EKS-XET-00331

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00331

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	284.2	9.2E-85	55	313	259

Status

Reviewed

Ensembl Protein

ENSXETP00000016002

UniProt Accession

B1WAS2;

Protein Name

Hormonally up-regulated neu tumor-associated kinase homolog

Protein Synonyms/Alias

Serine/threonine-protein kinase MAK-V;

Gene Name

hunk

Gene Synonyms/Alias

hunk; makv;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007352	ENSXETP00000062495	ENSXETT00000060153
ENSXETG00000007352	ENSXETP00000016002	ENSXETT00000016002

Organism

Xenopus tropicalis

Functional Description

Protein Length

697

Protein Sequence
(FASTA)

MPAAAGDGLG ESPSRFLAGE KPPVQLAESF LPACVSSVSR ETLRTFQHTK RVGSYLIGRK 60

LGEGSFAKVR EGLHVGTGEK VAIKVIDKKK AKKDTYVTKN LRREGQIQQM IRHPNITQLL 120

DILETENSYY LVMELCTGGN LMHKIYERKR IEEHEARKYI RQLILAVEHL HRAGVVHRDL 180

KIENLLLDEN NNIKLIDFGL SNCAGILGYT DPFSTQCGSP AYAAPELLAR KKYGPKVDVW 240

SIGVNMYAML TGTLPFTVEP FSLRALYQKM VDKDMNPLPT HLSPAAISFL RSLLEPDPLK 300

RPNIQQALAN RWLNDNYHGK GLHTYPNRIH LEDLSQSVVL HMSEKLGYKH SDVINVILSN 360

RACHTLAVYF LLNRKLENYL LNMRKPDIND NVCHKNQFHQ LEKYKMNKNS YEERRSKDLE 420

KRGEQQQQQQ RAMQRKLEKC SPSHRQSNCL TPQGHISKGP VKERRSSKSE RESFGGLSPF 480

HEVRITKPGC MTSCSLEYLE MQSPDPRTPK IMRRQDSHSQ ETVNVNMGSR IRETHLNVVR 540

SFESVNREDQ IESLSPNHQY RVLGSPVSFS PRHSSERILS PIFQFDNTSP IKGHSNQASF 600

TYDDKSSPSS PESMSPTSPH SPHSPSCNNN ISGNLGSPNC VRSRGRFPMM GIGQMLRKRN 660

QVVSPKAEKP LETRMPALHQ MSPGYASFNS SDMNGFC 697

Nucleotide Sequence
(FASTA)

ATGCCGGCTG CCGCTGGGGA CGGGCTCGGC GAGTCGCCCT CCAGGTTCTT AGCCGGGGAG 60

AAGCCCCCCG TACAGCTGGC AGAGAGCTTC CTACCGGCCT GTGTCAGCTC CGTGTCCCGG 120

GAAACTCTGC GCACCTTCCA GCACACCAAG CGGGTCGGCA GCTACCTGAT CGGCCGGAAA 180

CTGGGGGAAG GCTCCTTTGC CAAAGTCCGA GAGGGGCTTC ATGTGGGCAC CGGAGAGAAG 240

GTGGCCATCA AGGTGATCGA TAAGAAGAAA GCCAAGAAGG ACACATATGT TACTAAGAAC 300

CTGCGGCGGG AGGGCCAGAT CCAACAAATG ATTAGGCACC CCAACATCAC CCAGCTCCTT 360

GACATTTTGG AGACAGAGAA CAGCTACTAT TTAGTCATGG AACTTTGCAC TGGGGGTAAC 420

CTCATGCACA AGATATACGA GAGGAAGAGA ATAGAGGAGC ACGAGGCAAG GAAATACATC 480

AGGCAACTTA TCTTGGCCGT GGAGCATCTG CACAGAGCAG GAGTCGTACA CAGAGACCTG 540

AAGATTGAAA ATCTGTTACT GGATGAGAAC AACAACATCA AGCTGATCGA TTTTGGACTG 600

AGCAACTGTG CTGGTATCCT GGGATACACC GACCCATTTA GTACACAGTG TGGGAGTCCC 660

GCCTATGCTG CCCCAGAATT ACTTGCAAGA AAGAAGTATG GCCCCAAAGT GGATGTTTGG 720

TCTATTGGCG TTAATATGTA TGCCATGCTG ACGGGCACGC TGCCATTCAC TGTGGAGCCT 780

TTCAGCCTGA GAGCTTTGTA CCAGAAGATG GTAGACAAAG ATATGAATCC TCTGCCCACC 840

CATCTCTCTC CGGCCGCCAT CAGCTTCCTC CGATCTCTGC TAGAACCCGA CCCTCTTAAG 900

CGGCCAAACA TACAACAAGC ACTGGCAAAC CGCTGGCTTA ACGATAATTA CCACGGCAAA 960

GGACTGCACA CCTACCCAAA CAGGATTCAC CTGGAAGATC TCAGCCAAAG CGTGGTGCTC 1020

CATATGTCCG AGAAACTTGG CTACAAACAC AGCGACGTTA TCAACGTCAT TCTCTCCAAC 1080

CGAGCTTGCC ATACCCTGGC TGTCTACTTC CTCCTAAACA GGAAACTCGA GAACTATTTA 1140

CTAAACATGC GGAAACCAGA CATCAATGAC AACGTGTGCC ACAAAAACCA GTTTCATCAG 1200

TTGGAAAAAT ACAAGATGAA CAAGAACTCT TATGAGGAAC GGAGAAGTAA GGATCTAGAG 1260

AAAAGAGGAG AGCAGCAGCA GCAGCAGCAA CGGGCCATGC AGAGGAAACT GGAGAAATGT 1320

TCCCCCTCAC ACAGGCAAAG TAACTGCCTG ACGCCACAAG GGCACATCAG CAAAGGGCCT 1380

GTTAAGGAAA GGAGATCCTC TAAGTCTGAG AGAGAATCCT TTGGAGGGCT AAGTCCTTTC 1440

CATGAAGTCA GGATAACCAA GCCGGGGTGC ATGACGTCTT GCTCGCTGGA GTATCTGGAA 1500

ATGCAAAGTC CAGACCCGAG GACCCCAAAG ATTATGAGAC GTCAAGATTC CCACTCCCAG 1560

GAGACTGTAA ATGTGAACAT GGGAAGCCGG ATAAGGGAAA CCCACCTCAA CGTTGTGCGT 1620

TCCTTTGAGT CCGTCAACAG GGAAGACCAA ATAGAATCGT TGTCCCCAAA TCACCAGTAC 1680

AGAGTTCTTG GGTCCCCAGT GTCCTTCTCT CCCAGGCATT CAAGTGAAAG AATTCTATCC 1740

CCAATCTTTC AGTTTGACAA CACATCCCCT ATAAAGGGCC ATTCCAATCA AGCGTCCTTC 1800

ACATACGATG ACAAAAGCAG TCCATCAAGT CCAGAATCAA TGTCGCCCAC TTCTCCCCAT 1860

TCCCCCCATT CCCCTTCTTG TAACAATAAC ATTTCTGGCA ATTTAGGAAG CCCCAACTGT 1920

GTGAGAAGTA GGGGCCGCTT CCCAATGATG GGCATTGGAC AGATGTTGAG GAAGAGAAAC 1980

CAAGTTGTAT CCCCCAAAGC AGAAAAGCCT CTTGAAACAC GTATGCCCGC ATTGCATCAG 2040

ATGAGCCCAG GCTATGCCAG CTTTAACTCA AGTGATATGA ATGGGTTTTG CTAG 2094

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y ++++lGegsf+kV++  h  t+ekva+K+i+kkk+  ++  +++++rE +i+++++hp

Q: 55    YLIGRKLGEGSFAKVREGLHVGTGEKVAIKVIDKKKAkkDTYVTKNLRREGQIQQMIRHP  114

         77899*****************************99854555688***************

S: 59    niikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskg  118

         ni++ll+++et++++ylv+e+++gg+L+++i e++r++e+eark+++ql+ av++lh+ g

Q: 115   NITQLLDILETENSYYLVMELCTGGNLMHKIYERKRIEEHEARKYIRQLILAVEHLHRAG  174

         ************************************************************

S: 119   ivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkgkkYe  175

         +vHrDlK eNllld+++nik++DFGl+n   ++ + + ++t+cGsp+YaaPell++kkY

Q: 175   VVHRDLKIENLLLDENNNIKLIDFGLSNcagILGYTDPFSTQCGSPAYAAPELLARKKY-  233

         ****************************77777888***********************.

S: 176   gpkvDvWslGvvLyalvtgklPfdee..nlkellekilkgkl.eipkklskelesLlrkl  232

         gpkvDvWs+Gv +ya++tg+lPf+ e  +l++l++k+ ++++  +p++ls+ ++s+lr+l

Q: 234   GPKVDVWSIGVNMYAMLTGTLPFTVEpfSLRALYQKMVDKDMnPLPTHLSPAAISFLRSL  293

         ************************998999*******99999789***************

S: 233   LvvdpekRatieeilkhewl  252

         L+ dp kR++i++ l+++wl

Q: 294   LEPDPLKRPNIQQALANRWL  313

         *******************7

Domain Sequence
(FASTA)

YLIGRKLGEG SFAKVREGLH VGTGEKVAIK VIDKKKAKKD TYVTKNLRRE GQIQQMIRHP 60

NITQLLDILE TENSYYLVME LCTGGNLMHK IYERKRIEEH EARKYIRQLI LAVEHLHRAG 120

VVHRDLKIEN LLLDENNNIK LIDFGLSNCA GILGYTDPFS TQCGSPAYAA PELLARKKYG 180

PKVDVWSIGV NMYAMLTGTL PFTVEPFSLR ALYQKMVDKD MNPLPTHLSP AAISFLRSLL 240

EPDPLKRPNI QQALANRWL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:100145703

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013