EKS-XET-00486

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00486

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	405.6	8.5E-122	270	523	254

Status

Unreviewed

Ensembl Protein

ENSXETP00000013582

UniProt Accession

F7DYP1;

Protein Name

Protein Synonyms/Alias

Gene Name

frk

Gene Synonyms/Alias

frk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006166	ENSXETP00000013582	ENSXETT00000013582

Organism

Xenopus tropicalis

Functional Description

Protein Length

540

Protein Sequence
(FASTA)

CYSCTRGIAE KLISEMGNCC RKNCSCLSCV LPCVFKEEKR SGSNSFNGIV IQNPVITTQL 60

DGPQVPPRFV NQGEQQRNSY VALYSYEGRT PDELSFKAGD QMLIIDTTHA SWWKAKLLRT 120

RGKAEGYVPF NYVAPVSSIE SMPWFFKDIK RSEAERLLVR PGNTTGSFLI RESESQKGEY 180

SLSVRESESQ KVFDGIAVKH YRLRKLDDGG FYITSKSKFV SMNELVEYYG KREEGLCCKL 240

LKPCITTGIP LPPDLCYHTA DHWEINRNSL KFLKKLGQGQ FGEVWEGLWN NTIPVAIKTL 300

KTGTMNPQDF LREAQFMKNL RHPKLIQLQA VCTLEEPVYI ITELMRHGSL LSYLQNDNGT 360

SIHIPNQVDM AAQVASGMAY LETQSFIHRD LAARNVLVGE NGVYKVADFG LARVFKNKGE 420

DVYEAKNDTK LPLKWTAPEA IRYNRFTIKS DVWAFGILIF EIVTYGKMPY PGLTGRQALD 480

KLENGYRIPK PFNCPHDLYK IMLECWNAKP EERPTFETLQ WKLEDYFETD PSSYLEANNF 540

Nucleotide Sequence
(FASTA)

TGCTATAGCT GTACCAGAGG AATTGCTGAA AAATTAATCT CAGAGATGGG GAATTGTTGT 60

AGGAAAAATT GCAGCTGCTT AAGCTGTGTG CTTCCCTGTG TCTTTAAAGA AGAGAAGAGG 120

TCAGGTTCTA ATTCTTTTAA TGGCATTGTG ATTCAAAATC CAGTTATAAC TACTCAACTT 180

GATGGTCCAC AAGTCCCTCC ACGTTTTGTT AACCAGGGAG AACAACAAAG AAATTCTTAT 240

GTGGCATTGT ACAGTTATGA AGGACGGACA CCTGATGAGC TGAGTTTCAA GGCTGGGGAC 300

CAGATGCTTA TCATAGACAC CACACATGCT AGTTGGTGGA AAGCTAAACT TTTAAGGACA 360

CGAGGAAAAG CAGAGGGATA TGTCCCATTC AATTATGTTG CTCCTGTCTC CAGCATTGAG 420

TCCATGCCGT GGTTTTTTAA AGACATAAAG CGGTCAGAAG CTGAAAGACT GTTAGTGCGA 480

CCAGGCAATA CAACCGGATC TTTTTTAATC AGAGAAAGTG AAAGCCAAAA GGGTGAATAC 540

TCTCTTTCTG TCAGAGAAAG TGAAAGCCAA AAGGTGTTTG ATGGAATCGC CGTGAAACAT 600

TATAGGCTAA GAAAACTTGA TGATGGCGGG TTTTACATAA CTTCAAAGAG TAAATTTGTA 660

TCTATGAATG AGCTTGTTGA ATATTACGGT AAAAGAGAGG AAGGACTGTG CTGCAAACTC 720

TTAAAGCCAT GCATAACGAC AGGAATACCT CTTCCTCCAG ACCTGTGCTA CCACACTGCA 780

GATCACTGGG AGATTAACAG AAACTCTCTG AAGTTTTTGA AAAAACTTGG CCAAGGGCAA 840

TTTGGTGAAG TATGGGAAGG ATTATGGAAC AATACTATAC CAGTGGCTAT TAAGACTTTA 900

AAAACAGGAA CCATGAATCC ACAGGATTTC TTACGGGAGG CGCAGTTCAT GAAGAACCTT 960

AGACATCCAA AACTTATCCA ACTCCAAGCA GTTTGTACTT TGGAAGAGCC AGTATATATT 1020

ATAACTGAAC TCATGAGACA TGGAAGTCTG CTTTCTTATC TCCAAAATGA TAACGGAACA 1080

TCAATCCATA TTCCTAACCA GGTGGACATG GCTGCACAGG TGGCCTCAGG AATGGCTTAC 1140

CTGGAAACAC AAAGCTTCAT TCATAGAGAT CTGGCAGCCA GAAATGTACT TGTCGGTGAA 1200

AATGGTGTTT ACAAAGTGGC AGATTTTGGC TTAGCCAGAG TTTTCAAGAA TAAGGGTGAG 1260

GATGTTTATG AGGCAAAAAA TGATACAAAG CTTCCTCTGA AGTGGACAGC ACCAGAAGCT 1320

ATCAGATACA ACAGATTCAC CATTAAGTCT GACGTCTGGG CCTTTGGCAT CCTTATATTT 1380

GAAATAGTGA CGTACGGGAA GATGCCATAT CCTGGTTTGA CAGGAAGACA AGCGTTAGAT 1440

AAGTTGGAGA ATGGTTATAG AATCCCAAAA CCATTCAACT GCCCCCATGA CCTGTATAAA 1500

ATCATGCTCG AATGCTGGAA TGCAAAGCCA GAAGAGAGAC CAACATTTGA AACATTACAG 1560

TGGAAGCTGG AAGATTATTT TGAAACAGAT CCTTCGTCAT ATCTTGAAGC AAATAACTTC 1620

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk++kklG+GqfGevw+g+w+++++va+ktlk+gt++p++fl+eaq +k+lrh+kl++l

Q: 270   LKFLKKLGQGQFGEVWEGLWNNTIPVAIKTLKTGTMNPQDFLREAQFMKNLRHPKLIQLQ  329

         5789********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ eeP+yi+telm++Gsll++l++++g+++++p++vd+aaqva+Gmayle++ +ihr

Q: 330   AVCTLEEPVYIITELMRHGSLLSYLQNDNGTSIHIPNQVDMAAQVASGMAYLETQSFIHR  389

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge+ v+kvadfGlar+++   +d y+ak+++klP+kWtaPeai++++ftik

Q: 390   DLAARNVLVGENGVYKVADFGLARVFKnkgEDVYEAKNDTKLPLKWTAPEAIRYNRFTIK  449

         **************************98899*****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvW+fGil++eivt+Gk+PypG+t +++l+++e+gyr+p+p +cp++ly+++lecw+++

Q: 450   SDVWAFGILIFEIVTYGKMPYPGLTGRQALDKLENGYRIPKPFNCPHDLYKIMLECWNAK  509

         ************************************************************

S: 238   peerPtfetlqevl  251

         peerPtfetlq++l

Q: 510   PEERPTFETLQWKL  523

         ***********986

Domain Sequence
(FASTA)

LKFLKKLGQG QFGEVWEGLW NNTIPVAIKT LKTGTMNPQD FLREAQFMKN LRHPKLIQLQ 60

AVCTLEEPVY IITELMRHGS LLSYLQNDNG TSIHIPNQVD MAAQVASGMA YLETQSFIHR 120

DLAARNVLVG ENGVYKVADF GLARVFKNKG EDVYEAKNDT KLPLKWTAPE AIRYNRFTIK 180

SDVWAFGILI FEIVTYGKMP YPGLTGRQAL DKLENGYRIP KPFNCPHDLY KIMLECWNAK 240

PEERPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013