EKS-XET-00615

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00615

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	408.3	1.8E-122	50	342	293

Status

Unreviewed

Ensembl Protein

ENSXETP00000013745

UniProt Accession

F7E265;

Protein Name

Protein Synonyms/Alias

Gene Name

mapk7

Gene Synonyms/Alias

mapk7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006274	ENSXETP00000013745	ENSXETT00000013745

Organism

Xenopus tropicalis

Functional Description

Protein Length

925

Protein Sequence
(FASTA)

MAEPRKEPEE VPDGSGTKLD PGGSTSMPAK GFSILKERSF DVNFEVGDEY EIIETIGVGA 60

YGVVSSARRK GCGQRVAIKK IPNAFDVVTN AKRTLRELKI LKHFKHDNII AIKDILKPSV 120

PYNDFRSVYV VLDLMESDLH QIIHSSQPLT LEHARYFLYQ LLRGLKYIHS ANVLHRDLKP 180

SNLLINENCE LKIGDFGMAR GLCTKPDEYK YFMTEYVATR WYRPPELMLS LHEYTQAIDM 240

WSVGCIFAEM LGRKPLFPGK NYLHQLHLIM TVLGTPSSQV IRAIGAERVR AYIQSLPSRQ 300

PVPWATLYPQ AGKKALDLLS KMLRFDPRDR ISVAEALRHP FLSKYHDPDD EPECVPAFDF 360

GFDKKILTKD QIKEAITAEI DGFHRRREGI RRQISFKPAL RPAVEGPIGD GPIQEDAFQS 420

PPLPPPTEGL DIEMPSANSA RDKADFPMES PRVPENTETI DLTSPVEKEE TEVLGDDHEG 480

KEETLVVKAE PEPLPKREGA ISEDTKAALK AALLKSALRN KSKDAPTSVP EVPETRKPVT 540

AQERQREREE KRRRRHERAR EREKKQKEKE RREVKKIEGF GGLVLSENDK NLLERWSRMV 600

DQTQLQPAVP PAQITGPGHA NSAVNICTVA QPLQQSVFGV ANLAPLIEVG RQQNGTIAAP 660

AVPPTIQFIP RCLNPCAVTN LLHYVPPSSA GFQISSVMLT AQAKQDSNPI AAQLPADVSF 720

VSRGQVLTNN FPTPPRMNPP WPRCVAQEGW SGANRVDCKS VDTSLFLHKP PDLQQPQGGV 780

PGLAYSNGSV FQNPEQHKSF PPLPPTSYSS ANAPQATSPD INLVTQQLSK SQVEDILPPV 840

FSVTPKGSGA GYGVGFDLEE FLNQSFDMAA ENRESHVDSA PLSASLLADW LDIHSMNPAD 900

MASLQEDLQL GSPMSLSDIP DLQDT 925

Nucleotide Sequence
(FASTA)

ATGGCGGAGC CAAGGAAAGA GCCAGAGGAG GTACCAGATG GATCGGGCAC CAAACTGGAC 60

CCAGGTGGCA GCACCTCCAT GCCAGCCAAG GGCTTCTCCA TACTCAAAGA GCGCTCCTTC 120

GACGTCAACT TCGAAGTTGG GGACGAGTAC GAGATCATCG AAACCATCGG CGTCGGCGCT 180

TACGGGGTGG TGTCCTCGGC CAGGCGGAAA GGCTGTGGGC AAAGGGTCGC CATTAAGAAA 240

ATCCCCAACG CCTTCGACGT GGTTACGAAC GCCAAGCGCA CCCTGCGGGA ACTTAAGATC 300

CTGAAGCATT TCAAGCACGA CAACATCATT GCCATAAAGG ACATCTTAAA GCCGTCTGTG 360

CCTTACAACG ACTTCAGATC TGTATATGTG GTGTTGGACC TTATGGAGAG CGATTTGCAC 420

CAAATCATCC ACTCGTCGCA GCCACTTACC CTCGAACACG CCCGCTACTT CCTGTACCAG 480

CTTCTGCGCG GCCTGAAATA CATCCACTCG GCCAATGTTT TGCACCGGGA CCTGAAGCCC 540

AGCAACCTTC TGATTAACGA GAACTGTGAG CTGAAGATCG GGGATTTCGG AATGGCCCGG 600

GGGCTCTGCA CCAAGCCGGA CGAGTACAAG TATTTCATGA CCGAGTATGT GGCCACTCGG 660

TGGTATCGGC CCCCTGAACT GATGTTGTCT CTCCACGAGT ACACGCAGGC CATTGATATG 720

TGGTCCGTAG GGTGCATATT TGCTGAAATG TTGGGACGTA AGCCTCTCTT TCCAGGCAAA 780

AACTACCTCC ACCAGCTACA TCTCATCATG ACTGTGCTGG GCACACCCTC CAGTCAGGTG 840

ATCCGAGCCA TTGGGGCGGA GAGAGTGAGG GCTTATATCC AAAGTCTTCC CTCGCGCCAA 900

CCAGTGCCTT GGGCAACCCT CTACCCCCAA GCTGGCAAGA AGGCTCTGGA TCTGCTGTCA 960

AAAATGCTAC GTTTTGACCC ACGTGACCGC ATTTCCGTAG CAGAGGCACT TCGGCACCCT 1020

TTCCTGTCCA AATATCACGA CCCCGACGAC GAACCAGAAT GCGTCCCGGC CTTTGATTTT 1080

GGATTCGATA AAAAGATTCT CACAAAGGAC CAAATAAAAG AGGCTATAAC GGCAGAGATA 1140

GACGGCTTTC ACCGTAGAAG GGAGGGCATA CGACGGCAGA TCAGCTTTAA ACCAGCACTC 1200

AGACCAGCCG TGGAAGGGCC CATCGGGGAC GGACCTATTC AAGAAGATGC CTTCCAATCG 1260

CCACCACTAC CCCCACCCAC CGAGGGATTG GATATAGAGA TGCCCAGTGC CAATTCGGCT 1320

CGGGACAAGG CAGATTTCCC AATGGAGTCT CCCCGGGTTC CAGAGAACAC AGAGACCATC 1380

GATCTCACCT CTCCTGTGGA GAAGGAAGAG ACAGAGGTGC TGGGGGACGA TCATGAAGGC 1440

AAAGAAGAAA CCCTAGTGGT TAAAGCTGAA CCGGAGCCCT TGCCAAAGCG AGAAGGGGCA 1500

ATATCGGAGG ATACTAAAGC AGCGCTTAAG GCCGCTCTCT TGAAGTCAGC TTTACGGAAC 1560

AAGAGTAAAG ATGCACCCAC TTCCGTCCCT GAGGTTCCCG AAACCCGGAA ACCAGTCACG 1620

GCTCAGGAGC GACAGCGGGA GCGGGAGGAG AAGCGAAGGC GGCGCCACGA ACGCGCCAGG 1680

GAGCGGGAGA AAAAGCAGAA AGAGAAGGAG CGTCGGGAAG TGAAGAAGAT AGAAGGCTTC 1740

GGAGGCCTGG TGCTGAGCGA GAACGATAAG AATTTGTTGG AACGCTGGAG TCGAATGGTC 1800

GACCAGACCC AGCTGCAGCC GGCCGTTCCT CCTGCTCAGA TAACCGGGCC CGGTCATGCC 1860

AATTCAGCCG TTAACATTTG CACTGTGGCT CAGCCGCTGC AGCAGTCTGT GTTTGGTGTG 1920

GCCAACTTAG CTCCTCTTAT AGAGGTTGGG AGGCAACAGA ACGGTACTAT TGCTGCCCCA 1980

GCGGTACCGC CTACCATCCA GTTCATTCCG AGGTGTCTGA ACCCTTGCGC CGTGACCAAC 2040

CTGCTCCATT ATGTCCCGCC CTCCTCTGCG GGCTTTCAGA TTAGTTCCGT TATGCTGACC 2100

GCCCAAGCGA AGCAAGACTC CAATCCCATA GCTGCCCAGC TGCCGGCCGA TGTCTCATTC 2160

GTTAGCAGAG GACAAGTCCT GACCAATAAC TTTCCTACGC CCCCACGAAT GAATCCCCCT 2220

TGGCCCCGGT GTGTAGCTCA GGAGGGCTGG TCTGGGGCAA ACAGAGTGGA TTGCAAGAGC 2280

GTGGACACTT CCCTCTTCCT CCATAAGCCC CCCGACCTCC AACAGCCACA GGGAGGAGTC 2340

CCAGGACTTG CATATTCTAA TGGATCCGTC TTCCAGAACC CGGAACAGCA CAAAAGTTTC 2400

CCACCTCTTC CGCCCACGTC GTACAGCAGC GCCAACGCCC CCCAGGCAAC ATCTCCAGAC 2460

ATCAACTTGG TGACTCAGCA ACTTTCCAAA TCCCAGGTTG AAGATATCCT TCCTCCAGTT 2520

TTCTCGGTCA CTCCGAAAGG AAGTGGAGCC GGGTACGGAG TGGGGTTCGA TCTGGAAGAA 2580

TTTCTCAATC AGTCCTTTGA TATGGCAGCA GAGAACCGGG AAAGCCACGT GGACTCCGCC 2640

CCCCTTTCTG CGTCGCTACT GGCCGACTGG CTGGACATTC ACAGCATGAA CCCGGCGGAC 2700

ATGGCTTCCC TACAGGAGGA TCTGCAGCTG GGCTCCCCCA TGAGTCTCTC CGACATCCCC 2760

GACCTACAGG ACACCTAA 2778

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye ++++g Gaygvv sa +k +++rvaikk+ ++f+  t+akrtlRElk+lk++kh+Ni

Q: 50    YEIIETIGVGAYGVVSSARRKGCGQRVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI  109

         77899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i + d+++p+  ++++++vY+v +lme+dL+++i+s+  l+ eh++++lyq+lrglky+H

Q: 110   IAIKDILKPSVPYNDFRSVYVVLDLMESDLHQIIHSSqPLTLEHARYFLYQLLRGLKYIH  169

         ***********************************9889*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176

         sanv+HrDlKPsNll+ne+celki dFG+ar   ++ ++    +teyvatrwYr Pe++l

Q: 170   SANVLHRDLKPSNLLINENCELKIGDFGMARGLCTKPDEYkyfMTEYVATRWYRPPELML  229

         *******************************955554433478*****************

S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236

         sl+eyt+a+D+WsvGCI+aE+l +kplfpgk++++ql++i++vlgtps++++++i  e++

Q: 230   SLHEYTQAIDMWSVGCIFAEMLGRKPLFPGKNYLHQLHLIMTVLGTPSSQVIRAIGAERV  289

         ************************************************************

S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         r+yi+slp+++  ++++l+p+a ++aldLl+k+L +dp++Risv+eaL+hp+l

Q: 290   RAYIQSLPSRQPVPWATLYPQAGKKALDLLSKMLRFDPRDRISVAEALRHPFL  342

         ***************************************************97

Domain Sequence
(FASTA)

YEIIETIGVG AYGVVSSARR KGCGQRVAIK KIPNAFDVVT NAKRTLRELK ILKHFKHDNI 60

IAIKDILKPS VPYNDFRSVY VVLDLMESDL HQIIHSSQPL TLEHARYFLY QLLRGLKYIH 120

SANVLHRDLK PSNLLINENC ELKIGDFGMA RGLCTKPDEY KYFMTEYVAT RWYRPPELML 180

SLHEYTQAID MWSVGCIFAE MLGRKPLFPG KNYLHQLHLI MTVLGTPSSQ VIRAIGAERV 240

RAYIQSLPSR QPVPWATLYP QAGKKALDLL SKMLRFDPRD RISVAEALRH PFL 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013