EKS-XET-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	622.2	1.0E-187	387	666	280

Status

Reviewed

Ensembl Protein

ENSXETP00000058437

UniProt Accession

Q08CW1;

Protein Name

Serine/threonine-protein kinase tousled-like 2

Protein Synonyms/Alias

Tousled-like kinase 2;

Gene Name

tlk2

Gene Synonyms/Alias

tlk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000007854	ENSXETP00000058437	ENSXETT00000062296
ENSXETG00000007854	ENSXETP00000017169	ENSXETT00000017169

Organism

Xenopus tropicalis

Functional Description

Negative regulator of amino acid starvation-inducedautophagy (By similarity).

Protein Length

697

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVAKAPL NSESSNQSLC SLGSLSDKEL EQTPEKKQND 60

QRNRKRKADP YETSQGKNTP RGHKISDYFE FACGSGPGTS PGRSVPPVAR SSPQHSLSNP 120

LPLPSQQCSP PSTAPVNPEH SCASFKHISV QHRCTQSDLT MDKISALENS KSSDLEKKEG 180

RIDDLLRVNC DLRRQMDEQK KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR 240

LRLGHFTTVR HGASFTEQWT DGYAFQNLIK QQERINTQRE EIERQRKMLA KRKPPAMGQT 300

PPANNEQKQR KNKTNGAENE ALTLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN 360

LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL 420

NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY 480

LKQHKLMTEK EARSIIMQIV NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG 540

LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL 600

YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR KEDRIDVQQL 660

ACDPYLLPHI RKSVSTSIPA NAAVASTSGS SNNSLSN 697

Nucleotide Sequence
(FASTA)

ATGATGGAAG AGTTGCATAG TCTGGATCCA AGGCGCCAGG AATTGTTGGA AGCACGGTTC 60

ACAGGGGTAG GTGTTGCAAA GGCTCCTTTA AACAGTGAAT CCTCCAACCA AAGTCTTTGC 120

AGTTTGGGTT CTCTGAGTGA CAAAGAACTT GAGCAGACTC CTGAGAAGAA GCAGAATGAT 180

CAGAGGAATC GGAAGAGAAA AGCAGATCCA TATGAAACTA GCCAAGGGAA GAACACTCCA 240

AGAGGACATA AAATTAGTGA TTATTTTGAG TTTGCTTGTG GAAGTGGACC GGGGACAAGC 300

CCAGGCAGAA GTGTTCCACC TGTAGCCCGA TCCTCACCAC AACATTCCTT ATCAAACCCA 360

TTACCTTTAC CGAGTCAGCA ATGCAGCCCT CCTTCTACTG CACCAGTGAA CCCAGAGCAT 420

TCCTGCGCGT CCTTTAAACA TATTTCCGTC CAGCACAGGT GCACACAGTC TGACCTCACA 480

ATGGATAAGA TATCTGCTCT TGAAAACAGC AAAAGTTCCG ACCTTGAAAA AAAGGAGGGA 540

AGAATAGATG ATTTATTAAG GGTAAACTGT GACCTAAGGC GACAGATGGA CGAGCAGAAG 600

AAAATGCTGG AAAAATATAA AGAACGGTTA AACAGATGCG TGACAATGAG CAAAAAGTTG 660

CTCATAGAGA AGTCTAAACA GGAGAAAATG GCTTGTCGGG ATAAAAGCAT GCAGGATCGC 720

CTGCGCCTGG GACACTTTAC TACTGTCCGA CATGGGGCCT CTTTCACTGA GCAGTGGACA 780

GATGGTTATG CCTTCCAGAA CCTTATCAAG CAACAAGAAC GTATAAATAC CCAAAGGGAG 840

GAGATTGAAA GGCAAAGAAA AATGCTGGCA AAACGGAAAC CACCTGCAAT GGGCCAAACC 900

CCTCCAGCCA ACAATGAGCA GAAGCAAAGA AAAAACAAGA CAAATGGAGC AGAGAATGAA 960

GCGTTGACAT TAGCAGAGTA CCATGAACAG GAAGAGATCT TCAAGCTAAG ATTAGGACAT 1020

CTTAAAAAGG AAGAAGCTGA AATTCAAGCA GAACTTGAAC GTCTCGAGAG AGTGAGGAAT 1080

TTGCACATTA GAGAGCTAAA AAGAATACAC AATGAAGATA ACTCACAATT TAAAGACCAT 1140

CCAACGCTAA ATGATCGATA TCTGTTGCTT CATCTTTTGG GTAGAGGAGG CTTCAGTGAA 1200

GTGTATAAGG CGTTTGACTT AACGGAGCAA AGATATGTAG CTGTGAAAAT TCACCAATTA 1260

AATAAAAATT GGAGGGATGA AAAGAAGGAA AATTACCATA AACATGCCTG CAGGGAGTAT 1320

CGTATCCACA AAGAGCTTGA CCATCCAAGG ATTGTGAAGC TGTATGACTA TTTCTCCCTT 1380

GACACAGACT CGTTTTGCAC TGTGCTCGAG TACTGCGAGG GAAATGATCT TGACTTCTAC 1440

TTGAAGCAGC ACAAGCTAAT GACAGAAAAG GAAGCTCGCT CTATCATCAT GCAGATTGTA 1500

AATGCCCTTA AGTACCTGAA TGAAATCAAA CCGCCCATTA TACATTATGA CCTGAAGCCA 1560

GGTAATATTC TGTTAGTCAA CGGTACTGCT TGTGGGGAGA TTAAAATCAC AGATTTTGGT 1620

CTTTCAAAAA TAATGGATGA TGACAGTTAT AATTCAGTTG ATGGAATGGA GCTTACATCA 1680

CAAGGAGCTG GAACCTACTG GTATCTGCCT CCTGAATGTT TTGTAGTTGG AAAAGAACCT 1740

CCAAAAATCT CAAACAAAGT GGATGTATGG TCTGTAGGAG TCATTTTCTA CCAGTGTTTG 1800

TATGGTCGGA AGCCCTTTGG ACACAACCAG TCCCAGCAAG ATATCCTGCA AGAAAACACC 1860

ATCTTAAAAG CCACAGAGGT GCAATTTCCT CCCAAGCCAG TTGTGACCCC TGAAGCCAAG 1920

GCTTTTATCC GTCGATGCCT CGCCTACAGG AAAGAAGATC GAATAGATGT GCAGCAGCTT 1980

GCTTGTGATC CTTACCTACT GCCACACATC CGCAAATCAG TCTCTACAAG TATCCCAGCC 2040

AACGCTGCTG TAGCGTCTAC ATCTGGTTCC TCCAATAATA GCTTGTCAAA CTGA 2094

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 387   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  446

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl++ekearsiimqiv+alkyl

Q: 447   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYL  506

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 507   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  566

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 567   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  626

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 627   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  666

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MTEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Coiled coil; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:780168

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013