EKS-XET-00485

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00485

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.1	3.2E-130	245	493	249

Status

Unreviewed

Ensembl Protein

ENSXETP00000011470

UniProt Accession

F6ULV4;

Protein Name

Protein Synonyms/Alias

Gene Name

lck

Gene Synonyms/Alias

lck;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000005250	ENSXETP00000011470	ENSXETT00000011470

Organism

Xenopus tropicalis

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MGCGCSSEYE DDWIENFDVC DHCHLPRQKL TKMAAILLIT CYDIQDPLVS YTGLNPPSSP 60

LHDNLVVALY NYEPMHDEDL GFEAGEKLHV LEQKDEWWKA KSLRTGQVGY IPYNFVASVN 120

GIESEMWFFR DLGRKDAERQ LLAPGNQQGS FLVRESETTK GSYSLSVRDL DQNQGEVVKH 180

YKIRNLDNGG FYISPRKTFQ TLQELVQHYR RSSDGLCTLL KEPCQTQRPQ KPWWADEWEI 240

PRNKLQLVKK LGAGQFGEVW MGYYNGHTKV AIKSLKPGTM SPEAFLAEAN LMKQLQHPRL 300

VRLNAVVTQE PIYIVTEYME KGCLVDYLKT SEGLKLTIYK LIDMSAQVAE GMAFLEHKNY 360

IHRDLRAANI LVSESLCCKI ADFGLARVIV DNEYTAKEGA KFPIKWTAPE AINYGTFTIK 420

SDVWSFGVLL TEIVTYGRIP YPGMTNPEVI ENLERGYRMP QPDNCPMELY ELMLRCWKEE 480

PEERPTFEFL RSLLEDFFTA TEGPYQSQP 509

Nucleotide Sequence
(FASTA)

ATGGGATGTG GGTGCAGCTC TGAGTATGAA GATGACTGGA TTGAAAATTT TGATGTGTGT 60

GATCACTGCC ATCTTCCTAG ACAGAAACTA ACCAAGATGG CAGCTATATT ACTCATCACA 120

TGCTATGATA TTCAGGACCC CTTGGTTTCA TACACAGGCT TAAATCCACC TAGCTCTCCG 180

CTGCATGATA ACCTGGTGGT GGCCTTGTAT AATTATGAGC CTATGCATGA TGAAGATCTG 240

GGATTTGAAG CTGGAGAGAA GCTGCATGTC CTGGAGCAGA AAGACGAATG GTGGAAGGCT 300

AAGTCTCTAC GAACAGGGCA GGTGGGATAC ATACCATATA ACTTTGTGGC ATCTGTAAAT 360

GGCATTGAAT CTGAAATGTG GTTTTTTAGA GATCTGGGCA GAAAAGATGC AGAACGACAG 420

CTTCTGGCTC CTGGAAATCA ACAGGGATCC TTCCTAGTGA GGGAGAGTGA GACTACCAAA 480

GGATCCTACT CTCTTTCTGT GAGGGATCTG GATCAAAATC AGGGAGAGGT GGTGAAACAT 540

TACAAGATTC GAAATCTGGA CAACGGTGGA TTTTATATAT CTCCTAGAAA AACGTTCCAA 600

ACGCTACAAG AACTGGTGCA GCATTACAGG CGTTCCTCAG ATGGGCTGTG CACTCTTTTG 660

AAAGAGCCAT GCCAGACTCA ACGTCCTCAA AAACCATGGT GGGCAGATGA ATGGGAAATA 720

CCTCGCAACA AACTGCAACT GGTCAAGAAG CTTGGTGCTG GGCAGTTTGG TGAGGTGTGG 780

ATGGGCTACT ATAATGGACA CACAAAAGTT GCCATAAAGA GCCTAAAACC GGGTACAATG 840

TCTCCAGAAG CCTTCTTGGC TGAGGCTAAT TTAATGAAAC AATTGCAGCA CCCACGACTG 900

GTTCGATTAA ATGCTGTTGT AACTCAGGAG CCCATATATA TTGTAACAGA GTACATGGAG 960

AAAGGTTGCC TTGTGGATTA TTTAAAAACC TCAGAAGGTC TCAAATTAAC CATCTATAAA 1020

CTAATAGACA TGTCTGCTCA GGTGGCAGAG GGAATGGCTT TCCTAGAGCA TAAGAATTAC 1080

ATTCACCGGG ATCTGCGAGC CGCTAATATT CTTGTGTCTG AGTCTCTGTG TTGCAAGATA 1140

GCTGATTTTG GACTGGCTCG AGTAATAGTT GACAATGAGT ACACAGCAAA AGAAGGAGCC 1200

AAATTTCCTA TAAAATGGAC AGCTCCTGAA GCCATTAATT ATGGCACTTT CACCATCAAA 1260

TCAGATGTGT GGTCATTTGG TGTACTGCTA ACTGAAATTG TCACTTATGG AAGAATTCCA 1320

TACCCAGGCA TGACTAATCC AGAGGTTATA GAAAATCTGG AACGAGGTTA TCGTATGCCT 1380

CAGCCAGACA ACTGTCCTAT GGAATTGTAT GAGCTGATGC TTCGTTGTTG GAAGGAGGAA 1440

CCTGAGGAAA GGCCCACGTT TGAATTTCTA CGATCCTTGC TTGAAGATTT CTTCACAGCT 1500

ACAGAGGGCC CATATCAGTC TCAGCCATAA 1530

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+lvkklG+GqfGevw+g+++g++kva+k+lk+gt+speafl+ea+++k+l+h++lv+l

Q: 245   LQLVKKLGAGQFGEVWMGYYNGHTKVAIKSLKPGTMSPEAFLAEANLMKQLQHPRLVRLN  304

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+m+kG+l+d+lk++eg kl++ kl+d++aqvaeGma+le+kn+ihr

Q: 305   AVVTQ-EPIYIVTEYMEKGCLVDYLKTSEGLKLTIYKLIDMSAQVAEGMAFLEHKNYIHR  363

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+esl++k+adfGlar+i d+eytakegak+PikWtaPeai++g+ftiksdv

Q: 364   DLRAANILVSESLCCKIADFGLARVIVDNEYTAKEGAKFPIKWTAPEAINYGTFTIKSDV  423

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+llteivt+G++PypGmtn ev+e++ergyr+p+p++cp elyel+l+cwk++pee

Q: 424   WSFGVLLTEIVTYGRIPYPGMTNPEVIENLERGYRMPQPDNCPMELYELMLRCWKEEPEE  483

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+l++

Q: 484   RPTFEFLRSL  493

         *******986

Domain Sequence
(FASTA)

LQLVKKLGAG QFGEVWMGYY NGHTKVAIKS LKPGTMSPEA FLAEANLMKQ LQHPRLVRLN 60

AVVTQEPIYI VTEYMEKGCL VDYLKTSEGL KLTIYKLIDM SAQVAEGMAF LEHKNYIHRD 120

LRAANILVSE SLCCKIADFG LARVIVDNEY TAKEGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGVLLTEIV TYGRIPYPGM TNPEVIENLE RGYRMPQPDN CPMELYELML RCWKEEPEER 240

PTFEFLRSL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013