EKS-XET-00488

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00488

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	332.5	1.7E-99	243	497	255

Status

Unreviewed

Ensembl Protein

ENSXETP00000060040

UniProt Accession

F7EFA1;

Protein Name

Protein Synonyms/Alias

Gene Name

lyn

Gene Synonyms/Alias

lyn;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000005650	ENSXETP00000012464	ENSXETT00000012464
ENSXETG00000005650	ENSXETP00000060040	ENSXETT00000065618

Organism

Xenopus tropicalis

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSRQST PQDDMGKNNP VRKNDRTIYV PDPTAKLQRP VTCSPPLPWQ QHKQREIEEQ 60

GNIVIALYPY QGIHQDDLTF KKGEKLKVIE EHGEWWKAKS LSSKKEGFIP SNYVARVNTL 120

ETEEWFFKDI TRKDAERQLL APGNNPGAFL IRESETSKGS YSLSIRDYDP KTGDVIKHYK 180

IRTLDNGGYY ISPRITFTSI CDMIQHYQKQ ADGLCRKLDK PCYSPKPQKP WDKDAWEIPR 240

ESIKLVKKLG AGQFGEVWMD FYLHSTMQGQ KRLQPTVSSS ASLQEPQIRK TLVGKMWHRP 300

YRLPTPSESS YVLTQSCAFL LTGSLLDFLK SDEGAKVILP KLIDFSAQIA EGMAYIEKKN 360

YIHRDLRAAN VLVSESLMCK IADFGLARVI EDNEYTAREG AKFPIKWTAP EAINFGSFTI 420

KSDVWSFGVL LYEIITTGKI PYPGKGMSNS DVMTALQRGY RMPRMENCPV ELYDIMKECW 480

KEKAEERPTF DYLQSVLDDF YTATEAQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCGAG ACAGTCCACT CCTCAAGATG ATATGGGGAA GAATAATCCA 60

GTACGTAAAA ATGATCGAAC TATTTATGTG CCAGATCCAA CGGCTAAACT GCAAAGGCCA 120

GTAACATGCT CCCCTCCCCT CCCCTGGCAG CAGCACAAGC AGAGAGAAAT CGAAGAACAG 180

GGGAACATTG TGATAGCCTT ATATCCATAT CAGGGAATCC ACCAAGATGA CTTGACTTTC 240

AAAAAAGGAG AAAAACTTAA GGTCATTGAA GAGCATGGAG AATGGTGGAA AGCTAAATCT 300

TTATCAAGCA AAAAAGAGGG TTTTATACCA AGCAATTATG TGGCCCGAGT GAACACACTA 360

GAAACAGAAG AATGGTTTTT TAAGGACATT ACCAGAAAAG ATGCAGAAAG ACAACTTTTG 420

GCACCTGGTA ACAATCCTGG AGCTTTCCTG ATCAGAGAAA GTGAAACATC AAAAGGCAGC 480

TACTCACTGT CAATTAGAGA TTATGATCCA AAGACTGGAG ATGTTATCAA GCACTACAAG 540

ATCAGGACTT TAGATAATGG TGGCTATTAC ATTTCTCCTA GAATTACATT TACTAGCATC 600

TGTGACATGA TCCAGCATTA CCAAAAGCAA GCGGATGGCC TATGCAGGAA ACTTGACAAA 660

CCGTGTTATA GCCCTAAACC ACAGAAACCT TGGGACAAAG ACGCTTGGGA AATTCCAAGG 720

GAATCCATAA AGCTGGTGAA AAAGCTCGGA GCTGGTCAGT TTGGTGAAGT GTGGATGGAC 780

TTTTATCTCC ACTCCACAAT GCAGGGCCAG AAGAGGTTGC AACCAACTGT TTCCTCTTCA 840

GCGTCACTTC AGGAGCCACA GATCAGAAAA ACTTTGGTAG GGAAGATGTG GCATAGGCCT 900

TATAGATTAC CTACCCCCTC TGAGTCTAGC TATGTGTTAA CACAGTCTTG TGCATTTTTG 960

TTAACAGGGA GTCTTCTAGA TTTTCTGAAG AGCGACGAAG GGGCCAAAGT AATCCTTCCT 1020

AAATTAATTG ACTTCTCTGC TCAGATTGCT GAAGGCATGG CTTATATAGA AAAAAAGAAC 1080

TACATCCACC GAGATCTGAG AGCCGCTAAT GTGCTTGTTT CAGAATCCTT AATGTGCAAA 1140

ATTGCTGACT TTGGTCTTGC CCGAGTAATT GAAGATAATG AGTACACCGC AAGGGAAGGT 1200

GCTAAGTTCC CTATCAAATG GACTGCGCCA GAGGCAATTA ATTTCGGTTC ATTTACAATA 1260

AAATCTGATG TGTGGTCTTT TGGCGTTCTG TTGTATGAAA TAATAACCAC TGGAAAGATC 1320

CCTTATCCAG GTAAAGGAAT GAGCAATTCA GATGTGATGA CCGCCCTGCA GCGAGGCTAC 1380

CGTATGCCCC GCATGGAAAA CTGTCCCGTA GAACTGTATG ACATCATGAA AGAGTGCTGG 1440

AAGGAGAAGG CAGAGGAACG GCCAACATTT GATTATTTAC AAAGCGTTCT GGATGATTTC 1500

TACACAGCAA CAGAGGCACA ATATCAACAG CAGCCTTAG 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvkklG+GqfGevw+  + +s+    k l++ t+s++a l+e qi k+l  +   + y

Q: 243   IKLVKKLGAGQFGEVWMDFYLHSTMQGQKRLQP-TVSSSASLQEPQIRKTLVGKMWHRPY  301

         689****************************98.67888999******************

S: 61    avvseeePiyivte...lmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknl  117

          + +  e  y++t+   ++  Gslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+

Q: 302   RLPTPSESSYVLTQscaFLLTGSLLDFLKSDEGAKVILPKLIDFSAQIAEGMAYIEKKNY  361

         ************96555899****************************************

S: 118   ihrdlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftik  177

         ihrdl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftik

Q: 362   IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIK  421

         ************************************************************

S: 178   sdvWsfGillteivtkGkvPyp..Gmtneevleqvergyrlprpeecpeelyelllecwk  235

         sdvWsfG+ll+ei+t+Gk+Pyp  Gm+n++v+++++rgyr+pr+e+cp ely++++ecwk

Q: 422   SDVWSFGVLLYEIITTGKIPYPgkGMSNSDVMTALQRGYRMPRMENCPVELYDIMKECWK  481

         *********************84469**********************************

S: 236   kdpeerPtfetlqevl  251

         +++eerPtf++lq+vl

Q: 482   EKAEERPTFDYLQSVL  497

         *************986

Domain Sequence
(FASTA)

IKLVKKLGAG QFGEVWMDFY LHSTMQGQKR LQPTVSSSAS LQEPQIRKTL VGKMWHRPYR 60

LPTPSESSYV LTQSCAFLLT GSLLDFLKSD EGAKVILPKL IDFSAQIAEG MAYIEKKNYI 120

HRDLRAANVL VSESLMCKIA DFGLARVIED NEYTAREGAK FPIKWTAPEA INFGSFTIKS 180

DVWSFGVLLY EIITTGKIPY PGKGMSNSDV MTALQRGYRM PRMENCPVEL YDIMKECWKE 240

KAEERPTFDY LQSVL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013