILHL  588

         ************************************************************

S: 122   dlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDm  181

         dlkpenil+++++++qiK+idFGlar++k++eklkv+fgtpef+aPEvvn+++vs+ tDm

Q: 589   DLKPENILCVNRTGNQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDM  648

         ************************************************************

S: 182   WsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkek  241

         WsvGvity+LlsGlsPFlg++d+et++ + ++++df++e+f++vseeakdFiskll+ke+

Q: 649   WSVGVITYMLLSGLSPFLGESDAETMNYIVNCNWDFESESFEQVSEEAKDFISKLLIKER  708

         ************************************************************

S: 242   kkRmsaeeaLkhkwl  256

         ++R+sa ++Lkh wl

Q: 709   SCRLSAGQCLKHDWL  723

         **************8

Domain Sequence
(FASTA)

SQHEVLGGGR FGQVHKCIEK ATGLQLAAKI IKVKGAKDRD EVKNEINVMN QLNHVNLIQL 60

YDAFECKNDL TLIMEYLDGG ELFDRITDEN YSLTELDAIM FTKQICEGIY YLHQQYILHL 120

DLKPENILCV NRTGNQIKII DFGLARRYKP REKLKVNFGT PEFLAPEVVN YDFVSFPTDM 180

WSVGVITYML LSGLSPFLGE SDAETMNYIV NCNWDFESES FEQVSEEAKD FISKLLIKER 240

SCRLSAGQCL KHDWL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0003007	; P:heart morphogenesis
GO:0048769	; P:sarcomerogenesis
GO:0055005	; P:ventricular cardiac myofibril development

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013