EPS-XET-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XET-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	447.4	2.5E-134	125	462	338

Status

Unreviewed

Ensembl Protein

ENSXETP00000014758

UniProt Accession

F6WBL1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

ppef1

Gene Synonyms/Alias

ppef1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000006754	ENSXETP00000014758	ENSXETT00000014758

Organism

Xenopus tropicalis

Functional Description

Protein Length

660

Protein Sequence
(FASTA)

MSASRGSKEI QLTELAIKAA ILIQRWYRFY TARLEMRRRY TLNIFQSIEY AEEQAQLQLS 60

NFFTFMMDHF AHWKGQGPGR QNFLLERRSN SKEGHKFIDY EKIEVPNSYG GPRITFPLTV 120

SDTNALLRAF KQGQQLHARY VLQLFHETKK FLKQLPNIVH LSTSYSKEIT ICGDLHGKLD 180

DLLLIFYKNG LPSTENHYLF NGDLVDRGKN SIEILVLLFT FLLMYPNNVH INRGNHEDPI 240

MNLRYGFTNE VIQKYKGHAR NILLLLEDIY SRLPLATIVD SKVLILHGGI GDKTDLDFLS 300

SIDRFKLTAL RTPKTDSEKC TSRDKMLDGK NKKSSVDVGA NQNRANKHMT TSSNISQNRS 360

QQVVDILWSD PRNQNGCTPN SFRGGGCYFG PNVTKKLLAK YNFKMLIRSH ECKQEGYELC 420

HNGKVVTIFS ASNYYDEGSN RGAYLKLSPD LTPRFVPYQV SKCTRKLTLH QRVSAVEDTA 480

LRALREKIYA HRSELINAFK LCDPKETGKI SISEWASAVE AVLHLDLPWR TLRPRLIKLT 540

SDGSVDYLSS FEDLQIEQPI KEVQPNLVET IYRYKADLEI IFNIIDKDHS GLISVEEFRQ 600

TWKLFSSHLH INIDDSAIDD LAHSIDTNKD GSIDFNEFLE AFRVVQKFDS KANKTCTALG 660

Nucleotide Sequence
(FASTA)

ATGAGCGCCA GCCGGGGGTC TAAGGAAATC CAATTGACAG AATTAGCCAT TAAAGCAGCA 60

ATCCTTATAC AGAGATGGTA TCGTTTCTAC ACTGCGCGAC TAGAAATGAG GCGCCGTTAT 120

ACCCTGAACA TATTTCAGTC AATAGAATAT GCCGAAGAGC AAGCACAACT TCAGCTTTCC 180

AACTTTTTTA CATTCATGAT GGACCACTTT GCACATTGGA AAGGACAAGG CCCAGGCAGG 240

CAGAACTTTC TTCTAGAGAG AAGATCTAAC TCAAAAGAGG GCCACAAGTT TATAGATTAT 300

GAAAAGATTG AAGTTCCTAA CTCTTATGGT GGGCCGCGGA TTACCTTCCC TCTAACTGTG 360

TCGGACACTA ACGCTCTTCT TCGTGCTTTC AAGCAAGGGC AGCAACTCCA TGCCCGATAT 420

GTTCTACAGC TCTTTCATGA AACAAAGAAG TTTCTTAAAC AATTGCCAAA TATTGTCCAT 480

CTATCTACAT CATATTCTAA AGAGATAACA ATTTGTGGGG ACCTCCATGG GAAGCTGGAT 540

GATTTATTGC TTATATTTTA CAAGAATGGT CTCCCTTCAA CAGAAAATCA CTACCTTTTT 600

AATGGAGACT TGGTAGATCG AGGGAAGAAT TCCATAGAAA TACTAGTACT GTTGTTCACA 660

TTCCTCCTCA TGTATCCAAA TAATGTACAT ATAAACCGAG GCAATCATGA AGATCCGATC 720

ATGAACCTGA GATATGGCTT CACAAATGAA GTAATACAAA AATATAAGGG GCATGCCCGA 780

AATATTCTAC TTCTTTTGGA AGACATATAC AGCAGATTGC CACTTGCTAC CATTGTTGAC 840

AGCAAGGTGC TTATCCTGCA TGGAGGGATA GGAGACAAAA CTGACCTAGA TTTTTTATCC 900

TCAATTGACA GATTTAAGTT AACAGCTCTG CGAACTCCAA AAACAGACTC TGAAAAGTGT 960

ACTTCCAGGG ATAAAATGCT TGATGGAAAA AACAAAAAAT CTTCTGTAGA TGTTGGCGCA 1020

AACCAAAATA GGGCAAACAA GCATATGACG ACATCCAGCA ATATATCCCA AAATAGATCT 1080

CAACAAGTTG TTGACATACT TTGGAGTGAT CCAAGAAATC AAAATGGCTG CACACCAAAC 1140

AGTTTTCGTG GGGGTGGTTG TTATTTTGGG CCAAATGTAA CCAAAAAGTT ACTTGCTAAA 1200

TACAATTTTA AAATGCTGAT ACGTTCTCAT GAATGCAAAC AAGAAGGGTA TGAGCTATGT 1260

CACAATGGAA AGGTTGTTAC AATCTTTTCA GCTTCCAATT ACTATGATGA AGGTAGCAAC 1320

AGGGGAGCCT ATCTTAAACT GAGCCCAGAT CTGACCCCAC GTTTTGTTCC ATACCAAGTT 1380

AGTAAATGCA CAAGGAAGCT AACTCTCCAT CAAAGAGTGA GTGCTGTTGA AGACACTGCG 1440

TTGAGGGCAC TCCGTGAAAA AATCTATGCA CACCGTTCAG AGCTTATAAA TGCTTTTAAA 1500

TTATGTGATC CGAAAGAAAC AGGAAAAATA TCCATCAGTG AGTGGGCATC TGCAGTTGAA 1560

GCTGTTCTGC ATCTAGATCT TCCTTGGAGG ACACTGCGTC CTAGGCTCAT AAAGCTCACT 1620

TCTGATGGAA GTGTAGATTA CCTTTCGTCT TTTGAAGACC TTCAGATTGA GCAGCCTATA 1680

AAAGAAGTGC AACCAAACTT GGTTGAAACC ATATACAGAT ACAAGGCAGA CCTGGAGATA 1740

ATATTTAATA TTATTGACAA GGATCATTCA GGTCTTATAT CAGTCGAGGA GTTCCGTCAG 1800

ACCTGGAAGC TTTTCAGCTC TCACTTGCAT ATTAACATAG ATGATTCTGC TATCGATGAC 1860

CTGGCTCACA GCATTGATAC CAATAAAGAT GGCAGCATTG ACTTTAATGA GTTTCTAGAA 1920

GCCTTTCGTG TTGTTCAGAA GTTTGATAGC AAAGCTAACA AAACTTGCAC TGCCCTAGGC 1980

Domain Profile

S: 3     lllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlll  62

          ll +fk+ ++lha+yvl++++e+kk lkqlpni h+st+ ske+t++GdlhGklddlll

Q: 125   ALLRAFKQGQQLHARYVLQLFHETKKFLKQLPNIVHLSTSYSKEITICGDLHGKLDDLLL  184

         5899********************************************************

S: 63    vlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnar  122

         +++knGlPs +n y+fnGd vdrGk+++e+l++l ++ l++Pn+v++nrGnhed +mn+r

Q: 185   IFYKNGLPSTENHYLFNGDLVDRGKNSIEILVLLFTFLLMYPNNVHINRGNHEDPIMNLR  244

         ************************************************************

S: 123   yGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksver  182

         yGf++ev +kyk + ++il +le++y  lPl++ivds+vl++hGG+ + t+ld l s++r

Q: 245   YGFTNEVIQKYKGHARNILLLLEDIYSRLPLATIVDSKVLILHGGIGDKTDLDFLSSIDR  304

         ************************************************************

S: 183   kkrksvllpPeessrd......................lgrldtdgepreslteteweqi  220

          k  ++  p ++s  +                      + r ++++ ++ ++ ++  +q+

Q: 305   FKLTALRTPKTDS-EKctsrdkmldgknkkssvdvganQNRANKHMTTSSNISQNRSQQV  363

         **98765555544.4458999**************999999999****************

S: 221   idilwsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdg  280

         +dilwsdPr +nG++Pn  rG+G+yfGP+vt+++l ky++k++irsheck egye++h+g

Q: 364   VDILWSDPRNQNGCTPNSFRGGGCYFGPNVTKKLLAKYNFKMLIRSHECKQEGYELCHNG  423

         ************************************************************

S: 281   kvvtifsasnyyeegsnkgayiklnsqltprfvqyivak  319

         kvvtifsasnyy+egsn+gay+kl+ +ltprfv y+v+k

Q: 424   KVVTIFSASNYYDEGSNRGAYLKLSPDLTPRFVPYQVSK  462

         ************************************975

Domain Sequence
(FASTA)

ALLRAFKQGQ QLHARYVLQL FHETKKFLKQ LPNIVHLSTS YSKEITICGD LHGKLDDLLL 60

IFYKNGLPST ENHYLFNGDL VDRGKNSIEI LVLLFTFLLM YPNNVHINRG NHEDPIMNLR 120

YGFTNEVIQK YKGHARNILL LLEDIYSRLP LATIVDSKVL ILHGGIGDKT DLDFLSSIDR 180

FKLTALRTPK TDSEKCTSRD KMLDGKNKKS SVDVGANQNR ANKHMTTSSN ISQNRSQQVV 240

DILWSDPRNQ NGCTPNSFRG GGCYFGPNVT KKLLAKYNFK MLIRSHECKQ EGYELCHNGK 300

VVTIFSASNY YDEGSNRGAY LKLSPDLTPR FVPYQVSK 338

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0004721	; F:phosphoprotein phosphatase activity

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013