EKS-XET-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKN	462.8	3.4E-139	661	925	265

Status

Unreviewed

Ensembl Protein

ENSXETP00000013445

UniProt Accession

F7CM85;

Protein Name

Protein Synonyms/Alias

Gene Name

pkn2

Gene Synonyms/Alias

pkn2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006092	ENSXETP00000013445	ENSXETT00000013445

Organism

Xenopus tropicalis

Functional Description

Protein Length

993

Protein Sequence
(FASTA)

LQKNVPSGQV LSAILLGDPR SSIVAEPMGI FPKIDFSDPL AQPHLDEMKD QIKREIRKEL 60

KIKEGAENLR KVTTDKKNLA YVDNILKKSN KKLEELHNNL QELNAHIVMR EAENLPDCPK 120

TPDTPKSDSG SSAFNGRLIA LQKQLDIELK VKQGAENMIQ TYSNGPSKDR KLLGTAQQML 180

QDSKTKIEVI RMQILQANQQ TNEMSFDNAK PVISPLELRM EELRHHVRIE FAVTEGAKNV 240

MKLLGSGKVT DRKALSEAHS RFNESSQKLD LLKYSLEQRL SELPKNHPKS SVIIEELSLV 300

ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK AASATLPAWS 360

PSEARSSFMS RTSKNKSGSS RNLLKTEEFS RDEVCAMLKL DNTVVGQTNW KPISNQSWDQ 420

KFTLELDRSR ELEISVFWRD WRSLCAVKFL RLEDFLDNQR HGMCLYLEPQ GTLFAEVTFF 480

NPVIERRPKL QRQKKIFSKQ QGKTFLRAPQ MNINIATWGR LVRRAIPTVN HSGTYSPQVA 540

VPAAVPVVDP RNLELSPISS ESTVAKLDFD LEPEAPPAPP RSSSLGDLYQ PSAEHKAPNV 600

PVPVSDTNYE NSNNRISVIA KPTAEVTIEP EIPVSDMNYS TIEESEDRRI QQRFQFSLQD 660

FHCCAVLGRG HFGKVLLAEY KSTNEMFAIK ALKKGDIVAR DEVVLFCSLM CEKRIFETVN 720

SVRHPFLVNL FACFQTKDHV CFVMEYAAGG DLMMHIHTDV FSEPRAVFYA ACVVLGLQYL 780

HEHKIVYRDL KLDNLLLDTE GFVKIADFGL CKEGMGFGDR TSTFCGTPEF LAPEVLTETS 840

YTRAVDWWGL GVLIYEMLVG EVRFKPAGYD NLPAFPKLPE NDGTLCEVMA LSAYTTNLQL 900

LRRNPERRLG ASEKDAEDVK KHPFFRHTDW NALLAKKVKP PFVPTIKGRE DVSNFDDEFT 960

SEAPILTPPR EPRILTEEEQ EAFRDFDYIA DWC 993

Nucleotide Sequence
(FASTA)

CTACAGAAAA ATGTGCCCTC TGGGCAAGTA TTATCAGCTA TACTGTTAGG TGACCCCAGA 60

AGCAGTATAG TCGCTGAACC CATGGGCATT TTTCCAAAAA TCGACTTTTC AGATCCACTG 120

GCTCAGCCGC ATTTGGATGA GATGAAGGAC CAGATAAAGC GTGAAATTAG AAAAGAACTT 180

AAAATCAAAG AAGGTGCTGA AAATCTTCGT AAAGTCACTA CGGATAAAAA AAACTTGGCT 240

TATGTGGACA ATATATTAAA AAAGTCAAAC AAAAAACTAG AAGAGCTTCA CAACAATCTG 300

CAAGAACTAA ATGCACATAT TGTAATGCGA GAGGCAGAGA ATCTTCCAGA TTGTCCAAAA 360

ACTCCAGATA CTCCTAAAAG TGATTCTGGC TCTTCAGCTT TTAATGGAAG GCTGATAGCA 420

TTACAGAAGC AACTAGACAT TGAGTTAAAA GTGAAGCAAG GAGCTGAAAA CATGATTCAG 480

ACCTACTCTA ATGGACCTTC AAAAGATCGA AAACTTCTTG GCACTGCTCA GCAAATGCTC 540

CAGGATAGCA AGACTAAAAT AGAAGTAATA CGCATGCAAA TTTTACAAGC CAATCAGCAG 600

ACTAATGAGA TGTCTTTTGA CAATGCAAAA CCTGTGATAA GCCCCCTTGA GCTGAGAATG 660

GAAGAACTAC GACACCACGT TAGGATAGAA TTTGCTGTAA CTGAAGGAGC AAAGAATGTC 720

ATGAAGCTTT TGGGTTCAGG AAAAGTTACA GACAGAAAGG CTCTTTCTGA AGCTCACTCA 780

AGATTTAACG AGTCAAGTCA GAAGCTGGAT CTCTTAAAAT ATTCCTTGGA ACAGAGACTC 840

AGTGAACTTC CAAAAAACCA TCCCAAGAGC AGTGTTATTA TTGAGGAGCT TTCCCTAGTT 900

GCATCTCCAA CATTAAGTCC ACGCCAAAGC ATGATTTCTA CACAGAATCA GTACAGTACA 960

CTATCCAAGC CAGCGGCTTT AACAGGTACC TTGGAAGTTC GACTTATGGG CTGTCAAGAT 1020

ATACTGGAAA ATGTACCAGG CAGATCCAAG GCTGCCTCTG CTACCTTACC AGCATGGAGC 1080

CCAAGTGAAG CACGGTCCTC CTTCATGAGC AGAACGAGTA AAAATAAAAG TGGTAGCAGT 1140

CGGAACCTTC TGAAGACAGA GGAATTTTCC AGAGATGAGG TCTGTGCTAT GTTAAAGCTG 1200

GACAATACTG TGGTTGGTCA GACCAACTGG AAACCAATAT CCAATCAGTC ATGGGATCAG 1260

AAGTTTACAC TGGAACTGGA TAGGTCACGA GAGTTGGAGA TCTCTGTTTT TTGGCGTGAC 1320

TGGAGGTCGT TATGTGCAGT TAAGTTTCTG AGGCTAGAAG ATTTCTTGGA CAACCAGCGA 1380

CATGGCATGT GCCTATATTT AGAACCTCAG GGCACACTCT TTGCTGAGGT AACCTTCTTT 1440

AACCCGGTTA TTGAAAGAAG GCCAAAACTT CAGAGGCAAA AGAAAATATT TTCCAAGCAG 1500

CAAGGCAAAA CATTTCTCCG TGCTCCTCAG ATGAACATTA ATATTGCCAC ATGGGGTAGG 1560

CTGGTGAGAA GGGCAATCCC TACAGTGAAT CATTCTGGAA CCTACAGCCC TCAGGTTGCT 1620

GTTCCTGCCG CCGTGCCTGT TGTGGACCCA CGAAACCTAG AACTTTCACC AATCAGCAGT 1680

GAGTCTACTG TAGCAAAATT GGATTTCGAC TTAGAACCTG AAGCTCCTCC CGCTCCTCCT 1740

CGGTCGTCAT CTCTCGGTGA CCTCTATCAA CCTTCAGCAG AACATAAAGC ACCTAACGTC 1800

CCAGTGCCGG TATCAGATAC AAATTATGAA AACTCAAATA ACAGAATCAG TGTCATTGCA 1860

AAGCCAACGG CAGAAGTAAC TATTGAACCA GAGATTCCAG TATCCGATAT GAACTATAGC 1920

ACAATTGAAG AATCGGAGGA CAGACGGATT CAACAGCGTT TCCAGTTCAG TCTTCAAGAT 1980

TTCCATTGTT GTGCTGTGCT CGGTAGGGGA CATTTTGGAA AGGTGTTGTT GGCAGAGTAC 2040

AAAAGCACAA ATGAGATGTT TGCAATCAAA GCCTTAAAAA AAGGAGACAT TGTTGCACGA 2100

GATGAAGTTG TATTATTTTG CAGCCTTATG TGTGAAAAGC GCATTTTTGA AACTGTGAAT 2160

AGTGTACGCC ACCCTTTCTT GGTAAACTTA TTTGCCTGCT TCCAAACCAA AGATCACGTC 2220

TGCTTTGTTA TGGAATATGC AGCTGGTGGG GACCTAATGA TGCACATTCA TACTGATGTA 2280

TTTTCAGAAC CAAGGGCAGT TTTTTATGCA GCCTGTGTCG TCCTTGGTTT GCAGTATTTG 2340

CATGAGCACA AAATTGTTTA TAGAGATCTG AAGTTGGATA ACCTGTTGTT GGACACTGAA 2400

GGATTTGTGA AAATTGCAGA CTTTGGTCTT TGCAAAGAAG GAATGGGTTT TGGGGACCGG 2460

ACAAGCACTT TCTGCGGGAC TCCTGAGTTC CTGGCTCCAG AGGTGCTTAC AGAAACATCG 2520

TACACCAGAG CAGTGGATTG GTGGGGTTTG GGAGTACTCA TTTATGAGAT GCTTGTTGGT 2580

GAGGTAAGAT TTAAGCCAGC AGGTTACGAC AATTTACCTG CTTTTCCCAA GCTGCCTGAA 2640

AATGATGGGA CTCTCTGTGA AGTCATGGCT CTAAGTGCCT ATACTACTAA TTTGCAGCTT 2700

TTGAGAAGAA ATCCAGAGCG TCGACTTGGT GCAAGTGAAA AAGATGCTGA AGACGTAAAG 2760

AAGCACCCTT TCTTCAGACA TACAGACTGG AACGCTTTGC TAGCAAAGAA AGTCAAGCCC 2820

CCATTTGTAC CCACCATCAA AGGACGGGAA GATGTGAGCA ATTTTGATGA CGAATTTACC 2880

TCAGAAGCTC CTATTTTAAC GCCACCCCGG GAGCCAAGGA TACTGACAGA AGAAGAGCAA 2940

GAAGCATTTA GAGATTTTGA TTACATCGCG GATTGGTGTT GA 2982

Domain Profile

S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardeve...sllcekrileavs  57

         f+++avlgrghfgkvll+eykst+e++aikalkkgdi+ardev    sl+cekri+e+v+

Q: 661   FHCCAVLGRGHFGKVLLAEYKSTNEMFAIKALKKGDIVARDEVVlfcSLMCEKRIFETVN  720

         89****************************************954559************

S: 58    svrhpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqfl  117

         svrhpflvnl+acfqtk+hvcfvmeyaaggdlm+hih+dvfsepravfyaacvvlglq+l

Q: 721   SVRHPFLVNLFACFQTKDHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYL  780

         ************************************************************

S: 118   hekkivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltets  177

         he+kivyrdlkldnllldteg+vkiadfglckeg+g+gdrtstfcgtpeflapevltets

Q: 781   HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTETS  840

         ************************************************************

S: 178   ytravdwwglgvllyemlvgespf..pgddeeevfdsivndevryprflsveaieilrrl  235

         ytravdwwglgvl+yemlvge  f  +g d+   f  + +++    + +++ a +   +l

Q: 841   YTRAVDWWGLGVLIYEMLVGEVRFkpAGYDNLPAFPKLPENDGTLCEVMALSAYTTNLQL  900

         ***********************95458899999**************************

S: 236   lrknpekrlgaserdaedvkkqpff  260

         lr+npe+rlgase+daedvkk+pff

Q: 901   LRRNPERRLGASEKDAEDVKKHPFF  925

         ************************9

Domain Sequence
(FASTA)

FHCCAVLGRG HFGKVLLAEY KSTNEMFAIK ALKKGDIVAR DEVVLFCSLM CEKRIFETVN 60

SVRHPFLVNL FACFQTKDHV CFVMEYAAGG DLMMHIHTDV FSEPRAVFYA ACVVLGLQYL 120

HEHKIVYRDL KLDNLLLDTE GFVKIADFGL CKEGMGFGDR TSTFCGTPEF LAPEVLTETS 180

YTRAVDWWGL GVLIYEMLVG EVRFKPAGYD NLPAFPKLPE NDGTLCEVMA LSAYTTNLQL 240

LRRNPERRLG ASEKDAEDVK KHPFF 265

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 3.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00239	; C2; 1.
SM00742	; Hr1; 3.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013