EKS-XET-00612

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00612

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	417.1	3.7E-125	64	359	296

Status

Unreviewed

Ensembl Protein

ENSXETP00000063747

UniProt Accession

F7CYE3;

Protein Name

Protein Synonyms/Alias

Gene Name

mapk10

Gene Synonyms/Alias

mapk10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006199	ENSXETP00000013630	ENSXETT00000013630
ENSXETG00000006199	ENSXETP00000063747	ENSXETT00000064743

Organism

Xenopus tropicalis

Functional Description

Protein Length

441

Protein Sequence
(FASTA)

MSRHFLYNCS EPTLDVKIAF CQGFGNQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKSLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DEALQHPYIN 360

VWYDPSEVEA GPLRDIWNEQ PVKTKNNEKP PPQIYDKQLD EREHTIEEWK ELIYKEVMNF 420

EEKTKNGVVK GQPSPSAQVQ Q 441

Nucleotide Sequence
(FASTA)

ATGAGCCGTC ATTTCTTGTA TAACTGCAGT GAACCTACTC TGGATGTGAA GATTGCCTTT 60

TGTCAGGGAT TCGGTAATCA AGTGGATGTG TCGTATATTG CTAAACATTA CAACATGAGC 120

AAAAGCAAAG TTGACAACCA GTTCTACAGT GTGGAAGTAG GAGACTCGAC ATTCACTGTT 180

CTTAAACGCT ACCAGAATCT AAAACCTATA GGCTCTGGAG CTCAGGGAAT AGTTTGTGCT 240

GCCTATGATG CTGTCCTTGA TAGAAATGTG GCAATTAAGA AACTAAGTAG ACCATTTCAG 300

AATCAAACAC ATGCCAAACG GGCATATAGA GAGTTGGTCC TTATGAAGTG TGTAAATCAT 360

AAAAATATTA TCAGTTTATT AAATGTCTTC ACACCCCAGA AATCTCTTGA GGAGTTCCAG 420

GATGTATACC TAGTTATGGA ACTGATGGAT GCTAACTTGT GCCAAGTGAT TCAGATGGAA 480

CTAGATCATG AACGAATGTC TTATTTGCTC TACCAAATGC TATGTGGAAT AAAGCACCTT 540

CATTCAGCTG GAATTATACA TAGGGATCTA AAGCCAAGTA ATATTGTTGT GAAGTCGGAT 600

TGCACATTGA AGATCCTTGA CTTTGGATTG GCAAGGACAG CTGGTACTAG TTTCATGATG 660

ACTCCTTATG TAGTTACCCG TTACTACAGA GCTCCAGAAG TTATACTTGG GATGGGATAC 720

AAAGAGAATG TGGATATTTG GTCTGTGGGA TGCATTATGG GAGAAATGGT CCGCCACAAG 780

ATCCTCTTTC CAGGAAGGGA CTATATTGAC CAGTGGAACA AAGTAATAGA ACAGCTGGGA 840

ACTCCGTGCC CAGAGTTTAT GAAAAAGCTA CAACCAACAG TACGAAACTA TGTGGAAAAT 900

CGACCTAAAT ATGCTGGTCT CACTTTTCCG AAGCTATTTC CCGATTCCCT CTTTCCAGCA 960

GATTCAGAGC ATAATAAACT CAAAGCCAGT CAAGCAAGAG ATCTTTTATC AAAGATGCTT 1020

GTCATTGATC CAGCCAAGAG AATATCAGTT GATGAAGCGC TACAGCATCC GTATATCAAT 1080

GTCTGGTATG ACCCTTCAGA AGTTGAGGCG GGCCCTCTGA GGGATATATG GAATGAACAG 1140

CCAGTCAAAA CAAAGAATAA TGAAAAGCCT CCCCCTCAAA TCTATGACAA ACAACTGGAT 1200

GAAAGAGAAC ATACCATTGA AGAATGGAAA GAACTAATCT ATAAGGAAGT GATGAACTTT 1260

GAAGAAAAAA CTAAAAATGG TGTTGTAAAA GGACAGCCCT CTCCTTCAGC ACAGGTGCAG 1320

CAGTGA 1326

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv+eaL+hpY

Q: 299   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDEALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013