EKS-XET-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	514.2	5.0E-155	620	879	260

Status

Unreviewed

Ensembl Protein

ENSXETP00000016595

UniProt Accession

F6QKP3;

Protein Name

Protein Synonyms/Alias

Gene Name

epha4

Gene Synonyms/Alias

epha4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007614	ENSXETP00000016595	ENSXETT00000016595

Organism

Xenopus tropicalis

Functional Description

Protein Length

987

Protein Sequence
(FASTA)

MAGIVHGILF CGLFGLCWAV TGSRIYPASE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60

DEKNTPIRTY QVCNVMESSQ NNWLRTDWIP RSGAQRVYVE IKFTLRDCNS LPGVMGTCKE 120

TFNLYYYESN NDKERFIRET QYVKIDTIAA DESFTQVDIG DRIMKLNTEV RDVGPLSKKG 180

FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG SDTSSLVEVR GSCVDNSEEK 240

DVPKMYCGAD GEWLVPIGNC LCNAGFEERN GGCQACKVGY YKALSTDAAC SKCPPHSYAL 300

REGSTSCTCD RGYFRADTDP ASMPCTRPPS APQNLISNVN ETSVNLEWSP PQNSGGRPDV 360

TYNLVCKRCG SDLTRCRPCG SGVHYSPQQN GLKTTKVSIT DLQAHTNYTF EVWAINGVSK 420

QNPGQDQAVS VTVTTNQAAP STVTQIQPKE ITRHSVSLTW PEPERANGVI LEYEVKYYEK 480

DQNERSYRIV KTASRSADIK GLNPLTAYVF HVRARTAAGY GEFSGPFEFT TNTVPSPMIG 540

EGASPTVLLV SVAGSIVLVV ILIAAFVISR RRSKYSKAKQ EADEEKHLNQ GVKTYVDPFT 600

YEDPNQAVRE FAKEIDASCI KIEKVIGVVK GEFGEVCSGR LKVPGKREIY VAIKTLKAGY 660

TDKQRRDFLS EASIMGQFDH PNIIHLEGVV TKCKPVMIIT EYMENGSLDA FLRKNDGRFT 720

VIQLVGMLRG IGSGMKYLSD MSYVHRDLAA RNILVNSNLV CKVSDFGMSR VLEDDPEAAY 780

TTRGGKIPIR WTAPEAIAYR KFTSASDVWS YGIVMWEVMS YGERPYWDMS NQDVIKAIEE 840

GYRLPPPMDC PIALHQLMLD CWQKERSDRP KFGQIVSMLD KLIRNPNSLK RTGLDNSRTN 900

TALLDPSSPE WSQVASVLDW LQAIKMERYK DNFTAAGYTS LEAVVHVNQD DLTRIGISSP 960

SHQNKILSSV QGMRTQMQQM QGRMVPV 987

Nucleotide Sequence
(FASTA)

ATGGCTGGGA TTGTACATGG CATCTTGTTT TGTGGCCTCT TTGGACTTTG TTGGGCAGTG 60

ACGGGTTCTA GGATTTACCC AGCCAGTGAA GTTACCCTGC TGGATTCCAG GTCAGTGCAA 120

GGAGAACTTG GCTGGATAGC AAGTCCTTTA GAAGGAGGGT GGGAAGAAGT GAGTATCATG 180

GATGAAAAGA ATACACCTAT ACGAACTTAC CAAGTCTGCA ATGTGATGGA ATCAAGCCAA 240

AACAACTGGT TACGGACTGA CTGGATTCCA CGAAGTGGAG CTCAGAGAGT GTATGTTGAA 300

ATTAAATTTA CCTTAAGGGA CTGCAACAGC TTGCCTGGGG TAATGGGTAC CTGCAAAGAG 360

ACCTTTAATC TATATTATTA CGAGTCCAAC AATGACAAAG AGCGTTTCAT TCGTGAAACT 420

CAATATGTGA AAATTGATAC CATTGCAGCC GATGAGAGCT TCACCCAAGT TGATATTGGG 480

GACCGTATTA TGAAGCTGAA CACTGAGGTC AGAGATGTTG GGCCACTCAG TAAGAAGGGC 540

TTCTACTTGG CCTTTCAGGA TGTGGGAGCA TGCATTGCCC TTGTGTCTGT CCGGGTGTTC 600

TACAAGAAAT GCCCATTGAC TGTAAGAAAC CTGGCACAAT TCCCTGACAC CATTACTGGT 660

TCAGATACAT CTTCCTTGGT GGAAGTTCGA GGATCTTGTG TTGACAACTC AGAAGAGAAA 720

GATGTGCCTA AGATGTACTG TGGTGCTGAT GGAGAGTGGC TGGTGCCCAT TGGGAACTGC 780

TTGTGTAATG CTGGGTTTGA GGAGCGCAAT GGAGGATGCC AAGCCTGCAA AGTTGGATAC 840

TACAAAGCCC TCTCAACAGA TGCAGCTTGC TCCAAGTGTC CCCCCCACAG TTATGCTCTC 900

CGGGAAGGCT CGACCTCCTG CACCTGTGAC CGAGGCTATT TTCGGGCTGA CACTGACCCA 960

GCTTCAATGC CCTGCACCAG ACCCCCATCT GCTCCTCAGA ACCTAATTTC AAATGTCAAC 1020

GAGACTTCTG TGAATCTGGA GTGGAGTCCT CCACAGAATT CTGGTGGAAG ACCTGATGTC 1080

ACCTACAATT TGGTCTGTAA AAGGTGCGGT TCTGACCTGA CTCGCTGTCG GCCTTGTGGC 1140

AGTGGAGTGC ACTATAGCCC CCAGCAGAAT GGCCTGAAAA CTACCAAAGT GTCCATCACT 1200

GACCTGCAAG CCCATACCAA CTACACCTTT GAGGTCTGGG CCATTAATGG TGTCTCCAAG 1260

CAGAACCCAG GACAAGATCA GGCTGTGTCA GTTACTGTGA CCACCAACCA AGCAGCTCCT 1320

TCAACTGTAA CCCAGATACA GCCAAAAGAG ATAACCAGGC ACAGTGTTTC GTTGACTTGG 1380

CCAGAGCCTG AGCGTGCCAA TGGTGTCATC CTGGAATATG AAGTCAAGTA TTATGAAAAG 1440

GACCAGAACG AGCGTAGCTA CCGCATTGTT AAGACGGCGT CGCGGAGCGC AGACATCAAA 1500

GGTCTCAATC CCCTTACGGC CTATGTGTTC CATGTTCGTG CTCGGACTGC TGCAGGATAT 1560

GGGGAGTTTA GTGGACCCTT TGAGTTCACT ACAAATACAG TGCCATCGCC GATGATTGGT 1620

GAAGGAGCCA GCCCAACTGT GCTTTTGGTG TCCGTGGCTG GAAGCATTGT ACTTGTGGTC 1680

ATTCTCATTG CTGCTTTTGT CATCAGCAGA AGGCGGAGTA AATACAGTAA AGCCAAGCAG 1740

GAAGCAGATG AGGAAAAACA TTTAAACCAA GGAGTGAAGA CTTATGTGGA CCCATTTACT 1800

TATGAAGATC CTAACCAGGC CGTCCGTGAA TTTGCAAAGG AAATTGATGC CTCTTGTATT 1860

AAGATTGAGA AAGTAATTGG AGTAGTCAAA GGTGAATTTG GTGAAGTGTG CAGTGGGCGT 1920

CTGAAGGTCC CTGGAAAGAG GGAGATTTAT GTTGCAATTA AGACCCTGAA AGCTGGATAT 1980

ACAGATAAGC AGAGGAGAGA CTTTCTGAGT GAGGCTAGCA TCATGGGTCA GTTTGACCAT 2040

CCCAACATCA TCCACCTTGA AGGCGTTGTC ACCAAATGCA AGCCAGTCAT GATCATCACT 2100

GAGTACATGG AGAACGGATC CTTGGATGCA TTCCTTCGGA AGAACGACGG TCGGTTTACG 2160

GTGATACAGC TTGTGGGAAT GCTGCGTGGC ATTGGGTCTG GTATGAAATA CCTGTCTGAC 2220

ATGAGTTATG TACACCGGGA CCTAGCTGCT CGTAATATCC TAGTGAACAG CAACCTAGTC 2280

TGTAAGGTCT CTGACTTTGG GATGTCTCGG GTGCTAGAAG ATGACCCTGA AGCAGCCTAC 2340

ACAACCAGGG GTGGCAAGAT TCCAATTCGG TGGACGGCAC CAGAAGCTAT TGCATACAGA 2400

AAATTCACCT CTGCCAGTGA TGTCTGGAGC TATGGCATTG TAATGTGGGA AGTCATGTCT 2460

TATGGAGAGA GGCCTTACTG GGATATGTCC AATCAGGATG TCATTAAAGC AATTGAAGAA 2520

GGATACAGAC TGCCCCCACC TATGGACTGC CCTATCGCAC TGCATCAGCT CATGTTGGAC 2580

TGCTGGCAGA AGGAGCGTAG CGACCGACCC AAGTTTGGGC AGATAGTCAG CATGCTGGAT 2640

AAGCTCATCA GGAACCCAAA CAGCTTGAAA AGGACTGGGC TGGATAATTC AAGAACAAAC 2700

ACGGCTCTGC TGGACCCCAG CTCGCCTGAA TGGTCCCAGG TGGCTTCTGT GCTTGATTGG 2760

CTGCAGGCCA TCAAAATGGA AAGATACAAA GATAACTTCA CAGCAGCCGG ATACACCAGC 2820

TTGGAAGCAG TCGTGCATGT GAATCAAGAT GACTTGACCA GAATCGGCAT TAGTTCCCCC 2880

TCCCACCAGA ACAAGATTCT GAGCAGTGTC CAGGGAATGA GAACCCAGAT GCAGCAAATG 2940

CAAGGAAGGA TGGTTCCTGT TTGA 2964

Domain Profile

S: 1     vkiekviG..aGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfd  58

         +kiekviG  +GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfd

Q: 620   IKIEKVIGvvKGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTDKQRRDFLSEASIMGQFD  679

         79*****95569************************************************

S: 59    hpniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkyls  118

         hpnii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkyls

Q: 680   HPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS  739

         ************************************************************

S: 119   dmgyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiay  178

         dm+yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiay

Q: 740   DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY  799

         ************************************************************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlml

Q: 800   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLML  859

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcwqk+r++rpkf qivs+l

Q: 860   DCWQKERSDRPKFGQIVSML  879

         *****************986

Domain Sequence
(FASTA)

IKIEKVIGVV KGEFGEVCSG RLKVPGKREI YVAIKTLKAG YTDKQRRDFL SEASIMGQFD 60

HPNIIHLEGV VTKCKPVMII TEYMENGSLD AFLRKNDGRF TVIQLVGMLR GIGSGMKYLS 120

DMSYVHRDLA ARNILVNSNL VCKVSDFGMS RVLEDDPEAA YTTRGGKIPI RWTAPEAIAY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVIKAIE EGYRLPPPMD CPIALHQLML 240

DCWQKERSDR PKFGQIVSML 260

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013