EKS-XET-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	528.6	2.9E-159	488	764	277

Status

Unreviewed

Ensembl Protein

ENSXETP00000015723

UniProt Accession

F6VYS9;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

fgfr4

Gene Synonyms/Alias

fgfr4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007231	ENSXETP00000015723	ENSXETT00000015723

Organism

Xenopus tropicalis

Functional Description

Protein Length

827

Protein Sequence
(FASTA)

MSGSVKRSFY AMQNFARLLL GVLFVATLSS CRPALSEDEA NWKGETEISE SEVEEHLLLD 60

PGNALRLFCD TNQSSSINWY REQERLLPGG KIRMVGTVLE VSDVTYEDSG LYICVVRGTG 120

KILRRFSISV VDSLASGDEE DDEDGRREDS AADINEEPVY FFQAPYWTQP HRMDKKLHAV 180

PAGNTVKFRC PAGGSPLPTI RWLKNGREFR GEHRIGGIQL RHQHWSLVME SVVPSDRGNY 240

TCVVENRIGS LTYTYFLDVL ERSSHRPILQ AGLPANTTAR VGSDVEFYCK VYSDAQPHIQ 300

WLKHIEVNGS RFGPDDFPYV QVLKTADINT SEVEVLHLRN ITMEDAGEYT CLAGNSIGLS 360

HQSAWLIVLP SEDFLEQAEP AESRYMDIII YTSGFLAVAM AIVIVVLCRM QTPHSKQTLQ 420

PPTVHKLAKF PLIRQFSLES SSSGKSSAPL IRITRLSSSC APMLPGVMEV ELPLDAKWEF 480

PRDSPKRLVL GKPLGEGCFG QVVRAEGYGI DKERPEKPVT VAVKMLKDNG TDKDLSDLIS 540

EMELMKVIGK HKNIINLLGV CTQEGPLFVI VEYASKGNLR EFLRARRPPT PEDAFDITKV 600

PEELLSFKDL VSCAYQVARG MEYLESKRCI HRDLAARNVL VAEDNVMKIA DFGLARGVHD 660

IDYYKKTSNG RLPVKWMAPE ALFDRVYTHQ SDIWSFGVLT WEIFTLGGSP YPGIPVEELF 720

KLLREGHRMD KPSNCTHELY MLMRECWHAV PSQRPTFKQL VEQLDRILTA VSEEYLDLSM 780

PFEQYSPSCE DSASTCSSSD DSVFAHDPVP SSPCLFNYHN VHTHLGT 827

Nucleotide Sequence
(FASTA)

ATGTCTGGAT CCGTAAAAAG AAGCTTTTAT GCCATGCAGA ACTTTGCCAG GTTGCTGTTG 60

GGTGTTCTGT TCGTTGCCAC GTTAAGCTCA TGCAGGCCAG CATTATCCGA AGATGAGGCC 120

AACTGGAAAG GGGAAACAGA AATATCTGAG TCTGAGGTTG AAGAACATCT ACTTCTAGAC 180

CCTGGGAATG CTCTGCGACT GTTTTGTGAC ACCAACCAAA GCAGCAGCAT CAACTGGTAC 240

CGTGAGCAGG AACGTTTGCT GCCGGGAGGG AAGATTCGCA TGGTGGGAAC TGTGCTAGAA 300

GTCTCAGATG TGACCTATGA AGACTCTGGC CTTTATATAT GTGTGGTCAG AGGAACAGGC 360

AAAATCCTTC GAAGGTTCTC TATATCTGTT GTTGACTCGT TGGCATCTGG AGATGAAGAA 420

GATGATGAGG ATGGCCGTAG GGAGGACTCA GCCGCTGATA TTAATGAGGA GCCTGTTTAT 480

TTTTTCCAAG CACCATACTG GACCCAGCCA CACCGCATGG ACAAGAAACT TCATGCTGTA 540

CCAGCTGGTA ACACTGTCAA GTTCCGCTGT CCGGCTGGTG GAAGTCCTCT TCCCACTATT 600

CGATGGCTAA AAAATGGCAG AGAATTTCGA GGGGAGCACA GAATTGGTGG GATCCAGCTT 660

CGGCATCAAC ACTGGAGTCT GGTAATGGAA AGTGTGGTTC CATCAGACCG TGGCAACTAC 720

ACCTGTGTGG TGGAGAACAG AATTGGCAGC CTTACATATA CCTACTTTTT GGATGTGCTA 780

GAGAGGTCAT CTCACCGGCC TATCCTGCAA GCCGGCCTTC CAGCAAACAC CACAGCACGT 840

GTGGGTAGCG ATGTTGAATT CTACTGCAAA GTGTACAGTG ATGCTCAGCC ACATATCCAA 900

TGGCTCAAAC ATATTGAAGT GAACGGAAGT CGTTTTGGCC CCGATGACTT TCCATATGTA 960

CAGGTGCTGA AGACAGCAGA TATTAACACT TCAGAAGTAG AGGTGCTTCA CCTACGGAAT 1020

ATCACAATGG AGGATGCAGG GGAATACACA TGTCTGGCAG GCAATTCTAT TGGTCTTTCT 1080

CATCAGTCTG CTTGGCTGAT TGTGCTTCCA AGCGAAGATT TCCTTGAGCA AGCCGAGCCA 1140

GCAGAGTCAA GATATATGGA CATAATCATA TACACTTCTG GATTCCTGGC TGTAGCAATG 1200

GCCATCGTGA TTGTGGTTCT GTGCCGAATG CAGACACCCC ACAGCAAGCA AACTCTCCAA 1260

CCACCAACTG TCCATAAATT GGCCAAGTTC CCCCTCATAC GGCAGTTCTC TTTGGAGTCC 1320

AGTTCATCTG GGAAGTCCAG TGCTCCACTG ATTCGCATAA CTCGTCTCTC CTCAAGCTGT 1380

GCCCCCATGC TGCCTGGTGT CATGGAGGTT GAGTTACCAC TGGATGCTAA ATGGGAGTTC 1440

CCCAGAGACA GTCCCAAAAG GCTTGTTTTG GGAAAGCCAC TTGGAGAGGG CTGCTTTGGA 1500

CAAGTGGTAA GAGCAGAAGG ATATGGGATT GATAAAGAAC GGCCTGAGAA ACCAGTTACT 1560

GTTGCAGTGA AGATGCTCAA AGATAATGGC ACAGACAAGG ACTTATCGGA TCTGATCTCT 1620

GAAATGGAGT TGATGAAGGT CATTGGAAAA CACAAAAATA TAATCAACTT GCTCGGTGTC 1680

TGCACTCAAG AGGGACCATT ATTTGTTATA GTTGAATATG CTTCTAAGGG CAATCTGCGT 1740

GAGTTTCTAC GTGCAAGGCG CCCTCCCACG CCAGAAGATG CCTTTGATAT CACCAAGGTT 1800

CCAGAGGAAC TTCTGTCATT TAAGGACCTA GTATCTTGTG CTTATCAGGT TGCCCGTGGC 1860

ATGGAGTACC TTGAATCTAA GAGGTGCATC CACCGGGATC TGGCAGCCAG GAATGTTCTT 1920

GTGGCTGAAG ACAATGTTAT GAAGATAGCA GATTTTGGCT TGGCACGAGG GGTTCACGAT 1980

ATTGATTATT ACAAGAAAAC TAGCAACGGT CGACTGCCTG TGAAATGGAT GGCTCCAGAA 2040

GCTTTATTTG ACAGAGTTTA CACCCACCAA AGTGACATAT GGTCTTTTGG AGTGTTGACA 2100

TGGGAAATCT TTACTCTTGG AGGGTCTCCA TACCCTGGAA TTCCAGTGGA AGAATTATTT 2160

AAACTCTTGC GGGAAGGACA CCGAATGGAC AAACCATCCA ATTGTACTCA TGAATTGTAC 2220

ATGTTGATGA GGGAGTGCTG GCATGCAGTT CCATCACAGA GACCAACATT TAAACAGCTG 2280

GTTGAACAAC TGGACAGGAT CCTTACAGCT GTTTCTGAAG AGTATCTGGA CTTATCTATG 2340

CCATTTGAAC AGTATTCTCC TTCCTGTGAA GATTCTGCAA GCACGTGCTC TTCATCTGAT 2400

GACTCTGTTT TTGCCCATGA TCCTGTGCCA TCCTCTCCCT GTCTCTTCAA TTATCACAAT 2460

GTTCACACTC ACCTCGGGAC TTGA 2484

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+ae  g+dk++++k vtvavkmlk++ tdkdl+dl+seme++k+

Q: 488   LVLGKPLGEGCFGQVVRAEGYGIDKERPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKV  547

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllG+ctqeGpl+viveya+kGnlreflrarrp++ e   d +k++ee l++

Q: 548   IGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSF  607

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeyl+sk+cihrdlaarnvlv+ednv+kiadfGlar+vh+idyykkt

Q: 608   KDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKT  667

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         +nGrlpvkwmapealfdrvyt+qsd+wsfGvl wei+tlGgspypgi+veelfkll+eGh

Q: 668   SNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGH  727

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely+lmrecwha++s+rptfkqlve+l

Q: 728   RMDKPSNCTHELYMLMRECWHAVPSQRPTFKQLVEQL  764

         ***********************************87

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEG YGIDKERPEK PVTVAVKMLK DNGTDKDLSD LISEMELMKV 60

IGKHKNIINL LGVCTQEGPL FVIVEYASKG NLREFLRARR PPTPEDAFDI TKVPEELLSF 120

KDLVSCAYQV ARGMEYLESK RCIHRDLAAR NVLVAEDNVM KIADFGLARG VHDIDYYKKT 180

SNGRLPVKWM APEALFDRVY THQSDIWSFG VLTWEIFTLG GSPYPGIPVE ELFKLLREGH 240

RMDKPSNCTH ELYMLMRECW HAVPSQRPTF KQLVEQL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013