EKS-XET-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	323.9	8.2E-97	384	631	248

Status

Unreviewed

Ensembl Protein

ENSXETP00000011654

UniProt Accession

A0JP99;

Protein Name

Protein Synonyms/Alias

LOC100036644 protein;

Gene Name

pak4

Gene Synonyms/Alias

pak4; LOC100036644;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000005314	ENSXETP00000011654	ENSXETT00000011654

Organism

Xenopus tropicalis

Functional Description

Protein Length

650

Protein Sequence
(FASTA)

MFGKKKKRIE ISAPLNFEHR VHTGFDQQEQ KFTGLPRQWQ SLIEESAKRP KPLVDPSYIT 60

TINHVPQKTI VRGSKMSLDG SLAWLLDEFD AMSICRSNSL RRESPPCHPR EDRFHQENGM 120

SEVRVRQQRE DGQRGSERNR SEHSRRERQR EEHKAVPQQP RGQEPSNKHR PPPPDYPKDI 180

PEKRGTRSHE KGDGRREYPV NDRGYSEPVE RVVKREKGEE KRPKSSYTSA EGSPQSPRDK 240

RPLSGPSIRT PGSSSTEGVV KQTQTGRAFN TYPRAETDPS RGAPHQVPDS HSTVPLDSKS 300

TVSKSSSRPQ QGQVKPKLPD KPHPTQLVPH SSDPQLSHPV QTQHPAQPRS PQREPQRVSH 360

EQFRAALQMV VDPGDPRTYL DNFIKIGEGS TGIVCIATIK SSGKLVAVKK MDLRKQQRRE 420

LLFNEVVIMR DYQHENVVEM YNSYLVGDEL WVIMEFLEGG ALTDIVTHTR MNEEQIATVC 480

VSVLKALSVL HAQGVIHRDI KSDSILLTHD GRVKLSDFGF CAQVNKEVPR RKSLVGTPYW 540

MAPELISRLP YGPEVDIWSL GIMVIEMVDG EPPYFNEPPL KAMKMIRDNL PPKLKNAQKV 600

SPLLKGFLDR LLVRDPSQRA SANELLKHPF LGKAGPPSCI VPLMRQNRLR 650

Nucleotide Sequence
(FASTA)

ATGTTTGGTA AGAAGAAAAA GCGTATCGAG ATCTCTGCTC CATTAAATTT TGAACACCGG 60

GTGCATACTG GCTTTGATCA GCAGGAACAG AAGTTCACAG GTCTTCCTCG ACAGTGGCAA 120

AGCTTAATTG AGGAGTCTGC CAAGAGACCA AAGCCACTGG TTGACCCATC CTATATCACA 180

ACAATTAATC ATGTCCCTCA GAAGACTATT GTTCGTGGCA GCAAGATGTC ATTGGATGGG 240

TCCTTGGCAT GGCTCCTGGA TGAGTTTGAT GCCATGTCAA TTTGCCGCTC AAACTCTTTG 300

CGTAGAGAGA GTCCTCCATG TCACCCCCGA GAGGACCGGT TTCACCAGGA AAATGGTATG 360

AGTGAAGTCC GTGTACGGCA GCAAAGGGAA GATGGACAAA GAGGGTCAGA GAGAAACAGA 420

TCAGAACATT CCAGAAGAGA GAGACAAAGA GAAGAACACA AAGCAGTTCC CCAGCAACCA 480

CGAGGACAAG AACCAAGCAA TAAGCACAGA CCGCCACCAC CAGACTATCC TAAAGATATA 540

CCTGAGAAAA GAGGCACACG CTCGCATGAA AAGGGTGATG GGAGAAGAGA ATACCCTGTA 600

AATGACCGTG GCTATAGTGA ACCTGTAGAA CGAGTAGTAA AGAGGGAAAA GGGAGAAGAG 660

AAGAGACCTA AGTCATCATA CACAAGTGCA GAGGGCAGCC CGCAGTCTCC AAGAGACAAG 720

AGGCCTCTCT CTGGGCCCAG TATTCGCACT CCTGGTAGTT CTTCTACAGA GGGAGTAGTA 780

AAACAAACAC AGACAGGAAG GGCATTCAAT ACCTACCCCC GTGCTGAAAC TGACCCCAGT 840

AGAGGGGCAC CTCACCAGGT GCCTGATTCT CATTCTACTG TTCCACTTGA CTCCAAAAGC 900

ACTGTAAGCA AAAGCTCTTC TCGTCCTCAG CAAGGACAAG TCAAGCCCAA GCTTCCAGAC 960

AAGCCTCATC CTACACAGCT TGTCCCACAC AGCTCAGATC CTCAGCTCTC CCATCCTGTT 1020

CAGACCCAGC ATCCTGCCCA GCCCCGTTCT CCACAGAGAG AGCCACAGCG CGTGTCTCAT 1080

GAGCAGTTTC GGGCAGCCCT GCAAATGGTT GTGGACCCTG GTGATCCAAG GACTTACTTA 1140

GATAACTTTA TTAAAATTGG TGAGGGCTCA ACAGGAATTG TTTGCATTGC TACCATAAAG 1200

AGCAGTGGGA AACTTGTAGC TGTAAAAAAA ATGGACCTTC GTAAACAACA GAGGCGAGAA 1260

CTACTCTTCA ACGAGGTTGT TATAATGAGG GATTACCAAC ATGAGAATGT GGTTGAGATG 1320

TACAACAGTT ACCTTGTGGG GGATGAACTA TGGGTTATTA TGGAGTTCCT GGAAGGAGGT 1380

GCACTTACTG ACATTGTAAC ACACACCAGG ATGAACGAAG AACAGATAGC TACTGTCTGC 1440

GTGTCTGTGC TAAAAGCTTT GTCTGTACTT CATGCTCAAG GCGTCATTCA CCGAGATATT 1500

AAGAGCGATT CCATACTACT AACACATGAT GGACGGGTGA AACTTTCAGA TTTTGGATTC 1560

TGTGCTCAAG TTAATAAGGA AGTTCCTCGA CGCAAATCTT TAGTTGGCAC ACCTTACTGG 1620

ATGGCTCCAG AGCTAATTTC GCGGCTACCA TATGGACCAG AGGTTGATAT TTGGTCTCTT 1680

GGAATAATGG TGATTGAGAT GGTGGACGGA GAACCTCCTT ATTTTAATGA GCCCCCACTA 1740

AAGGCTATGA AAATGATTCG GGACAATCTC CCCCCCAAGC TAAAAAATGC ACAGAAGGTA 1800

TCTCCATTGC TAAAGGGATT TTTGGATCGA CTTCTTGTTA GAGATCCCAG CCAAAGAGCT 1860

TCAGCTAATG AGCTTCTTAA ACACCCCTTC TTGGGGAAAG CTGGACCGCC ATCTTGTATT 1920

GTCCCACTAA TGAGACAGAA TCGTTTGAGA TGA 1953

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ k++g+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++s

Q: 384   IKIGEGSTGIVCIATIKSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNS  443

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw++me+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ lH+++viHrdi

Q: 444   YLVGDELWVIMEFLEGGALTDIVT---HTRMNEEQIATVCVSVLKALSVLHAQGVIHRDI  500

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g+VkLsdfg++aq++k++ +rk++vgtpywmAPE+i+  +  Y  ++Diw

Q: 501   KSDSILLTHDGRVKLSDFGFCAQVNKEVPRRKSLVGTPYWMAPELIS--RLPYGPEVDIW  558

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++plka+ +i +n ppklk+ +k+s+ +k f++++l ++p++

Q: 559   SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNAQKVSPLLKGFLDRLLVRDPSQ  618

         ************************************************************

S: 245   RpsasellkhkFl  257

         R+sa+ellkh+Fl

Q: 619   RASANELLKHPFL  631

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATIKSSG KLVAVKKMDL RKQQRRELLF NEVVIMRDYQ HENVVEMYNS 60

YLVGDELWVI MEFLEGGALT DIVTHTRMNE EQIATVCVSV LKALSVLHAQ GVIHRDIKSD 120

SILLTHDGRV KLSDFGFCAQ VNKEVPRRKS LVGTPYWMAP ELISRLPYGP EVDIWSLGIM 180

VIEMVDGEPP YFNEPPLKAM KMIRDNLPPK LKNAQKVSPL LKGFLDRLLV RDPSQRASAN 240

ELLKHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:100036644

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013