EKS-XET-00086

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00086

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	355.6	3.2E-106	340	649	310

Status

Unreviewed

Ensembl Protein

ENSXETP00000013856

UniProt Accession

F6T2A1;

Protein Name

Protein Synonyms/Alias

Gene Name

mtor

Gene Synonyms/Alias

mtor;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006322	ENSXETP00000058567	ENSXETT00000061430
ENSXETG00000006322	ENSXETP00000013856	ENSXETT00000013856

Organism

Xenopus tropicalis

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

MNFEAVLHFK HQNHPRDEKK VRHPSTASAP PEGSESESEG ESNDNSPVSS PVQKKPSEDI 60

SHTLLLYTVP AVQGFFRSIS LSRGNNLQDT LRVLTLWFDY GHWPDVNEAL VEGIKTIQID 120

TWLQVIPQLI ARIDTPRALV GRLIHQLLTD IGRYHPQALI YPLTVASKST TTARHNAANK 180

ILKNMCEHSN TLVQQAMMVS EELIRVAILW HEMWHEGLEE ASRLYFGERN VKGMFAVLDP 240

LHAMMERGPQ TLKETSFNQA YGRDLMEAQD WCRKYMKSGN VKDLTQAWDL YYHVFRRISK 300

QLPQLTSLEL QYVSPKLLMC RDLELAVPGT YDPNQPIIRI QSIAPSLQVI TSKQRPRKLT 360

LMGMRRETHT FLIQSHEAHR LVQNILQFVG KGNIRLSTNF YCFIHICSIQ RYAVIPLSTN 420

SGLIGWVPHC DTLHALIRDY REKKKILLNI EHRIMLRMAP DYDHLTLMQK VEVFEHAVNN 480

TAGDDLAKLL WLKSPSSEVW FDRRTNYTRS LAVMSMVGYI LGLGDRHPSN LMLDRLSGKI 540

LHIDFGDCFE VAMTREKFPE KIPFRLTRML TNAMEVTGLD GNYRITCHTV MEVLREHKDS 600

VMAVLEAFVY DPLLNWRLMD TNIKGNKRSR TRTDSYSAGQ SGAEHIKKVI LRSVFKHRKT 660

FYDILEFQNA SYVFKLLYIG DGCIKNVYLV HKIIINVCKI MKKLNRRDFS HEETLDVATQ 720

VELLIKQATS HENLCQCYIG WCPFW 745

Nucleotide Sequence
(FASTA)

ATGAACTTTG AGGCAGTTCT GCATTTCAAA CACCAGAATC ATCCCCGTGA TGAAAAAAAG 60

GTGCGTCATC CCAGTACTGC CAGTGCGCCT CCCGAAGGCA GTGAAAGTGA GAGTGAAGGC 120

GAGAGCAATG ACAACAGCCC TGTGTCTTCT CCTGTGCAGA AAAAACCTTC AGAGGATATA 180

TCTCACACCC TTTTATTGTA TACTGTCCCT GCTGTGCAAG GCTTTTTCCG TTCCATCTCT 240

TTATCTCGAG GGAATAACCT TCAGGACACA CTGAGAGTCC TTACGCTGTG GTTTGATTAT 300

GGGCACTGGC CAGATGTAAA TGAGGCACTA GTGGAAGGAA TCAAAACTAT TCAGATAGAT 360

ACATGGTTAC AGGTGATTCC ACAGCTTATT GCAAGGATAG ACACGCCAAG GGCTCTTGTA 420

GGCCGTCTTA TTCATCAGCT TCTCACAGAT ATTGGCAGAT ACCATCCACA GGCTTTAATT 480

TACCCACTCA CAGTGGCCTC TAAATCAACA ACCACCGCTC GCCACAATGC AGCCAATAAA 540

ATTCTAAAGA ACATGTGTGA ACATAGCAAC ACGTTAGTGC AGCAAGCCAT GATGGTAAGT 600

GAAGAGCTTA TTCGTGTGGC TATTCTTTGG CATGAGATGT GGCATGAAGG CCTAGAAGAA 660

GCATCACGCT TATATTTTGG CGAAAGGAAT GTGAAAGGGA TGTTTGCTGT ACTTGATCCA 720

CTGCATGCCA TGATGGAGAG GGGACCTCAG ACTCTTAAGG AAACCTCTTT TAATCAGGCA 780

TATGGTAGAG ACCTTATGGA AGCTCAGGAC TGGTGTAGAA AGTACATGAA ATCTGGAAAT 840

GTAAAGGATC TCACACAGGC CTGGGACCTA TATTACCATG TTTTCCGAAG AATCTCAAAG 900

CAGCTGCCTC AGCTCACTTC TTTGGAACTT CAGTATGTAT CCCCAAAATT ACTTATGTGT 960

CGAGATCTGG AGTTAGCTGT GCCAGGAACA TATGACCCAA ATCAACCAAT CATACGTATT 1020

CAGTCTATTG CACCATCTCT TCAGGTCATA ACCTCCAAAC AGAGGCCTCG AAAATTAACC 1080

TTAATGGGTA TGAGAAGAGA AACTCACACT TTTCTAATAC AATCACATGA AGCACACAGA 1140

CTTGTCCAAA ATATATTGCA GTTCGTGGGC AAAGGAAATA TTAGATTATC TACTAATTTC 1200

TATTGTTTTA TTCATATCTG TAGTATCCAG CGATATGCTG TAATCCCCTT GTCCACAAAC 1260

TCAGGACTGA TTGGATGGGT ACCGCATTGT GACACACTTC ATGCATTAAT TCGAGACTAT 1320

CGTGAAAAAA AGAAAATTTT GCTGAATATT GAGCATCGAA TTATGTTAAG GATGGCTCCA 1380

GATTACGATC ACCTAACGTT AATGCAAAAA GTGGAGGTTT TTGAGCATGC TGTGAACAAT 1440

ACTGCTGGCG ATGACCTAGC AAAGTTACTT TGGCTAAAAA GCCCCAGCTC TGAGGTCTGG 1500

TTTGACAGAC GAACAAATTA CACACGTTCC TTGGCAGTGA TGTCTATGGT GGGATACATC 1560

CTTGGACTGG GAGACAGGCA CCCATCTAAC CTGATGTTGG ATCGACTCAG TGGGAAAATC 1620

CTACATATAG ACTTTGGGGA TTGTTTTGAG GTGGCCATGA CAAGAGAGAA GTTCCCAGAA 1680

AAGATCCCAT TCCGCCTAAC ACGAATGTTA ACCAATGCTA TGGAGGTGAC AGGACTTGAT 1740

GGAAATTACA GAATAACATG CCATACAGTG ATGGAGGTAT TAAGGGAGCA TAAAGACAGT 1800

GTCATGGCTG TGCTAGAGGC TTTTGTATAT GATCCTCTAC TAAACTGGAG ACTCATGGAT 1860

ACCAACATAA AGGGCAATAA GCGCTCTCGC ACACGGACAG ATTCCTACTC AGCTGGACAG 1920

TCTGGAGCTG AACACATAAA GAAAGTAATT CTGAGGAGTG TATTTAAACA TCGCAAAACA 1980

TTTTATGATA TTCTAGAGTT TCAAAATGCA TCTTATGTGT TTAAATTACT GTATATTGGG 2040

GATGGGTGTA TTAAAAATGT GTATTTGGTG CACAAAATAA TAATAAATGT TTGCAAAATT 2100

ATGAAAAAAT TAAACCGTCG AGACTTTTCT CATGAAGAAA CTCTAGATGT AGCCACACAA 2160

GTGGAGCTCT TAATAAAACA AGCCACATCT CATGAGAACC TTTGTCAGTG TTACATTGGA 2220

TGGTGCCCTT TCTGGTAA 2238

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i+++++++++++skq+p+kl+l+G    ++ +L++ +e  r  + +lq+ +  N  L ++

Q: 340   IQSIAPSLQVITSKQRPRKLTLMGMRRETHTFLIQSHEAHRLVQNILQFVGKGNIRLSTN  399

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

           +     +i++y+V+plst+sgli+wv+++++L++l+++++ekk++ll+        ++

Q: 400   FYCFIHICSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN-------IEH  452

         *************************************************9.......9**

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +++ +++p+++hl+l+  +evf+++++n ++ d l+kll+ k+ps+e+wf++r++ytrsl

Q: 453   RIMLRMAPDYDHLTLMqkVEVFEHAVNN-TAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL  511

         ****************************.999****************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         Av+s+vgyiLgLgdrh++nl++d+ +g+++hidfg +fe a+t++k+pek+PFRLTr+++

Q: 512   AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT  571

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeela  298

         na++vtg++G++r++c++v++vlre+k++++++Le+f+ydpl++w+ ++++ k+++++++

Q: 572   NAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNIKGNKRSRT  631

         ************************************************************

S: 299   ekakaealki.kkllskv  315

         ++++++a ++  + ++kv

Q: 632   RTDSYSAGQSgAEHIKKV  649

         *****9988723444444

Domain Sequence
(FASTA)

IQSIAPSLQV ITSKQRPRKL TLMGMRRETH TFLIQSHEAH RLVQNILQFV GKGNIRLSTN 60

FYCFIHICSI QRYAVIPLST NSGLIGWVPH CDTLHALIRD YREKKKILLN IEHRIMLRMA 120

PDYDHLTLMQ KVEVFEHAVN NTAGDDLAKL LWLKSPSSEV WFDRRTNYTR SLAVMSMVGY 180

ILGLGDRHPS NLMLDRLSGK ILHIDFGDCF EVAMTREKFP EKIPFRLTRM LTNAMEVTGL 240

DGNYRITCHT VMEVLREHKD SVMAVLEAFV YDPLLNWRLM DTNIKGNKRS RTRTDSYSAG 300

QSGAEHIKKV 310

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013