EKS-XET-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	467.3	2.8E-140	213	526	314

Status

Unreviewed

Ensembl Protein

ENSXETP00000015969

UniProt Accession

F6WMH0;

Protein Name

Protein Synonyms/Alias

Gene Name

dyrk2

Gene Synonyms/Alias

dyrk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007333	ENSXETP00000015969	ENSXETT00000015969

Organism

Xenopus tropicalis

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

LLGNIPCPEL WCLFCASGRG GRGTGQLQPS PGLPRSAAGT GPPSPVSLPP LRTGNPTHTT 60

GGNKHTMNEH LHVTSHGQIQ VQQLFEENSN KRTVLTTQPN GLTTVGKSTL PVVSERQLES 120

THRRQGSSSS LKSAEGITKL KSSSLTPEQA MKQYMQKLTA FEHHEIFNYP EIYFLGPNAK 180

KRQGVIGGPN NGGYDDDQGS YVQVPHDHVA YRYEVLKVIG KGSFGQVVKA YDHKLHQHVA 240

LKMVRNEKRF HRQAAEEIRI LEHLKKQDKD NNMNVIHMLE NFTFRNHICM TFELLSMNLY 300

ELIKKNKFQG FSLPLVRKFA HSILQCLDAL HKNRIIHCDL KPENILLKQQ GRSGIKVIDF 360

GSSCYEHQRV YTYIQSRFYR APEVILGGRY GMPIDMWSLG CILAELLTGY PLLPGEDEGD 420

QLACMIELLG MPSQKLLDAS KRGKNFFSSK GYPRYCTVTS LPDGSVVLNG GRSRRGKLRG 480

PPGSRDWVTA LKGCDDPLFL DFLTQCLEWD PSLRMTPSQA LRHHWLRRRL PKPPTGEKIS 540

TKRITESTGA ITSISKLPPT SGSAAKLRTN LTQITDANGN IQQRTVLPKL VS 592

Nucleotide Sequence
(FASTA)

TTATTGGGGA ACATTCCTTG CCCTGAGCTA TGGTGTTTGT TTTGTGCTTC AGGCAGAGGA 60

GGTAGAGGCA CCGGTCAGCT GCAGCCCTCC CCGGGATTAC CGCGATCTGC AGCCGGAACT 120

GGCCCCCCAT CCCCCGTGTC ATTGCCGCCC CTCAGAACCG GCAATCCAAC GCATACGACT 180

GGAGGCAATA AGCACACAAT GAATGAACAT CTACATGTGA CCAGCCATGG ACAAATCCAG 240

GTGCAACAAC TGTTTGAAGA GAACAGCAAC AAAAGAACTG TCCTGACAAC ACAACCAAAT 300

GGGCTTACAA CTGTTGGCAA ATCTACTTTA CCTGTAGTTT CAGAGAGGCA GCTTGAAAGT 360

ACTCATAGAA GACAAGGAAG CTCTAGCTCT TTAAAATCAG CAGAGGGCAT AACCAAGTTG 420

AAGTCTTCTT CATTAACTCC TGAACAAGCA ATGAAGCAAT ACATGCAGAA GTTGACTGCT 480

TTTGAGCACC ATGAAATCTT TAATTACCCT GAAATTTATT TTTTGGGTCC AAATGCTAAA 540

AAACGACAAG GTGTAATTGG CGGCCCAAAC AATGGTGGCT ATGATGATGA TCAGGGCTCA 600

TATGTACAAG TGCCGCACGA TCATGTTGCC TACAGGTATG AAGTTCTGAA GGTTATTGGA 660

AAAGGAAGTT TTGGGCAAGT TGTGAAAGCT TATGACCACA AACTTCATCA GCATGTGGCA 720

CTAAAAATGG TAAGGAATGA AAAGCGTTTT CATCGGCAGG CTGCAGAGGA AATCAGAATT 780

CTAGAACACC TGAAAAAACA AGATAAAGAT AACAATATGA ATGTCATTCA CATGCTGGAG 840

AACTTCACAT TCCGCAATCA TATATGTATG ACATTTGAAT TATTGAGTAT GAATCTCTAT 900

GAACTGATCA AGAAGAATAA ATTTCAGGGC TTTAGCTTGC CTTTAGTTCG CAAGTTTGCT 960

CACTCAATCT TGCAGTGCTT GGATGCTTTG CACAAAAACA GAATAATCCA CTGTGACCTT 1020

AAACCTGAAA ACATTCTGTT GAAACAACAG GGCAGAAGTG GCATTAAAGT TATTGATTTT 1080

GGTTCTAGTT GTTATGAGCA CCAGCGTGTG TATACATACA TACAATCACG TTTCTACCGG 1140

GCACCAGAAG TTATTCTTGG TGGTCGCTAT GGGATGCCTA TTGATATGTG GAGCTTGGGT 1200

TGTATTCTTG CGGAACTGTT GACTGGCTAT CCACTTTTAC CCGGAGAAGA TGAAGGTGAT 1260

CAGCTGGCAT GTATGATTGA GTTACTGGGT ATGCCTTCTC AAAAGCTTCT AGATGCTTCA 1320

AAAAGGGGTA AAAATTTTTT TAGCTCCAAA GGTTACCCAC GCTATTGCAC TGTTACAAGT 1380

CTGCCTGATG GTTCCGTGGT ATTAAATGGT GGTCGTTCAC GAAGAGGTAA ACTAAGAGGC 1440

CCCCCTGGAA GTAGAGACTG GGTAACTGCT TTAAAGGGCT GCGATGATCC CCTGTTTCTT 1500

GATTTCCTGA CACAATGTTT AGAATGGGAT CCTTCTCTCC GGATGACACC TAGCCAAGCA 1560

CTGCGCCATC ATTGGTTAAG GAGGCGGTTG CCCAAGCCTC CAACTGGGGA AAAGATCTCC 1620

ACTAAAAGAA TAACAGAAAG CACTGGTGCT ATAACATCTA TTTCTAAGTT ACCTCCAACA 1680

TCAGGCTCAG CTGCAAAGTT AAGAACTAAT CTGACCCAGA TAACGGATGC CAATGGAAAT 1740

ATTCAGCAAA GGACAGTCTT GCCAAAGTTG GTTAGCTGA 1779

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 213   YEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNN  272

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 273   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  332

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 333   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGGRYG  391

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ k+ff++k+

Q: 392   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKG  451

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  d +++l+ ++++++k r +p+s+++++alk ++d lf d+l+++le+dp

Q: 452   YPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLTQCLEWDP  511

         ************************************************************

S: 301   akRitpkealkhpfv  315

         + R+tp++al+h+++

Q: 512   SLRMTPSQALRHHWL  526

         *************96

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKLHQHVALK MVRNEKRFHR QAAEEIRILE HLKKQDKDNN 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGGRYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR GKNFFSSKGY 240

PRYCTVTSLP DGSVVLNGGR SRRGKLRGPP GSRDWVTALK GCDDPLFLDF LTQCLEWDPS 300

LRMTPSQALR HHWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013