EKS-XET-00306

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00306

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	315.8	2.5E-94	169	420	252

Status

Unreviewed

Ensembl Protein

ENSXETP00000059976

UniProt Accession

F6YUW6;

Protein Name

Protein Synonyms/Alias

Gene Name

map2k5

Gene Synonyms/Alias

map2k5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007809	ENSXETP00000059976	ENSXETT00000063070
ENSXETG00000007809	ENSXETP00000017054	ENSXETT00000017054

Organism

Xenopus tropicalis

Functional Description

Protein Length

449

Protein Sequence
(FASTA)

MLLFGFGLPL DMDSQALVIR IRIPDGGAVD WTVQPATQLL FRDILDVIGQ VLPDATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYCTMVL EQQGSGPLTE PLQIYPRACK PPGKRNIHGL 120

KVNTRAGSSS NSSPSVPDNI AGNSLKKSSA ELKKILANGQ INELDIQCRD ILGHGNGGTV 180

YKAYHVPSGK ILAVKVIPLD ITVELQRQIM SELEILYKCD SLYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKIPEQVL GRIAVAVLKG LTYLWSLKIL HRDVKPSNML VNTRGHVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERIAG EQYGIHSDVW SLGISFMELG IYRIPFLPQI 360

QKNHGSLMPL QILQCIVDEE CPVLPLGEFS ESFVHFITQC MRKPPKERPA PEELMDHPFI 420

VQFNDGNTEA VSMWVCRALE ERRMQSGQA 449

Nucleotide Sequence
(FASTA)

ATGCTGTTAT TTGGCTTCGG CCTGCCTCTG GACATGGATA GCCAGGCTCT GGTTATTCGG 60

ATACGAATCC CTGATGGGGG CGCCGTTGAC TGGACAGTAC AGCCGGCCAC TCAGTTGCTG 120

TTCCGGGACA TCTTGGATGT GATTGGTCAG GTTCTCCCAG ATGCAACAAC CACTGCCTTT 180

GAGTATGAAG ATGAGGATGG TGATCGGATT ACAGTTCGGA GTGATGAAGA AATGAAGGCC 240

ATGTTGTCAT ATTATTGCAC CATGGTCCTT GAGCAACAGG GGAGTGGCCC TCTGACTGAA 300

CCTCTGCAGA TCTATCCACG TGCCTGCAAG CCTCCCGGGA AGCGGAACAT ACATGGCCTC 360

AAGGTGAACA CCAGAGCCGG ATCTTCCAGT AACAGCAGTC CGTCTGTGCC AGACAATATT 420

GCCGGCAATA GCTTAAAGAA GTCCTCTGCT GAGCTGAAGA AGATTTTGGC TAATGGACAG 480

ATTAATGAGC TTGATATCCA GTGCCGTGAC ATTCTGGGGC ATGGAAATGG AGGGACCGTG 540

TATAAAGCAT ATCATGTGCC AAGTGGGAAG ATTCTGGCTG TAAAGGTCAT CCCATTAGAT 600

ATTACTGTGG AGCTGCAGAG ACAGATTATG TCAGAGCTGG AAATCCTGTA CAAGTGCGAT 660

TCTCTGTACA TAATTGGGTT TTACGGAGCA TTTTTTGTGG AAAACCGGAT TTCCATCTGT 720

ACTGAATTTA TGGATGGTGG ATCCCTGGAT GTGTACCGGA AGATTCCAGA ACAGGTCCTT 780

GGAAGAATTG CTGTTGCTGT ATTAAAAGGC TTGACTTACC TGTGGAGCTT AAAGATTTTA 840

CACAGAGATG TAAAGCCTTC TAACATGCTG GTGAACACAC GTGGCCATGT GAAGTTGTGC 900

GACTTTGGTG TGAGCACACA GTTGGTGAAT TCTATCGCCA AGACGTATGT GGGAACAAAC 960

GCTTATATGG CGCCAGAGCG TATTGCAGGA GAACAGTATG GAATCCACTC TGATGTCTGG 1020

AGTTTGGGCA TCTCTTTTAT GGAGTTAGGG ATCTATAGAA TCCCATTTCT TCCACAGATT 1080

CAGAAAAACC ACGGATCTTT AATGCCGCTC CAGATATTGC AATGCATTGT TGATGAGGAG 1140

TGTCCCGTGC TCCCTTTGGG TGAATTCTCA GAGTCCTTCG TACACTTCAT TACACAGTGT 1200

ATGAGAAAGC CACCAAAGGA GAGACCAGCA CCTGAAGAGC TAATGGATCA CCCTTTCATT 1260

GTCCAGTTTA ATGATGGCAA CACAGAAGCA GTGTCCATGT GGGTGTGCCG GGCACTGGAA 1320

GAGCGGAGGA TGCAAAGTGG ACAGGCGTGA 1350

Domain Profile

S: 4     leelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivkf  63

          + lG+Gngg+V+k+ h +sgkilavK i l+i+ e q+qi++ele+l k+ +s yi++f

Q: 169   RDILGHGNGGTVYKAYHVPSGKILAVKVIPLDITVELQRQIMSELEILYKC-DSLYIIGF  227

         5679***********************************************.********

S: 64    yGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkeklk  123

         yGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavav+k+l+yl+ +lk

Q: 228   YGAFFVENRISICTEFMDGGSLD-VYRK-------IPEQVLGRIAVAVLKGLTYLW-SLK  278

         ***********************.6876.......9********************.78*

S: 124   iiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvks  183

         i+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri g ++Y ++s

Q: 279   ILHRDVKPSNMLVNTRGHVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERIAG-EQYGIHS  337

         ****************************************************.*******

S: 184   dvWslGltlvelatgrypyeklke.......ilellkaivneeppklpeeefseefqefv  236

         dvWslG++++el + r p+ ++ +       +l+ l++iv+ee p+lp  efse+f++f+

Q: 338   DVWSLGISFMELGIYRIPFLPQIQknhgslmPLQILQCIVDEECPVLPLGEFSESFVHFI  397

         ******************8665555899999*****************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k +keRp  +el++h+fi

Q: 398   TQCMRKPPKERPAPEELMDHPFI  420

         **********************7

Domain Sequence
(FASTA)

RDILGHGNGG TVYKAYHVPS GKILAVKVIP LDITVELQRQ IMSELEILYK CDSLYIIGFY 60

GAFFVENRIS ICTEFMDGGS LDVYRKIPEQ VLGRIAVAVL KGLTYLWSLK ILHRDVKPSN 120

MLVNTRGHVK LCDFGVSTQL VNSIAKTYVG TNAYMAPERI AGEQYGIHSD VWSLGISFME 180

LGIYRIPFLP QIQKNHGSLM PLQILQCIVD EECPVLPLGE FSESFVHFIT QCMRKPPKER 240

PAPEELMDHP FI 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013