EKS-XET-00103

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00103

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	442.0	7.6E-133	1056	1312	257

Status

Unreviewed

Ensembl Protein

ENSXETP00000015919

UniProt Accession

F6XEZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

mst1r

Gene Synonyms/Alias

mst1r;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007306	ENSXETP00000015919	ENSXETT00000015919

Organism

Xenopus tropicalis

Functional Description

Protein Length

1368

Protein Sequence
(FASTA)

MGTLCTALLS LLLLPTITTS QCPSLPPSLT LDTKVRYQFP NFTASRPIQN LVSFEDSLFL 60

TTTNHLYVLK GNELHLLQNI TTGPTDSQCT LCSKCQLGEA LPKQPEDTVS QVLAVDPEES 120

VIYSCGSSLH GLCYMHIIAS SKIVESECLF RQSGNSASSC PDCIASPLGT LLSVVTQSRG 180

VYFYTASSLD SRIAESYSPT SISIRRLLGS QDGFSPGFHS LSVLESYRDS YPIHYVHTFV 240

SGSYVYFLTV QPEHPLSNTY HSRVVRLSKN EEEMRSYREL ILECRLEPKR RRRRRRAEPK 300

IFNVLKAAHV ATVGSTLAGE LDISEKDPVL FAVFAQSEPK SAQPRYNSAV CAFPLRLIDL 360

SIEDGMNACC SNTNSVRLTR GLNFFQPEMD CPQKDNQSDT SCKNVPTLVL PPLRRVDIFN 420

GQLDGVLLTS VYVSPQEDLT IGFLGTSAGR LLQVVLQRNS NPRTLSNFSI SDNYPVSREV 480

TQIGDSLFFV TGNQVTKVNI TGPGCRHFLT CSRCLRAPRF MGCSWCKNVC CQQGECEGEC 540

AQNTCLPAIT DFYPKTAPLR GNTNITLCGR DFQSSVVYNA PPKAKITAGT HRVSVGPRTC 600

IVNPGKSNST SLVCTLQTEG PPDTASTADI ALTIDENLTG TPYYIKGTIS AAGFNFVEPA 660

ITSIEPNFGP LAGGTMLTLK GQNLRSGETQ RVFISGAECM ISGSLCPAEV LCCVSPRSLS 720

LGPLNVSALL DGAEISSPAQ FQYKPDPLVS VIRPNCSLAS GTRLTIQGSN LDSVSSIKIS 780

YSGQKTVSSD CQGTFSSDRI VCRTPEYPYF GRPGNLTLAL DAVNYIYPYR FRYLQNYVIH 840

PFRPKDPDGG ILKLKKGEDE IETHQENLEQ VATCLKVSMT VGGRECNPTV LKNEITCRIP 900

KGMVIPSEGS IVQVCVDDDC TTVGLVMIVN MLDPVLGIVL GSVASVLVVA VLIFLLLKHQ 960

RKKKKKPAVE ALELLSNNNR EPVLSPISLL HVDYRTSYIP SSNSGGMLSH GAGYSGGSLG 1020

GGSMPILLTS LLDSLRPELL EEVKDVLIPE RCLTTHRDRI IGKGHFGSVY HGTYVDEDQQ 1080

EVHCAVKSLN RITDLEEVEE FLREGILMKS FHHPNVLSLI GIFLPQEGLP LVVLPFMKHG 1140

DLRHFIRCQE RNPTVKDLVG FGLQVSRGME YLANRKFVHR DLAARNCMLD ETFHVKVADF 1200

GLARDVFDKE YYSVRRHKNA RLPVKWMALE SLQTQKFTTK SDVWSFGVLL WELMTRGAPP 1260

YPDVDPYDIT RYLFRGRRLA QPEYCPDPLY SLMLSCWNPQ PEERPTFTQL VGDMEVISNS 1320

LCGDHYINLN VTYVNLDRDQ PFPPAHPPSE DELEEENSST EEEENPIA 1368

Nucleotide Sequence
(FASTA)

ATGGGCACCC TCTGCACAGC GCTGCTGTCT TTGCTGCTCT TGCCAACCAT CACGACATCT 60

CAGTGTCCGA GCCTGCCCCC TAGCTTGACT CTGGACACGA AGGTCCGGTA CCAGTTTCCA 120

AATTTCACAG CTTCTCGACC CATCCAGAAC CTGGTTAGCT TTGAGGACTC GCTTTTCCTG 180

ACCACTACCA ATCACTTGTA TGTTCTCAAA GGCAATGAAC TTCATTTGTT ACAAAACATC 240

ACCACTGGTC CTACTGACTC CCAGTGTACT CTCTGCTCCA AATGCCAATT GGGAGAAGCT 300

TTACCAAAGC AGCCCGAAGA TACTGTGAGC CAAGTCTTGG CAGTAGATCC AGAGGAAAGT 360

GTTATATACA GCTGTGGATC CTCTCTGCAT GGCCTTTGCT ACATGCACAT AATTGCATCC 420

TCAAAGATTG TTGAATCTGA GTGCCTTTTC AGGCAGAGTG GAAACAGTGC CTCTTCATGC 480

CCAGACTGCA TAGCAAGCCC CCTTGGAACA TTGCTATCAG TAGTGACACA AAGCAGGGGA 540

GTGTATTTTT ATACAGCATC ATCACTGGAT TCCCGCATTG CTGAGAGTTA CAGCCCAACA 600

TCAATATCTA TAAGGCGCCT CCTTGGCTCT CAAGATGGCT TTTCCCCTGG CTTCCATTCA 660

CTGTCAGTGT TAGAGTCATA CAGGGACTCT TACCCCATCC ATTATGTGCA CACCTTTGTT 720

AGTGGATCAT ATGTTTATTT CCTGACTGTC CAGCCTGAAC ACCCACTTTC CAACACCTAT 780

CATAGCAGGG TGGTGCGTCT CAGCAAGAAT GAAGAGGAAA TGCGAAGTTA CCGAGAACTG 840

ATTCTAGAAT GTCGCCTTGA GCCTAAGCGA AGAAGAAGAA GACGAAGAGC AGAGCCTAAA 900

ATTTTCAATG TTTTAAAGGC AGCGCATGTT GCCACTGTAG GGAGCACACT AGCTGGGGAA 960

CTGGACATAA GCGAGAAGGA CCCAGTGCTC TTTGCTGTTT TTGCTCAGAG TGAGCCAAAG 1020

AGTGCACAAC CCCGCTACAA TTCTGCAGTC TGTGCCTTCC CTCTTCGCTT AATTGATCTC 1080

TCTATTGAAG ATGGGATGAA TGCATGCTGC TCCAACACAA ATTCTGTGAG GTTGACGAGG 1140

GGGCTCAATT TCTTCCAACC AGAGATGGAC TGTCCCCAAA AAGACAACCA GTCTGACACA 1200

AGCTGCAAGA ATGTGCCCAC GTTAGTCTTG CCTCCTTTAC GACGTGTTGA TATATTCAAT 1260

GGGCAGTTGG ACGGGGTACT TCTCACCTCT GTCTATGTTA GTCCTCAGGA AGATTTAACC 1320

ATTGGCTTCC TTGGTACTTC TGCTGGAAGG CTGCTGCAGG TGGTCCTGCA GCGCAACAGT 1380

AACCCCCGCA CTCTGTCAAA CTTCTCTATA AGTGATAACT ATCCTGTATC ACGCGAGGTC 1440

ACCCAGATTG GAGACAGCCT CTTTTTTGTC ACTGGAAACC AGGTGACCAA AGTCAATATC 1500

ACAGGCCCGG GATGCCGCCA CTTCCTCACC TGCAGCAGAT GCCTACGTGC CCCTCGCTTT 1560

ATGGGTTGCA GTTGGTGTAA AAATGTCTGC TGTCAGCAGG GAGAATGTGA GGGAGAGTGT 1620

GCTCAGAATA CCTGTCTTCC TGCAATTACT GACTTTTATC CCAAGACAGC ACCATTACGT 1680

GGGAACACGA ATATCACCCT GTGTGGCCGA GACTTCCAGT CCAGTGTTGT GTATAATGCC 1740

CCTCCAAAGG CAAAGATCAC AGCAGGGACT CACAGAGTGA GCGTGGGACC TCGCACGTGT 1800

ATTGTTAACC CCGGAAAGAG CAATAGTACA AGTTTGGTTT GCACATTGCA GACGGAGGGG 1860

CCTCCTGACA CCGCATCAAC AGCAGATATT GCCTTAACTA TTGATGAGAA CCTAACGGGG 1920

ACCCCTTACT ACATAAAAGG AACCATATCT GCTGCAGGCT TTAACTTTGT GGAACCAGCT 1980

ATTACCTCTA TTGAACCCAA CTTTGGGCCC CTGGCTGGAG GTACCATGTT GACACTAAAA 2040

GGGCAGAATC TGAGATCTGG CGAGACTCAG AGGGTTTTCA TTAGCGGCGC TGAGTGCATG 2100

ATCAGTGGGT CCCTGTGCCC AGCAGAGGTC CTGTGCTGTG TGTCTCCCAG ATCCCTCTCT 2160

CTCGGACCTT TAAATGTCTC TGCTCTGTTG GATGGAGCTG AGATTTCTTC CCCAGCACAA 2220

TTCCAATACA AGCCAGACCC ACTTGTCTCT GTCATCAGAC CTAACTGCAG CCTGGCAAGT 2280

GGCACTCGCC TCACTATACA GGGATCAAAC CTGGATTCTG TCTCCAGCAT CAAAATCTCG 2340

TACAGTGGTC AAAAGACGGT CAGTTCGGAT TGCCAAGGGA CCTTTTCCTC TGACCGTATT 2400

GTGTGTCGTA CTCCAGAATA CCCTTATTTT GGCAGACCTG GAAACTTGAC CTTGGCTCTT 2460

GATGCTGTTA ATTATATATA CCCTTATCGG TTCCGATATC TCCAGAACTA TGTCATTCAC 2520

CCATTCCGTC CAAAAGATCC AGATGGGGGA ATCTTGAAGC TAAAGAAGGG CGAAGATGAA 2580

ATTGAGACAC ATCAAGAGAA CTTGGAACAG GTGGCCACAT GTTTGAAAGT CTCCATGACA 2640

GTTGGTGGAA GAGAGTGCAA CCCTACTGTG CTGAAGAATG AGATCACCTG CAGAATTCCC 2700

AAAGGCATGG TTATTCCCTC TGAAGGCTCC ATAGTGCAGG TTTGCGTGGA TGACGATTGC 2760

ACCACTGTGG GACTTGTGAT GATTGTGAAC ATGCTCGATC CAGTGCTAGG CATTGTACTT 2820

GGCAGCGTTG CCTCGGTCTT GGTGGTCGCA GTTCTCATCT TCTTGCTTCT CAAACATCAA 2880

AGAAAAAAGA AAAAGAAGCC AGCTGTGGAG GCACTGGAGC TGCTATCAAA TAATAACAGA 2940

GAACCTGTCT TGTCCCCAAT TTCCCTTCTT CATGTAGACT ACAGGACATC ATATATACCC 3000

AGTAGCAACT CTGGAGGGAT GCTGTCCCAC GGTGCAGGTT ATTCCGGAGG CAGTCTTGGT 3060

GGGGGGTCCA TGCCCATCCT ACTTACTAGT TTGCTTGACA GTCTGAGACC AGAACTGCTT 3120

GAGGAGGTCA AAGATGTTCT GATTCCAGAG AGATGTCTGA CAACTCATCG GGACAGGATT 3180

ATTGGAAAAG GTCACTTCGG GAGTGTTTAC CATGGCACCT ATGTGGATGA AGATCAGCAG 3240

GAGGTGCACT GTGCTGTCAA ATCTCTAAAC AGAATCACAG ATTTGGAGGA GGTGGAGGAG 3300

TTTCTTCGGG AAGGAATTTT AATGAAGAGC TTCCACCATC CAAATGTACT ATCCCTCATT 3360

GGCATTTTTT TGCCCCAGGA AGGGCTCCCC CTTGTGGTCC TTCCATTTAT GAAACATGGC 3420

GACCTGAGAC ATTTCATCCG CTGTCAGGAG AGGAATCCAA CAGTAAAAGA CCTGGTTGGA 3480

TTTGGGCTGC AAGTTTCCCG GGGAATGGAA TACTTGGCTA ATAGGAAGTT TGTACACAGA 3540

GACCTTGCTG CTCGCAACTG CATGCTGGAT GAGACATTCC ATGTGAAGGT GGCTGACTTT 3600

GGCCTGGCAA GAGATGTGTT TGACAAGGAA TATTACAGTG TCAGACGCCA CAAGAACGCC 3660

AGATTGCCTG TTAAGTGGAT GGCTCTGGAG AGTCTACAGA CCCAAAAATT TACCACTAAG 3720

AGTGATGTGT GGTCATTTGG AGTGCTGCTG TGGGAGCTGA TGACACGAGG AGCACCGCCG 3780

TATCCTGATG TAGATCCCTA TGATATTACT CGATACTTGT TCCGAGGAAG GCGTCTGGCA 3840

CAACCAGAAT ACTGTCCTGA CCCACTGTAT TCTCTTATGC TGAGCTGCTG GAACCCACAG 3900

CCGGAGGAGC GACCAACATT TACTCAGCTG GTCGGGGACA TGGAAGTGAT CTCCAATTCC 3960

CTTTGTGGCG ATCACTATAT CAATCTTAAT GTTACCTACG TCAACTTAGA TCGCGACCAG 4020

CCTTTTCCAC CGGCTCACCC ACCCTCGGAA GATGAGTTGG AAGAGGAAAA TTCATCAACA 4080

GAGGAAGAGG AGAACCCTAT AGCATAA 4107

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + +++iGkGhfG vy+g+++d++++++++avksl+ritd+e+veeflreg++mk ++hpn

Q: 1056  HRDRIIGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDLEEVEEFLREGILMKSFHHPN  1115

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsl+Gi l++eglplvvlp+mk+Gdl++fir +ern+tvkdl++f+lqv++gmeyla++

Q: 1116  VLSLIGIFLPQEGLPLVVLPFMKHGDLRHFIRCQERNPTVKDLVGFGLQVSRGMEYLANR  1175

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde+++vkvadfGlardv+dke+y+v+++++arlpvkw+aleslqt+

Q: 1176  KFVHRDLAARNCMLDETFHVKVADFGLARDVFDKEYYSVRRHKNARLPVKWMALESLQTQ  1235

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvwsfGvllwel+trga+py++v+++d+t yl +grrl +peycpd ly +ml

Q: 1236  K-FTTKSDVWSFGVLLWELMTRGAPPYPDVDPYDITRYLFRGRRLAQPEYCPDPLYSLML  1294

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvs  259

         +cw+++p+erp+f++lv

Q: 1295  SCWNPQPEERPTFTQLVG  1312

         ***************996

Domain Sequence
(FASTA)

HRDRIIGKGH FGSVYHGTYV DEDQQEVHCA VKSLNRITDL EEVEEFLREG ILMKSFHHPN 60

VLSLIGIFLP QEGLPLVVLP FMKHGDLRHF IRCQERNPTV KDLVGFGLQV SRGMEYLANR 120

KFVHRDLAAR NCMLDETFHV KVADFGLARD VFDKEYYSVR RHKNARLPVK WMALESLQTQ 180

KFTTKSDVWS FGVLLWELMT RGAPPYPDVD PYDITRYLFR GRRLAQPEYC PDPLYSLMLS 240

CWNPQPEERP TFTQLVG 257

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

xtr:100496572

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013